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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HERC1
Full Name:
Probable E3 ubiquitin-protein ligase HERC1
Alias:
EC 6.3.2.-; Guanine nucleotide exchange factor p532; Hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1; P532; P619; Probable E3 ubiquitin-protein ligase HERC1
Type:
Ubiquitin conjugating system, Ligase, Guanine nucleotide exchange factor, ARF
Mass (Da):
532186
Number AA:
4861
UniProt ID:
Q15751
International Prot ID:
IPI00022479
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005737
GO:0005794
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0005083
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
GO:0006508
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
K
W
L
E
H
L
N
S
S
W
I
T
E
D
S
Site 2
T22
H
L
N
S
S
W
I
T
E
D
S
E
S
I
A
Site 3
S25
S
S
W
I
T
E
D
S
E
S
I
A
T
R
E
Site 4
S27
W
I
T
E
D
S
E
S
I
A
T
R
E
G
V
Site 5
Y38
R
E
G
V
A
V
L
Y
S
K
L
V
S
N
K
Site 6
S39
E
G
V
A
V
L
Y
S
K
L
V
S
N
K
E
Site 7
S69
L
P
D
F
E
R
E
S
L
S
S
D
E
Q
D
Site 8
S71
D
F
E
R
E
S
L
S
S
D
E
Q
D
H
Y
Site 9
S72
F
E
R
E
S
L
S
S
D
E
Q
D
H
Y
L
Site 10
Y78
S
S
D
E
Q
D
H
Y
L
D
A
L
L
S
S
Site 11
Y121
F
Y
A
L
S
N
K
Y
H
D
K
G
K
V
K
Site 12
S133
K
V
K
Q
Q
Q
H
S
P
E
S
S
S
G
S
Site 13
S136
Q
Q
Q
H
S
P
E
S
S
S
G
S
A
D
V
Site 14
S137
Q
Q
H
S
P
E
S
S
S
G
S
A
D
V
H
Site 15
S138
Q
H
S
P
E
S
S
S
G
S
A
D
V
H
S
Site 16
S140
S
P
E
S
S
S
G
S
A
D
V
H
S
V
S
Site 17
S145
S
G
S
A
D
V
H
S
V
S
E
R
P
R
S
Site 18
S147
S
A
D
V
H
S
V
S
E
R
P
R
S
S
T
Site 19
S152
S
V
S
E
R
P
R
S
S
T
D
A
L
I
E
Site 20
S153
V
S
E
R
P
R
S
S
T
D
A
L
I
E
M
Site 21
T154
S
E
R
P
R
S
S
T
D
A
L
I
E
M
G
Site 22
S223
P
M
G
L
D
C
L
S
Q
V
T
T
F
L
K
Site 23
S237
K
G
V
T
I
P
N
S
G
A
D
T
L
G
R
Site 24
T241
I
P
N
S
G
A
D
T
L
G
R
R
L
A
S
Site 25
S260
G
L
A
A
Q
R
G
S
L
R
Y
L
L
E
W
Site 26
S288
M
E
K
G
K
L
L
S
S
Q
E
G
M
I
S
Site 27
S289
E
K
G
K
L
L
S
S
Q
E
G
M
I
S
F
Site 28
S309
I
L
M
Q
M
R
R
S
L
G
S
S
A
D
R
Site 29
S312
Q
M
R
R
S
L
G
S
S
A
D
R
S
Q
W
Site 30
S313
M
R
R
S
L
G
S
S
A
D
R
S
Q
W
R
Site 31
S317
L
G
S
S
A
D
R
S
Q
W
R
E
P
T
R
Site 32
T323
R
S
Q
W
R
E
P
T
R
T
S
D
G
L
C
Site 33
T325
Q
W
R
E
P
T
R
T
S
D
G
L
C
S
L
Site 34
S326
W
R
E
P
T
R
T
S
D
G
L
C
S
L
Y
Site 35
S348
E
E
V
C
R
M
A
S
D
Y
S
R
T
C
A
Site 36
Y350
V
C
R
M
A
S
D
Y
S
R
T
C
A
S
P
Site 37
S356
D
Y
S
R
T
C
A
S
P
D
S
I
Q
T
G
Site 38
S359
R
T
C
A
S
P
D
S
I
Q
T
G
D
A
P
Site 39
Y375
V
S
E
T
C
E
V
Y
V
W
G
S
N
S
S
Site 40
S381
V
Y
V
W
G
S
N
S
S
H
Q
L
V
E
G
Site 41
S401
L
Q
P
K
L
A
P
S
F
S
D
A
Q
T
I
Site 42
S403
P
K
L
A
P
S
F
S
D
A
Q
T
I
E
A
Site 43
T407
P
S
F
S
D
A
Q
T
I
E
A
G
Q
Y
C
Site 44
S431
V
R
A
C
G
K
G
S
Y
G
R
L
G
L
G
Site 45
Y432
R
A
C
G
K
G
S
Y
G
R
L
G
L
G
D
Site 46
S440
G
R
L
G
L
G
D
S
N
N
Q
S
T
L
K
Site 47
S444
L
G
D
S
N
N
Q
S
T
L
K
K
L
T
F
Site 48
T450
Q
S
T
L
K
K
L
T
F
E
P
H
R
S
I
Site 49
S456
L
T
F
E
P
H
R
S
I
K
K
V
S
S
S
Site 50
S461
H
R
S
I
K
K
V
S
S
S
K
G
S
D
G
Site 51
S462
R
S
I
K
K
V
S
S
S
K
G
S
D
G
H
Site 52
S463
S
I
K
K
V
S
S
S
K
G
S
D
G
H
T
Site 53
S466
K
V
S
S
S
K
G
S
D
G
H
T
L
A
F
Site 54
T470
S
K
G
S
D
G
H
T
L
A
F
T
T
E
G
Site 55
S481
T
T
E
G
E
V
F
S
W
G
D
G
D
Y
G
Site 56
Y487
F
S
W
G
D
G
D
Y
G
K
L
G
H
G
N
Site 57
S495
G
K
L
G
H
G
N
S
S
T
Q
K
Y
P
K
Site 58
Y500
G
N
S
S
T
Q
K
Y
P
K
L
I
Q
G
P
Site 59
S523
V
S
A
G
Y
R
H
S
A
A
V
T
E
D
G
Site 60
T527
Y
R
H
S
A
A
V
T
E
D
G
E
L
Y
T
Site 61
Y533
V
T
E
D
G
E
L
Y
T
W
G
E
G
D
F
Site 62
S548
G
R
L
G
H
G
D
S
N
S
R
N
I
P
T
Site 63
S550
L
G
H
G
D
S
N
S
R
N
I
P
T
L
V
Site 64
T555
S
N
S
R
N
I
P
T
L
V
K
D
I
S
N
Site 65
S571
G
E
V
S
C
G
S
S
H
T
I
A
L
S
K
Site 66
S577
S
S
H
T
I
A
L
S
K
D
G
R
T
V
W
Site 67
T582
A
L
S
K
D
G
R
T
V
W
S
F
G
G
G
Site 68
S585
K
D
G
R
T
V
W
S
F
G
G
G
D
N
G
Site 69
T599
G
K
L
G
H
G
D
T
N
R
V
Y
K
P
K
Site 70
Y603
H
G
D
T
N
R
V
Y
K
P
K
V
I
E
A
Site 71
T630
S
Q
S
S
L
A
L
T
S
T
G
Q
V
Y
A
Site 72
S681
D
S
H
C
L
A
L
S
H
D
N
E
V
Y
A
Site 73
Y687
L
S
H
D
N
E
V
Y
A
W
G
N
N
S
M
Site 74
S702
G
Q
C
G
Q
G
N
S
T
G
P
I
T
K
P
Site 75
T707
G
N
S
T
G
P
I
T
K
P
K
K
V
S
G
Site 76
S728
Q
Q
I
S
A
G
T
S
H
S
L
A
W
T
A
Site 77
T734
T
S
H
S
L
A
W
T
A
L
P
R
D
R
Q
Site 78
Y749
V
V
A
W
H
R
P
Y
C
V
D
L
E
E
S
Site 79
T757
C
V
D
L
E
E
S
T
F
S
H
L
R
S
F
Site 80
S759
D
L
E
E
S
T
F
S
H
L
R
S
F
L
E
Site 81
S763
S
T
F
S
H
L
R
S
F
L
E
R
Y
C
D
Site 82
Y768
L
R
S
F
L
E
R
Y
C
D
K
I
N
S
E
Site 83
S783
I
P
P
L
P
F
P
S
S
R
E
H
H
S
F
Site 84
S784
P
P
L
P
F
P
S
S
R
E
H
H
S
F
L
Site 85
S789
P
S
S
R
E
H
H
S
F
L
K
L
C
L
K
Site 86
T833
L
F
R
L
M
D
S
T
V
P
D
E
I
Q
E
Site 87
S866
E
R
M
E
L
L
H
S
L
L
P
Q
G
P
D
Site 88
S877
Q
G
P
D
R
W
E
S
L
S
K
G
Q
R
M
Site 89
S879
P
D
R
W
E
S
L
S
K
G
Q
R
M
Q
L
Site 90
S901
Q
D
H
T
H
V
A
S
L
L
G
Y
S
S
P
Site 91
S907
A
S
L
L
G
Y
S
S
P
S
D
A
A
D
L
Site 92
S909
L
L
G
Y
S
S
P
S
D
A
A
D
L
S
S
Site 93
S915
P
S
D
A
A
D
L
S
S
V
C
T
G
Y
G
Site 94
S916
S
D
A
A
D
L
S
S
V
C
T
G
Y
G
N
Site 95
T919
A
D
L
S
S
V
C
T
G
Y
G
N
L
S
D
Site 96
Y921
L
S
S
V
C
T
G
Y
G
N
L
S
D
Q
P
Site 97
S925
C
T
G
Y
G
N
L
S
D
Q
P
Y
G
T
Q
Site 98
Y929
G
N
L
S
D
Q
P
Y
G
T
Q
S
C
H
P
Site 99
T931
L
S
D
Q
P
Y
G
T
Q
S
C
H
P
D
T
Site 100
T938
T
Q
S
C
H
P
D
T
H
L
A
E
I
L
M
Site 101
Y955
L
L
R
N
L
G
F
Y
T
D
Q
A
F
G
E
Site 102
S967
F
G
E
L
E
K
N
S
D
K
F
L
L
G
T
Site 103
T974
S
D
K
F
L
L
G
T
S
S
S
E
N
S
Q
Site 104
S975
D
K
F
L
L
G
T
S
S
S
E
N
S
Q
P
Site 105
S976
K
F
L
L
G
T
S
S
S
E
N
S
Q
P
A
Site 106
S977
F
L
L
G
T
S
S
S
E
N
S
Q
P
A
H
Site 107
S980
G
T
S
S
S
E
N
S
Q
P
A
H
L
H
E
Site 108
S1006
F
C
H
I
N
N
I
S
E
N
S
S
S
V
A
Site 109
S1009
I
N
N
I
S
E
N
S
S
S
V
A
L
L
H
Site 110
S1010
N
N
I
S
E
N
S
S
S
V
A
L
L
H
K
Site 111
S1011
N
I
S
E
N
S
S
S
V
A
L
L
H
K
H
Site 112
T1027
Q
L
L
L
P
H
A
T
D
I
Y
S
R
S
A
Site 113
Y1030
L
P
H
A
T
D
I
Y
S
R
S
A
N
L
L
Site 114
S1031
P
H
A
T
D
I
Y
S
R
S
A
N
L
L
K
Site 115
S1040
S
A
N
L
L
K
E
S
P
W
N
G
S
V
G
Site 116
S1045
K
E
S
P
W
N
G
S
V
G
E
K
L
R
D
Site 117
S1160
L
G
G
M
L
Q
G
S
P
V
S
P
E
E
Q
Site 118
S1163
M
L
Q
G
S
P
V
S
P
E
E
Q
D
T
A
Site 119
T1169
V
S
P
E
E
Q
D
T
A
Y
W
M
K
T
P
Site 120
Y1171
P
E
E
Q
D
T
A
Y
W
M
K
T
P
L
F
Site 121
T1175
D
T
A
Y
W
M
K
T
P
L
F
S
D
G
V
Site 122
T1186
S
D
G
V
E
M
D
T
P
Q
L
D
K
C
M
Site 123
S1202
C
L
L
E
V
A
L
S
G
N
E
E
Q
K
P
Site 124
Y1212
E
E
Q
K
P
F
D
Y
K
L
R
P
E
I
A
Site 125
S1235
C
S
K
E
P
A
R
S
L
W
I
S
M
Q
D
Site 126
S1239
P
A
R
S
L
W
I
S
M
Q
D
Y
A
V
S
Site 127
Y1243
L
W
I
S
M
Q
D
Y
A
V
S
K
D
W
D
Site 128
S1251
A
V
S
K
D
W
D
S
A
T
L
S
N
E
S
Site 129
T1253
S
K
D
W
D
S
A
T
L
S
N
E
S
L
L
Site 130
S1255
D
W
D
S
A
T
L
S
N
E
S
L
L
D
T
Site 131
S1258
S
A
T
L
S
N
E
S
L
L
D
T
V
S
R
Site 132
S1279
L
K
H
T
N
L
L
S
Q
A
C
G
E
S
R
Site 133
S1294
Y
Q
P
G
K
H
L
S
E
V
Y
R
C
V
Y
Site 134
Y1301
S
E
V
Y
R
C
V
Y
K
V
R
S
R
L
L
Site 135
T1318
K
N
L
E
L
I
Q
T
R
S
S
S
R
D
R
Site 136
S1320
L
E
L
I
Q
T
R
S
S
S
R
D
R
W
I
Site 137
S1321
E
L
I
Q
T
R
S
S
S
R
D
R
W
I
S
Site 138
S1322
L
I
Q
T
R
S
S
S
R
D
R
W
I
S
E
Site 139
S1328
S
S
R
D
R
W
I
S
E
N
Q
D
S
A
D
Site 140
S1333
W
I
S
E
N
Q
D
S
A
D
V
D
P
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L
Site 444
S4653
H
E
M
I
P
L
D
S
F
V
G
Q
S
A
D
Site 445
T4676
G
G
N
S
I
P
L
T
F
S
N
R
K
E
Y
Site 446
S4678
N
S
I
P
L
T
F
S
N
R
K
E
Y
V
E
Site 447
Y4683
T
F
S
N
R
K
E
Y
V
E
R
A
I
E
Y
Site 448
T4786
R
S
R
L
P
A
N
T
A
D
I
S
Q
R
F
Site 449
S4790
P
A
N
T
A
D
I
S
Q
R
F
Q
I
M
K
Site 450
Y4802
I
M
K
V
D
R
P
Y
D
S
L
P
T
S
Q
Site 451
S4804
K
V
D
R
P
Y
D
S
L
P
T
S
Q
T
C
Site 452
S4808
P
Y
D
S
L
P
T
S
Q
T
C
F
F
Q
L
Site 453
T4810
D
S
L
P
T
S
Q
T
C
F
F
Q
L
R
L
Site 454
S4821
Q
L
R
L
P
P
Y
S
S
Q
L
V
M
A
E
Site 455
S4822
L
R
L
P
P
Y
S
S
Q
L
V
M
A
E
R
Site 456
Y4832
V
M
A
E
R
L
R
Y
A
I
N
N
C
R
S
Site 457
Y4845
R
S
I
D
M
D
N
Y
M
L
S
R
N
V
D
Site 458
S4857
N
V
D
N
A
E
G
S
D
T
D
Y
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation