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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NCOA2
Full Name:
Nuclear receptor coactivator 2
Alias:
BHLHe75; Glucocorticoid receptor-interacting protein-1; GRIP1; KAT13C; NCoA-2; Nuclear receptor coactivator 2; TIF2; Transcriptional intermediary factor 2
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
159157
Number AA:
1464
UniProt ID:
Q15596
International Prot ID:
IPI00018251
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003712
GO:0003713
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0000122
GO:0006139
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
G
M
G
E
N
T
S
Site 2
T8
M
S
G
M
G
E
N
T
S
D
P
S
R
A
E
Site 3
S9
S
G
M
G
E
N
T
S
D
P
S
R
A
E
T
Site 4
S12
G
E
N
T
S
D
P
S
R
A
E
T
R
K
R
Site 5
T16
S
D
P
S
R
A
E
T
R
K
R
K
E
C
P
Site 6
S29
C
P
D
Q
L
G
P
S
P
K
R
N
T
E
K
Site 7
T34
G
P
S
P
K
R
N
T
E
K
R
N
R
E
Q
Site 8
S100
N
I
D
E
V
Q
K
S
D
V
S
S
T
G
Q
Site 9
S104
V
Q
K
S
D
V
S
S
T
G
Q
G
V
I
D
Site 10
T144
V
F
V
S
E
N
V
T
Q
Y
L
R
Y
N
Q
Site 11
Y146
V
S
E
N
V
T
Q
Y
L
R
Y
N
Q
E
E
Site 12
S158
Q
E
E
L
M
N
K
S
V
Y
S
I
L
H
V
Site 13
S161
L
M
N
K
S
V
Y
S
I
L
H
V
G
D
H
Site 14
S179
V
K
N
L
L
P
K
S
I
V
N
G
G
S
W
Site 15
S185
K
S
I
V
N
G
G
S
W
S
G
E
P
P
R
Site 16
S187
I
V
N
G
G
S
W
S
G
E
P
P
R
R
N
Site 17
S195
G
E
P
P
R
R
N
S
H
T
F
N
C
R
M
Site 18
T197
P
P
R
R
N
S
H
T
F
N
C
R
M
L
V
Site 19
S210
L
V
K
P
L
P
D
S
E
E
E
G
H
D
N
Site 20
Y224
N
Q
E
A
H
Q
K
Y
E
T
M
Q
C
F
A
Site 21
S233
T
M
Q
C
F
A
V
S
Q
P
K
S
I
K
E
Site 22
S237
F
A
V
S
Q
P
K
S
I
K
E
E
G
E
D
Site 23
S247
E
E
G
E
D
L
Q
S
C
L
I
C
V
A
R
Site 24
S266
K
E
R
P
V
L
P
S
S
E
S
F
T
T
R
Site 25
S267
E
R
P
V
L
P
S
S
E
S
F
T
T
R
Q
Site 26
S269
P
V
L
P
S
S
E
S
F
T
T
R
Q
D
L
Site 27
T271
L
P
S
S
E
S
F
T
T
R
Q
D
L
Q
G
Site 28
T272
P
S
S
E
S
F
T
T
R
Q
D
L
Q
G
K
Site 29
S282
D
L
Q
G
K
I
T
S
L
D
T
S
T
M
R
Site 30
S286
K
I
T
S
L
D
T
S
T
M
R
A
A
M
K
Site 31
T287
I
T
S
L
D
T
S
T
M
R
A
A
M
K
P
Site 32
S317
Q
H
E
G
E
S
V
S
Y
A
K
R
H
H
H
Site 33
Y318
H
E
G
E
S
V
S
Y
A
K
R
H
H
H
E
Site 34
T345
R
F
S
L
S
D
G
T
L
V
A
A
Q
T
K
Site 35
S353
L
V
A
A
Q
T
K
S
K
L
I
R
S
Q
T
Site 36
S358
T
K
S
K
L
I
R
S
Q
T
T
N
E
P
Q
Site 37
T360
S
K
L
I
R
S
Q
T
T
N
E
P
Q
L
V
Site 38
T387
C
V
M
N
P
D
L
T
G
Q
T
M
G
K
P
Site 39
S399
G
K
P
L
N
P
I
S
S
N
S
P
A
H
Q
Site 40
S400
K
P
L
N
P
I
S
S
N
S
P
A
H
Q
A
Site 41
S402
L
N
P
I
S
S
N
S
P
A
H
Q
A
L
C
Site 42
T418
G
N
P
G
Q
D
M
T
L
S
S
N
I
N
F
Site 43
S420
P
G
Q
D
M
T
L
S
S
N
I
N
F
P
I
Site 44
S444
P
M
G
R
F
G
G
S
G
G
M
N
H
V
S
Site 45
S451
S
G
G
M
N
H
V
S
G
M
Q
A
T
T
P
Site 46
T457
V
S
G
M
Q
A
T
T
P
Q
G
S
N
Y
A
Site 47
S469
N
Y
A
L
K
M
N
S
P
S
Q
S
S
P
G
Site 48
S471
A
L
K
M
N
S
P
S
Q
S
S
P
G
M
N
Site 49
S473
K
M
N
S
P
S
Q
S
S
P
G
M
N
P
G
Site 50
S474
M
N
S
P
S
Q
S
S
P
G
M
N
P
G
Q
Site 51
T483
G
M
N
P
G
Q
P
T
S
M
L
S
P
R
H
Site 52
S484
M
N
P
G
Q
P
T
S
M
L
S
P
R
H
R
Site 53
S487
G
Q
P
T
S
M
L
S
P
R
H
R
M
S
P
Site 54
S493
L
S
P
R
H
R
M
S
P
G
V
A
G
S
P
Site 55
S499
M
S
P
G
V
A
G
S
P
R
I
P
P
S
Q
Site 56
S505
G
S
P
R
I
P
P
S
Q
F
S
P
A
G
S
Site 57
S508
R
I
P
P
S
Q
F
S
P
A
G
S
L
H
S
Site 58
S512
S
Q
F
S
P
A
G
S
L
H
S
P
V
G
V
Site 59
S515
S
P
A
G
S
L
H
S
P
V
G
V
C
S
S
Site 60
S521
H
S
P
V
G
V
C
S
S
T
G
N
S
H
S
Site 61
S522
S
P
V
G
V
C
S
S
T
G
N
S
H
S
Y
Site 62
T523
P
V
G
V
C
S
S
T
G
N
S
H
S
Y
T
Site 63
S526
V
C
S
S
T
G
N
S
H
S
Y
T
N
S
S
Site 64
S528
S
S
T
G
N
S
H
S
Y
T
N
S
S
L
N
Site 65
Y529
S
T
G
N
S
H
S
Y
T
N
S
S
L
N
A
Site 66
T530
T
G
N
S
H
S
Y
T
N
S
S
L
N
A
L
Site 67
S532
N
S
H
S
Y
T
N
S
S
L
N
A
L
Q
A
Site 68
S533
S
H
S
Y
T
N
S
S
L
N
A
L
Q
A
L
Site 69
S551
H
G
V
S
L
G
S
S
L
A
S
P
D
L
K
Site 70
S554
S
L
G
S
S
L
A
S
P
D
L
K
M
G
N
Site 71
S565
K
M
G
N
L
Q
N
S
P
V
N
M
N
P
P
Site 72
S575
N
M
N
P
P
P
L
S
K
M
G
S
L
D
S
Site 73
S579
P
P
L
S
K
M
G
S
L
D
S
K
D
C
F
Site 74
S582
S
K
M
G
S
L
D
S
K
D
C
F
G
L
Y
Site 75
Y589
S
K
D
C
F
G
L
Y
G
E
P
S
E
G
T
Site 76
S593
F
G
L
Y
G
E
P
S
E
G
T
T
G
Q
A
Site 77
T597
G
E
P
S
E
G
T
T
G
Q
A
E
S
S
C
Site 78
S602
G
T
T
G
Q
A
E
S
S
C
H
P
G
E
Q
Site 79
T612
H
P
G
E
Q
K
E
T
N
D
P
N
L
P
P
Site 80
S622
P
N
L
P
P
A
V
S
S
E
R
A
D
G
Q
Site 81
S623
N
L
P
P
A
V
S
S
E
R
A
D
G
Q
S
Site 82
S630
S
E
R
A
D
G
Q
S
R
L
H
D
S
K
G
Site 83
T639
L
H
D
S
K
G
Q
T
K
L
L
Q
L
L
T
Site 84
S649
L
Q
L
L
T
T
K
S
D
Q
M
E
P
S
P
Site 85
S655
K
S
D
Q
M
E
P
S
P
L
A
S
S
L
S
Site 86
S659
M
E
P
S
P
L
A
S
S
L
S
D
T
N
K
Site 87
S660
E
P
S
P
L
A
S
S
L
S
D
T
N
K
D
Site 88
S662
S
P
L
A
S
S
L
S
D
T
N
K
D
S
T
Site 89
T664
L
A
S
S
L
S
D
T
N
K
D
S
T
G
S
Site 90
S668
L
S
D
T
N
K
D
S
T
G
S
L
P
G
S
Site 91
T669
S
D
T
N
K
D
S
T
G
S
L
P
G
S
G
Site 92
S671
T
N
K
D
S
T
G
S
L
P
G
S
G
S
T
Site 93
S675
S
T
G
S
L
P
G
S
G
S
T
H
G
T
S
Site 94
S677
G
S
L
P
G
S
G
S
T
H
G
T
S
L
K
Site 95
T681
G
S
G
S
T
H
G
T
S
L
K
E
K
H
K
Site 96
S682
S
G
S
T
H
G
T
S
L
K
E
K
H
K
I
Site 97
S697
L
H
R
L
L
Q
D
S
S
S
P
V
D
L
A
Site 98
S698
H
R
L
L
Q
D
S
S
S
P
V
D
L
A
K
Site 99
S699
R
L
L
Q
D
S
S
S
P
V
D
L
A
K
L
Site 100
S716
E
A
T
G
K
D
L
S
Q
E
S
S
S
T
A
Site 101
S719
G
K
D
L
S
Q
E
S
S
S
T
A
P
G
S
Site 102
S720
K
D
L
S
Q
E
S
S
S
T
A
P
G
S
E
Site 103
S721
D
L
S
Q
E
S
S
S
T
A
P
G
S
E
V
Site 104
T722
L
S
Q
E
S
S
S
T
A
P
G
S
E
V
T
Site 105
S726
S
S
S
T
A
P
G
S
E
V
T
I
K
Q
E
Site 106
T729
T
A
P
G
S
E
V
T
I
K
Q
E
P
V
S
Site 107
S736
T
I
K
Q
E
P
V
S
P
K
K
K
E
N
A
Site 108
T754
Y
L
L
D
K
D
D
T
K
D
I
G
L
P
E
Site 109
T763
D
I
G
L
P
E
I
T
P
K
L
E
R
L
D
Site 110
S771
P
K
L
E
R
L
D
S
K
T
D
P
A
S
N
Site 111
T773
L
E
R
L
D
S
K
T
D
P
A
S
N
T
K
Site 112
S777
D
S
K
T
D
P
A
S
N
T
K
L
I
A
M
Site 113
T786
T
K
L
I
A
M
K
T
E
K
E
E
M
S
F
Site 114
S792
K
T
E
K
E
E
M
S
F
E
P
G
D
Q
P
Site 115
S801
E
P
G
D
Q
P
G
S
E
L
D
N
L
E
E
Site 116
S816
I
L
D
D
L
Q
N
S
Q
L
P
Q
L
F
P
Site 117
T825
L
P
Q
L
F
P
D
T
R
P
G
A
P
A
G
Site 118
T847
I
N
D
L
M
Q
L
T
A
E
N
S
P
V
T
Site 119
S851
M
Q
L
T
A
E
N
S
P
V
T
P
V
G
A
Site 120
T854
T
A
E
N
S
P
V
T
P
V
G
A
Q
K
T
Site 121
T861
T
P
V
G
A
Q
K
T
A
L
R
I
S
Q
S
Site 122
S866
Q
K
T
A
L
R
I
S
Q
S
T
F
N
N
P
Site 123
S868
T
A
L
R
I
S
Q
S
T
F
N
N
P
R
P
Site 124
T869
A
L
R
I
S
Q
S
T
F
N
N
P
R
P
G
Site 125
T892
Q
N
L
P
L
D
I
T
L
Q
S
P
T
G
A
Site 126
S908
P
F
P
P
I
R
N
S
S
P
Y
S
V
I
P
Site 127
S909
F
P
P
I
R
N
S
S
P
Y
S
V
I
P
Q
Site 128
Y911
P
I
R
N
S
S
P
Y
S
V
I
P
Q
P
G
Site 129
S912
I
R
N
S
S
P
Y
S
V
I
P
Q
P
G
M
Site 130
S936
Q
G
N
L
G
N
S
S
T
G
M
I
G
N
S
Site 131
T937
G
N
L
G
N
S
S
T
G
M
I
G
N
S
A
Site 132
S943
S
T
G
M
I
G
N
S
A
S
R
P
T
M
P
Site 133
S945
G
M
I
G
N
S
A
S
R
P
T
M
P
S
G
Site 134
T948
G
N
S
A
S
R
P
T
M
P
S
G
E
W
A
Site 135
S951
A
S
R
P
T
M
P
S
G
E
W
A
P
Q
S
Site 136
S958
S
G
E
W
A
P
Q
S
S
A
V
R
V
T
C
Site 137
S959
G
E
W
A
P
Q
S
S
A
V
R
V
T
C
A
Site 138
S987
M
I
R
N
P
A
A
S
I
P
M
R
P
S
S
Site 139
S993
A
S
I
P
M
R
P
S
S
Q
P
G
Q
R
Q
Site 140
S994
S
I
P
M
R
P
S
S
Q
P
G
Q
R
Q
T
Site 141
T1001
S
Q
P
G
Q
R
Q
T
L
Q
S
Q
V
M
N
Site 142
S1004
G
Q
R
Q
T
L
Q
S
Q
V
M
N
I
G
P
Site 143
S1024
N
M
G
G
P
Q
Y
S
Q
Q
Q
A
P
P
N
Site 144
S1039
Q
T
A
P
W
P
E
S
I
L
P
I
D
Q
A
Site 145
S1047
I
L
P
I
D
Q
A
S
F
A
S
Q
N
R
Q
Site 146
S1050
I
D
Q
A
S
F
A
S
Q
N
R
Q
P
F
G
Site 147
S1058
Q
N
R
Q
P
F
G
S
S
P
D
D
L
L
C
Site 148
S1059
N
R
Q
P
F
G
S
S
P
D
D
L
L
C
P
Site 149
S1072
C
P
H
P
A
A
E
S
P
S
D
E
G
A
L
Site 150
S1074
H
P
A
A
E
S
P
S
D
E
G
A
L
L
D
Site 151
S1109
I
P
E
L
V
S
Q
S
Q
A
V
D
P
E
Q
Site 152
S1118
A
V
D
P
E
Q
F
S
S
Q
D
S
N
I
M
Site 153
S1119
V
D
P
E
Q
F
S
S
Q
D
S
N
I
M
L
Site 154
S1122
E
Q
F
S
S
Q
D
S
N
I
M
L
E
Q
K
Site 155
S1139
V
F
P
Q
Q
Y
A
S
Q
A
Q
M
A
Q
G
Site 156
S1149
Q
M
A
Q
G
S
Y
S
P
M
Q
D
P
N
F
Site 157
T1158
M
Q
D
P
N
F
H
T
M
G
Q
R
P
S
Y
Site 158
S1164
H
T
M
G
Q
R
P
S
Y
A
T
L
R
M
Q
Site 159
Y1165
T
M
G
Q
R
P
S
Y
A
T
L
R
M
Q
P
Site 160
T1167
G
Q
R
P
S
Y
A
T
L
R
M
Q
P
R
P
Site 161
T1179
P
R
P
G
L
R
P
T
G
L
V
Q
N
Q
P
Site 162
T1219
N
V
S
N
V
N
L
T
L
R
P
G
V
P
T
Site 163
T1226
T
L
R
P
G
V
P
T
Q
A
P
I
N
A
Q
Site 164
T1273
R
G
Q
G
L
N
M
T
P
S
M
V
A
P
S
Site 165
T1285
A
P
S
G
M
P
A
T
M
S
N
P
R
I
P
Site 166
S1287
S
G
M
P
A
T
M
S
N
P
R
I
P
Q
A
Site 167
Y1305
Q
F
P
F
P
P
N
Y
G
I
S
Q
Q
P
D
Site 168
S1308
F
P
P
N
Y
G
I
S
Q
Q
P
D
P
G
F
Site 169
T1319
D
P
G
F
T
G
A
T
T
P
Q
S
P
L
M
Site 170
T1320
P
G
F
T
G
A
T
T
P
Q
S
P
L
M
S
Site 171
S1323
T
G
A
T
T
P
Q
S
P
L
M
S
P
R
M
Site 172
S1327
T
P
Q
S
P
L
M
S
P
R
M
A
H
T
Q
Site 173
T1333
M
S
P
R
M
A
H
T
Q
S
P
M
M
Q
Q
Site 174
S1335
P
R
M
A
H
T
Q
S
P
M
M
Q
Q
S
Q
Site 175
S1341
Q
S
P
M
M
Q
Q
S
Q
A
N
P
A
Y
Q
Site 176
Y1347
Q
S
Q
A
N
P
A
Y
Q
A
P
S
D
I
N
Site 177
S1365
Q
G
N
M
G
G
N
S
M
F
S
Q
Q
S
P
Site 178
S1368
M
G
G
N
S
M
F
S
Q
Q
S
P
P
H
F
Site 179
S1371
N
S
M
F
S
Q
Q
S
P
P
H
F
G
Q
Q
Site 180
T1398
N
V
S
M
A
T
N
T
G
G
M
S
S
M
N
Site 181
S1412
N
Q
M
T
G
Q
I
S
M
T
S
V
T
S
V
Site 182
S1415
T
G
Q
I
S
M
T
S
V
T
S
V
P
T
S
Site 183
S1425
S
V
P
T
S
G
L
S
S
M
G
P
E
Q
V
Site 184
S1426
V
P
T
S
G
L
S
S
M
G
P
E
Q
V
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation