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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ITSN1
Full Name:
Intersectin-1
Alias:
Intersectin 1; Intersectin 1 (SH3 domain protein); Intersectin 1 short form variant 3; Intersectin 1 short form variant, 11; Intersectin short variant 12; Intersectin-SH3 domain-containing protein SH3P17; ITN1; ITSN; MGC134948; MGC134949; SH3 domain protein-1A; SH3 domain-containing protein 1A; SH3D1A; SH3P17; Srcy 3 domain-containing protein
Type:
Adaptor/scaffold; Calcium-binding protein; Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
195422
Number AA:
1721
UniProt ID:
Q15811
International Prot ID:
IPI00220592
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005829
GO:0012505
Uniprot
OncoNet
Molecular Function:
GO:0005089
GO:0005509
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
S
L
D
I
W
A
I
T
V
E
E
R
A
K
H
Site 2
S31
K
H
D
Q
Q
F
H
S
L
K
P
I
S
G
F
Site 3
S36
F
H
S
L
K
P
I
S
G
F
I
T
G
D
Q
Site 4
T40
K
P
I
S
G
F
I
T
G
D
Q
A
R
N
F
Site 5
Y92
I
K
L
K
L
Q
G
Y
Q
L
P
S
A
L
P
Site 6
S182
P
A
A
T
L
P
K
S
S
S
F
S
R
S
G
Site 7
S184
A
T
L
P
K
S
S
S
F
S
R
S
G
P
G
Site 8
S186
L
P
K
S
S
S
F
S
R
S
G
P
G
S
Q
Site 9
S188
K
S
S
S
F
S
R
S
G
P
G
S
Q
L
N
Site 10
S192
F
S
R
S
G
P
G
S
Q
L
N
T
K
L
Q
Site 11
T196
G
P
G
S
Q
L
N
T
K
L
Q
K
A
Q
S
Site 12
S203
T
K
L
Q
K
A
Q
S
F
D
V
A
S
V
P
Site 13
S220
A
E
W
A
V
P
Q
S
S
R
L
K
Y
R
Q
Site 14
S221
E
W
A
V
P
Q
S
S
R
L
K
Y
R
Q
L
Site 15
Y225
P
Q
S
S
R
L
K
Y
R
Q
L
F
N
S
H
Site 16
S231
K
Y
R
Q
L
F
N
S
H
D
K
T
M
S
G
Site 17
T235
L
F
N
S
H
D
K
T
M
S
G
H
L
T
G
Site 18
S237
N
S
H
D
K
T
M
S
G
H
L
T
G
P
Q
Site 19
T241
K
T
M
S
G
H
L
T
G
P
Q
A
R
T
I
Site 20
S266
L
A
S
I
W
N
L
S
D
I
D
Q
D
G
K
Site 21
Y303
P
P
V
L
P
P
E
Y
I
P
P
S
F
R
R
Site 22
S307
P
P
E
Y
I
P
P
S
F
R
R
V
R
S
G
Site 23
S313
P
S
F
R
R
V
R
S
G
S
G
I
S
V
I
Site 24
S315
F
R
R
V
R
S
G
S
G
I
S
V
I
S
S
Site 25
S318
V
R
S
G
S
G
I
S
V
I
S
S
T
S
V
Site 26
S321
G
S
G
I
S
V
I
S
S
T
S
V
D
Q
R
Site 27
S322
S
G
I
S
V
I
S
S
T
S
V
D
Q
R
L
Site 28
T323
G
I
S
V
I
S
S
T
S
V
D
Q
R
L
P
Site 29
S324
I
S
V
I
S
S
T
S
V
D
Q
R
L
P
E
Site 30
T349
L
E
K
K
L
P
V
T
F
E
D
K
K
R
E
Site 31
T477
V
L
K
A
K
K
K
T
L
E
F
E
L
E
A
Site 32
T504
Q
D
I
R
C
R
L
T
T
Q
R
Q
E
I
E
Site 33
T505
D
I
R
C
R
L
T
T
Q
R
Q
E
I
E
S
Site 34
S512
T
Q
R
Q
E
I
E
S
T
N
K
S
R
E
L
Site 35
T513
Q
R
Q
E
I
E
S
T
N
K
S
R
E
L
R
Site 36
S516
E
I
E
S
T
N
K
S
R
E
L
R
I
A
E
Site 37
T525
E
L
R
I
A
E
I
T
H
L
Q
Q
Q
L
Q
Site 38
S534
L
Q
Q
Q
L
Q
E
S
Q
Q
M
L
G
R
L
Site 39
S559
L
K
Q
V
Q
Q
N
S
L
H
R
D
S
L
V
Site 40
S564
Q
N
S
L
H
R
D
S
L
V
T
L
K
R
A
Site 41
T567
L
H
R
D
S
L
V
T
L
K
R
A
L
E
A
Site 42
S624
Q
Q
L
Q
K
Q
K
S
M
E
A
E
R
L
K
Site 43
S687
E
K
L
K
R
E
E
S
V
K
K
K
D
G
E
Site 44
S725
P
A
V
Q
A
P
W
S
T
A
E
K
G
P
L
Site 45
T733
T
A
E
K
G
P
L
T
I
S
A
Q
E
N
V
Site 46
Y744
Q
E
N
V
K
V
V
Y
Y
R
A
L
Y
P
F
Site 47
Y749
V
V
Y
Y
R
A
L
Y
P
F
E
S
R
S
H
Site 48
S753
R
A
L
Y
P
F
E
S
R
S
H
D
E
I
T
Site 49
S755
L
Y
P
F
E
S
R
S
H
D
E
I
T
I
Q
Site 50
T760
S
R
S
H
D
E
I
T
I
Q
P
G
D
I
V
Site 51
S777
K
G
E
W
V
D
E
S
Q
T
G
E
P
G
W
Site 52
T779
E
W
V
D
E
S
Q
T
G
E
P
G
W
L
G
Site 53
T793
G
G
E
L
K
G
K
T
G
W
F
P
A
N
Y
Site 54
Y800
T
G
W
F
P
A
N
Y
A
E
K
I
P
E
N
Site 55
T817
P
A
P
V
K
P
V
T
D
S
T
S
A
P
A
Site 56
S819
P
V
K
P
V
T
D
S
T
S
A
P
A
P
K
Site 57
T820
V
K
P
V
T
D
S
T
S
A
P
A
P
K
L
Site 58
S821
K
P
V
T
D
S
T
S
A
P
A
P
K
L
A
Site 59
T839
T
P
A
P
L
A
V
T
S
S
E
P
S
T
T
Site 60
S840
P
A
P
L
A
V
T
S
S
E
P
S
T
T
P
Site 61
S841
A
P
L
A
V
T
S
S
E
P
S
T
T
P
N
Site 62
S844
A
V
T
S
S
E
P
S
T
T
P
N
N
W
A
Site 63
T845
V
T
S
S
E
P
S
T
T
P
N
N
W
A
D
Site 64
T846
T
S
S
E
P
S
T
T
P
N
N
W
A
D
F
Site 65
T856
N
W
A
D
F
S
S
T
W
P
T
S
T
N
E
Site 66
T859
D
F
S
S
T
W
P
T
S
T
N
E
K
P
E
Site 67
S860
F
S
S
T
W
P
T
S
T
N
E
K
P
E
T
Site 68
T861
S
S
T
W
P
T
S
T
N
E
K
P
E
T
D
Site 69
S878
D
A
W
A
A
Q
P
S
L
T
V
P
S
A
G
Site 70
S891
A
G
Q
L
R
Q
R
S
A
F
T
P
A
T
A
Site 71
T894
L
R
Q
R
S
A
F
T
P
A
T
A
T
G
S
Site 72
T897
R
S
A
F
T
P
A
T
A
T
G
S
S
P
S
Site 73
T899
A
F
T
P
A
T
A
T
G
S
S
P
S
P
V
Site 74
S901
T
P
A
T
A
T
G
S
S
P
S
P
V
L
G
Site 75
S902
P
A
T
A
T
G
S
S
P
S
P
V
L
G
Q
Site 76
S904
T
A
T
G
S
S
P
S
P
V
L
G
Q
G
E
Site 77
Y922
G
L
Q
A
Q
A
L
Y
P
W
R
A
K
K
D
Site 78
T941
F
N
K
N
D
V
I
T
V
L
E
Q
Q
D
M
Site 79
S964
Q
K
G
W
F
P
K
S
Y
V
K
L
I
S
G
Site 80
Y965
K
G
W
F
P
K
S
Y
V
K
L
I
S
G
P
Site 81
S970
K
S
Y
V
K
L
I
S
G
P
I
R
K
S
T
Site 82
S976
I
S
G
P
I
R
K
S
T
S
M
D
S
G
S
Site 83
T977
S
G
P
I
R
K
S
T
S
M
D
S
G
S
S
Site 84
S978
G
P
I
R
K
S
T
S
M
D
S
G
S
S
E
Site 85
S981
R
K
S
T
S
M
D
S
G
S
S
E
S
P
A
Site 86
S983
S
T
S
M
D
S
G
S
S
E
S
P
A
S
L
Site 87
S984
T
S
M
D
S
G
S
S
E
S
P
A
S
L
K
Site 88
S986
M
D
S
G
S
S
E
S
P
A
S
L
K
R
V
Site 89
S989
G
S
S
E
S
P
A
S
L
K
R
V
A
S
P
Site 90
S995
A
S
L
K
R
V
A
S
P
A
A
K
P
V
V
Site 91
Y1011
G
E
E
F
I
A
M
Y
T
Y
E
S
S
E
Q
Site 92
T1012
E
E
F
I
A
M
Y
T
Y
E
S
S
E
Q
G
Site 93
Y1013
E
F
I
A
M
Y
T
Y
E
S
S
E
Q
G
D
Site 94
T1022
S
S
E
Q
G
D
L
T
F
Q
Q
G
D
V
I
Site 95
T1040
K
K
D
G
D
W
W
T
G
T
V
G
D
K
A
Site 96
S1052
D
K
A
G
V
F
P
S
N
Y
V
R
L
K
D
Site 97
Y1054
A
G
V
F
P
S
N
Y
V
R
L
K
D
S
E
Site 98
S1060
N
Y
V
R
L
K
D
S
E
G
S
G
T
A
G
Site 99
T1065
K
D
S
E
G
S
G
T
A
G
K
T
G
S
L
Site 100
S1071
G
T
A
G
K
T
G
S
L
G
K
K
P
E
I
Site 101
Y1132
I
G
W
F
P
A
N
Y
V
K
L
L
S
P
G
Site 102
S1137
A
N
Y
V
K
L
L
S
P
G
T
S
K
I
T
Site 103
S1141
K
L
L
S
P
G
T
S
K
I
T
P
T
E
P
Site 104
T1144
S
P
G
T
S
K
I
T
P
T
E
P
P
K
S
Site 105
T1146
G
T
S
K
I
T
P
T
E
P
P
K
S
T
A
Site 106
S1151
T
P
T
E
P
P
K
S
T
A
L
A
A
V
C
Site 107
Y1166
Q
V
I
G
M
Y
D
Y
T
A
Q
N
D
D
E
Site 108
T1212
P
S
N
Y
V
K
L
T
T
D
M
D
P
S
Q
Site 109
T1232
L
H
L
L
D
M
L
T
P
T
E
R
K
R
Q
Site 110
T1234
L
L
D
M
L
T
P
T
E
R
K
R
Q
G
Y
Site 111
Y1241
T
E
R
K
R
Q
G
Y
I
H
E
L
I
V
T
Site 112
T1248
Y
I
H
E
L
I
V
T
E
E
N
Y
V
N
D
Site 113
S1306
L
R
V
R
K
K
M
S
G
E
K
M
P
V
K
Site 114
Y1329
Q
L
P
H
M
Q
P
Y
I
R
F
C
S
R
Q
Site 115
S1334
Q
P
Y
I
R
F
C
S
R
Q
L
N
G
A
A
Site 116
T1347
A
A
L
I
Q
Q
K
T
D
E
A
P
D
F
K
Site 117
T1383
L
K
P
M
Q
R
V
T
R
Y
P
L
I
I
K
Site 118
Y1385
P
M
Q
R
V
T
R
Y
P
L
I
I
K
N
I
Site 119
T1396
I
K
N
I
L
E
N
T
P
E
N
H
P
D
H
Site 120
S1404
P
E
N
H
P
D
H
S
H
L
K
H
A
L
E
Site 121
S1418
E
K
A
E
E
L
C
S
Q
V
N
E
G
V
R
Site 122
S1430
G
V
R
E
K
E
N
S
D
R
L
E
W
I
Q
Site 123
T1455
Q
L
V
F
N
S
V
T
N
C
L
G
P
R
K
Site 124
S1466
G
P
R
K
F
L
H
S
G
K
L
Y
K
A
K
Site 125
Y1470
F
L
H
S
G
K
L
Y
K
A
K
S
N
K
E
Site 126
S1474
G
K
L
Y
K
A
K
S
N
K
E
L
Y
G
F
Site 127
Y1479
A
K
S
N
K
E
L
Y
G
F
L
F
N
D
F
Site 128
T1501
K
P
L
G
S
S
G
T
D
K
V
F
S
P
K
Site 129
S1506
S
G
T
D
K
V
F
S
P
K
S
N
L
Q
Y
Site 130
S1509
D
K
V
F
S
P
K
S
N
L
Q
Y
K
M
Y
Site 131
Y1513
S
P
K
S
N
L
Q
Y
K
M
Y
K
T
P
I
Site 132
Y1516
S
N
L
Q
Y
K
M
Y
K
T
P
I
F
L
N
Site 133
T1518
L
Q
Y
K
M
Y
K
T
P
I
F
L
N
E
V
Site 134
S1534
V
K
L
P
T
D
P
S
G
D
E
P
I
F
H
Site 135
Y1549
I
S
H
I
D
R
V
Y
T
L
R
A
E
S
I
Site 136
T1550
S
H
I
D
R
V
Y
T
L
R
A
E
S
I
N
Site 137
S1555
V
Y
T
L
R
A
E
S
I
N
E
R
T
A
W
Site 138
Y1585
K
K
K
R
E
K
A
Y
L
V
R
S
Q
R
A
Site 139
S1589
E
K
A
Y
L
V
R
S
Q
R
A
T
G
I
G
Site 140
S1613
I
E
L
K
P
C
R
S
H
G
K
S
N
P
Y
Site 141
S1617
P
C
R
S
H
G
K
S
N
P
Y
C
E
V
T
Site 142
Y1620
S
H
G
K
S
N
P
Y
C
E
V
T
M
G
S
Site 143
T1634
S
Q
C
H
I
T
K
T
I
Q
D
T
L
N
P
Site 144
T1638
I
T
K
T
I
Q
D
T
L
N
P
K
W
N
S
Site 145
S1645
T
L
N
P
K
W
N
S
N
C
Q
F
F
I
R
Site 146
T1662
E
Q
E
V
L
C
I
T
V
F
E
R
D
Q
F
Site 147
S1670
V
F
E
R
D
Q
F
S
P
D
D
F
L
G
R
Site 148
S1691
D
I
K
K
D
Q
G
S
K
G
P
V
T
K
C
Site 149
T1696
Q
G
S
K
G
P
V
T
K
C
L
L
L
H
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation