KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
Shb
Full Name:
SH2 domain-containing adapter protein B
Alias:
Srcy 2 domain containing adaptor protein B
Type:
Adapter/scaffold protein
Mass (Da):
55042
Number AA:
509
UniProt ID:
Q15464
International Prot ID:
IPI00017578
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005070
PhosphoSite+
KinaseNET
Biological Process:
GO:0001525
GO:0006915
GO:0030154
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
A
K
W
L
N
K
Y
F
S
L
G
N
S
K
Site 2
S10
K
W
L
N
K
Y
F
S
L
G
N
S
K
T
K
Site 3
S14
K
Y
F
S
L
G
N
S
K
T
K
S
P
P
Q
Site 4
T16
F
S
L
G
N
S
K
T
K
S
P
P
Q
P
P
Site 5
S18
L
G
N
S
K
T
K
S
P
P
Q
P
P
R
P
Site 6
Y27
P
Q
P
P
R
P
D
Y
R
E
Q
R
R
R
G
Site 7
S38
R
R
R
G
E
R
P
S
Q
P
P
Q
A
V
P
Site 8
S48
P
Q
A
V
P
Q
A
S
S
A
A
S
A
S
C
Site 9
S49
Q
A
V
P
Q
A
S
S
A
A
S
A
S
C
G
Site 10
S52
P
Q
A
S
S
A
A
S
A
S
C
G
P
A
T
Site 11
S66
T
A
S
C
F
S
A
S
S
G
S
L
P
D
D
Site 12
S69
C
F
S
A
S
S
G
S
L
P
D
D
S
G
S
Site 13
S74
S
G
S
L
P
D
D
S
G
S
T
S
D
L
I
Site 14
S76
S
L
P
D
D
S
G
S
T
S
D
L
I
R
A
Site 15
S78
P
D
D
S
G
S
T
S
D
L
I
R
A
Y
R
Site 16
Y84
T
S
D
L
I
R
A
Y
R
A
Q
K
E
R
D
Site 17
Y96
E
R
D
F
E
D
P
Y
N
G
P
G
S
S
L
Site 18
S101
D
P
Y
N
G
P
G
S
S
L
R
K
L
R
A
Site 19
S102
P
Y
N
G
P
G
S
S
L
R
K
L
R
A
M
Site 20
Y114
R
A
M
C
R
L
D
Y
C
G
G
S
G
E
P
Site 21
S118
R
L
D
Y
C
G
G
S
G
E
P
G
G
V
Q
Site 22
S129
G
G
V
Q
R
A
F
S
A
S
S
A
S
G
A
Site 23
S151
S
G
A
G
A
A
A
S
S
S
S
S
S
G
S
Site 24
S152
G
A
G
A
A
A
S
S
S
S
S
S
G
S
P
Site 25
S153
A
G
A
A
A
S
S
S
S
S
S
G
S
P
H
Site 26
S154
G
A
A
A
S
S
S
S
S
S
G
S
P
H
L
Site 27
S155
A
A
A
S
S
S
S
S
S
G
S
P
H
L
Y
Site 28
S156
A
A
S
S
S
S
S
S
G
S
P
H
L
Y
R
Site 29
S158
S
S
S
S
S
S
G
S
P
H
L
Y
R
S
S
Site 30
Y162
S
S
G
S
P
H
L
Y
R
S
S
S
E
R
R
Site 31
S164
G
S
P
H
L
Y
R
S
S
S
E
R
R
P
A
Site 32
S165
S
P
H
L
Y
R
S
S
S
E
R
R
P
A
T
Site 33
S166
P
H
L
Y
R
S
S
S
E
R
R
P
A
T
P
Site 34
T172
S
S
E
R
R
P
A
T
P
A
E
V
R
Y
I
Site 35
Y178
A
T
P
A
E
V
R
Y
I
S
P
K
H
R
L
Site 36
S180
P
A
E
V
R
Y
I
S
P
K
H
R
L
I
K
Site 37
S190
H
R
L
I
K
V
E
S
A
A
G
G
G
A
G
Site 38
S211
C
A
G
G
R
T
W
S
P
T
A
C
G
G
K
Site 39
T213
G
G
R
T
W
S
P
T
A
C
G
G
K
K
L
Site 40
T241
A
G
K
K
D
K
V
T
I
A
D
D
Y
S
D
Site 41
Y246
K
V
T
I
A
D
D
Y
S
D
P
F
D
A
K
Site 42
S247
V
T
I
A
D
D
Y
S
D
P
F
D
A
K
N
Site 43
S258
D
A
K
N
D
L
K
S
K
A
G
K
G
E
S
Site 44
S265
S
K
A
G
K
G
E
S
A
G
Y
M
E
P
Y
Site 45
Y268
G
K
G
E
S
A
G
Y
M
E
P
Y
E
A
Q
Site 46
Y272
S
A
G
Y
M
E
P
Y
E
A
Q
R
I
M
T
Site 47
T279
Y
E
A
Q
R
I
M
T
E
F
Q
R
Q
E
S
Site 48
S286
T
E
F
Q
R
Q
E
S
V
R
S
Q
H
K
G
Site 49
S289
Q
R
Q
E
S
V
R
S
Q
H
K
G
I
Q
L
Site 50
Y297
Q
H
K
G
I
Q
L
Y
D
T
P
Y
E
P
E
Site 51
T299
K
G
I
Q
L
Y
D
T
P
Y
E
P
E
G
Q
Site 52
Y301
I
Q
L
Y
D
T
P
Y
E
P
E
G
Q
S
V
Site 53
S307
P
Y
E
P
E
G
Q
S
V
D
S
D
S
E
S
Site 54
S310
P
E
G
Q
S
V
D
S
D
S
E
S
T
V
S
Site 55
S312
G
Q
S
V
D
S
D
S
E
S
T
V
S
P
R
Site 56
S314
S
V
D
S
D
S
E
S
T
V
S
P
R
L
R
Site 57
T315
V
D
S
D
S
E
S
T
V
S
P
R
L
R
E
Site 58
S317
S
D
S
E
S
T
V
S
P
R
L
R
E
S
K
Site 59
S323
V
S
P
R
L
R
E
S
K
L
P
Q
D
D
D
Site 60
Y336
D
D
R
P
A
D
E
Y
D
Q
P
W
E
W
N
Site 61
T346
P
W
E
W
N
R
V
T
I
P
A
L
A
A
Q
Site 62
S362
N
G
N
E
K
R
Q
S
S
P
S
P
S
R
D
Site 63
S363
G
N
E
K
R
Q
S
S
P
S
P
S
R
D
R
Site 64
S365
E
K
R
Q
S
S
P
S
P
S
R
D
R
R
R
Site 65
S367
R
Q
S
S
P
S
P
S
R
D
R
R
R
Q
L
Site 66
S388
F
K
P
I
K
H
G
S
P
E
F
C
G
I
L
Site 67
Y411
P
L
E
K
Q
I
W
Y
H
G
A
I
S
R
G
Site 68
S431
L
R
L
C
K
E
C
S
Y
L
V
R
N
S
Q
Site 69
Y432
R
L
C
K
E
C
S
Y
L
V
R
N
S
Q
T
Site 70
S437
C
S
Y
L
V
R
N
S
Q
T
S
K
H
D
Y
Site 71
S440
L
V
R
N
S
Q
T
S
K
H
D
Y
S
L
S
Site 72
Y444
S
Q
T
S
K
H
D
Y
S
L
S
L
R
S
N
Site 73
S445
Q
T
S
K
H
D
Y
S
L
S
L
R
S
N
Q
Site 74
S447
S
K
H
D
Y
S
L
S
L
R
S
N
Q
G
F
Site 75
Y466
L
A
K
T
K
E
K
Y
V
L
G
Q
N
S
P
Site 76
S472
K
Y
V
L
G
Q
N
S
P
P
F
D
S
V
P
Site 77
S477
Q
N
S
P
P
F
D
S
V
P
E
V
I
H
Y
Site 78
Y484
S
V
P
E
V
I
H
Y
Y
T
T
R
K
L
P
Site 79
Y485
V
P
E
V
I
H
Y
Y
T
T
R
K
L
P
I
Site 80
T486
P
E
V
I
H
Y
Y
T
T
R
K
L
P
I
K
Site 81
T508
L
Y
P
V
A
V
R
T
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation