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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SAFB
Full Name:
Scaffold attachment factor B1
Alias:
HAP; HET; HSP27 ERE- TATA-binding protein; Hsp27 ERE-TATA binding protein; HSP27 estrogen response element-TATA box-binding protein; SAF-B; SAFB1; SAF-B1; Scaffold attachment factor B; SFB1
Type:
DNA binding protein; Nuclear receptor co-regulator
Mass (Da):
102642
Number AA:
915
UniProt ID:
Q15424
International Prot ID:
IPI00300631
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0003690
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0006325
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
A
E
T
L
S
G
L
G
D
S
Site 2
S6
_
_
M
A
E
T
L
S
G
L
G
D
S
G
A
Site 3
S11
T
L
S
G
L
G
D
S
G
A
A
G
A
A
A
Site 4
S20
A
A
G
A
A
A
L
S
S
A
S
S
E
T
G
Site 5
S21
A
G
A
A
A
L
S
S
A
S
S
E
T
G
T
Site 6
S23
A
A
A
L
S
S
A
S
S
E
T
G
T
R
R
Site 7
S24
A
A
L
S
S
A
S
S
E
T
G
T
R
R
L
Site 8
T26
L
S
S
A
S
S
E
T
G
T
R
R
L
S
D
Site 9
T28
S
A
S
S
E
T
G
T
R
R
L
S
D
L
R
Site 10
S32
E
T
G
T
R
R
L
S
D
L
R
V
I
D
L
Site 11
S50
L
R
K
R
N
V
D
S
S
G
N
K
S
V
L
Site 12
S51
R
K
R
N
V
D
S
S
G
N
K
S
V
L
M
Site 13
S55
V
D
S
S
G
N
K
S
V
L
M
E
R
L
K
Site 14
T78
N
P
D
E
I
E
I
T
S
E
G
N
K
K
T
Site 15
T85
T
S
E
G
N
K
K
T
S
K
R
S
S
K
G
Site 16
S86
S
E
G
N
K
K
T
S
K
R
S
S
K
G
R
Site 17
S90
K
K
T
S
K
R
S
S
K
G
R
K
P
E
E
Site 18
S109
D
N
G
L
E
E
N
S
G
D
G
Q
E
D
V
Site 19
T118
D
G
Q
E
D
V
E
T
S
L
E
N
L
Q
D
Site 20
S143
E
A
E
I
D
N
G
S
V
A
D
C
V
E
D
Site 21
S159
D
A
D
N
L
Q
E
S
L
S
D
S
R
E
L
Site 22
S161
D
N
L
Q
E
S
L
S
D
S
R
E
L
V
E
Site 23
S163
L
Q
E
S
L
S
D
S
R
E
L
V
E
G
E
Site 24
T188
H
A
I
E
D
K
E
T
I
N
N
L
D
T
S
Site 25
T194
E
T
I
N
N
L
D
T
S
S
S
D
F
T
I
Site 26
S195
T
I
N
N
L
D
T
S
S
S
D
F
T
I
L
Site 27
S196
I
N
N
L
D
T
S
S
S
D
F
T
I
L
Q
Site 28
S197
N
N
L
D
T
S
S
S
D
F
T
I
L
Q
E
Site 29
T200
D
T
S
S
S
D
F
T
I
L
Q
E
I
E
E
Site 30
S209
L
Q
E
I
E
E
P
S
L
E
P
E
N
E
K
Site 31
S227
I
L
G
E
T
C
K
S
E
P
V
K
E
E
S
Site 32
S234
S
E
P
V
K
E
E
S
S
E
L
E
Q
P
F
Site 33
S235
E
P
V
K
E
E
S
S
E
L
E
Q
P
F
A
Site 34
T245
E
Q
P
F
A
Q
D
T
S
S
V
G
P
D
R
Site 35
S246
Q
P
F
A
Q
D
T
S
S
V
G
P
D
R
K
Site 36
S247
P
F
A
Q
D
T
S
S
V
G
P
D
R
K
L
Site 37
S263
E
E
E
D
L
F
D
S
A
H
P
E
E
G
D
Site 38
S275
E
G
D
L
D
L
A
S
E
S
T
A
H
A
Q
Site 39
S277
D
L
D
L
A
S
E
S
T
A
H
A
Q
S
S
Site 40
S284
S
T
A
H
A
Q
S
S
K
A
D
S
L
L
A
Site 41
S288
A
Q
S
S
K
A
D
S
L
L
A
V
V
K
R
Site 42
S322
E
P
A
V
E
Q
S
S
A
A
S
E
L
A
E
Site 43
S325
V
E
Q
S
S
A
A
S
E
L
A
E
A
S
S
Site 44
S331
A
S
E
L
A
E
A
S
S
E
E
L
A
E
A
Site 45
S332
S
E
L
A
E
A
S
S
E
E
L
A
E
A
P
Site 46
T340
E
E
L
A
E
A
P
T
E
A
P
S
P
E
A
Site 47
S344
E
A
P
T
E
A
P
S
P
E
A
R
D
S
K
Site 48
S350
P
S
P
E
A
R
D
S
K
E
D
G
R
K
F
Site 49
S373
P
P
A
P
K
E
S
S
T
S
E
G
A
D
Q
Site 50
S375
A
P
K
E
S
S
T
S
E
G
A
D
Q
K
M
Site 51
S383
E
G
A
D
Q
K
M
S
S
P
E
D
D
S
D
Site 52
S384
G
A
D
Q
K
M
S
S
P
E
D
D
S
D
T
Site 53
S389
M
S
S
P
E
D
D
S
D
T
K
R
L
S
K
Site 54
T391
S
P
E
D
D
S
D
T
K
R
L
S
K
E
E
Site 55
S395
D
S
D
T
K
R
L
S
K
E
E
K
G
R
S
Site 56
S402
S
K
E
E
K
G
R
S
S
C
G
R
N
F
W
Site 57
S403
K
E
E
K
G
R
S
S
C
G
R
N
F
W
V
Site 58
S411
C
G
R
N
F
W
V
S
G
L
S
S
T
T
R
Site 59
S415
F
W
V
S
G
L
S
S
T
T
R
A
T
D
L
Site 60
T416
W
V
S
G
L
S
S
T
T
R
A
T
D
L
K
Site 61
T420
L
S
S
T
T
R
A
T
D
L
K
N
L
F
S
Site 62
S427
T
D
L
K
N
L
F
S
K
Y
G
K
V
V
G
Site 63
Y429
L
K
N
L
F
S
K
Y
G
K
V
V
G
A
K
Site 64
T439
V
V
G
A
K
V
V
T
N
A
R
S
P
G
A
Site 65
S443
K
V
V
T
N
A
R
S
P
G
A
R
C
Y
G
Site 66
Y449
R
S
P
G
A
R
C
Y
G
F
V
T
M
S
T
Site 67
T453
A
R
C
Y
G
F
V
T
M
S
T
A
E
E
A
Site 68
S455
C
Y
G
F
V
T
M
S
T
A
E
E
A
T
K
Site 69
S478
E
L
H
G
K
M
I
S
V
E
K
A
K
N
E
Site 70
S492
E
P
V
G
K
K
T
S
D
K
R
D
S
D
G
Site 71
S497
K
T
S
D
K
R
D
S
D
G
K
K
E
K
S
Site 72
S504
S
D
G
K
K
E
K
S
S
N
S
D
R
S
T
Site 73
S505
D
G
K
K
E
K
S
S
N
S
D
R
S
T
N
Site 74
S507
K
K
E
K
S
S
N
S
D
R
S
T
N
L
K
Site 75
S510
K
S
S
N
S
D
R
S
T
N
L
K
R
D
D
Site 76
T511
S
S
N
S
D
R
S
T
N
L
K
R
D
D
K
Site 77
S532
A
K
K
G
D
D
G
S
G
E
K
S
K
D
Q
Site 78
S536
D
D
G
S
G
E
K
S
K
D
Q
D
D
Q
K
Site 79
S547
D
D
Q
K
P
G
P
S
E
R
S
R
A
T
K
Site 80
S550
K
P
G
P
S
E
R
S
R
A
T
K
S
G
S
Site 81
T553
P
S
E
R
S
R
A
T
K
S
G
S
R
G
T
Site 82
S555
E
R
S
R
A
T
K
S
G
S
R
G
T
E
R
Site 83
S557
S
R
A
T
K
S
G
S
R
G
T
E
R
T
V
Site 84
T560
T
K
S
G
S
R
G
T
E
R
T
V
V
M
D
Site 85
T563
G
S
R
G
T
E
R
T
V
V
M
D
K
S
K
Site 86
S569
R
T
V
V
M
D
K
S
K
G
V
P
V
I
S
Site 87
S576
S
K
G
V
P
V
I
S
V
K
T
S
G
S
K
Site 88
T579
V
P
V
I
S
V
K
T
S
G
S
K
E
R
A
Site 89
S580
P
V
I
S
V
K
T
S
G
S
K
E
R
A
S
Site 90
S582
I
S
V
K
T
S
G
S
K
E
R
A
S
K
S
Site 91
S587
S
G
S
K
E
R
A
S
K
S
Q
D
R
K
S
Site 92
S589
S
K
E
R
A
S
K
S
Q
D
R
K
S
A
S
Site 93
S594
S
K
S
Q
D
R
K
S
A
S
R
E
K
R
S
Site 94
S596
S
Q
D
R
K
S
A
S
R
E
K
R
S
V
V
Site 95
S601
S
A
S
R
E
K
R
S
V
V
S
F
D
K
V
Site 96
S604
R
E
K
R
S
V
V
S
F
D
K
V
K
E
P
Site 97
S614
K
V
K
E
P
R
K
S
R
D
S
E
S
H
S
Site 98
S617
E
P
R
K
S
R
D
S
E
S
H
S
R
V
R
Site 99
S619
R
K
S
R
D
S
E
S
H
S
R
V
R
E
R
Site 100
S621
S
R
D
S
E
S
H
S
R
V
R
E
R
S
E
Site 101
S627
H
S
R
V
R
E
R
S
E
R
E
Q
R
M
Q
Site 102
Y714
R
P
A
V
R
R
P
Y
D
L
D
R
R
D
D
Site 103
Y723
L
D
R
R
D
D
A
Y
W
P
E
A
K
R
A
Site 104
Y736
R
A
A
L
D
E
R
Y
H
S
D
F
N
R
Q
Site 105
S738
A
L
D
E
R
Y
H
S
D
F
N
R
Q
D
R
Site 106
Y757
D
H
R
D
R
G
R
Y
P
D
H
S
V
D
R
Site 107
S761
R
G
R
Y
P
D
H
S
V
D
R
R
E
G
S
Site 108
S768
S
V
D
R
R
E
G
S
R
S
M
M
G
E
R
Site 109
S770
D
R
R
E
G
S
R
S
M
M
G
E
R
E
G
Site 110
Y780
G
E
R
E
G
Q
H
Y
P
E
R
H
G
G
P
Site 111
S794
P
E
R
H
G
R
D
S
R
D
G
W
G
G
Y
Site 112
Y801
S
R
D
G
W
G
G
Y
G
S
D
K
R
M
S
Site 113
S803
D
G
W
G
G
Y
G
S
D
K
R
M
S
E
G
Site 114
S808
Y
G
S
D
K
R
M
S
E
G
R
G
L
P
P
Site 115
S832
G
R
R
E
D
D
R
S
W
Q
G
T
A
D
G
Site 116
S855
R
W
Q
G
G
E
R
S
M
S
G
H
S
G
P
Site 117
S857
Q
G
G
E
R
S
M
S
G
H
S
G
P
G
H
Site 118
S872
M
M
N
R
G
G
M
S
G
R
G
S
F
A
P
Site 119
S876
G
G
M
S
G
R
G
S
F
A
P
G
G
A
S
Site 120
S901
Q
G
G
F
G
G
Q
S
R
G
S
R
P
S
D
Site 121
S904
F
G
G
Q
S
R
G
S
R
P
S
D
A
R
F
Site 122
S907
Q
S
R
G
S
R
P
S
D
A
R
F
T
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation