KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TAB1
Full Name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Alias:
MAP3K7IP1; Mitogen-activated protein kinase kinase kinase 7 interacting protein 1; TAK1-binding protein 1
Type:
Activator protein
Mass (Da):
54644
Number AA:
504
UniProt ID:
Q15750
International Prot ID:
IPI00019459
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0005515
GO:0004672
PhosphoSite+
KinaseNET
Biological Process:
GO:0000185
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
A
Q
R
R
S
L
L
Q
S
E
Q
Q
Site 2
S11
Q
R
R
S
L
L
Q
S
E
Q
Q
P
S
W
T
Site 3
S16
L
Q
S
E
Q
Q
P
S
W
T
D
D
L
P
L
Site 4
S31
C
H
L
S
G
V
G
S
A
S
N
R
S
Y
S
Site 5
S33
L
S
G
V
G
S
A
S
N
R
S
Y
S
A
D
Site 6
S36
V
G
S
A
S
N
R
S
Y
S
A
D
G
K
G
Site 7
Y37
G
S
A
S
N
R
S
Y
S
A
D
G
K
G
T
Site 8
S38
S
A
S
N
R
S
Y
S
A
D
G
K
G
T
E
Site 9
S46
A
D
G
K
G
T
E
S
H
P
P
E
D
S
W
Site 10
S52
E
S
H
P
P
E
D
S
W
L
K
F
R
S
E
Site 11
Y65
S
E
N
N
C
F
L
Y
G
V
F
N
G
Y
D
Site 12
T77
G
Y
D
G
N
R
V
T
N
F
V
A
Q
R
L
Site 13
S116
A
F
D
V
V
E
R
S
F
L
E
S
I
D
D
Site 14
S120
V
E
R
S
F
L
E
S
I
D
D
A
L
A
E
Site 15
S130
D
A
L
A
E
K
A
S
L
Q
S
Q
L
P
E
Site 16
S133
A
E
K
A
S
L
Q
S
Q
L
P
E
G
V
P
Site 17
Y148
Q
H
Q
L
P
P
Q
Y
Q
K
I
L
E
R
L
Site 18
T157
K
I
L
E
R
L
K
T
L
E
R
E
I
S
G
Site 19
Y179
V
L
L
N
N
K
L
Y
V
A
N
V
G
T
N
Site 20
T185
L
Y
V
A
N
V
G
T
N
R
A
L
L
C
K
Site 21
T208
T
Q
L
N
V
D
H
T
T
E
N
E
D
E
L
Site 22
S219
E
D
E
L
F
R
L
S
Q
L
G
L
D
A
G
Site 23
Y246
S
T
R
R
I
G
D
Y
K
V
K
Y
G
Y
T
Site 24
Y250
I
G
D
Y
K
V
K
Y
G
Y
T
D
I
D
L
Site 25
S259
Y
T
D
I
D
L
L
S
A
A
K
S
K
P
I
Site 26
S339
D
R
V
K
R
I
H
S
D
T
F
A
S
G
G
Site 27
T341
V
K
R
I
H
S
D
T
F
A
S
G
G
E
R
Site 28
Y367
L
L
V
R
N
F
G
Y
P
L
G
E
M
S
Q
Site 29
S373
G
Y
P
L
G
E
M
S
Q
P
T
P
S
P
A
Site 30
T376
L
G
E
M
S
Q
P
T
P
S
P
A
P
A
A
Site 31
S378
E
M
S
Q
P
T
P
S
P
A
P
A
A
G
G
Site 32
Y388
P
A
A
G
G
R
V
Y
P
V
S
V
P
Y
S
Site 33
S391
G
G
R
V
Y
P
V
S
V
P
Y
S
S
A
Q
Site 34
S395
Y
P
V
S
V
P
Y
S
S
A
Q
S
T
S
K
Site 35
S396
P
V
S
V
P
Y
S
S
A
Q
S
T
S
K
T
Site 36
S399
V
P
Y
S
S
A
Q
S
T
S
K
T
S
V
T
Site 37
T400
P
Y
S
S
A
Q
S
T
S
K
T
S
V
T
L
Site 38
S401
Y
S
S
A
Q
S
T
S
K
T
S
V
T
L
S
Site 39
T403
S
A
Q
S
T
S
K
T
S
V
T
L
S
L
V
Site 40
S423
Q
M
V
N
G
A
H
S
A
S
T
L
D
E
A
Site 41
T431
A
S
T
L
D
E
A
T
P
T
L
T
N
Q
S
Site 42
T433
T
L
D
E
A
T
P
T
L
T
N
Q
S
P
T
Site 43
S438
T
P
T
L
T
N
Q
S
P
T
L
T
L
Q
S
Site 44
T442
T
N
Q
S
P
T
L
T
L
Q
S
T
N
T
H
Site 45
T446
P
T
L
T
L
Q
S
T
N
T
H
T
Q
S
S
Site 46
T448
L
T
L
Q
S
T
N
T
H
T
Q
S
S
S
S
Site 47
T450
L
Q
S
T
N
T
H
T
Q
S
S
S
S
S
S
Site 48
S452
S
T
N
T
H
T
Q
S
S
S
S
S
S
D
G
Site 49
S453
T
N
T
H
T
Q
S
S
S
S
S
S
D
G
G
Site 50
S454
N
T
H
T
Q
S
S
S
S
S
S
D
G
G
L
Site 51
S455
T
H
T
Q
S
S
S
S
S
S
D
G
G
L
F
Site 52
S456
H
T
Q
S
S
S
S
S
S
D
G
G
L
F
R
Site 53
S457
T
Q
S
S
S
S
S
S
D
G
G
L
F
R
S
Site 54
S464
S
D
G
G
L
F
R
S
R
P
A
H
S
L
P
Site 55
S469
F
R
S
R
P
A
H
S
L
P
P
G
E
D
G
Site 56
Y481
E
D
G
R
V
E
P
Y
V
D
F
A
E
F
Y
Site 57
Y488
Y
V
D
F
A
E
F
Y
R
L
W
S
V
D
H
Site 58
S492
A
E
F
Y
R
L
W
S
V
D
H
G
E
Q
S
Site 59
S499
S
V
D
H
G
E
Q
S
V
V
T
A
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation