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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SHH
Full Name:
Sonic hedgehog protein
Alias:
HHG-1
Type:
Mass (Da):
49607
Number AA:
462
UniProt ID:
Q15465
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T40
R
R
H
P
K
K
L
T
P
L
A
Y
K
Q
F
Site 2
T55
I
P
N
V
A
E
K
T
L
G
A
S
G
R
Y
Site 3
S59
A
E
K
T
L
G
A
S
G
R
Y
E
G
K
I
Site 4
S67
G
R
Y
E
G
K
I
S
R
N
S
E
R
F
K
Site 5
S70
E
G
K
I
S
R
N
S
E
R
F
K
E
L
T
Site 6
T77
S
E
R
F
K
E
L
T
P
N
Y
N
P
D
I
Site 7
Y80
F
K
E
L
T
P
N
Y
N
P
D
I
I
F
K
Site 8
T99
T
G
A
D
R
L
M
T
Q
R
C
K
D
K
L
Site 9
T125
P
G
V
K
L
R
V
T
E
G
W
D
E
D
G
Site 10
S135
W
D
E
D
G
H
H
S
E
E
S
L
H
Y
E
Site 11
S138
D
G
H
H
S
E
E
S
L
H
Y
E
G
R
A
Site 12
Y141
H
S
E
E
S
L
H
Y
E
G
R
A
V
D
I
Site 13
T149
E
G
R
A
V
D
I
T
T
S
D
R
D
R
S
Site 14
T150
G
R
A
V
D
I
T
T
S
D
R
D
R
S
K
Site 15
S151
R
A
V
D
I
T
T
S
D
R
D
R
S
K
Y
Site 16
S156
T
T
S
D
R
D
R
S
K
Y
G
M
L
A
R
Site 17
Y158
S
D
R
D
R
S
K
Y
G
M
L
A
R
L
A
Site 18
Y174
E
A
G
F
D
W
V
Y
Y
E
S
K
A
H
I
Site 19
Y175
A
G
F
D
W
V
Y
Y
E
S
K
A
H
I
H
Site 20
S177
F
D
W
V
Y
Y
E
S
K
A
H
I
H
C
S
Site 21
S184
S
K
A
H
I
H
C
S
V
K
A
E
N
S
V
Site 22
S190
C
S
V
K
A
E
N
S
V
A
A
K
S
G
G
Site 23
S195
E
N
S
V
A
A
K
S
G
G
C
F
P
G
S
Site 24
S202
S
G
G
C
F
P
G
S
A
T
V
H
L
E
Q
Site 25
T204
G
C
F
P
G
S
A
T
V
H
L
E
Q
G
G
Site 26
S219
T
K
L
V
K
D
L
S
P
G
D
R
V
L
A
Site 27
Y235
D
D
Q
G
R
L
L
Y
S
D
F
L
T
F
L
Site 28
S236
D
Q
G
R
L
L
Y
S
D
F
L
T
F
L
D
Site 29
T240
L
L
Y
S
D
F
L
T
F
L
D
R
D
D
G
Site 30
Y253
D
G
A
K
K
V
F
Y
V
I
E
T
R
E
P
Site 31
S280
F
V
A
P
H
N
D
S
A
T
G
E
P
E
A
Site 32
T282
A
P
H
N
D
S
A
T
G
E
P
E
A
S
S
Site 33
S288
A
T
G
E
P
E
A
S
S
G
S
G
P
P
S
Site 34
S289
T
G
E
P
E
A
S
S
G
S
G
P
P
S
G
Site 35
S291
E
P
E
A
S
S
G
S
G
P
P
S
G
G
A
Site 36
S295
S
S
G
S
G
P
P
S
G
G
A
L
G
P
R
Site 37
S307
G
P
R
A
L
F
A
S
R
V
R
P
G
Q
R
Site 38
Y316
V
R
P
G
Q
R
V
Y
V
V
A
E
R
D
G
Site 39
Y364
N
R
V
L
A
S
C
Y
A
V
I
E
E
H
S
Site 40
T395
A
A
L
A
P
A
R
T
D
R
G
G
D
S
G
Site 41
S401
R
T
D
R
G
G
D
S
G
G
G
D
R
G
G
Site 42
T416
G
G
G
R
V
A
L
T
A
P
G
A
A
D
A
Site 43
T429
D
A
P
G
A
G
A
T
A
G
I
H
W
Y
S
Site 44
Y440
H
W
Y
S
Q
L
L
Y
Q
I
G
T
W
L
L
Site 45
S449
I
G
T
W
L
L
D
S
E
A
L
H
P
L
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation