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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TAF1C
Full Name:
TATA box-binding protein-associated factor RNA polymerase I subunit C
Alias:
MGC39976; SL1; SL1, 110kD subunit; TAFI110; TAFI95; TATA box binding protein (TBP)-associated factor; TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa; TBP-associated factor 1C; TBP-associated factor RNA polymerase I 110 kDa; transcription factor SL1
Type:
Transcription initiation complex
Mass (Da):
95274
Number AA:
869
UniProt ID:
Q15572
International Prot ID:
IPI00246842
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003701
GO:0016251
PhosphoSite+
KinaseNET
Biological Process:
GO:0006360
GO:0006366
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
L
S
D
V
P
D
L
S
F
M
C
S
W
R
D
Site 2
T36
C
S
W
R
D
A
L
T
L
P
E
A
Q
P
Q
Site 3
T81
D
P
W
D
P
G
L
T
A
R
D
L
L
F
R
Site 4
Y91
D
L
L
F
R
G
G
Y
R
Y
R
K
R
P
R
Site 5
Y93
L
F
R
G
G
Y
R
Y
R
K
R
P
R
V
V
Site 6
S108
L
D
V
T
E
Q
I
S
R
F
L
L
D
H
G
Site 7
S137
F
K
L
E
G
A
G
S
R
T
K
K
K
T
V
Site 8
T143
G
S
R
T
K
K
K
T
V
V
S
V
K
K
L
Site 9
S146
T
K
K
K
T
V
V
S
V
K
K
L
L
Q
D
Site 10
S175
S
N
R
Q
R
R
F
S
I
L
G
G
P
I
L
Site 11
Y231
P
Q
F
G
Q
L
V
Y
P
A
G
G
A
Q
D
Site 12
T248
H
F
Q
E
V
V
L
T
P
G
D
N
P
Q
F
Site 13
T275
V
R
Q
V
V
T
C
T
V
Q
G
E
S
K
A
Site 14
S305
P
G
P
F
H
P
S
S
A
L
L
A
V
R
S
Site 15
S343
E
K
G
A
T
G
I
S
L
S
P
H
L
P
G
Site 16
S365
S
G
A
V
C
L
W
S
P
E
D
G
L
R
Q
Site 17
Y374
E
D
G
L
R
Q
I
Y
R
D
P
E
T
L
V
Site 18
T379
Q
I
Y
R
D
P
E
T
L
V
F
R
D
S
S
Site 19
S385
E
T
L
V
F
R
D
S
S
S
W
R
W
A
D
Site 20
S386
T
L
V
F
R
D
S
S
S
W
R
W
A
D
F
Site 21
S387
L
V
F
R
D
S
S
S
W
R
W
A
D
F
T
Site 22
T401
T
A
H
P
R
V
L
T
V
G
D
R
T
G
V
Site 23
T413
T
G
V
K
M
L
D
T
Q
G
P
P
G
C
G
Site 24
S431
F
R
L
G
A
E
A
S
C
Q
K
G
E
R
V
Site 25
T441
K
G
E
R
V
L
L
T
Q
Y
L
G
H
S
S
Site 26
Y443
E
R
V
L
L
T
Q
Y
L
G
H
S
S
P
K
Site 27
S448
T
Q
Y
L
G
H
S
S
P
K
C
L
P
P
T
Site 28
S486
K
W
N
H
G
L
P
S
P
L
L
L
A
R
L
Site 29
S525
H
L
A
G
E
G
A
S
V
P
R
L
A
G
P
Site 30
S535
R
L
A
G
P
P
Q
S
L
P
S
R
I
D
S
Site 31
S538
G
P
P
Q
S
L
P
S
R
I
D
S
L
P
A
Site 32
Y596
S
A
A
G
D
V
F
Y
Q
Q
L
R
P
Q
V
Site 33
S605
Q
L
R
P
Q
V
D
S
S
L
R
R
D
A
G
Site 34
S606
L
R
P
Q
V
D
S
S
L
R
R
D
A
G
P
Site 35
T625
Q
P
D
C
H
A
P
T
A
S
W
T
S
Q
D
Site 36
S627
D
C
H
A
P
T
A
S
W
T
S
Q
D
T
A
Site 37
S637
S
Q
D
T
A
G
C
S
Q
W
L
K
A
L
L
Site 38
T654
P
L
A
P
P
V
W
T
A
P
T
F
T
H
R
Site 39
T659
V
W
T
A
P
T
F
T
H
R
Q
M
L
G
S
Site 40
S666
T
H
R
Q
M
L
G
S
T
E
L
R
R
E
E
Site 41
S699
L
L
Q
R
D
L
G
S
L
P
A
A
E
P
P
Site 42
S711
E
P
P
P
A
P
E
S
G
L
E
D
K
L
S
Site 43
S718
S
G
L
E
D
K
L
S
E
R
L
G
E
A
W
Site 44
T740
W
E
R
Q
Q
G
R
T
S
E
P
G
R
Q
T
Site 45
S741
E
R
Q
Q
G
R
T
S
E
P
G
R
Q
T
R
Site 46
T747
T
S
E
P
G
R
Q
T
R
R
P
K
R
R
T
Site 47
T754
T
R
R
P
K
R
R
T
Q
L
S
S
S
F
S
Site 48
S757
P
K
R
R
T
Q
L
S
S
S
F
S
L
S
G
Site 49
S758
K
R
R
T
Q
L
S
S
S
F
S
L
S
G
H
Site 50
S759
R
R
T
Q
L
S
S
S
F
S
L
S
G
H
V
Site 51
S761
T
Q
L
S
S
S
F
S
L
S
G
H
V
D
P
Site 52
S763
L
S
S
S
F
S
L
S
G
H
V
D
P
S
E
Site 53
S769
L
S
G
H
V
D
P
S
E
D
T
S
S
P
H
Site 54
T772
H
V
D
P
S
E
D
T
S
S
P
H
S
P
E
Site 55
S773
V
D
P
S
E
D
T
S
S
P
H
S
P
E
W
Site 56
S774
D
P
S
E
D
T
S
S
P
H
S
P
E
W
P
Site 57
S777
E
D
T
S
S
P
H
S
P
E
W
P
P
A
D
Site 58
T791
D
A
L
P
L
P
P
T
T
P
P
S
Q
E
L
Site 59
T792
A
L
P
L
P
P
T
T
P
P
S
Q
E
L
T
Site 60
S795
L
P
P
T
T
P
P
S
Q
E
L
T
P
D
A
Site 61
T799
T
P
P
S
Q
E
L
T
P
D
A
C
A
Q
G
Site 62
Y818
Q
R
Q
M
L
R
D
Y
M
A
K
L
P
P
Q
Site 63
T828
K
L
P
P
Q
R
D
T
P
G
C
A
T
T
P
Site 64
T833
R
D
T
P
G
C
A
T
T
P
P
H
S
Q
A
Site 65
T834
D
T
P
G
C
A
T
T
P
P
H
S
Q
A
S
Site 66
S838
C
A
T
T
P
P
H
S
Q
A
S
S
V
R
A
Site 67
S842
P
P
H
S
Q
A
S
S
V
R
A
T
R
S
Q
Site 68
T846
Q
A
S
S
V
R
A
T
R
S
Q
Q
H
T
P
Site 69
S848
S
S
V
R
A
T
R
S
Q
Q
H
T
P
V
L
Site 70
T852
A
T
R
S
Q
Q
H
T
P
V
L
S
S
S
Q
Site 71
S856
Q
Q
H
T
P
V
L
S
S
S
Q
P
L
R
K
Site 72
S857
Q
H
T
P
V
L
S
S
S
Q
P
L
R
K
K
Site 73
S858
H
T
P
V
L
S
S
S
Q
P
L
R
K
K
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation