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Updated November 2019
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Protein Info
Short Name:
CDSN
Full Name:
Corneodesmosin
Alias:
S protein
Type:
Mass (Da):
51522
Number AA:
529
UniProt ID:
Q15517
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T37
T
L
A
K
S
I
G
T
F
S
D
P
C
K
D
Site 2
S39
A
K
S
I
G
T
F
S
D
P
C
K
D
P
T
Site 3
T46
S
D
P
C
K
D
P
T
R
I
T
S
P
N
D
Site 4
T49
C
K
D
P
T
R
I
T
S
P
N
D
P
C
L
Site 5
S50
K
D
P
T
R
I
T
S
P
N
D
P
C
L
T
Site 6
T57
S
P
N
D
P
C
L
T
G
K
G
D
S
S
G
Site 7
S62
C
L
T
G
K
G
D
S
S
G
F
S
S
Y
S
Site 8
S63
L
T
G
K
G
D
S
S
G
F
S
S
Y
S
G
Site 9
S66
K
G
D
S
S
G
F
S
S
Y
S
G
S
S
S
Site 10
S67
G
D
S
S
G
F
S
S
Y
S
G
S
S
S
S
Site 11
Y68
D
S
S
G
F
S
S
Y
S
G
S
S
S
S
G
Site 12
S69
S
S
G
F
S
S
Y
S
G
S
S
S
S
G
S
Site 13
S71
G
F
S
S
Y
S
G
S
S
S
S
G
S
S
I
Site 14
S72
F
S
S
Y
S
G
S
S
S
S
G
S
S
I
S
Site 15
S73
S
S
Y
S
G
S
S
S
S
G
S
S
I
S
S
Site 16
S74
S
Y
S
G
S
S
S
S
G
S
S
I
S
S
A
Site 17
S76
S
G
S
S
S
S
G
S
S
I
S
S
A
R
S
Site 18
S77
G
S
S
S
S
G
S
S
I
S
S
A
R
S
S
Site 19
S79
S
S
S
G
S
S
I
S
S
A
R
S
S
G
G
Site 20
S80
S
S
G
S
S
I
S
S
A
R
S
S
G
G
G
Site 21
S83
S
S
I
S
S
A
R
S
S
G
G
G
S
S
G
Site 22
S84
S
I
S
S
A
R
S
S
G
G
G
S
S
G
S
Site 23
S88
A
R
S
S
G
G
G
S
S
G
S
S
S
G
S
Site 24
S89
R
S
S
G
G
G
S
S
G
S
S
S
G
S
S
Site 25
S91
S
G
G
G
S
S
G
S
S
S
G
S
S
I
A
Site 26
S92
G
G
G
S
S
G
S
S
S
G
S
S
I
A
Q
Site 27
S93
G
G
S
S
G
S
S
S
G
S
S
I
A
Q
G
Site 28
S95
S
S
G
S
S
S
G
S
S
I
A
Q
G
G
S
Site 29
S96
S
G
S
S
S
G
S
S
I
A
Q
G
G
S
A
Site 30
S102
S
S
I
A
Q
G
G
S
A
G
S
F
K
P
G
Site 31
S105
A
Q
G
G
S
A
G
S
F
K
P
G
T
G
Y
Site 32
T110
A
G
S
F
K
P
G
T
G
Y
S
Q
V
S
Y
Site 33
Y112
S
F
K
P
G
T
G
Y
S
Q
V
S
Y
S
S
Site 34
S113
F
K
P
G
T
G
Y
S
Q
V
S
Y
S
S
G
Site 35
S116
G
T
G
Y
S
Q
V
S
Y
S
S
G
S
G
S
Site 36
Y117
T
G
Y
S
Q
V
S
Y
S
S
G
S
G
S
S
Site 37
S118
G
Y
S
Q
V
S
Y
S
S
G
S
G
S
S
L
Site 38
S119
Y
S
Q
V
S
Y
S
S
G
S
G
S
S
L
Q
Site 39
S121
Q
V
S
Y
S
S
G
S
G
S
S
L
Q
G
A
Site 40
S123
S
Y
S
S
G
S
G
S
S
L
Q
G
A
S
G
Site 41
S124
Y
S
S
G
S
G
S
S
L
Q
G
A
S
G
S
Site 42
S129
G
S
S
L
Q
G
A
S
G
S
S
Q
L
G
S
Site 43
S131
S
L
Q
G
A
S
G
S
S
Q
L
G
S
S
S
Site 44
S132
L
Q
G
A
S
G
S
S
Q
L
G
S
S
S
S
Site 45
S136
S
G
S
S
Q
L
G
S
S
S
S
H
S
G
S
Site 46
S137
G
S
S
Q
L
G
S
S
S
S
H
S
G
S
S
Site 47
S138
S
S
Q
L
G
S
S
S
S
H
S
G
S
S
G
Site 48
S139
S
Q
L
G
S
S
S
S
H
S
G
S
S
G
S
Site 49
S141
L
G
S
S
S
S
H
S
G
S
S
G
S
H
S
Site 50
S143
S
S
S
S
H
S
G
S
S
G
S
H
S
G
S
Site 51
S144
S
S
S
H
S
G
S
S
G
S
H
S
G
S
S
Site 52
S146
S
H
S
G
S
S
G
S
H
S
G
S
S
S
S
Site 53
S148
S
G
S
S
G
S
H
S
G
S
S
S
S
H
S
Site 54
S150
S
S
G
S
H
S
G
S
S
S
S
H
S
S
S
Site 55
S151
S
G
S
H
S
G
S
S
S
S
H
S
S
S
S
Site 56
S152
G
S
H
S
G
S
S
S
S
H
S
S
S
S
S
Site 57
S153
S
H
S
G
S
S
S
S
H
S
S
S
S
S
S
Site 58
S155
S
G
S
S
S
S
H
S
S
S
S
S
S
F
Q
Site 59
S156
G
S
S
S
S
H
S
S
S
S
S
S
F
Q
F
Site 60
S157
S
S
S
S
H
S
S
S
S
S
S
F
Q
F
S
Site 61
S158
S
S
S
H
S
S
S
S
S
S
F
Q
F
S
S
Site 62
S159
S
S
H
S
S
S
S
S
S
F
Q
F
S
S
S
Site 63
S160
S
H
S
S
S
S
S
S
F
Q
F
S
S
S
S
Site 64
S164
S
S
S
S
F
Q
F
S
S
S
S
F
Q
V
G
Site 65
S165
S
S
S
F
Q
F
S
S
S
S
F
Q
V
G
N
Site 66
S166
S
S
F
Q
F
S
S
S
S
F
Q
V
G
N
G
Site 67
S167
S
F
Q
F
S
S
S
S
F
Q
V
G
N
G
S
Site 68
S174
S
F
Q
V
G
N
G
S
A
L
P
T
N
D
N
Site 69
T178
G
N
G
S
A
L
P
T
N
D
N
S
Y
R
G
Site 70
S182
A
L
P
T
N
D
N
S
Y
R
G
I
L
N
P
Site 71
Y183
L
P
T
N
D
N
S
Y
R
G
I
L
N
P
S
Site 72
S190
Y
R
G
I
L
N
P
S
Q
P
G
Q
S
S
S
Site 73
S195
N
P
S
Q
P
G
Q
S
S
S
S
S
Q
T
S
Site 74
S196
P
S
Q
P
G
Q
S
S
S
S
S
Q
T
S
G
Site 75
S197
S
Q
P
G
Q
S
S
S
S
S
Q
T
S
G
V
Site 76
S198
Q
P
G
Q
S
S
S
S
S
Q
T
S
G
V
S
Site 77
S199
P
G
Q
S
S
S
S
S
Q
T
S
G
V
S
S
Site 78
T201
Q
S
S
S
S
S
Q
T
S
G
V
S
S
S
G
Site 79
S202
S
S
S
S
S
Q
T
S
G
V
S
S
S
G
Q
Site 80
S205
S
S
Q
T
S
G
V
S
S
S
G
Q
S
V
S
Site 81
S206
S
Q
T
S
G
V
S
S
S
G
Q
S
V
S
S
Site 82
S207
Q
T
S
G
V
S
S
S
G
Q
S
V
S
S
N
Site 83
S210
G
V
S
S
S
G
Q
S
V
S
S
N
Q
R
P
Site 84
S212
S
S
S
G
Q
S
V
S
S
N
Q
R
P
C
S
Site 85
S213
S
S
G
Q
S
V
S
S
N
Q
R
P
C
S
S
Site 86
S219
S
S
N
Q
R
P
C
S
S
D
I
P
D
S
P
Site 87
S220
S
N
Q
R
P
C
S
S
D
I
P
D
S
P
C
Site 88
S225
C
S
S
D
I
P
D
S
P
C
S
G
G
P
I
Site 89
S228
D
I
P
D
S
P
C
S
G
G
P
I
V
S
H
Site 90
S234
C
S
G
G
P
I
V
S
H
S
G
P
Y
I
P
Site 91
S236
G
G
P
I
V
S
H
S
G
P
Y
I
P
S
S
Site 92
Y239
I
V
S
H
S
G
P
Y
I
P
S
S
H
S
V
Site 93
S242
H
S
G
P
Y
I
P
S
S
H
S
V
S
G
G
Site 94
S243
S
G
P
Y
I
P
S
S
H
S
V
S
G
G
Q
Site 95
S245
P
Y
I
P
S
S
H
S
V
S
G
G
Q
R
P
Site 96
S247
I
P
S
S
H
S
V
S
G
G
Q
R
P
V
V
Site 97
S274
V
V
Q
G
P
P
C
S
N
G
G
L
P
G
K
Site 98
T287
G
K
P
C
P
P
I
T
S
V
D
K
S
Y
G
Site 99
S288
K
P
C
P
P
I
T
S
V
D
K
S
Y
G
G
Site 100
S292
P
I
T
S
V
D
K
S
Y
G
G
Y
E
V
V
Site 101
Y293
I
T
S
V
D
K
S
Y
G
G
Y
E
V
V
G
Site 102
Y296
V
D
K
S
Y
G
G
Y
E
V
V
G
G
S
S
Site 103
S305
V
V
G
G
S
S
D
S
Y
L
V
P
G
M
T
Site 104
Y306
V
G
G
S
S
D
S
Y
L
V
P
G
M
T
Y
Site 105
T312
S
Y
L
V
P
G
M
T
Y
S
K
G
K
I
Y
Site 106
Y319
T
Y
S
K
G
K
I
Y
P
V
G
Y
F
T
K
Site 107
Y323
G
K
I
Y
P
V
G
Y
F
T
K
E
N
P
V
Site 108
S333
K
E
N
P
V
K
G
S
P
G
V
P
S
F
A
Site 109
S338
K
G
S
P
G
V
P
S
F
A
A
G
P
P
I
Site 110
S346
F
A
A
G
P
P
I
S
E
G
K
Y
F
S
S
Site 111
Y350
P
P
I
S
E
G
K
Y
F
S
S
N
P
I
I
Site 112
S352
I
S
E
G
K
Y
F
S
S
N
P
I
I
P
S
Site 113
S353
S
E
G
K
Y
F
S
S
N
P
I
I
P
S
Q
Site 114
S359
S
S
N
P
I
I
P
S
Q
S
A
A
S
S
A
Site 115
S384
V
Q
L
C
G
G
G
S
T
G
S
K
G
P
C
Site 116
S387
C
G
G
G
S
T
G
S
K
G
P
C
S
P
S
Site 117
S392
T
G
S
K
G
P
C
S
P
S
S
S
R
V
P
Site 118
S394
S
K
G
P
C
S
P
S
S
S
R
V
P
S
S
Site 119
S395
K
G
P
C
S
P
S
S
S
R
V
P
S
S
S
Site 120
S396
G
P
C
S
P
S
S
S
R
V
P
S
S
S
S
Site 121
S400
P
S
S
S
R
V
P
S
S
S
S
I
S
S
S
Site 122
S401
S
S
S
R
V
P
S
S
S
S
I
S
S
S
S
Site 123
S402
S
S
R
V
P
S
S
S
S
I
S
S
S
S
G
Site 124
S403
S
R
V
P
S
S
S
S
I
S
S
S
S
G
S
Site 125
S405
V
P
S
S
S
S
I
S
S
S
S
G
S
P
Y
Site 126
S406
P
S
S
S
S
I
S
S
S
S
G
S
P
Y
H
Site 127
S407
S
S
S
S
I
S
S
S
S
G
S
P
Y
H
P
Site 128
S408
S
S
S
I
S
S
S
S
G
S
P
Y
H
P
C
Site 129
S410
S
I
S
S
S
S
G
S
P
Y
H
P
C
G
S
Site 130
Y412
S
S
S
S
G
S
P
Y
H
P
C
G
S
A
S
Site 131
S417
S
P
Y
H
P
C
G
S
A
S
Q
S
P
C
S
Site 132
S419
Y
H
P
C
G
S
A
S
Q
S
P
C
S
P
P
Site 133
S421
P
C
G
S
A
S
Q
S
P
C
S
P
P
G
T
Site 134
S424
S
A
S
Q
S
P
C
S
P
P
G
T
G
S
F
Site 135
T428
S
P
C
S
P
P
G
T
G
S
F
S
S
S
S
Site 136
S430
C
S
P
P
G
T
G
S
F
S
S
S
S
S
S
Site 137
S432
P
P
G
T
G
S
F
S
S
S
S
S
S
Q
S
Site 138
S433
P
G
T
G
S
F
S
S
S
S
S
S
Q
S
S
Site 139
S434
G
T
G
S
F
S
S
S
S
S
S
Q
S
S
G
Site 140
S435
T
G
S
F
S
S
S
S
S
S
Q
S
S
G
K
Site 141
S436
G
S
F
S
S
S
S
S
S
Q
S
S
G
K
I
Site 142
S437
S
F
S
S
S
S
S
S
Q
S
S
G
K
I
I
Site 143
S439
S
S
S
S
S
S
Q
S
S
G
K
I
I
L
Q
Site 144
S440
S
S
S
S
S
Q
S
S
G
K
I
I
L
Q
P
Site 145
S450
I
I
L
Q
P
C
G
S
K
S
S
S
S
G
H
Site 146
S452
L
Q
P
C
G
S
K
S
S
S
S
G
H
P
C
Site 147
S453
Q
P
C
G
S
K
S
S
S
S
G
H
P
C
M
Site 148
S454
P
C
G
S
K
S
S
S
S
G
H
P
C
M
S
Site 149
S455
C
G
S
K
S
S
S
S
G
H
P
C
M
S
V
Site 150
T468
S
V
S
S
L
T
L
T
G
G
P
D
G
S
P
Site 151
S474
L
T
G
G
P
D
G
S
P
H
P
D
P
S
A
Site 152
S480
G
S
P
H
P
D
P
S
A
G
A
K
P
C
G
Site 153
S488
A
G
A
K
P
C
G
S
S
S
A
G
K
I
P
Site 154
S490
A
K
P
C
G
S
S
S
A
G
K
I
P
C
R
Site 155
S498
A
G
K
I
P
C
R
S
I
R
D
I
L
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation