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Updated November 2019
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Protein Info
Short Name:
JMJD1C
Full Name:
Probable JmjC domain-containing histone demethylation protein 2C
Alias:
DKFZp761F0118; FLJ14374; JHD2C; JJ1C; JMJ1C; Jumonji domain containing 1C; Jumonji domain containing protein 1C; KIAA1380; Probable JmjC domain-containing histone demethylation protein 2C: Jumonji domain-containing protein 1C: Thyroid receptor-interacting protein 8: Probable JmjC domain-containing histone demethylation protein 2C: Jumonji domain-containing protein 1C: Thyroid receptor-interacting protein 8; Thyroid receptor interacting protein 8; TRIP8; TRIP-8
Type:
Nuclear receptor co-regulator; EC 1.14.11.-; Demethylase; Oxidoreductase; Transcription, coactivator/corepressor
Mass (Da):
284525
Number AA:
2540
UniProt ID:
Q15652
International Prot ID:
IPI00384202
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005506
GO:0016702
GO:0046966
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0055114
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
A
V
G
D
E
A
R
S
E
R
W
E
S
G
R
Site 2
S30
A
R
S
E
R
W
E
S
G
R
G
W
R
S
W
Site 3
S36
E
S
G
R
G
W
R
S
W
R
A
G
V
I
R
Site 4
S46
A
G
V
I
R
A
V
S
H
R
D
S
R
N
P
Site 5
S50
R
A
V
S
H
R
D
S
R
N
P
D
L
A
V
Site 6
Y58
R
N
P
D
L
A
V
Y
V
E
F
D
D
L
E
Site 7
Y75
K
R
E
W
V
K
V
Y
E
D
F
S
T
F
L
Site 8
T80
K
V
Y
E
D
F
S
T
F
L
V
E
Y
H
L
Site 9
S96
W
A
K
R
N
D
P
S
Q
T
Q
G
S
K
S
Site 10
S101
D
P
S
Q
T
Q
G
S
K
S
K
Q
I
Q
W
Site 11
S103
S
Q
T
Q
G
S
K
S
K
Q
I
Q
W
P
A
Site 12
T112
Q
I
Q
W
P
A
L
T
F
K
P
L
V
E
R
Site 13
T140
D
K
Q
L
D
F
L
T
E
D
S
A
F
Q
P
Site 14
S154
P
Y
Q
D
D
I
D
S
L
N
P
V
L
R
D
Site 15
S188
I
F
M
Q
G
P
Y
S
L
N
G
Y
R
V
R
Site 16
Y192
G
P
Y
S
L
N
G
Y
R
V
R
V
Y
R
Q
Site 17
Y197
N
G
Y
R
V
R
V
Y
R
Q
D
S
A
T
Q
Site 18
S201
V
R
V
Y
R
Q
D
S
A
T
Q
W
F
T
G
Site 19
S236
E
P
Q
N
V
D
P
S
M
V
Q
M
T
F
L
Site 20
T259
K
G
E
N
I
G
I
T
S
R
R
R
S
R
A
Site 21
S260
G
E
N
I
G
I
T
S
R
R
R
S
R
A
N
Site 22
S264
G
I
T
S
R
R
R
S
R
A
N
Q
N
V
N
Site 23
Y277
V
N
A
V
H
S
H
Y
T
R
A
Q
A
N
S
Site 24
S284
Y
T
R
A
Q
A
N
S
P
R
P
A
M
N
S
Site 25
S291
S
P
R
P
A
M
N
S
Q
A
A
V
P
K
Q
Site 26
S308
H
Q
Q
Q
Q
Q
R
S
I
R
P
N
K
R
K
Site 27
S317
R
P
N
K
R
K
G
S
D
S
S
I
P
D
E
Site 28
S319
N
K
R
K
G
S
D
S
S
I
P
D
E
E
K
Site 29
S320
K
R
K
G
S
D
S
S
I
P
D
E
E
K
M
Site 30
Y332
E
K
M
K
E
E
K
Y
D
Y
I
S
R
G
E
Site 31
Y334
M
K
E
E
K
Y
D
Y
I
S
R
G
E
N
P
Site 32
T369
L
N
M
K
R
L
R
T
D
N
V
S
D
F
S
Site 33
S373
R
L
R
T
D
N
V
S
D
F
S
E
S
S
D
Site 34
S376
T
D
N
V
S
D
F
S
E
S
S
D
S
E
N
Site 35
S378
N
V
S
D
F
S
E
S
S
D
S
E
N
S
N
Site 36
S379
V
S
D
F
S
E
S
S
D
S
E
N
S
N
K
Site 37
S381
D
F
S
E
S
S
D
S
E
N
S
N
K
R
I
Site 38
S384
E
S
S
D
S
E
N
S
N
K
R
I
I
D
N
Site 39
S392
N
K
R
I
I
D
N
S
S
E
Q
K
P
E
N
Site 40
S393
K
R
I
I
D
N
S
S
E
Q
K
P
E
N
E
Site 41
S430
G
E
E
T
L
K
N
S
Q
P
P
W
D
Q
I
Site 42
S451
E
E
A
E
K
R
K
S
V
D
T
Q
L
Q
E
Site 43
T454
E
K
R
K
S
V
D
T
Q
L
Q
E
D
M
I
Site 44
S464
Q
E
D
M
I
I
H
S
S
E
Q
S
T
V
S
Site 45
S465
E
D
M
I
I
H
S
S
E
Q
S
T
V
S
D
Site 46
S468
I
I
H
S
S
E
Q
S
T
V
S
D
H
N
S
Site 47
T469
I
H
S
S
E
Q
S
T
V
S
D
H
N
S
N
Site 48
S471
S
S
E
Q
S
T
V
S
D
H
N
S
N
D
L
Site 49
S475
S
T
V
S
D
H
N
S
N
D
L
L
P
Q
E
Site 50
T488
Q
E
C
N
M
D
K
T
H
T
M
E
L
L
P
Site 51
S501
L
P
K
E
K
F
V
S
R
P
P
T
P
K
C
Site 52
T505
K
F
V
S
R
P
P
T
P
K
C
V
I
D
I
Site 53
T513
P
K
C
V
I
D
I
T
N
D
T
N
L
E
K
Site 54
T528
V
A
Q
E
N
S
S
T
F
G
L
Q
T
L
Q
Site 55
T533
S
S
T
F
G
L
Q
T
L
Q
K
M
D
P
N
Site 56
S542
Q
K
M
D
P
N
V
S
D
S
K
H
S
I
A
Site 57
S544
M
D
P
N
V
S
D
S
K
H
S
I
A
N
A
Site 58
T556
A
N
A
K
F
L
E
T
A
K
K
D
S
D
Q
Site 59
S561
L
E
T
A
K
K
D
S
D
Q
S
W
V
S
D
Site 60
S564
A
K
K
D
S
D
Q
S
W
V
S
D
V
V
K
Site 61
T575
D
V
V
K
V
D
L
T
Q
S
S
V
T
N
A
Site 62
S578
K
V
D
L
T
Q
S
S
V
T
N
A
S
S
G
Site 63
T580
D
L
T
Q
S
S
V
T
N
A
S
S
G
N
D
Site 64
S584
S
S
V
T
N
A
S
S
G
N
D
H
L
N
M
Site 65
Y596
L
N
M
E
K
E
K
Y
V
S
Y
I
S
P
L
Site 66
S598
M
E
K
E
K
Y
V
S
Y
I
S
P
L
S
A
Site 67
Y599
E
K
E
K
Y
V
S
Y
I
S
P
L
S
A
V
Site 68
S617
E
D
K
L
H
K
R
S
P
P
P
E
T
I
K
Site 69
T622
K
R
S
P
P
P
E
T
I
K
S
K
L
N
T
Site 70
S625
P
P
P
E
T
I
K
S
K
L
N
T
S
V
D
Site 71
T629
T
I
K
S
K
L
N
T
S
V
D
T
H
K
I
Site 72
S630
I
K
S
K
L
N
T
S
V
D
T
H
K
I
K
Site 73
S638
V
D
T
H
K
I
K
S
S
P
S
P
E
V
V
Site 74
S639
D
T
H
K
I
K
S
S
P
S
P
E
V
V
K
Site 75
S641
H
K
I
K
S
S
P
S
P
E
V
V
K
P
K
Site 76
T650
E
V
V
K
P
K
I
T
H
S
P
D
S
V
K
Site 77
S652
V
K
P
K
I
T
H
S
P
D
S
V
K
S
K
Site 78
S655
K
I
T
H
S
P
D
S
V
K
S
K
A
T
Y
Site 79
S658
H
S
P
D
S
V
K
S
K
A
T
Y
V
N
S
Site 80
Y662
S
V
K
S
K
A
T
Y
V
N
S
Q
A
T
G
Site 81
S665
S
K
A
T
Y
V
N
S
Q
A
T
G
E
R
R
Site 82
S682
N
K
I
E
H
E
L
S
R
C
S
F
H
P
I
Site 83
S685
E
H
E
L
S
R
C
S
F
H
P
I
P
T
R
Site 84
S694
H
P
I
P
T
R
S
S
T
L
E
T
T
K
S
Site 85
T695
P
I
P
T
R
S
S
T
L
E
T
T
K
S
P
Site 86
T698
T
R
S
S
T
L
E
T
T
K
S
P
L
I
I
Site 87
T699
R
S
S
T
L
E
T
T
K
S
P
L
I
I
D
Site 88
S701
S
T
L
E
T
T
K
S
P
L
I
I
D
K
N
Site 89
T712
I
D
K
N
E
H
F
T
V
Y
R
D
P
A
L
Site 90
Y714
K
N
E
H
F
T
V
Y
R
D
P
A
L
I
G
Site 91
S722
R
D
P
A
L
I
G
S
E
T
G
A
N
H
I
Site 92
S730
E
T
G
A
N
H
I
S
P
F
L
S
Q
H
P
Site 93
S734
N
H
I
S
P
F
L
S
Q
H
P
F
P
L
H
Site 94
S742
Q
H
P
F
P
L
H
S
S
S
H
R
T
C
L
Site 95
S744
P
F
P
L
H
S
S
S
H
R
T
C
L
N
P
Site 96
T747
L
H
S
S
S
H
R
T
C
L
N
P
G
T
H
Site 97
T753
R
T
C
L
N
P
G
T
H
H
P
A
L
T
P
Site 98
S769
P
H
L
L
A
G
S
S
S
Q
T
P
L
P
T
Site 99
T772
L
A
G
S
S
S
Q
T
P
L
P
T
I
N
T
Site 100
T776
S
S
Q
T
P
L
P
T
I
N
T
H
P
L
T
Site 101
T783
T
I
N
T
H
P
L
T
S
G
P
H
H
A
V
Site 102
S817
G
G
H
P
R
L
E
S
A
H
A
S
S
L
S
Site 103
S821
R
L
E
S
A
H
A
S
S
L
S
H
L
A
L
Site 104
S841
Q
Q
L
L
Q
H
Q
S
P
H
L
L
G
Q
A
Site 105
S853
G
Q
A
H
P
S
A
S
Y
N
Q
L
G
L
Y
Site 106
Y860
S
Y
N
Q
L
G
L
Y
P
I
I
W
Q
Y
P
Site 107
S874
P
N
G
T
H
A
Y
S
G
L
G
L
P
S
S
Site 108
S881
S
G
L
G
L
P
S
S
K
W
V
H
P
E
N
Site 109
S895
N
A
V
N
A
E
A
S
L
R
R
N
S
P
S
Site 110
S900
E
A
S
L
R
R
N
S
P
S
P
W
L
H
Q
Site 111
S902
S
L
R
R
N
S
P
S
P
W
L
H
Q
P
T
Site 112
T909
S
P
W
L
H
Q
P
T
P
V
T
S
A
D
G
Site 113
S928
S
H
I
P
V
R
P
S
S
A
E
P
H
R
P
Site 114
S929
H
I
P
V
R
P
S
S
A
E
P
H
R
P
L
Site 115
T939
P
H
R
P
L
K
I
T
A
H
S
S
P
P
L
Site 116
S942
P
L
K
I
T
A
H
S
S
P
P
L
T
K
T
Site 117
S943
L
K
I
T
A
H
S
S
P
P
L
T
K
T
L
Site 118
T947
A
H
S
S
P
P
L
T
K
T
L
V
D
H
H
Site 119
T949
S
S
P
P
L
T
K
T
L
V
D
H
H
K
E
Site 120
S969
A
F
M
E
P
L
R
S
V
A
S
T
S
A
K
Site 121
S972
E
P
L
R
S
V
A
S
T
S
A
K
N
D
L
Site 122
T973
P
L
R
S
V
A
S
T
S
A
K
N
D
L
D
Site 123
S984
N
D
L
D
L
N
R
S
Q
T
G
K
D
C
H
Site 124
T986
L
D
L
N
R
S
Q
T
G
K
D
C
H
L
H
Site 125
T1011
L
Q
R
P
P
Q
E
T
G
E
R
L
N
K
Y
Site 126
Y1018
T
G
E
R
L
N
K
Y
K
E
E
H
R
R
I
Site 127
S1029
H
R
R
I
L
Q
E
S
I
D
V
A
P
F
T
Site 128
Y1049
L
E
G
E
R
E
N
Y
S
R
V
A
S
S
S
Site 129
S1050
E
G
E
R
E
N
Y
S
R
V
A
S
S
S
S
Site 130
S1054
E
N
Y
S
R
V
A
S
S
S
S
S
P
K
S
Site 131
S1055
N
Y
S
R
V
A
S
S
S
S
S
P
K
S
H
Site 132
S1056
Y
S
R
V
A
S
S
S
S
S
P
K
S
H
I
Site 133
S1057
S
R
V
A
S
S
S
S
S
P
K
S
H
I
I
Site 134
S1058
R
V
A
S
S
S
S
S
P
K
S
H
I
I
K
Site 135
S1061
S
S
S
S
S
P
K
S
H
I
I
K
Q
D
M
Site 136
S1073
Q
D
M
D
V
E
R
S
V
S
D
L
Y
K
M
Site 137
S1075
M
D
V
E
R
S
V
S
D
L
Y
K
M
K
H
Site 138
Y1078
E
R
S
V
S
D
L
Y
K
M
K
H
S
V
P
Site 139
S1083
D
L
Y
K
M
K
H
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L
W
L
K
D
Y
K
N
S
S
N
W
K
Site 292
S2177
L
K
D
Y
K
N
S
S
N
W
K
L
F
K
E
Site 293
S2212
L
W
K
A
E
S
I
S
L
D
F
G
D
H
Q
Site 294
S2228
D
L
L
N
C
K
D
S
I
I
S
N
A
N
V
Site 295
S2246
W
D
G
F
E
E
V
S
K
R
Q
K
N
K
S
Site 296
S2253
S
K
R
Q
K
N
K
S
G
E
T
V
V
L
K
Site 297
S2266
L
K
L
K
D
W
P
S
G
E
D
F
K
T
M
Site 298
T2272
P
S
G
E
D
F
K
T
M
M
P
A
R
Y
E
Site 299
S2284
R
Y
E
D
L
L
K
S
L
P
L
P
E
Y
C
Site 300
Y2290
K
S
L
P
L
P
E
Y
C
N
P
E
G
K
F
Site 301
S2359
A
K
G
N
G
I
L
S
K
A
G
I
L
K
K
Site 302
S2384
R
K
R
L
K
D
S
S
E
I
P
G
A
L
W
Site 303
Y2394
P
G
A
L
W
H
I
Y
A
G
K
D
V
D
K
Site 304
Y2430
P
I
R
D
Q
S
W
Y
V
N
K
K
L
R
Q
Site 305
Y2443
R
Q
R
L
L
E
E
Y
G
V
R
T
C
T
L
Site 306
S2483
Q
V
T
E
D
F
V
S
P
E
H
L
V
E
S
Site 307
S2490
S
P
E
H
L
V
E
S
F
H
L
T
Q
E
L
Site 308
Y2506
L
L
K
E
E
I
N
Y
D
D
K
L
Q
V
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation