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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LLGL1
Full Name:
Lethal(2) giant larvae protein homolog 1
Alias:
DLG4; HUGL; Hugl-1; Human homolog to the D-lgl gene protein; L2GL1; Lethal giant larvae 1; Lethal(2) giant larvae 1; LLGL
Type:
Cytoskeletal protein; Adhesion
Mass (Da):
115418
Number AA:
1064
UniProt ID:
Q15334
International Prot ID:
IPI00105532
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030864
Uniprot
OncoNet
Molecular Function:
GO:0019901
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0030866
GO:0006887
GO:0006461
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T28
E
L
F
A
F
N
K
T
V
E
H
G
F
P
N
Site 2
T77
G
L
H
R
D
A
A
T
V
T
Q
M
H
F
L
Site 3
T79
H
R
D
A
A
T
V
T
Q
M
H
F
L
T
G
Site 4
S92
T
G
Q
G
R
L
L
S
L
L
D
D
S
S
L
Site 5
S118
A
H
L
E
E
A
L
S
F
Q
L
P
S
R
P
Site 6
S123
A
L
S
F
Q
L
P
S
R
P
G
F
D
G
A
Site 7
S131
R
P
G
F
D
G
A
S
A
P
L
S
L
T
R
Site 8
S184
A
P
G
E
V
L
R
S
V
P
D
D
Y
R
C
Site 9
Y189
L
R
S
V
P
D
D
Y
R
C
G
K
A
L
G
Site 10
S200
K
A
L
G
P
V
E
S
L
Q
G
H
L
R
D
Site 11
T209
Q
G
H
L
R
D
P
T
K
I
L
I
G
Y
S
Site 12
S242
L
G
N
Q
Q
L
E
S
L
C
W
G
R
D
S
Site 13
S249
S
L
C
W
G
R
D
S
S
T
V
V
S
S
H
Site 14
S250
L
C
W
G
R
D
S
S
T
V
V
S
S
H
S
Site 15
T251
C
W
G
R
D
S
S
T
V
V
S
S
H
S
D
Site 16
S254
R
D
S
S
T
V
V
S
S
H
S
D
G
S
Y
Site 17
S255
D
S
S
T
V
V
S
S
H
S
D
G
S
Y
A
Site 18
S257
S
T
V
V
S
S
H
S
D
G
S
Y
A
V
W
Site 19
S260
V
S
S
H
S
D
G
S
Y
A
V
W
S
V
D
Site 20
Y261
S
S
H
S
D
G
S
Y
A
V
W
S
V
D
A
Site 21
S265
D
G
S
Y
A
V
W
S
V
D
A
G
S
F
P
Site 22
T277
S
F
P
T
L
Q
P
T
V
A
T
T
P
Y
G
Site 23
S316
S
G
G
M
P
R
A
S
Y
G
D
R
H
C
V
Site 24
Y317
G
G
M
P
R
A
S
Y
G
D
R
H
C
V
S
Site 25
S324
Y
G
D
R
H
C
V
S
V
L
R
A
E
T
L
Site 26
T345
S
R
I
I
D
F
F
T
V
H
S
T
R
P
E
Site 27
S348
I
D
F
F
T
V
H
S
T
R
P
E
D
E
F
Site 28
S414
K
L
W
A
R
I
V
S
A
G
E
Q
Q
S
P
Site 29
S420
V
S
A
G
E
Q
Q
S
P
Q
P
V
S
S
A
Site 30
S425
Q
Q
S
P
Q
P
V
S
S
A
L
S
W
P
I
Site 31
S426
Q
S
P
Q
P
V
S
S
A
L
S
W
P
I
T
Site 32
S429
Q
P
V
S
S
A
L
S
W
P
I
T
G
G
R
Site 33
T433
S
A
L
S
W
P
I
T
G
G
R
N
L
A
Q
Site 34
S443
R
N
L
A
Q
E
P
S
Q
R
G
L
L
L
T
Site 35
T450
S
Q
R
G
L
L
L
T
G
H
E
D
G
T
V
Site 36
T456
L
T
G
H
E
D
G
T
V
R
F
W
D
A
S
Site 37
T475
R
P
L
Y
K
L
S
T
A
G
L
F
Q
T
D
Site 38
S488
T
D
C
E
H
A
D
S
L
A
Q
A
A
E
D
Site 39
Y509
K
V
G
C
F
D
P
Y
S
D
D
P
R
L
G
Site 40
S510
V
G
C
F
D
P
Y
S
D
D
P
R
L
G
V
Site 41
T567
L
Q
D
R
E
G
F
T
W
K
G
H
E
R
L
Site 42
S575
W
K
G
H
E
R
L
S
P
R
T
G
P
L
P
Site 43
T578
H
E
R
L
S
P
R
T
G
P
L
P
W
P
A
Site 44
Y626
H
G
F
G
L
F
D
Y
Q
R
K
S
P
V
L
Site 45
S630
L
F
D
Y
Q
R
K
S
P
V
L
A
R
C
T
Site 46
T637
S
P
V
L
A
R
C
T
L
H
P
N
D
S
L
Site 47
S643
C
T
L
H
P
N
D
S
L
A
M
E
G
P
L
Site 48
S651
L
A
M
E
G
P
L
S
R
V
K
S
L
K
K
Site 49
S655
G
P
L
S
R
V
K
S
L
K
K
S
L
R
Q
Site 50
S659
R
V
K
S
L
K
K
S
L
R
Q
S
F
R
R
Site 51
S663
L
K
K
S
L
R
Q
S
F
R
R
I
R
K
S
Site 52
S670
S
F
R
R
I
R
K
S
R
V
S
G
K
K
R
Site 53
S673
R
I
R
K
S
R
V
S
G
K
K
R
A
A
N
Site 54
S682
K
K
R
A
A
N
A
S
S
K
L
Q
E
A
N
Site 55
T704
C
P
H
D
V
E
M
T
P
V
Q
R
R
I
E
Site 56
S714
Q
R
R
I
E
P
R
S
A
D
D
S
L
S
G
Site 57
S718
E
P
R
S
A
D
D
S
L
S
G
V
V
R
C
Site 58
S720
R
S
A
D
D
S
L
S
G
V
V
R
C
L
Y
Site 59
T837
E
E
Q
F
K
V
F
T
L
P
K
V
S
A
K
Site 60
Y901
G
L
R
P
Q
V
H
Y
S
C
I
R
K
E
D
Site 61
S902
L
R
P
Q
V
H
Y
S
C
I
R
K
E
D
I
Site 62
Y925
T
R
H
G
Q
G
F
Y
L
I
S
P
S
E
F
Site 63
S928
G
Q
G
F
Y
L
I
S
P
S
E
F
E
R
F
Site 64
S936
P
S
E
F
E
R
F
S
L
S
A
R
N
I
T
Site 65
S938
E
F
E
R
F
S
L
S
A
R
N
I
T
E
P
Site 66
T943
S
L
S
A
R
N
I
T
E
P
L
C
S
L
D
Site 67
T958
I
N
W
P
R
D
A
T
Q
A
S
Y
R
I
R
Site 68
S961
P
R
D
A
T
Q
A
S
Y
R
I
R
E
S
P
Site 69
Y962
R
D
A
T
Q
A
S
Y
R
I
R
E
S
P
K
Site 70
S967
A
S
Y
R
I
R
E
S
P
K
L
S
Q
A
N
Site 71
S971
I
R
E
S
P
K
L
S
Q
A
N
G
T
P
S
Site 72
S978
S
Q
A
N
G
T
P
S
I
L
L
A
P
Q
S
Site 73
S985
S
I
L
L
A
P
Q
S
L
D
G
S
P
D
P
Site 74
S989
A
P
Q
S
L
D
G
S
P
D
P
A
H
S
M
Site 75
S995
G
S
P
D
P
A
H
S
M
G
P
D
T
P
E
Site 76
T1000
A
H
S
M
G
P
D
T
P
E
P
P
E
A
A
Site 77
S1009
E
P
P
E
A
A
L
S
P
M
S
I
D
S
A
Site 78
S1015
L
S
P
M
S
I
D
S
A
T
S
A
D
T
T
Site 79
T1017
P
M
S
I
D
S
A
T
S
A
D
T
T
L
D
Site 80
T1022
S
A
T
S
A
D
T
T
L
D
T
T
G
D
V
Site 81
T1025
S
A
D
T
T
L
D
T
T
G
D
V
T
V
E
Site 82
T1026
A
D
T
T
L
D
T
T
G
D
V
T
V
E
D
Site 83
T1030
L
D
T
T
G
D
V
T
V
E
D
V
K
D
F
Site 84
S1040
D
V
K
D
F
L
G
S
S
E
E
S
E
K
N
Site 85
S1041
V
K
D
F
L
G
S
S
E
E
S
E
K
N
L
Site 86
S1044
F
L
G
S
S
E
E
S
E
K
N
L
R
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation