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Updated November 2019
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Protein Info
Short Name:
TRIP11
Full Name:
Thyroid receptor-interacting protein 11
Alias:
CEV14; Clonal evolution related gene on chromosome 14; GMAP-210; Golgi-associated microtubule-binding 210; Golgi-associated microtubule-binding protein 210; Thyroid hormone receptor interactor 11; Thyroid receptor-interacting 11; TRIP-11; Trip230; TRIPB
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Mass (Da):
227586
Number AA:
1979
UniProt ID:
Q15643
International Prot ID:
IPI00003515
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005856
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0006366
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
W
L
G
G
L
G
Site 2
S3
_
_
_
_
_
M
S
S
W
L
G
G
L
G
S
Site 3
S31
A
S
L
T
G
Q
I
S
N
F
T
K
D
M
L
Site 4
T34
T
G
Q
I
S
N
F
T
K
D
M
L
M
E
G
Site 5
S52
V
E
A
E
L
P
D
S
R
T
K
E
I
E
A
Site 6
T54
A
E
L
P
D
S
R
T
K
E
I
E
A
I
H
Site 7
T76
E
R
L
K
K
L
C
T
D
L
E
E
K
H
E
Site 8
S95
Q
I
K
Q
Q
S
T
S
Y
R
N
Q
L
Q
Q
Site 9
S126
D
Q
L
L
K
L
Q
S
A
A
Q
S
V
P
S
Site 10
S130
K
L
Q
S
A
A
Q
S
V
P
S
G
A
G
V
Site 11
S145
P
A
T
T
A
S
S
S
F
A
Y
G
I
S
H
Site 12
Y148
T
A
S
S
S
F
A
Y
G
I
S
H
H
P
S
Site 13
S151
S
S
F
A
Y
G
I
S
H
H
P
S
A
F
H
Site 14
S169
M
D
F
G
D
I
I
S
S
Q
Q
E
I
N
R
Site 15
S170
D
F
G
D
I
I
S
S
Q
Q
E
I
N
R
L
Site 16
S178
Q
Q
E
I
N
R
L
S
N
E
V
S
R
L
E
Site 17
S182
N
R
L
S
N
E
V
S
R
L
E
S
E
V
G
Site 18
S186
N
E
V
S
R
L
E
S
E
V
G
H
W
R
H
Site 19
S206
K
A
Q
G
T
D
N
S
D
Q
S
E
I
C
K
Site 20
S209
G
T
D
N
S
D
Q
S
E
I
C
K
L
Q
N
Site 21
S226
K
E
L
K
Q
N
R
S
Q
E
I
D
D
H
Q
Site 22
T248
N
A
H
Q
Q
K
L
T
E
I
S
R
R
H
R
Site 23
S251
Q
Q
K
L
T
E
I
S
R
R
H
R
E
E
L
Site 24
S259
R
R
H
R
E
E
L
S
D
Y
E
E
R
I
E
Site 25
Y261
H
R
E
E
L
S
D
Y
E
E
R
I
E
E
L
Site 26
S285
G
V
I
E
T
D
L
S
K
I
Y
E
M
Q
K
Site 27
Y288
E
T
D
L
S
K
I
Y
E
M
Q
K
T
I
Q
Site 28
T293
K
I
Y
E
M
Q
K
T
I
Q
V
L
Q
I
E
Site 29
S358
E
N
L
K
L
E
C
S
K
L
Q
P
S
A
V
Site 30
S363
E
C
S
K
L
Q
P
S
A
V
K
Q
S
D
T
Site 31
T370
S
A
V
K
Q
S
D
T
M
T
E
K
E
R
I
Site 32
T372
V
K
Q
S
D
T
M
T
E
K
E
R
I
L
A
Site 33
S381
K
E
R
I
L
A
Q
S
A
S
V
E
E
V
F
Site 34
S395
F
R
L
Q
Q
A
L
S
D
A
E
N
E
I
M
Site 35
S405
E
N
E
I
M
R
L
S
S
L
N
Q
D
N
S
Site 36
S406
N
E
I
M
R
L
S
S
L
N
Q
D
N
S
L
Site 37
S412
S
S
L
N
Q
D
N
S
L
A
E
D
N
L
K
Site 38
S432
E
V
L
E
K
E
K
S
L
L
S
Q
E
K
E
Site 39
S435
E
K
E
K
S
L
L
S
Q
E
K
E
E
L
Q
Site 40
S444
E
K
E
E
L
Q
M
S
L
L
K
L
N
N
E
Site 41
Y452
L
L
K
L
N
N
E
Y
E
V
I
K
S
T
A
Site 42
S457
N
E
Y
E
V
I
K
S
T
A
T
R
D
I
S
Site 43
T460
E
V
I
K
S
T
A
T
R
D
I
S
L
D
S
Site 44
S464
S
T
A
T
R
D
I
S
L
D
S
E
L
H
D
Site 45
S467
T
R
D
I
S
L
D
S
E
L
H
D
L
R
L
Site 46
S486
K
E
Q
E
L
N
Q
S
I
S
E
K
E
T
L
Site 47
S488
Q
E
L
N
Q
S
I
S
E
K
E
T
L
I
A
Site 48
T492
Q
S
I
S
E
K
E
T
L
I
A
E
I
E
E
Site 49
S519
I
L
I
K
D
Q
L
S
K
Q
Q
N
E
G
D
Site 50
S527
K
Q
Q
N
E
G
D
S
I
I
S
K
L
K
Q
Site 51
T554
E
D
D
K
M
D
I
T
K
E
L
D
V
Q
K
Site 52
S595
L
V
D
Q
L
N
K
S
Q
E
S
N
V
S
I
Site 53
S621
R
Q
N
E
E
E
L
S
R
I
R
N
E
L
M
Site 54
S630
I
R
N
E
L
M
Q
S
L
N
Q
D
S
N
S
Site 55
S637
S
L
N
Q
D
S
N
S
N
F
K
D
T
L
L
Site 56
S659
R
N
L
K
Q
N
L
S
E
L
E
Q
L
N
E
Site 57
S704
L
A
G
N
N
Q
L
S
L
E
K
N
T
I
V
Site 58
Y739
L
L
E
E
A
N
K
Y
E
K
T
I
E
E
L
Site 59
T742
E
A
N
K
Y
E
K
T
I
E
E
L
S
N
A
Site 60
S747
E
K
T
I
E
E
L
S
N
A
R
N
L
N
T
Site 61
S755
N
A
R
N
L
N
T
S
A
L
Q
L
E
H
E
Site 62
T787
K
N
I
E
Q
M
D
T
D
H
K
E
T
K
D
Site 63
S799
T
K
D
V
L
S
S
S
L
E
E
Q
K
Q
L
Site 64
S825
E
K
L
K
E
R
S
S
K
L
Q
E
E
L
D
Site 65
Y834
L
Q
E
E
L
D
K
Y
S
Q
A
L
R
K
N
Site 66
S835
Q
E
E
L
D
K
Y
S
Q
A
L
R
K
N
E
Site 67
T847
K
N
E
I
L
R
Q
T
I
E
E
K
D
R
S
Site 68
S854
T
I
E
E
K
D
R
S
L
G
S
M
K
E
E
Site 69
S857
E
K
D
R
S
L
G
S
M
K
E
E
N
N
H
Site 70
S877
E
R
L
R
E
E
Q
S
R
T
A
P
V
A
D
Site 71
T879
L
R
E
E
Q
S
R
T
A
P
V
A
D
P
K
Site 72
T887
A
P
V
A
D
P
K
T
L
D
S
V
T
E
L
Site 73
S890
A
D
P
K
T
L
D
S
V
T
E
L
A
S
E
Site 74
T892
P
K
T
L
D
S
V
T
E
L
A
S
E
V
S
Site 75
S896
D
S
V
T
E
L
A
S
E
V
S
Q
L
N
T
Site 76
T903
S
E
V
S
Q
L
N
T
I
K
E
H
L
E
E
Site 77
S925
I
I
E
D
Q
N
Q
S
K
M
Q
L
L
Q
S
Site 78
Y945
K
E
M
D
E
F
R
Y
Q
H
E
Q
M
N
A
Site 79
S967
E
K
D
E
E
I
K
S
L
Q
K
T
I
E
Q
Site 80
T971
E
I
K
S
L
Q
K
T
I
E
Q
I
K
T
Q
Site 81
T977
K
T
I
E
Q
I
K
T
Q
L
H
E
E
R
Q
Site 82
T988
E
E
R
Q
D
I
Q
T
D
N
S
D
I
F
Q
Site 83
S991
Q
D
I
Q
T
D
N
S
D
I
F
Q
E
T
K
Site 84
T997
N
S
D
I
F
Q
E
T
K
V
Q
S
L
N
I
Site 85
S1008
S
L
N
I
E
N
G
S
E
K
H
D
L
S
K
Site 86
S1014
G
S
E
K
H
D
L
S
K
A
E
T
E
R
L
Site 87
T1018
H
D
L
S
K
A
E
T
E
R
L
V
K
G
I
Site 88
S1041
L
L
N
E
K
N
I
S
L
T
K
Q
I
D
Q
Site 89
S1050
T
K
Q
I
D
Q
L
S
K
D
E
V
G
K
L
Site 90
S1076
Q
A
L
H
A
R
I
S
S
T
S
H
T
Q
D
Site 91
S1077
A
L
H
A
R
I
S
S
T
S
H
T
Q
D
V
Site 92
S1079
H
A
R
I
S
S
T
S
H
T
Q
D
V
V
Y
Site 93
T1081
R
I
S
S
T
S
H
T
Q
D
V
V
Y
L
Q
Site 94
Y1086
S
H
T
Q
D
V
V
Y
L
Q
Q
Q
L
Q
A
Site 95
S1113
N
E
K
T
R
E
N
S
H
L
K
T
E
Y
H
Site 96
S1144
Q
D
E
N
K
K
L
S
T
R
F
E
S
S
G
Site 97
T1145
D
E
N
K
K
L
S
T
R
F
E
S
S
G
Q
Site 98
S1149
K
L
S
T
R
F
E
S
S
G
Q
D
M
F
R
Site 99
T1158
G
Q
D
M
F
R
E
T
I
Q
N
L
S
R
I
Site 100
S1257
Q
A
Q
V
L
V
D
S
D
N
N
S
K
L
Q
Site 101
S1261
L
V
D
S
D
N
N
S
K
L
Q
V
D
Y
T
Site 102
Y1267
N
S
K
L
Q
V
D
Y
T
G
L
I
Q
S
Y
Site 103
T1268
S
K
L
Q
V
D
Y
T
G
L
I
Q
S
Y
E
Site 104
S1273
D
Y
T
G
L
I
Q
S
Y
E
Q
N
E
T
K
Site 105
S1320
S
P
Q
L
S
S
A
S
L
L
T
P
Q
S
A
Site 106
S1333
S
A
E
C
L
R
A
S
K
S
E
V
L
S
E
Site 107
S1335
E
C
L
R
A
S
K
S
E
V
L
S
E
S
S
Site 108
S1339
A
S
K
S
E
V
L
S
E
S
S
E
L
L
Q
Site 109
S1355
E
L
E
E
L
R
K
S
L
Q
E
K
D
A
T
Site 110
T1362
S
L
Q
E
K
D
A
T
I
R
T
L
Q
E
N
Site 111
S1374
Q
E
N
N
H
R
L
S
D
S
I
A
A
T
S
Site 112
S1376
N
N
H
R
L
S
D
S
I
A
A
T
S
E
L
Site 113
S1381
S
D
S
I
A
A
T
S
E
L
E
R
K
E
H
Site 114
T1391
E
R
K
E
H
E
Q
T
D
S
E
I
K
Q
L
Site 115
S1393
K
E
H
E
Q
T
D
S
E
I
K
Q
L
K
E
Site 116
S1420
D
L
L
I
K
A
K
S
D
Q
L
L
S
S
N
Site 117
S1426
K
S
D
Q
L
L
S
S
N
E
N
F
T
N
K
Site 118
Y1479
Y
R
G
K
E
T
E
Y
Q
A
L
Q
E
T
N
Site 119
T1522
K
E
K
E
Q
G
K
T
G
E
L
N
Q
L
L
Site 120
S1534
Q
L
L
N
A
V
K
S
M
Q
E
K
T
V
V
Site 121
T1539
V
K
S
M
Q
E
K
T
V
V
F
Q
Q
E
R
Site 122
S1577
L
R
D
K
E
F
R
S
N
Q
E
L
E
R
L
Site 123
S1594
H
L
L
E
S
E
D
S
Y
T
R
E
A
L
A
Site 124
Y1595
L
L
E
S
E
D
S
Y
T
R
E
A
L
A
A
Site 125
T1596
L
E
S
E
D
S
Y
T
R
E
A
L
A
A
E
Site 126
T1614
A
K
L
R
K
K
V
T
V
L
E
E
K
L
V
Site 127
S1631
S
N
A
M
E
N
A
S
H
Q
A
S
V
Q
V
Site 128
S1635
E
N
A
S
H
Q
A
S
V
Q
V
E
S
L
Q
Site 129
S1640
Q
A
S
V
Q
V
E
S
L
Q
E
Q
L
N
V
Site 130
T1655
V
S
K
Q
R
D
E
T
A
L
Q
L
S
V
S
Site 131
S1660
D
E
T
A
L
Q
L
S
V
S
Q
E
Q
V
K
Site 132
S1662
T
A
L
Q
L
S
V
S
Q
E
Q
V
K
Q
Y
Site 133
Y1691
Q
Q
E
E
K
A
M
Y
S
A
E
L
E
K
Q
Site 134
S1732
E
A
N
A
A
L
D
S
A
S
R
L
T
E
Q
Site 135
T1737
L
D
S
A
S
R
L
T
E
Q
L
D
V
K
E
Site 136
S1770
D
V
Q
K
K
L
M
S
L
A
N
S
S
E
G
Site 137
S1774
K
L
M
S
L
A
N
S
S
E
G
K
V
D
K
Site 138
S1775
L
M
S
L
A
N
S
S
E
G
K
V
D
K
V
Site 139
T1794
L
F
I
G
H
F
H
T
P
K
N
Q
R
H
E
Site 140
S1808
E
V
L
R
L
M
G
S
I
L
G
V
R
R
E
Site 141
T1833
G
S
V
T
R
W
M
T
G
W
L
G
G
G
S
Site 142
S1840
T
G
W
L
G
G
G
S
K
S
V
P
N
T
P
Site 143
S1842
W
L
G
G
G
S
K
S
V
P
N
T
P
L
R
Site 144
T1846
G
S
K
S
V
P
N
T
P
L
R
P
N
Q
Q
Site 145
S1854
P
L
R
P
N
Q
Q
S
V
V
N
S
S
F
S
Site 146
S1858
N
Q
Q
S
V
V
N
S
S
F
S
E
L
F
V
Site 147
S1859
Q
Q
S
V
V
N
S
S
F
S
E
L
F
V
K
Site 148
S1861
S
V
V
N
S
S
F
S
E
L
F
V
K
F
L
Site 149
S1872
V
K
F
L
E
T
E
S
H
P
S
I
P
P
P
Site 150
S1875
L
E
T
E
S
H
P
S
I
P
P
P
K
L
S
Site 151
S1882
S
I
P
P
P
K
L
S
V
H
D
M
K
P
L
Site 152
S1891
H
D
M
K
P
L
D
S
P
G
R
R
K
R
D
Site 153
T1899
P
G
R
R
K
R
D
T
N
A
P
E
S
F
K
Site 154
S1904
R
D
T
N
A
P
E
S
F
K
D
T
A
E
S
Site 155
T1908
A
P
E
S
F
K
D
T
A
E
S
R
S
G
R
Site 156
S1911
S
F
K
D
T
A
E
S
R
S
G
R
R
T
D
Site 157
S1913
K
D
T
A
E
S
R
S
G
R
R
T
D
V
N
Site 158
T1917
E
S
R
S
G
R
R
T
D
V
N
P
F
L
A
Site 159
S1952
H
L
L
L
K
P
I
S
D
V
L
P
T
F
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation