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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLCB4
Full Name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4
Alias:
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; Phosphoinositide phospholipase C; Phospholipase C, beta 4; Phospholipase C-beta-4; PI-PLC; PLC-beta-4
Type:
Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase
Mass (Da):
134464
Number AA:
1175
UniProt ID:
Q15147
International Prot ID:
IPI00014897
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004435
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0016042
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
N
W
Q
K
E
V
P
S
F
L
Q
E
G
A
V
Site 2
Y26
E
G
A
V
F
D
R
Y
E
E
E
S
F
V
F
Site 3
T49
D
E
F
G
F
F
L
T
W
R
S
E
G
K
E
Site 4
S52
G
F
F
L
T
W
R
S
E
G
K
E
G
Q
V
Site 5
S63
E
G
Q
V
L
E
C
S
L
I
N
S
I
R
S
Site 6
S142
N
F
R
A
N
N
V
S
P
M
T
C
L
K
K
Site 7
S168
N
G
K
I
P
V
R
S
I
T
R
T
F
A
S
Site 8
T170
K
I
P
V
R
S
I
T
R
T
F
A
S
G
K
Site 9
T172
P
V
R
S
I
T
R
T
F
A
S
G
K
T
E
Site 10
T202
K
N
D
E
I
E
P
T
A
F
S
Y
E
K
F
Site 11
S205
E
I
E
P
T
A
F
S
Y
E
K
F
Y
E
L
Site 12
T234
K
K
I
N
G
D
K
T
D
Y
L
T
V
D
Q
Site 13
Y236
I
N
G
D
K
T
D
Y
L
T
V
D
Q
L
V
Site 14
T238
G
D
K
T
D
Y
L
T
V
D
Q
L
V
S
F
Site 15
S244
L
T
V
D
Q
L
V
S
F
L
N
E
H
Q
R
Site 16
Y263
N
E
I
L
F
P
F
Y
D
A
K
R
A
M
Q
Site 17
Y275
A
M
Q
I
I
E
M
Y
E
P
D
E
D
L
K
Site 18
S288
L
K
K
K
G
L
I
S
S
D
G
F
C
R
Y
Site 19
S289
K
K
K
G
L
I
S
S
D
G
F
C
R
Y
L
Site 20
Y295
S
S
D
G
F
C
R
Y
L
M
S
D
E
N
A
Site 21
Y312
F
L
D
R
L
E
L
Y
Q
E
M
D
H
P
L
Site 22
Y322
M
D
H
P
L
A
H
Y
F
I
S
S
S
H
N
Site 23
S325
P
L
A
H
Y
F
I
S
S
S
H
N
T
Y
L
Site 24
T330
F
I
S
S
S
H
N
T
Y
L
T
G
R
Q
F
Site 25
Y331
I
S
S
S
H
N
T
Y
L
T
G
R
Q
F
G
Site 26
T333
S
S
H
N
T
Y
L
T
G
R
Q
F
G
G
K
Site 27
S341
G
R
Q
F
G
G
K
S
S
V
E
M
Y
R
Q
Site 28
S342
R
Q
F
G
G
K
S
S
V
E
M
Y
R
Q
V
Site 29
Y346
G
K
S
S
V
E
M
Y
R
Q
V
L
L
A
G
Site 30
T374
E
D
Q
E
P
I
I
T
H
G
K
A
M
C
T
Site 31
S407
S
E
Y
P
V
I
L
S
F
E
N
H
C
S
K
Site 32
Y415
F
E
N
H
C
S
K
Y
Q
Q
Y
K
M
S
K
Site 33
Y423
Q
Q
Y
K
M
S
K
Y
C
E
D
L
F
G
D
Site 34
S439
L
L
K
Q
A
L
E
S
H
P
L
E
P
G
R
Site 35
S450
E
P
G
R
A
L
P
S
P
N
D
L
K
R
K
Site 36
S479
K
Q
L
E
A
L
R
S
M
M
E
A
G
E
S
Site 37
S486
S
M
M
E
A
G
E
S
A
S
P
A
N
I
L
Site 38
S488
M
E
A
G
E
S
A
S
P
A
N
I
L
E
D
Site 39
S503
D
N
E
E
E
I
E
S
A
D
Q
E
E
E
A
Site 40
S521
F
K
F
G
N
E
L
S
A
D
D
L
G
H
K
Site 41
T541
S
V
K
K
G
L
V
T
V
E
D
E
Q
A
W
Site 42
Y564
A
T
T
N
I
H
P
Y
L
S
T
M
I
N
Y
Site 43
Y571
Y
L
S
T
M
I
N
Y
A
Q
P
V
K
F
Q
Site 44
Y590
A
E
E
R
N
I
H
Y
N
M
S
S
F
N
E
Site 45
S594
N
I
H
Y
N
M
S
S
F
N
E
S
V
G
L
Site 46
S598
N
M
S
S
F
N
E
S
V
G
L
G
Y
L
K
Site 47
Y614
H
A
I
E
F
V
N
Y
N
K
R
Q
M
S
R
Site 48
S620
N
Y
N
K
R
Q
M
S
R
I
Y
P
K
G
G
Site 49
Y623
K
R
Q
M
S
R
I
Y
P
K
G
G
R
V
D
Site 50
S631
P
K
G
G
R
V
D
S
S
N
Y
M
P
Q
I
Site 51
S632
K
G
G
R
V
D
S
S
N
Y
M
P
Q
I
F
Site 52
Y634
G
R
V
D
S
S
N
Y
M
P
Q
I
F
W
N
Site 53
Y667
L
N
Q
G
K
F
E
Y
N
G
S
C
G
Y
L
Site 54
S670
G
K
F
E
Y
N
G
S
C
G
Y
L
L
K
P
Site 55
T686
F
M
R
R
P
D
R
T
F
D
P
F
S
E
T
Site 56
S691
D
R
T
F
D
P
F
S
E
T
P
V
D
G
V
Site 57
S714
V
I
S
G
Q
F
L
S
D
K
K
I
G
T
Y
Site 58
Y721
S
D
K
K
I
G
T
Y
V
E
V
D
M
Y
G
Site 59
T733
M
Y
G
L
P
T
D
T
I
R
K
E
F
R
T
Site 60
T740
T
I
R
K
E
F
R
T
R
M
V
M
N
N
G
Site 61
Y752
N
N
G
L
N
P
V
Y
N
E
E
S
F
V
F
Site 62
Y796
L
D
G
L
Q
A
G
Y
R
H
I
S
L
R
N
Site 63
S800
Q
A
G
Y
R
H
I
S
L
R
N
E
G
N
K
Site 64
S810
N
E
G
N
K
P
L
S
L
P
T
I
F
C
N
Site 65
S836
G
D
I
V
D
A
L
S
D
P
K
K
F
L
S
Site 66
S843
S
D
P
K
K
F
L
S
I
T
E
K
R
A
D
Site 67
T845
P
K
K
F
L
S
I
T
E
K
R
A
D
Q
M
Site 68
S860
R
A
M
G
I
E
T
S
D
I
A
D
V
P
S
Site 69
S867
S
D
I
A
D
V
P
S
D
T
S
K
N
D
K
Site 70
S870
A
D
V
P
S
D
T
S
K
N
D
K
K
G
K
Site 71
T886
N
T
A
K
A
N
V
T
P
Q
S
S
S
E
L
Site 72
S889
K
A
N
V
T
P
Q
S
S
S
E
L
R
P
T
Site 73
S890
A
N
V
T
P
Q
S
S
S
E
L
R
P
T
T
Site 74
S891
N
V
T
P
Q
S
S
S
E
L
R
P
T
T
T
Site 75
T896
S
S
S
E
L
R
P
T
T
T
A
A
L
A
S
Site 76
T897
S
S
E
L
R
P
T
T
T
A
A
L
A
S
G
Site 77
S973
A
Q
Y
D
K
E
K
S
T
H
E
K
I
L
E
Site 78
S989
A
M
K
K
K
G
G
S
N
C
L
E
M
K
K
Site 79
T998
C
L
E
M
K
K
E
T
E
I
K
I
Q
T
L
Site 80
T1004
E
T
E
I
K
I
Q
T
L
T
S
D
H
K
S
Site 81
T1006
E
I
K
I
Q
T
L
T
S
D
H
K
S
K
V
Site 82
S1007
I
K
I
Q
T
L
T
S
D
H
K
S
K
V
K
Site 83
S1011
T
L
T
S
D
H
K
S
K
V
K
E
I
V
A
Site 84
T1021
K
E
I
V
A
Q
H
T
K
E
W
S
E
M
I
Site 85
T1030
E
W
S
E
M
I
N
T
H
S
A
E
E
Q
E
Site 86
S1032
S
E
M
I
N
T
H
S
A
E
E
Q
E
I
R
Site 87
S1044
E
I
R
D
L
H
L
S
Q
Q
C
E
L
L
K
Site 88
S1068
Q
T
Q
Q
L
K
L
S
H
D
R
E
S
K
E
Site 89
S1073
K
L
S
H
D
R
E
S
K
E
M
R
A
H
Q
Site 90
S1084
R
A
H
Q
A
K
I
S
M
E
N
S
K
A
I
Site 91
S1088
A
K
I
S
M
E
N
S
K
A
I
S
Q
D
K
Site 92
S1092
M
E
N
S
K
A
I
S
Q
D
K
S
I
K
N
Site 93
S1096
K
A
I
S
Q
D
K
S
I
K
N
K
A
E
R
Site 94
S1113
R
V
R
E
L
N
S
S
N
T
K
K
F
L
E
Site 95
S1130
K
R
L
A
M
K
Q
S
K
E
M
D
Q
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation