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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPRK
Full Name:
Receptor-type tyrosine-protein phosphatase kappa
Alias:
EC 3.1.3.48; Protein tyrosine phosphatase, receptor type, K; Protein-tyrosine phosphatase kappa; PTPK; PTP-kappa; R-PTP-kappa
Type:
Receptor protein phosphatase, tyrosine; EC 3.1.3.48
Mass (Da):
162102
Number AA:
1439
UniProt ID:
Q15262
International Prot ID:
IPI00015756
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005912
GO:0009986
GO:0005911
Uniprot
OncoNet
Molecular Function:
GO:0008013
GO:0045295
GO:0019901
PhosphoSite+
KinaseNET
Biological Process:
GO:0016477
GO:0034644
GO:0034614
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
S
P
W
P
L
L
G
S
A
Q
G
Q
F
S
A
Site 2
Y630
K
G
A
P
I
S
A
Y
Q
I
V
V
E
E
L
Site 3
S777
V
I
L
I
V
K
K
S
K
L
A
K
K
R
K
Site 4
S804
M
V
N
A
M
D
R
S
Y
A
D
Q
S
T
L
Site 5
Y805
V
N
A
M
D
R
S
Y
A
D
Q
S
T
L
H
Site 6
T810
R
S
Y
A
D
Q
S
T
L
H
A
E
D
P
L
Site 7
S818
L
H
A
E
D
P
L
S
I
T
F
M
D
Q
H
Site 8
T820
A
E
D
P
L
S
I
T
F
M
D
Q
H
N
F
Site 9
S828
F
M
D
Q
H
N
F
S
P
R
Y
E
N
H
S
Site 10
Y831
Q
H
N
F
S
P
R
Y
E
N
H
S
A
T
A
Site 11
S835
S
P
R
Y
E
N
H
S
A
T
A
E
S
S
R
Site 12
T837
R
Y
E
N
H
S
A
T
A
E
S
S
R
L
L
Site 13
Y849
R
L
L
D
V
P
R
Y
L
C
E
G
T
E
S
Site 14
T854
P
R
Y
L
C
E
G
T
E
S
P
Y
Q
T
G
Site 15
S856
Y
L
C
E
G
T
E
S
P
Y
Q
T
G
Q
L
Site 16
Y858
C
E
G
T
E
S
P
Y
Q
T
G
Q
L
H
P
Site 17
T860
G
T
E
S
P
Y
Q
T
G
Q
L
H
P
A
I
Site 18
S884
N
L
M
K
T
S
D
S
Y
G
F
K
E
E
Y
Site 19
Y885
L
M
K
T
S
D
S
Y
G
F
K
E
E
Y
E
Site 20
Y891
S
Y
G
F
K
E
E
Y
E
S
F
F
E
G
Q
Site 21
S893
G
F
K
E
E
Y
E
S
F
F
E
G
Q
S
A
Site 22
S901
F
F
E
G
Q
S
A
S
W
D
V
A
K
K
D
Site 23
Y916
Q
N
R
A
K
N
R
Y
G
N
I
I
A
Y
D
Site 24
Y922
R
Y
G
N
I
I
A
Y
D
H
S
R
V
I
L
Site 25
S937
Q
P
V
E
D
D
P
S
S
D
Y
I
N
A
N
Site 26
S938
P
V
E
D
D
P
S
S
D
Y
I
N
A
N
Y
Site 27
Y940
E
D
D
P
S
S
D
Y
I
N
A
N
Y
I
D
Site 28
Y945
S
D
Y
I
N
A
N
Y
I
D
G
Y
Q
R
P
Site 29
Y949
N
A
N
Y
I
D
G
Y
Q
R
P
S
H
Y
I
Site 30
Y955
G
Y
Q
R
P
S
H
Y
I
A
T
Q
G
P
V
Site 31
T958
R
P
S
H
Y
I
A
T
Q
G
P
V
H
E
T
Site 32
Y998
G
R
V
K
C
Y
K
Y
W
P
D
D
T
E
V
Site 33
T1028
E
Y
V
V
R
T
F
T
L
E
R
R
G
Y
N
Site 34
Y1034
F
T
L
E
R
R
G
Y
N
E
I
R
E
V
K
Site 35
Y1055
W
P
D
H
G
V
P
Y
H
A
T
G
L
L
S
Site 36
S1070
F
I
R
R
V
K
L
S
N
P
P
S
A
G
P
Site 37
Y1111
R
E
G
V
V
D
I
Y
N
C
V
K
A
L
R
Site 38
Y1158
V
C
E
F
K
A
A
Y
F
D
M
I
R
I
D
Site 39
S1166
F
D
M
I
R
I
D
S
Q
T
N
S
S
H
L
Site 40
T1168
M
I
R
I
D
S
Q
T
N
S
S
H
L
K
D
Site 41
S1170
R
I
D
S
Q
T
N
S
S
H
L
K
D
E
F
Site 42
S1182
D
E
F
Q
T
L
N
S
V
T
P
R
L
Q
A
Site 43
T1184
F
Q
T
L
N
S
V
T
P
R
L
Q
A
E
D
Site 44
S1193
R
L
Q
A
E
D
C
S
I
A
C
L
P
R
N
Site 45
Y1229
I
D
G
E
S
S
N
Y
I
N
A
A
L
M
D
Site 46
T1254
T
Q
Y
P
L
P
N
T
V
K
D
F
W
R
L
Site 47
Y1263
K
D
F
W
R
L
V
Y
D
Y
G
C
T
S
I
Site 48
Y1285
L
S
Q
G
C
P
Q
Y
W
P
E
E
G
M
L
Site 49
Y1294
P
E
E
G
M
L
R
Y
G
P
I
Q
V
E
C
Site 50
T1321
I
F
R
I
C
N
L
T
R
P
Q
E
G
Y
L
Site 51
Y1327
L
T
R
P
Q
E
G
Y
L
M
V
Q
Q
F
Q
Site 52
Y1335
L
M
V
Q
Q
F
Q
Y
L
G
W
A
S
H
R
Site 53
S1340
F
Q
Y
L
G
W
A
S
H
R
E
V
P
G
S
Site 54
S1347
S
H
R
E
V
P
G
S
K
R
S
F
L
K
L
Site 55
S1350
E
V
P
G
S
K
R
S
F
L
K
L
I
L
Q
Site 56
T1410
D
V
F
H
A
V
K
T
L
R
N
S
K
P
N
Site 57
S1414
A
V
K
T
L
R
N
S
K
P
N
M
V
E
A
Site 58
Y1429
P
E
Q
Y
R
F
C
Y
D
V
A
L
E
Y
L
Site 59
Y1435
C
Y
D
V
A
L
E
Y
L
E
S
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation