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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DIXDC1
Full Name:
Dixin
Alias:
Coiled-coil-DIX1; DIX domain containing 1; DIX domain-containing 1; DIXC1; Dixin; KIAA1735
Type:
Adhesion; Cell development/differentiation
Mass (Da):
77478
Number AA:
683
UniProt ID:
Q155Q3
International Prot ID:
IPI00028306
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005925
GO:0030054
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0004871
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0007275
GO:0007166
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y26
N
E
Q
Q
L
Q
A
Y
V
A
W
V
N
A
Q
Site 2
S74
K
L
S
G
V
Q
L
S
P
G
N
Q
Q
E
M
Site 3
S103
K
I
R
M
H
Q
T
S
A
K
D
I
V
D
G
Site 4
S130
A
A
H
F
K
P
G
S
S
R
T
V
N
Q
G
Site 5
T133
F
K
P
G
S
S
R
T
V
N
Q
G
R
D
S
Site 6
S140
T
V
N
Q
G
R
D
S
R
A
P
L
Q
S
H
Site 7
S146
D
S
R
A
P
L
Q
S
H
R
P
H
C
A
T
Site 8
T153
S
H
R
P
H
C
A
T
A
V
A
Q
G
A
A
Site 9
Y180
S
G
R
D
V
F
R
Y
R
Q
R
N
S
S
M
Site 10
S185
F
R
Y
R
Q
R
N
S
S
M
D
E
E
I
E
Site 11
S186
R
Y
R
Q
R
N
S
S
M
D
E
E
I
E
N
Site 12
Y195
D
E
E
I
E
N
P
Y
W
S
V
R
A
L
V
Site 13
S211
Q
Y
E
G
Q
Q
R
S
P
S
E
S
S
C
S
Site 14
S213
E
G
Q
Q
R
S
P
S
E
S
S
C
S
S
L
Site 15
S215
Q
Q
R
S
P
S
E
S
S
C
S
S
L
T
S
Site 16
S216
Q
R
S
P
S
E
S
S
C
S
S
L
T
S
P
Site 17
S218
S
P
S
E
S
S
C
S
S
L
T
S
P
S
P
Site 18
S219
P
S
E
S
S
C
S
S
L
T
S
P
S
P
I
Site 19
T221
E
S
S
C
S
S
L
T
S
P
S
P
I
H
S
Site 20
S222
S
S
C
S
S
L
T
S
P
S
P
I
H
S
A
Site 21
S224
C
S
S
L
T
S
P
S
P
I
H
S
A
K
S
Site 22
S228
T
S
P
S
P
I
H
S
A
K
S
E
S
I
I
Site 23
S231
S
P
I
H
S
A
K
S
E
S
I
I
T
Q
S
Site 24
T236
A
K
S
E
S
I
I
T
Q
S
E
E
K
A
D
Site 25
T259
I
E
N
R
T
E
G
T
D
S
P
L
S
R
D
Site 26
S261
N
R
T
E
G
T
D
S
P
L
S
R
D
W
R
Site 27
S264
E
G
T
D
S
P
L
S
R
D
W
R
P
G
S
Site 28
S271
S
R
D
W
R
P
G
S
P
G
T
Y
L
E
T
Site 29
Y275
R
P
G
S
P
G
T
Y
L
E
T
S
W
E
E
Site 30
S279
P
G
T
Y
L
E
T
S
W
E
E
Q
L
L
E
Site 31
Y290
Q
L
L
E
Q
Q
E
Y
L
E
K
E
M
E
E
Site 32
S313
Q
A
L
L
L
N
G
S
L
P
E
D
E
Q
E
Site 33
S341
E
Q
L
I
I
I
Q
S
R
L
D
Q
S
M
E
Site 34
S346
I
Q
S
R
L
D
Q
S
M
E
E
N
Q
D
L
Site 35
T379
D
A
L
Q
Q
R
L
T
Q
Q
D
T
S
V
L
Site 36
T383
Q
R
L
T
Q
Q
D
T
S
V
L
Q
L
K
Q
Site 37
S384
R
L
T
Q
Q
D
T
S
V
L
Q
L
K
Q
E
Site 38
Y423
R
N
R
L
L
G
E
Y
K
K
E
L
G
Q
K
Site 39
S449
E
E
A
L
R
K
L
S
D
V
S
Y
H
Q
V
Site 40
Y453
R
K
L
S
D
V
S
Y
H
Q
V
D
L
E
R
Site 41
T481
K
R
E
A
D
E
A
T
N
Y
N
S
H
N
S
Site 42
Y483
E
A
D
E
A
T
N
Y
N
S
H
N
S
Q
S
Site 43
S485
D
E
A
T
N
Y
N
S
H
N
S
Q
S
N
G
Site 44
S488
T
N
Y
N
S
H
N
S
Q
S
N
G
F
L
L
Site 45
S490
Y
N
S
H
N
S
Q
S
N
G
F
L
L
P
T
Site 46
S504
T
A
G
K
G
A
T
S
V
S
N
R
G
T
S
Site 47
S506
G
K
G
A
T
S
V
S
N
R
G
T
S
D
L
Site 48
T510
T
S
V
S
N
R
G
T
S
D
L
Q
L
V
R
Site 49
S511
S
V
S
N
R
G
T
S
D
L
Q
L
V
R
D
Site 50
S522
L
V
R
D
A
L
R
S
L
R
N
S
F
S
G
Site 51
S526
A
L
R
S
L
R
N
S
F
S
G
H
D
P
Q
Site 52
S528
R
S
L
R
N
S
F
S
G
H
D
P
Q
H
H
Site 53
S539
P
Q
H
H
T
I
D
S
L
E
Q
G
I
S
S
Site 54
S545
D
S
L
E
Q
G
I
S
S
L
M
E
R
L
H
Site 55
S546
S
L
E
Q
G
I
S
S
L
M
E
R
L
H
V
Site 56
S568
E
R
K
V
R
V
K
S
P
R
T
Q
V
G
S
Site 57
T571
V
R
V
K
S
P
R
T
Q
V
G
S
E
Y
R
Site 58
S575
S
P
R
T
Q
V
G
S
E
Y
R
E
S
W
P
Site 59
Y577
R
T
Q
V
G
S
E
Y
R
E
S
W
P
P
N
Site 60
S580
V
G
S
E
Y
R
E
S
W
P
P
N
S
K
L
Site 61
S585
R
E
S
W
P
P
N
S
K
L
P
H
S
Q
S
Site 62
S590
P
N
S
K
L
P
H
S
Q
S
S
P
T
V
S
Site 63
S592
S
K
L
P
H
S
Q
S
S
P
T
V
S
S
T
Site 64
S593
K
L
P
H
S
Q
S
S
P
T
V
S
S
T
C
Site 65
T595
P
H
S
Q
S
S
P
T
V
S
S
T
C
T
K
Site 66
S597
S
Q
S
S
P
T
V
S
S
T
C
T
K
V
L
Site 67
S598
Q
S
S
P
T
V
S
S
T
C
T
K
V
L
Y
Site 68
Y605
S
T
C
T
K
V
L
Y
F
T
D
R
S
L
T
Site 69
T626
P
K
R
L
E
E
V
T
L
K
D
F
K
A
A
Site 70
Y642
D
R
E
G
N
H
R
Y
H
F
K
A
L
D
P
Site 71
T653
A
L
D
P
E
F
G
T
V
K
E
E
I
F
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation