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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IRF-4
Full Name:
Interferon regulatory factor 4
Alias:
LSIRF; Lymphocyte-specific interferon regulatory factor; Multiple myeloma oncogene 1; MUM1; NF-EM5
Type:
Transcription factor
Mass (Da):
51772
Number AA:
451
UniProt ID:
Q15306
International Prot ID:
IPI00215970
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003702
GO:0016563
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0042110
GO:0045082
GO:0045368
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
R
G
G
E
F
G
M
S
A
V
S
C
G
N
G
Site 2
S34
W
L
I
D
Q
I
D
S
G
K
Y
P
G
L
V
Site 3
Y37
D
Q
I
D
S
G
K
Y
P
G
L
V
W
E
N
Site 4
Y62
K
H
A
G
K
Q
D
Y
N
R
E
E
D
A
A
Site 5
T92
I
D
K
P
D
P
P
T
W
K
T
R
L
R
C
Site 6
T95
P
D
P
P
T
W
K
T
R
L
R
C
A
L
N
Site 7
S104
L
R
C
A
L
N
K
S
N
D
F
E
E
L
V
Site 8
S119
E
R
S
Q
L
D
I
S
D
P
Y
K
V
Y
R
Site 9
Y122
Q
L
D
I
S
D
P
Y
K
V
Y
R
I
V
P
Site 10
Y125
I
S
D
P
Y
K
V
Y
R
I
V
P
E
G
A
Site 11
T140
K
K
G
A
K
Q
L
T
L
E
D
P
Q
M
S
Site 12
T153
M
S
M
S
H
P
Y
T
M
T
T
P
Y
P
S
Site 13
T156
S
H
P
Y
T
M
T
T
P
Y
P
S
L
P
A
Site 14
Y158
P
Y
T
M
T
T
P
Y
P
S
L
P
A
Q
Q
Site 15
S160
T
M
T
T
P
Y
P
S
L
P
A
Q
Q
V
H
Site 16
Y169
P
A
Q
Q
V
H
N
Y
M
M
P
P
L
D
R
Site 17
Y181
L
D
R
S
W
R
D
Y
V
P
D
Q
P
H
P
Site 18
Y192
Q
P
H
P
E
I
P
Y
Q
C
P
M
T
F
G
Site 19
S228
Y
A
C
A
P
P
E
S
Q
A
P
G
V
P
T
Site 20
S238
P
G
V
P
T
E
P
S
I
R
S
A
E
A
L
Site 21
T267
E
I
L
V
K
E
L
T
T
S
S
P
E
G
C
Site 22
T268
I
L
V
K
E
L
T
T
S
S
P
E
G
C
R
Site 23
S270
V
K
E
L
T
T
S
S
P
E
G
C
R
I
S
Site 24
S277
S
P
E
G
C
R
I
S
H
G
H
T
Y
D
A
Site 25
T281
C
R
I
S
H
G
H
T
Y
D
A
S
N
L
D
Site 26
Y282
R
I
S
H
G
H
T
Y
D
A
S
N
L
D
Q
Site 27
Y294
L
D
Q
V
L
F
P
Y
P
E
D
N
G
Q
R
Site 28
S309
K
N
I
E
K
L
L
S
H
L
E
R
G
V
V
Site 29
Y325
W
M
A
P
D
G
L
Y
A
K
R
L
C
Q
S
Site 30
Y335
R
L
C
Q
S
R
I
Y
W
D
G
P
L
A
L
Site 31
T355
N
K
L
E
R
D
Q
T
C
K
L
F
D
T
Q
Site 32
T361
Q
T
C
K
L
F
D
T
Q
Q
F
L
S
E
L
Site 33
S377
A
F
A
H
H
G
R
S
L
P
R
F
Q
V
T
Site 34
Y414
P
L
L
A
R
Q
L
Y
Y
F
A
Q
Q
N
S
Site 35
Y415
L
L
A
R
Q
L
Y
Y
F
A
Q
Q
N
S
G
Site 36
Y428
S
G
H
F
L
R
G
Y
D
L
P
E
H
I
S
Site 37
S435
Y
D
L
P
E
H
I
S
N
P
E
D
Y
H
R
Site 38
Y440
H
I
S
N
P
E
D
Y
H
R
S
I
R
H
S
Site 39
S443
N
P
E
D
Y
H
R
S
I
R
H
S
S
I
Q
Site 40
S447
Y
H
R
S
I
R
H
S
S
I
Q
E
_
_
_
Site 41
S448
H
R
S
I
R
H
S
S
I
Q
E
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation