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Updated November 2019
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Protein Info
Short Name:
RYR3
Full Name:
Ryanodine receptor 3
Alias:
Brain ryanodine receptor-calcium release channel; Brain-type ryanodine receptor; HBRR; RYR-3
Type:
Channel, calcium
Mass (Da):
551932
Number AA:
4870
UniProt ID:
Q15413
International Prot ID:
IPI00329784
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016020
GO:0016021
GO:0031224
Uniprot
OncoNet
Molecular Function:
GO:0004871
GO:0004872
GO:0005215
PhosphoSite+
KinaseNET
Biological Process:
GO:0006810
GO:0006811
GO:0006812
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S54
L
C
F
L
E
P
T
S
E
A
K
Y
I
P
P
Site 2
Y58
E
P
T
S
E
A
K
Y
I
P
P
D
L
C
V
Site 3
Y119
R
H
S
F
S
G
M
Y
L
T
C
L
T
T
S
Site 4
T121
S
F
S
G
M
Y
L
T
C
L
T
T
S
R
S
Site 5
T124
G
M
Y
L
T
C
L
T
T
S
R
S
Q
T
D
Site 6
T125
M
Y
L
T
C
L
T
T
S
R
S
Q
T
D
K
Site 7
S128
T
C
L
T
T
S
R
S
Q
T
D
K
L
A
F
Site 8
T130
L
T
T
S
R
S
Q
T
D
K
L
A
F
D
V
Site 9
S160
H
P
A
S
K
Q
R
S
E
G
E
K
V
R
I
Site 10
S177
D
L
I
L
V
S
V
S
S
E
R
Y
L
H
L
Site 11
S178
L
I
L
V
S
V
S
S
E
R
Y
L
H
L
S
Site 12
Y181
V
S
V
S
S
E
R
Y
L
H
L
S
V
S
N
Site 13
S185
S
E
R
Y
L
H
L
S
V
S
N
G
N
I
Q
Site 14
S187
R
Y
L
H
L
S
V
S
N
G
N
I
Q
V
D
Site 15
T207
T
L
W
N
V
H
P
T
C
S
G
S
S
I
E
Site 16
S209
W
N
V
H
P
T
C
S
G
S
S
I
E
E
G
Site 17
S211
V
H
P
T
C
S
G
S
S
I
E
E
G
Y
L
Site 18
T235
H
G
H
D
E
C
L
T
I
P
S
T
D
Q
N
Site 19
T239
E
C
L
T
I
P
S
T
D
Q
N
D
S
Q
H
Site 20
S244
P
S
T
D
Q
N
D
S
Q
H
R
R
I
F
Y
Site 21
Y251
S
Q
H
R
R
I
F
Y
E
A
G
G
A
G
T
Site 22
S261
G
G
A
G
T
R
A
S
S
L
W
R
V
E
P
Site 23
S262
G
A
G
T
R
A
S
S
L
W
R
V
E
P
L
Site 24
S272
R
V
E
P
L
R
I
S
W
S
G
S
N
I
R
Site 25
S274
E
P
L
R
I
S
W
S
G
S
N
I
R
W
G
Site 26
S276
L
R
I
S
W
S
G
S
N
I
R
W
G
Q
A
Site 27
Y294
R
H
L
T
T
G
H
Y
L
A
L
T
E
D
Q
Site 28
S311
I
L
Q
D
R
A
K
S
D
T
K
S
T
A
F
Site 29
T313
Q
D
R
A
K
S
D
T
K
S
T
A
F
S
F
Site 30
S315
R
A
K
S
D
T
K
S
T
A
F
S
F
R
A
Site 31
S319
D
T
K
S
T
A
F
S
F
R
A
S
K
E
L
Site 32
S323
T
A
F
S
F
R
A
S
K
E
L
K
E
K
L
Site 33
S332
E
L
K
E
K
L
D
S
S
H
K
R
D
I
E
Site 34
S333
L
K
E
K
L
D
S
S
H
K
R
D
I
E
G
Site 35
T373
Y
K
A
Q
D
A
K
T
S
R
L
G
P
L
K
Site 36
T396
G
H
M
D
D
G
L
T
L
Q
R
C
Q
R
E
Site 37
S405
Q
R
C
Q
R
E
E
S
Q
A
A
R
I
I
R
Site 38
T414
A
A
R
I
I
R
N
T
T
A
L
F
S
Q
F
Site 39
S419
R
N
T
T
A
L
F
S
Q
F
V
S
G
N
N
Site 40
S423
A
L
F
S
Q
F
V
S
G
N
N
R
T
A
A
Site 41
Y449
T
L
Q
D
L
I
A
Y
F
Q
P
P
E
E
E
Site 42
S468
D
K
Q
N
K
L
R
S
L
K
N
R
Q
N
L
Site 43
S509
A
G
I
A
R
E
E
S
G
M
A
W
K
E
I
Site 44
S547
N
N
L
D
W
L
I
S
K
L
D
R
L
E
S
Site 45
S554
S
K
L
D
R
L
E
S
S
S
G
I
L
E
V
Site 46
S556
L
D
R
L
E
S
S
S
G
I
L
E
V
L
H
Site 47
S586
G
H
I
K
S
I
I
S
L
L
D
K
H
G
R
Site 48
T640
T
R
L
I
N
D
V
T
S
I
R
P
N
I
F
Site 49
Y661
S
A
Q
Y
K
K
W
Y
F
E
L
I
I
D
Q
Site 50
T674
D
Q
V
D
P
F
L
T
A
E
P
T
H
L
R
Site 51
S686
H
L
R
V
G
W
A
S
S
S
G
Y
A
P
C
Site 52
S687
L
R
V
G
W
A
S
S
S
G
Y
A
P
C
P
Site 53
S688
R
V
G
W
A
S
S
S
G
Y
A
P
C
P
G
Site 54
Y690
G
W
A
S
S
S
G
Y
A
P
C
P
G
G
G
Site 55
Y710
N
G
V
G
D
D
L
Y
S
Y
G
F
D
G
L
Site 56
S711
G
V
G
D
D
L
Y
S
Y
G
F
D
G
L
H
Site 57
Y712
V
G
D
D
L
Y
S
Y
G
F
D
G
L
H
L
Site 58
S721
F
D
G
L
H
L
W
S
G
R
I
P
R
A
V
Site 59
S730
R
I
P
R
A
V
A
S
V
N
Q
H
L
L
R
Site 60
S738
V
N
Q
H
L
L
R
S
D
D
V
V
S
C
C
Site 61
S754
D
L
G
V
P
S
I
S
F
R
I
N
G
Q
P
Site 62
S804
E
F
K
F
L
P
P
S
G
Y
A
P
C
Y
E
Site 63
Y806
K
F
L
P
P
S
G
Y
A
P
C
Y
E
A
L
Site 64
Y810
P
S
G
Y
A
P
C
Y
E
A
L
L
P
K
E
Site 65
Y827
R
L
E
P
V
K
E
Y
K
R
D
A
D
G
I
Site 66
T890
N
K
I
E
L
G
W
T
F
G
K
I
R
D
D
Site 67
S923
K
N
Y
N
L
Q
M
S
T
E
T
L
K
T
L
Site 68
T924
N
Y
N
L
Q
M
S
T
E
T
L
K
T
L
L
Site 69
Y957
K
V
K
L
P
K
N
Y
M
M
S
N
G
Y
K
Site 70
S960
L
P
K
N
Y
M
M
S
N
G
Y
K
P
A
P
Site 71
S971
K
P
A
P
L
D
L
S
D
V
K
L
L
P
P
Site 72
S1032
L
D
E
R
T
K
K
S
N
R
D
S
L
R
E
Site 73
S1036
T
K
K
S
N
R
D
S
L
R
E
A
V
R
T
Site 74
T1043
S
L
R
E
A
V
R
T
F
V
G
Y
G
Y
N
Site 75
Y1047
A
V
R
T
F
V
G
Y
G
Y
N
I
E
P
S
Site 76
S1054
Y
G
Y
N
I
E
P
S
D
Q
E
L
A
D
S
Site 77
S1061
S
D
Q
E
L
A
D
S
A
V
E
K
V
S
I
Site 78
S1079
R
F
F
R
V
E
R
S
Y
A
V
R
S
G
K
Site 79
Y1080
F
F
R
V
E
R
S
Y
A
V
R
S
G
K
W
Site 80
Y1088
A
V
R
S
G
K
W
Y
F
E
F
E
V
V
T
Site 81
T1141
G
S
G
Y
F
G
R
T
W
Q
P
G
D
V
V
Site 82
T1170
L
N
G
E
L
L
I
T
N
K
G
S
E
L
A
Site 83
T1205
I
G
R
M
N
L
G
T
D
A
S
T
F
K
F
Site 84
T1209
N
L
G
T
D
A
S
T
F
K
F
Y
T
M
C
Site 85
T1214
A
S
T
F
K
F
Y
T
M
C
G
L
Q
E
G
Site 86
T1243
W
F
S
K
R
L
P
T
F
V
N
V
P
K
D
Site 87
T1262
E
V
M
R
I
D
G
T
M
D
S
P
P
C
L
Site 88
S1265
R
I
D
G
T
M
D
S
P
P
C
L
K
V
T
Site 89
T1275
C
L
K
V
T
H
K
T
F
G
T
Q
N
S
N
Site 90
Y1287
N
S
N
A
D
M
I
Y
C
R
L
S
M
P
V
Site 91
S1298
S
M
P
V
E
C
H
S
S
F
S
H
S
P
C
Site 92
S1299
M
P
V
E
C
H
S
S
F
S
H
S
P
C
L
Site 93
S1301
V
E
C
H
S
S
F
S
H
S
P
C
L
D
S
Site 94
S1303
C
H
S
S
F
S
H
S
P
C
L
D
S
E
A
Site 95
S1308
S
H
S
P
C
L
D
S
E
A
F
Q
K
R
K
Site 96
T1326
E
I
L
S
H
T
T
T
Q
C
Y
Y
A
I
R
Site 97
Y1329
S
H
T
T
T
Q
C
Y
Y
A
I
R
I
F
A
Site 98
Y1352
V
G
W
V
T
P
D
Y
H
L
Y
S
E
K
F
Site 99
Y1355
V
T
P
D
Y
H
L
Y
S
E
K
F
D
L
N
Site 100
S1356
T
P
D
Y
H
L
Y
S
E
K
F
D
L
N
K
Site 101
T1368
L
N
K
N
C
T
V
T
V
T
L
G
D
E
R
Site 102
S1381
E
R
G
R
V
H
E
S
V
K
R
S
N
C
Y
Site 103
S1385
V
H
E
S
V
K
R
S
N
C
Y
M
V
W
G
Site 104
Y1388
S
V
K
R
S
N
C
Y
M
V
W
G
G
D
I
Site 105
S1398
W
G
G
D
I
V
A
S
S
Q
R
S
N
R
S
Site 106
S1399
G
G
D
I
V
A
S
S
Q
R
S
N
R
S
N
Site 107
S1402
I
V
A
S
S
Q
R
S
N
R
S
N
V
D
L
Site 108
S1405
S
S
Q
R
S
N
R
S
N
V
D
L
E
I
G
Site 109
S1423
D
L
A
M
G
M
L
S
F
S
A
N
G
K
E
Site 110
Y1435
G
K
E
L
G
T
C
Y
Q
V
E
P
N
T
K
Site 111
S1477
L
S
A
A
I
F
R
S
E
E
K
N
P
V
P
Site 112
T1494
P
P
R
L
D
V
Q
T
I
Q
P
V
L
W
S
Site 113
S1506
L
W
S
R
M
P
N
S
F
L
K
V
E
T
E
Site 114
T1512
N
S
F
L
K
V
E
T
E
R
V
S
E
R
H
Site 115
S1516
K
V
E
T
E
R
V
S
E
R
H
G
W
V
V
Site 116
Y1559
E
D
L
M
R
F
H
Y
H
T
L
R
L
Y
S
Site 117
Y1578
L
G
N
S
R
V
A
Y
A
L
C
S
H
V
D
Site 118
Y1597
F
Y
A
I
D
N
K
Y
L
P
G
L
L
R
S
Site 119
Y1629
K
L
M
M
K
N
E
Y
I
I
P
I
T
S
T
Site 120
S1647
I
C
L
F
P
D
E
S
K
R
H
G
L
P
G
Site 121
S1683
G
E
D
H
Q
K
Q
S
P
E
I
P
L
E
S
Site 122
S1690
S
P
E
I
P
L
E
S
L
R
T
K
A
L
S
Site 123
T1797
P
V
K
G
L
L
Q
T
R
L
P
E
S
V
K
Site 124
S1802
L
Q
T
R
L
P
E
S
V
K
L
Q
M
C
E
Site 125
Y1845
Q
A
N
Q
K
F
R
Y
N
E
L
M
Q
A
L
Site 126
T1859
L
N
M
S
A
A
L
T
A
R
K
T
K
E
F
Site 127
T1863
A
A
L
T
A
R
K
T
K
E
F
R
S
P
P
Site 128
S1868
R
K
T
K
E
F
R
S
P
P
Q
E
Q
I
N
Site 129
Y1897
E
E
I
R
E
E
L
Y
D
F
H
E
D
L
L
Site 130
T1921
E
E
E
E
E
E
D
T
S
W
T
G
K
L
C
Site 131
S1922
E
E
E
E
E
D
T
S
W
T
G
K
L
C
A
Site 132
Y1932
G
K
L
C
A
L
V
Y
K
I
K
G
P
P
K
Site 133
T1954
E
E
E
E
R
C
P
T
T
L
K
E
L
I
S
Site 134
T1955
E
E
E
R
C
P
T
T
L
K
E
L
I
S
Q
Site 135
Y1990
F
N
L
L
R
R
Q
Y
D
S
I
G
E
L
L
Site 136
S1992
L
L
R
R
Q
Y
D
S
I
G
E
L
L
Q
A
Site 137
T2003
L
L
Q
A
L
R
K
T
Y
T
I
S
H
T
S
Site 138
Y2004
L
Q
A
L
R
K
T
Y
T
I
S
H
T
S
V
Site 139
T2005
Q
A
L
R
K
T
Y
T
I
S
H
T
S
V
S
Site 140
S2007
L
R
K
T
Y
T
I
S
H
T
S
V
S
D
T
Site 141
S2010
T
Y
T
I
S
H
T
S
V
S
D
T
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K
L
K
D
L
T
S
S
D
T
F
K
E
Site 294
S3924
L
K
L
K
D
L
T
S
S
D
T
F
K
E
Y
Site 295
S3925
K
L
K
D
L
T
S
S
D
T
F
K
E
Y
D
Site 296
T3927
K
D
L
T
S
S
D
T
F
K
E
Y
D
P
D
Site 297
Y3931
S
S
D
T
F
K
E
Y
D
P
D
G
K
G
I
Site 298
S3957
G
Q
K
Q
Y
T
Q
S
E
I
D
F
L
L
S
Site 299
S3964
S
E
I
D
F
L
L
S
C
A
E
A
D
E
N
Site 300
Y3976
D
E
N
D
M
F
N
Y
V
D
F
V
D
R
F
Site 301
S4002
A
V
L
L
T
N
L
S
E
H
M
P
N
D
S
Site 302
S4009
S
E
H
M
P
N
D
S
R
L
K
C
L
L
D
Site 303
Y4024
P
A
E
S
V
L
N
Y
F
E
P
Y
L
G
R
Site 304
Y4045
A
K
K
I
E
R
V
Y
F
E
I
S
E
S
S
Site 305
S4049
E
R
V
Y
F
E
I
S
E
S
S
R
T
Q
W
Site 306
S4051
V
Y
F
E
I
S
E
S
S
R
T
Q
W
E
K
Site 307
T4054
E
I
S
E
S
S
R
T
Q
W
E
K
P
Q
V
Site 308
S4064
E
K
P
Q
V
K
E
S
K
R
Q
F
I
F
D
Site 309
S4100
I
F
E
M
Q
L
A
S
Q
I
S
E
S
D
S
Site 310
S4103
M
Q
L
A
S
Q
I
S
E
S
D
S
A
D
R
Site 311
S4105
L
A
S
Q
I
S
E
S
D
S
A
D
R
P
E
Site 312
S4107
S
Q
I
S
E
S
D
S
A
D
R
P
E
E
E
Site 313
S4120
E
E
E
E
D
E
D
S
S
Y
V
L
E
I
A
Site 314
S4121
E
E
E
D
E
D
S
S
Y
V
L
E
I
A
G
Site 315
Y4122
E
E
D
E
D
S
S
Y
V
L
E
I
A
G
E
Site 316
S4135
G
E
E
E
E
D
G
S
L
E
P
A
S
A
F
Site 317
T4154
A
S
V
K
R
N
V
T
D
F
L
K
R
A
T
Site 318
T4161
T
D
F
L
K
R
A
T
L
K
N
L
R
K
Q
Site 319
Y4169
L
K
N
L
R
K
Q
Y
R
N
V
K
K
M
T
Site 320
T4229
G
A
K
N
I
R
V
T
K
I
L
G
D
M
P
Site 321
T4239
L
G
D
M
P
D
P
T
Q
F
G
I
H
D
D
Site 322
T4247
Q
F
G
I
H
D
D
T
M
E
A
E
R
A
E
Site 323
T4275
I
K
G
E
K
G
D
T
D
I
M
S
D
L
F
Site 324
S4279
K
G
D
T
D
I
M
S
D
L
F
G
L
H
P
Site 325
S4304
E
V
G
L
G
D
L
S
E
I
I
G
K
D
E
Site 326
T4314
I
G
K
D
E
P
P
T
L
E
S
T
V
Q
K
Site 327
T4318
E
P
P
T
L
E
S
T
V
Q
K
K
R
K
A
Site 328
Y4364
K
E
E
E
Q
A
E
Y
L
W
T
E
V
T
K
Site 329
T4367
E
Q
A
E
Y
L
W
T
E
V
T
K
K
K
K
Site 330
Y4398
F
F
K
G
L
E
I
Y
Q
T
K
L
L
H
Y
Site 331
T4400
K
G
L
E
I
Y
Q
T
K
L
L
H
Y
L
A
Site 332
Y4405
Y
Q
T
K
L
L
H
Y
L
A
R
N
F
Y
N
Site 333
T4434
I
L
L
F
Y
K
V
T
E
E
P
L
E
E
E
Site 334
S4451
D
V
A
N
L
W
N
S
F
N
D
E
E
E
E
Site 335
Y4472
V
L
Q
E
S
T
G
Y
M
A
P
T
L
R
A
Site 336
Y4521
K
L
E
F
D
G
L
Y
I
T
E
Q
P
S
E
Site 337
T4523
E
F
D
G
L
Y
I
T
E
Q
P
S
E
D
D
Site 338
T4542
W
D
R
L
V
I
N
T
P
S
F
P
N
N
Y
Site 339
Y4549
T
P
S
F
P
N
N
Y
W
D
K
F
V
K
R
Site 340
Y4562
K
R
K
V
I
N
K
Y
G
D
L
Y
G
A
E
Site 341
Y4566
I
N
K
Y
G
D
L
Y
G
A
E
R
I
A
E
Site 342
S4585
D
K
N
A
L
D
F
S
P
V
E
E
T
K
A
Site 343
S4596
E
T
K
A
E
A
A
S
L
V
S
W
L
S
S
Site 344
T4655
D
I
A
M
G
F
K
T
L
R
T
I
L
S
S
Site 345
T4658
M
G
F
K
T
L
R
T
I
L
S
S
V
T
H
Site 346
S4661
K
T
L
R
T
I
L
S
S
V
T
H
N
G
K
Site 347
S4662
T
L
R
T
I
L
S
S
V
T
H
N
G
K
Q
Site 348
T4664
R
T
I
L
S
S
V
T
H
N
G
K
Q
L
V
Site 349
Y4682
G
L
L
A
V
V
V
Y
L
Y
T
V
V
A
F
Site 350
Y4696
F
N
F
F
R
K
F
Y
N
K
S
E
D
D
D
Site 351
S4699
F
R
K
F
Y
N
K
S
E
D
D
D
E
P
D
Site 352
Y4742
E
D
P
A
G
D
P
Y
E
M
Y
R
I
V
F
Site 353
Y4745
A
G
D
P
Y
E
M
Y
R
I
V
F
D
I
T
Site 354
Y4800
I
C
G
I
G
N
D
Y
F
D
T
T
P
H
G
Site 355
T4834
Y
L
I
N
K
D
E
T
E
H
T
G
Q
E
S
Site 356
T4837
N
K
D
E
T
E
H
T
G
Q
E
S
Y
V
W
Site 357
Y4842
E
H
T
G
Q
E
S
Y
V
W
K
M
Y
Q
E
Site 358
Y4865
G
D
C
F
R
K
Q
Y
E
D
Q
L
G
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation