KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PPA1
Full Name:
Inorganic pyrophosphatase
Alias:
EC 3.6.1.1; IPYR; PPase; Pyrophosphate phospho-hydrolase
Type:
Enzyme - Hydrolase
Mass (Da):
32660
Number AA:
289
UniProt ID:
Q15181
International Prot ID:
IPI00015018
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005829
GO:0044424
Uniprot
OncoNet
Molecular Function:
GO:0000287
GO:0003824
GO:0004427
PhosphoSite+
KinaseNET
Biological Process:
GO:0006793
GO:0006796
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
G
F
S
T
E
E
R
Site 2
S5
_
_
_
M
S
G
F
S
T
E
E
R
A
A
P
Site 3
T6
_
_
M
S
G
F
S
T
E
E
R
A
A
P
F
Site 4
S14
E
E
R
A
A
P
F
S
L
E
Y
R
V
F
L
Site 5
Y17
A
A
P
F
S
L
E
Y
R
V
F
L
K
N
E
Site 6
Y28
L
K
N
E
K
G
Q
Y
I
S
P
F
H
D
I
Site 7
S30
N
E
K
G
Q
Y
I
S
P
F
H
D
I
P
I
Site 8
Y38
P
F
H
D
I
P
I
Y
A
D
K
D
V
F
H
Site 9
S54
V
V
E
V
P
R
W
S
N
A
K
M
E
I
A
Site 10
Y80
V
K
K
G
K
L
R
Y
V
A
N
L
F
P
Y
Site 11
Y94
Y
K
G
Y
I
W
N
Y
G
A
I
P
Q
T
W
Site 12
T100
N
Y
G
A
I
P
Q
T
W
E
D
P
G
H
N
Site 13
T111
P
G
H
N
D
K
H
T
G
C
C
G
D
N
D
Site 14
Y182
V
K
R
L
K
P
G
Y
L
E
A
T
V
D
W
Site 15
T186
K
P
G
Y
L
E
A
T
V
D
W
F
R
R
Y
Site 16
Y193
T
V
D
W
F
R
R
Y
K
V
P
D
G
K
P
Site 17
T235
K
A
L
V
T
K
K
T
N
G
K
G
I
S
C
Site 18
S241
K
T
N
G
K
G
I
S
C
M
N
T
T
L
S
Site 19
T245
K
G
I
S
C
M
N
T
T
L
S
E
S
P
F
Site 20
T246
G
I
S
C
M
N
T
T
L
S
E
S
P
F
K
Site 21
S248
S
C
M
N
T
T
L
S
E
S
P
F
K
C
D
Site 22
S250
M
N
T
T
L
S
E
S
P
F
K
C
D
P
D
Site 23
S272
A
L
P
P
P
C
E
S
A
C
T
V
P
T
D
Site 24
T275
P
P
C
E
S
A
C
T
V
P
T
D
V
D
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation