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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DLG2
Full Name:
Disks large homolog 2
Alias:
Channel associated protein of synapse-110; Chapsyn-110; Discs, large 2; Postsynaptic density protein PSD-93; PSD93; PSD-93
Type:
Adapter/scaffold protein
Mass (Da):
97552
Number AA:
870
UniProt ID:
Q15700
International Prot ID:
IPI00444727
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
GO:0030054
GO:0014069
Uniprot
OncoNet
Molecular Function:
GO:0004385
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Disks large homolog 2 pan-specific antibody AB-NN232-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN232-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
L
R
T
N
V
K
K
Y
R
Y
Q
D
E
D
A
Site 2
S28
E
D
A
P
H
D
H
S
L
P
R
L
T
H
E
Site 3
T33
D
H
S
L
P
R
L
T
H
E
V
R
G
P
E
Site 4
S45
G
P
E
L
V
H
V
S
E
K
N
L
S
Q
I
Site 5
S50
H
V
S
E
K
N
L
S
Q
I
E
N
V
H
G
Site 6
Y58
Q
I
E
N
V
H
G
Y
V
L
Q
S
H
I
S
Site 7
S62
V
H
G
Y
V
L
Q
S
H
I
S
P
L
K
A
Site 8
S65
Y
V
L
Q
S
H
I
S
P
L
K
A
S
P
A
Site 9
Y86
D
T
L
D
T
I
P
Y
V
N
G
T
E
I
E
Site 10
T100
E
Y
E
F
E
E
I
T
L
E
R
G
N
S
G
Site 11
S106
I
T
L
E
R
G
N
S
G
L
G
F
S
I
A
Site 12
S111
G
N
S
G
L
G
F
S
I
A
G
G
T
D
N
Site 13
T116
G
F
S
I
A
G
G
T
D
N
P
H
I
G
D
Site 14
S159
R
V
N
E
V
D
V
S
E
V
S
H
S
K
A
Site 15
S164
D
V
S
E
V
S
H
S
K
A
V
E
A
L
K
Site 16
S175
E
A
L
K
E
A
G
S
I
V
R
L
Y
V
R
Site 17
Y180
A
G
S
I
V
R
L
Y
V
R
R
R
R
P
I
Site 18
Y223
I
P
G
D
N
S
I
Y
V
T
K
I
I
D
G
Site 19
T225
G
D
N
S
I
Y
V
T
K
I
I
D
G
G
A
Site 20
S252
L
L
M
V
N
N
Y
S
L
E
E
V
T
H
E
Site 21
T257
N
Y
S
L
E
E
V
T
H
E
E
A
V
A
I
Site 22
S269
V
A
I
L
K
N
T
S
E
V
V
Y
L
K
V
Site 23
Y273
K
N
T
S
E
V
V
Y
L
K
V
G
K
P
T
Site 24
T281
L
K
V
G
K
P
T
T
I
Y
M
T
D
P
Y
Site 25
Y283
V
G
K
P
T
T
I
Y
M
T
D
P
Y
G
P
Site 26
T285
K
P
T
T
I
Y
M
T
D
P
Y
G
P
P
D
Site 27
Y288
T
I
Y
M
T
D
P
Y
G
P
P
D
I
T
H
Site 28
T294
P
Y
G
P
P
D
I
T
H
S
Y
S
P
P
M
Site 29
S296
G
P
P
D
I
T
H
S
Y
S
P
P
M
E
N
Site 30
Y297
P
P
D
I
T
H
S
Y
S
P
P
M
E
N
H
Site 31
S298
P
D
I
T
H
S
Y
S
P
P
M
E
N
H
L
Site 32
S307
P
M
E
N
H
L
L
S
G
N
N
G
T
L
E
Site 33
Y315
G
N
N
G
T
L
E
Y
K
T
S
L
P
P
I
Site 34
T317
N
G
T
L
E
Y
K
T
S
L
P
P
I
S
P
Site 35
S318
G
T
L
E
Y
K
T
S
L
P
P
I
S
P
G
Site 36
S323
K
T
S
L
P
P
I
S
P
G
R
Y
S
P
I
Site 37
Y327
P
P
I
S
P
G
R
Y
S
P
I
P
K
H
M
Site 38
S328
P
I
S
P
G
R
Y
S
P
I
P
K
H
M
L
Site 39
Y340
H
M
L
V
D
D
D
Y
T
R
P
P
E
P
V
Site 40
T341
M
L
V
D
D
D
Y
T
R
P
P
E
P
V
Y
Site 41
Y348
T
R
P
P
E
P
V
Y
S
T
V
N
K
L
C
Site 42
S349
R
P
P
E
P
V
Y
S
T
V
N
K
L
C
D
Site 43
T350
P
P
E
P
V
Y
S
T
V
N
K
L
C
D
K
Site 44
S360
K
L
C
D
K
P
A
S
P
R
H
Y
S
P
V
Site 45
Y364
K
P
A
S
P
R
H
Y
S
P
V
E
C
D
K
Site 46
S365
P
A
S
P
R
H
Y
S
P
V
E
C
D
K
S
Site 47
S372
S
P
V
E
C
D
K
S
F
L
L
S
A
P
Y
Site 48
S376
C
D
K
S
F
L
L
S
A
P
Y
S
H
Y
H
Site 49
Y379
S
F
L
L
S
A
P
Y
S
H
Y
H
L
G
L
Site 50
Y382
L
S
A
P
Y
S
H
Y
H
L
G
L
L
P
D
Site 51
S390
H
L
G
L
L
P
D
S
E
M
T
S
H
S
Q
Site 52
S394
L
P
D
S
E
M
T
S
H
S
Q
H
S
T
A
Site 53
S396
D
S
E
M
T
S
H
S
Q
H
S
T
A
T
R
Site 54
T400
T
S
H
S
Q
H
S
T
A
T
R
Q
P
S
M
Site 55
T402
H
S
Q
H
S
T
A
T
R
Q
P
S
M
T
L
Site 56
S406
S
T
A
T
R
Q
P
S
M
T
L
Q
R
A
V
Site 57
T408
A
T
R
Q
P
S
M
T
L
Q
R
A
V
S
L
Site 58
S414
M
T
L
Q
R
A
V
S
L
E
G
E
P
R
K
Site 59
S458
A
G
G
P
A
D
L
S
G
E
L
Q
R
G
D
Site 60
S469
Q
R
G
D
Q
I
L
S
V
N
G
I
D
L
R
Site 61
S479
G
I
D
L
R
G
A
S
H
E
Q
A
A
A
A
Site 62
Y500
T
V
T
I
I
A
Q
Y
Q
P
E
D
Y
A
R
Site 63
Y505
A
Q
Y
Q
P
E
D
Y
A
R
F
E
A
K
I
Site 64
S523
R
E
Q
M
M
N
H
S
M
S
S
G
S
G
S
Site 65
S525
Q
M
M
N
H
S
M
S
S
G
S
G
S
L
R
Site 66
S526
M
M
N
H
S
M
S
S
G
S
G
S
L
R
T
Site 67
S528
N
H
S
M
S
S
G
S
G
S
L
R
T
N
Q
Site 68
S530
S
M
S
S
G
S
G
S
L
R
T
N
Q
K
R
Site 69
T533
S
G
S
G
S
L
R
T
N
Q
K
R
S
L
Y
Site 70
S538
L
R
T
N
Q
K
R
S
L
Y
V
R
A
M
F
Site 71
Y540
T
N
Q
K
R
S
L
Y
V
R
A
M
F
D
Y
Site 72
Y547
Y
V
R
A
M
F
D
Y
D
K
S
K
D
S
G
Site 73
S550
A
M
F
D
Y
D
K
S
K
D
S
G
L
P
S
Site 74
S553
D
Y
D
K
S
K
D
S
G
L
P
S
Q
G
L
Site 75
S557
S
K
D
S
G
L
P
S
Q
G
L
S
F
K
Y
Site 76
S561
G
L
P
S
Q
G
L
S
F
K
Y
G
D
I
L
Site 77
S574
I
L
H
V
I
N
A
S
D
D
E
W
W
Q
A
Site 78
S598
E
E
M
G
V
I
P
S
K
R
R
V
E
R
K
Site 79
T612
K
E
R
A
R
L
K
T
V
K
F
N
A
K
P
Site 80
S624
A
K
P
G
V
I
D
S
K
G
S
F
N
D
K
Site 81
S627
G
V
I
D
S
K
G
S
F
N
D
K
R
K
K
Site 82
S635
F
N
D
K
R
K
K
S
F
I
F
S
R
K
F
Site 83
S639
R
K
K
S
F
I
F
S
R
K
F
P
F
Y
K
Site 84
Y645
F
S
R
K
F
P
F
Y
K
N
K
E
Q
S
E
Site 85
T655
K
E
Q
S
E
Q
E
T
S
D
P
E
R
G
Q
Site 86
S656
E
Q
S
E
Q
E
T
S
D
P
E
R
G
Q
E
Site 87
S668
G
Q
E
D
L
I
L
S
Y
E
P
V
T
R
Q
Site 88
Y679
V
T
R
Q
E
I
N
Y
T
R
P
V
I
I
L
Site 89
T680
T
R
Q
E
I
N
Y
T
R
P
V
I
I
L
G
Site 90
S699
R
I
N
D
D
L
I
S
E
F
P
D
K
F
G
Site 91
S707
E
F
P
D
K
F
G
S
C
V
P
H
T
T
R
Site 92
T712
F
G
S
C
V
P
H
T
T
R
P
K
R
D
Y
Site 93
Y719
T
T
R
P
K
R
D
Y
E
V
D
G
R
D
Y
Site 94
Y726
Y
E
V
D
G
R
D
Y
H
F
V
I
S
R
E
Site 95
Y750
K
F
I
E
A
G
Q
Y
N
D
N
L
Y
G
T
Site 96
Y755
G
Q
Y
N
D
N
L
Y
G
T
S
V
Q
S
V
Site 97
S761
L
Y
G
T
S
V
Q
S
V
R
F
V
A
E
R
Site 98
T812
M
E
M
N
K
R
L
T
E
E
Q
A
K
K
T
Site 99
Y833
L
E
Q
E
F
G
E
Y
F
T
A
I
V
Q
G
Site 100
T842
T
A
I
V
Q
G
D
T
L
E
D
I
Y
N
Q
Site 101
Y847
G
D
T
L
E
D
I
Y
N
Q
C
K
L
V
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation