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Updated November 2019
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Protein Info
Short Name:
TSC22D1
Full Name:
TSC22 domain family protein 1
Alias:
Hucep-2; Kiaa1994; Tgfb1i4; Transforming growth factor beta-1-induced transcript 4 protein; Tsc22; Tsc22 domain family, member 1; Tsc22d1
Type:
Transcription factor
Mass (Da):
109659
Number AA:
1073
UniProt ID:
Q15714
International Prot ID:
IPI00019355
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006351
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
H
Q
P
P
E
S
T
A
A
A
A
A
A
Site 2
S33
A
M
F
P
R
R
G
S
G
S
G
S
A
S
A
Site 3
S35
F
P
R
R
G
S
G
S
G
S
A
S
A
L
N
Site 4
S37
R
R
G
S
G
S
G
S
A
S
A
L
N
A
A
Site 5
S39
G
S
G
S
G
S
A
S
A
L
N
A
A
G
T
Site 6
S50
A
A
G
T
G
V
G
S
N
A
T
S
S
E
D
Site 7
S54
G
V
G
S
N
A
T
S
S
E
D
F
P
P
P
Site 8
S55
V
G
S
N
A
T
S
S
E
D
F
P
P
P
S
Site 9
S62
S
E
D
F
P
P
P
S
L
L
Q
P
P
P
P
Site 10
S72
Q
P
P
P
P
A
A
S
S
T
S
G
P
Q
P
Site 11
S73
P
P
P
P
A
A
S
S
T
S
G
P
Q
P
P
Site 12
T74
P
P
P
A
A
S
S
T
S
G
P
Q
P
P
P
Site 13
S75
P
P
A
A
S
S
T
S
G
P
Q
P
P
P
P
Site 14
S84
P
Q
P
P
P
P
Q
S
L
N
L
L
S
Q
A
Site 15
S89
P
Q
S
L
N
L
L
S
Q
A
Q
L
Q
A
Q
Site 16
S109
G
T
Q
M
K
K
K
S
G
F
Q
I
T
S
V
Site 17
S115
K
S
G
F
Q
I
T
S
V
T
P
A
Q
I
S
Site 18
S122
S
V
T
P
A
Q
I
S
A
S
I
S
S
N
N
Site 19
S124
T
P
A
Q
I
S
A
S
I
S
S
N
N
S
I
Site 20
S126
A
Q
I
S
A
S
I
S
S
N
N
S
I
A
E
Site 21
S130
A
S
I
S
S
N
N
S
I
A
E
D
T
E
S
Site 22
S137
S
I
A
E
D
T
E
S
Y
D
D
L
D
E
S
Site 23
S144
S
Y
D
D
L
D
E
S
H
T
E
D
L
S
S
Site 24
T146
D
D
L
D
E
S
H
T
E
D
L
S
S
S
E
Site 25
S150
E
S
H
T
E
D
L
S
S
S
E
I
L
D
V
Site 26
S151
S
H
T
E
D
L
S
S
S
E
I
L
D
V
S
Site 27
S152
H
T
E
D
L
S
S
S
E
I
L
D
V
S
L
Site 28
S158
S
S
E
I
L
D
V
S
L
S
R
A
T
D
L
Site 29
S160
E
I
L
D
V
S
L
S
R
A
T
D
L
G
E
Site 30
T163
D
V
S
L
S
R
A
T
D
L
G
E
P
E
R
Site 31
S171
D
L
G
E
P
E
R
S
S
S
E
E
T
L
N
Site 32
S172
L
G
E
P
E
R
S
S
S
E
E
T
L
N
N
Site 33
S173
G
E
P
E
R
S
S
S
E
E
T
L
N
N
F
Site 34
T176
E
R
S
S
S
E
E
T
L
N
N
F
Q
E
A
Site 35
T185
N
N
F
Q
E
A
E
T
P
G
A
V
S
P
N
Site 36
S190
A
E
T
P
G
A
V
S
P
N
Q
P
H
L
P
Site 37
S255
S
I
T
G
G
P
P
S
S
P
V
S
R
K
L
Site 38
S256
I
T
G
G
P
P
S
S
P
V
S
R
K
L
S
Site 39
S259
G
P
P
S
S
P
V
S
R
K
L
S
T
T
G
Site 40
S263
S
P
V
S
R
K
L
S
T
T
G
S
S
D
S
Site 41
T264
P
V
S
R
K
L
S
T
T
G
S
S
D
S
I
Site 42
T265
V
S
R
K
L
S
T
T
G
S
S
D
S
I
T
Site 43
S267
R
K
L
S
T
T
G
S
S
D
S
I
T
P
V
Site 44
S270
S
T
T
G
S
S
D
S
I
T
P
V
A
P
T
Site 45
T272
T
G
S
S
D
S
I
T
P
V
A
P
T
S
A
Site 46
S281
V
A
P
T
S
A
V
S
S
S
G
S
P
A
S
Site 47
S282
A
P
T
S
A
V
S
S
S
G
S
P
A
S
V
Site 48
S283
P
T
S
A
V
S
S
S
G
S
P
A
S
V
M
Site 49
S285
S
A
V
S
S
S
G
S
P
A
S
V
M
T
N
Site 50
S288
S
S
S
G
S
P
A
S
V
M
T
N
M
R
A
Site 51
T291
G
S
P
A
S
V
M
T
N
M
R
A
P
S
T
Site 52
S297
M
T
N
M
R
A
P
S
T
T
G
G
I
G
I
Site 53
T298
T
N
M
R
A
P
S
T
T
G
G
I
G
I
N
Site 54
T299
N
M
R
A
P
S
T
T
G
G
I
G
I
N
S
Site 55
T310
G
I
N
S
V
T
G
T
S
T
V
N
N
V
N
Site 56
S311
I
N
S
V
T
G
T
S
T
V
N
N
V
N
I
Site 57
T312
N
S
V
T
G
T
S
T
V
N
N
V
N
I
T
Site 58
S341
G
N
V
N
I
S
T
S
N
I
P
S
A
A
G
Site 59
S392
A
A
G
M
T
G
G
S
V
S
S
Q
Q
Q
Q
Site 60
S395
M
T
G
G
S
V
S
S
Q
Q
Q
Q
P
T
V
Site 61
T401
S
S
Q
Q
Q
Q
P
T
V
N
T
S
R
F
R
Site 62
S414
F
R
V
V
K
L
D
S
S
S
E
P
F
K
K
Site 63
S415
R
V
V
K
L
D
S
S
S
E
P
F
K
K
G
Site 64
S416
V
V
K
L
D
S
S
S
E
P
F
K
K
G
R
Site 65
T425
P
F
K
K
G
R
W
T
C
T
E
F
Y
E
K
Site 66
S460
Q
N
P
I
E
V
T
S
E
R
E
S
T
S
G
Site 67
S464
E
V
T
S
E
R
E
S
T
S
G
S
S
V
S
Site 68
T465
V
T
S
E
R
E
S
T
S
G
S
S
V
S
S
Site 69
S466
T
S
E
R
E
S
T
S
G
S
S
V
S
S
S
Site 70
S468
E
R
E
S
T
S
G
S
S
V
S
S
S
V
S
Site 71
S469
R
E
S
T
S
G
S
S
V
S
S
S
V
S
T
Site 72
S471
S
T
S
G
S
S
V
S
S
S
V
S
T
L
S
Site 73
S472
T
S
G
S
S
V
S
S
S
V
S
T
L
S
H
Site 74
S473
S
G
S
S
V
S
S
S
V
S
T
L
S
H
Y
Site 75
S475
S
S
V
S
S
S
V
S
T
L
S
H
Y
T
E
Site 76
T476
S
V
S
S
S
V
S
T
L
S
H
Y
T
E
S
Site 77
S478
S
S
S
V
S
T
L
S
H
Y
T
E
S
V
G
Site 78
Y480
S
V
S
T
L
S
H
Y
T
E
S
V
G
S
G
Site 79
S483
T
L
S
H
Y
T
E
S
V
G
S
G
E
M
G
Site 80
S486
H
Y
T
E
S
V
G
S
G
E
M
G
A
P
T
Site 81
T493
S
G
E
M
G
A
P
T
V
V
V
Q
Q
Q
Q
Site 82
S524
L
Q
Q
M
D
F
G
S
T
G
P
Q
S
I
P
Site 83
S534
P
Q
S
I
P
A
V
S
I
P
Q
S
I
S
Q
Site 84
S538
P
A
V
S
I
P
Q
S
I
S
Q
S
Q
I
S
Site 85
S540
V
S
I
P
Q
S
I
S
Q
S
Q
I
S
Q
V
Site 86
S542
I
P
Q
S
I
S
Q
S
Q
I
S
Q
V
Q
L
Site 87
S545
S
I
S
Q
S
Q
I
S
Q
V
Q
L
Q
S
Q
Site 88
S551
I
S
Q
V
Q
L
Q
S
Q
E
L
S
Y
Q
Q
Site 89
S555
Q
L
Q
S
Q
E
L
S
Y
Q
Q
K
Q
G
L
Site 90
Y556
L
Q
S
Q
E
L
S
Y
Q
Q
K
Q
G
L
Q
Site 91
S596
S
A
L
G
Q
Q
P
S
I
S
S
L
A
Q
P
Site 92
S598
L
G
Q
Q
P
S
I
S
S
L
A
Q
P
Q
L
Site 93
S599
G
Q
Q
P
S
I
S
S
L
A
Q
P
Q
L
P
Site 94
S608
A
Q
P
Q
L
P
Y
S
Q
A
A
P
P
V
Q
Site 95
T616
Q
A
A
P
P
V
Q
T
P
L
P
G
A
P
P
Site 96
Y629
P
P
P
Q
Q
L
Q
Y
G
Q
Q
Q
P
M
V
Site 97
S647
M
A
P
G
H
V
K
S
V
T
Q
N
P
A
S
Site 98
T649
P
G
H
V
K
S
V
T
Q
N
P
A
S
E
Y
Site 99
S654
S
V
T
Q
N
P
A
S
E
Y
V
Q
Q
Q
P
Site 100
Y656
T
Q
N
P
A
S
E
Y
V
Q
Q
Q
P
I
L
Site 101
T665
Q
Q
Q
P
I
L
Q
T
A
M
S
S
G
Q
P
Site 102
S668
P
I
L
Q
T
A
M
S
S
G
Q
P
S
S
A
Site 103
S669
I
L
Q
T
A
M
S
S
G
Q
P
S
S
A
G
Site 104
S673
A
M
S
S
G
Q
P
S
S
A
G
V
G
A
G
Site 105
S674
M
S
S
G
Q
P
S
S
A
G
V
G
A
G
T
Site 106
T681
S
A
G
V
G
A
G
T
T
V
I
P
V
A
Q
Site 107
S709
P
A
Q
P
A
G
A
S
V
Q
P
V
G
Q
A
Site 108
S746
P
T
A
V
Q
Q
P
S
T
Q
V
P
P
S
V
Site 109
T747
T
A
V
Q
Q
P
S
T
Q
V
P
P
S
V
I
Site 110
S752
P
S
T
Q
V
P
P
S
V
I
Q
Q
G
A
P
Site 111
S761
I
Q
Q
G
A
P
P
S
S
Q
V
V
P
P
A
Site 112
S762
Q
Q
G
A
P
P
S
S
Q
V
V
P
P
A
Q
Site 113
T779
I
I
H
Q
G
V
Q
T
S
A
P
S
L
P
Q
Site 114
S780
I
H
Q
G
V
Q
T
S
A
P
S
L
P
Q
Q
Site 115
S792
P
Q
Q
L
V
I
A
S
Q
S
S
L
L
T
V
Site 116
T798
A
S
Q
S
S
L
L
T
V
P
P
Q
P
Q
G
Site 117
S822
S
Q
Q
L
P
A
V
S
S
L
P
S
A
S
S
Site 118
T833
S
A
S
S
I
S
V
T
S
Q
V
S
S
T
G
Site 119
S834
A
S
S
I
S
V
T
S
Q
V
S
S
T
G
P
Site 120
S837
I
S
V
T
S
Q
V
S
S
T
G
P
S
G
M
Site 121
S838
S
V
T
S
Q
V
S
S
T
G
P
S
G
M
P
Site 122
S842
Q
V
S
S
T
G
P
S
G
M
P
S
A
P
T
Site 123
S846
T
G
P
S
G
M
P
S
A
P
T
N
L
V
P
Site 124
T849
S
G
M
P
S
A
P
T
N
L
V
P
P
Q
N
Site 125
T860
P
P
Q
N
I
A
Q
T
P
A
T
Q
N
G
N
Site 126
T863
N
I
A
Q
T
P
A
T
Q
N
G
N
L
V
Q
Site 127
S871
Q
N
G
N
L
V
Q
S
V
S
Q
P
P
L
I
Site 128
T882
P
P
L
I
A
T
N
T
N
L
P
L
A
Q
Q
Site 129
S893
L
A
Q
Q
I
P
L
S
S
T
Q
F
S
A
Q
Site 130
S894
A
Q
Q
I
P
L
S
S
T
Q
F
S
A
Q
S
Site 131
S898
P
L
S
S
T
Q
F
S
A
Q
S
L
A
Q
A
Site 132
S901
S
T
Q
F
S
A
Q
S
L
A
Q
A
I
G
S
Site 133
S908
S
L
A
Q
A
I
G
S
Q
I
E
D
A
R
R
Site 134
S920
A
R
R
A
A
E
P
S
L
V
G
L
P
Q
T
Site 135
S929
V
G
L
P
Q
T
I
S
G
D
S
G
G
M
S
Site 136
S932
P
Q
T
I
S
G
D
S
G
G
M
S
A
V
S
Site 137
S936
S
G
D
S
G
G
M
S
A
V
S
D
G
S
S
Site 138
S939
S
G
G
M
S
A
V
S
D
G
S
S
S
S
L
Site 139
S942
M
S
A
V
S
D
G
S
S
S
S
L
A
A
S
Site 140
S943
S
A
V
S
D
G
S
S
S
S
L
A
A
S
A
Site 141
S944
A
V
S
D
G
S
S
S
S
L
A
A
S
A
S
Site 142
S971
L
V
D
G
E
D
E
S
S
S
G
A
S
V
V
Site 143
S972
V
D
G
E
D
E
S
S
S
G
A
S
V
V
A
Site 144
S973
D
G
E
D
E
S
S
S
G
A
S
V
V
A
I
Site 145
S976
D
E
S
S
S
G
A
S
V
V
A
I
D
N
K
Site 146
S993
Q
A
M
D
L
V
K
S
H
L
M
Y
A
V
R
Site 147
Y997
L
V
K
S
H
L
M
Y
A
V
R
E
E
V
E
Site 148
S1018
K
E
L
I
E
K
N
S
Q
L
E
Q
E
N
N
Site 149
T1029
Q
E
N
N
L
L
K
T
L
A
S
P
E
Q
L
Site 150
S1032
N
L
L
K
T
L
A
S
P
E
Q
L
A
Q
F
Site 151
S1047
Q
A
Q
L
Q
T
G
S
P
P
A
T
T
Q
P
Site 152
T1051
Q
T
G
S
P
P
A
T
T
Q
P
Q
G
T
T
Site 153
S1066
Q
P
P
A
Q
P
A
S
Q
G
S
G
P
T
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation