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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PCBP1
Full Name:
Poly(rC)-binding protein 1
Alias:
Alpha-CP1; Heterogeneous nuclear ribonucleoprotein E1; HnRNP-E1; HNRPE1; HNRPX; Nucleic acid binding protein SUB2.3; PCB1; Poly (rC) binding protein 1
Type:
Translation; RNA binding protein
Mass (Da):
37498
Number AA:
356
UniProt ID:
Q15365
International Prot ID:
IPI00016610
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0030529
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003697
PhosphoSite+
KinaseNET
Biological Process:
GO:0000375
GO:0000377
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S35
I
I
G
K
K
G
E
S
V
K
R
I
R
E
E
Site 2
S43
V
K
R
I
R
E
E
S
G
A
R
I
N
I
S
Site 3
S50
S
G
A
R
I
N
I
S
E
G
N
C
P
E
R
Site 4
T60
N
C
P
E
R
I
I
T
L
T
G
P
T
N
A
Site 5
S85
K
L
E
E
D
I
N
S
S
M
T
N
S
T
A
Site 6
S86
L
E
E
D
I
N
S
S
M
T
N
S
T
A
A
Site 7
S90
I
N
S
S
M
T
N
S
T
A
A
S
R
P
P
Site 8
S94
M
T
N
S
T
A
A
S
R
P
P
V
T
L
R
Site 9
S126
K
I
K
E
I
R
E
S
T
G
A
Q
V
Q
V
Site 10
T127
I
K
E
I
R
E
S
T
G
A
Q
V
Q
V
A
Site 11
S141
A
G
D
M
L
P
N
S
T
E
R
A
I
T
I
Site 12
T142
G
D
M
L
P
N
S
T
E
R
A
I
T
I
A
Site 13
T147
N
S
T
E
R
A
I
T
I
A
G
V
P
Q
S
Site 14
S171
L
V
M
L
E
T
L
S
Q
S
P
Q
G
R
V
Site 15
S173
M
L
E
T
L
S
Q
S
P
Q
G
R
V
M
T
Site 16
T180
S
P
Q
G
R
V
M
T
I
P
Y
Q
P
M
P
Site 17
Y183
G
R
V
M
T
I
P
Y
Q
P
M
P
A
S
S
Site 18
S189
P
Y
Q
P
M
P
A
S
S
P
V
I
C
A
G
Site 19
S190
Y
Q
P
M
P
A
S
S
P
V
I
C
A
G
G
Site 20
S202
A
G
G
Q
D
R
C
S
D
A
A
G
Y
P
H
Site 21
Y207
R
C
S
D
A
A
G
Y
P
H
A
T
H
D
L
Site 22
T211
A
A
G
Y
P
H
A
T
H
D
L
E
G
P
P
Site 23
Y222
E
G
P
P
L
D
A
Y
S
I
Q
G
Q
H
T
Site 24
S223
G
P
P
L
D
A
Y
S
I
Q
G
Q
H
T
I
Site 25
T229
Y
S
I
Q
G
Q
H
T
I
S
P
L
D
L
A
Site 26
S231
I
Q
G
Q
H
T
I
S
P
L
D
L
A
K
L
Site 27
S246
N
Q
V
A
R
Q
Q
S
H
F
A
M
M
H
G
Site 28
T255
F
A
M
M
H
G
G
T
G
F
A
G
I
D
S
Site 29
S262
T
G
F
A
G
I
D
S
S
S
P
E
V
K
G
Site 30
S263
G
F
A
G
I
D
S
S
S
P
E
V
K
G
Y
Site 31
S264
F
A
G
I
D
S
S
S
P
E
V
K
G
Y
W
Site 32
Y270
S
S
P
E
V
K
G
Y
W
A
S
L
D
A
S
Site 33
S273
E
V
K
G
Y
W
A
S
L
D
A
S
T
Q
T
Site 34
S277
Y
W
A
S
L
D
A
S
T
Q
T
T
H
E
L
Site 35
T281
L
D
A
S
T
Q
T
T
H
E
L
T
I
P
N
Site 36
S309
I
N
E
I
R
Q
M
S
G
A
Q
I
K
I
A
Site 37
S323
A
N
P
V
E
G
S
S
G
R
Q
V
T
I
T
Site 38
T328
G
S
S
G
R
Q
V
T
I
T
G
S
A
A
S
Site 39
T330
S
G
R
Q
V
T
I
T
G
S
A
A
S
I
S
Site 40
S337
T
G
S
A
A
S
I
S
L
A
Q
Y
L
I
N
Site 41
Y341
A
S
I
S
L
A
Q
Y
L
I
N
A
R
L
S
Site 42
S348
Y
L
I
N
A
R
L
S
S
E
K
G
M
G
C
Site 43
S349
L
I
N
A
R
L
S
S
E
K
G
M
G
C
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation