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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBCE
Full Name:
Tubulin-specific chaperone E
Alias:
Beta-tubulin cofactor E; HRD; KCS; KCS1; Pac2; Tubulin folding cofactor E; Tubulin-folding cofactor E
Type:
Chaperone
Mass (Da):
59346
Number AA:
527
UniProt ID:
Q15813
International Prot ID:
IPI00018402
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0051087
PhosphoSite+
KinaseNET
Biological Process:
GO:0000226
GO:0006457
GO:0007017
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
D
T
L
T
A
D
V
Site 2
T4
_
_
_
_
M
S
D
T
L
T
A
D
V
I
G
Site 3
T6
_
_
M
S
D
T
L
T
A
D
V
I
G
R
R
Site 4
S52
E
R
G
K
H
D
G
S
H
E
G
T
V
Y
F
Site 5
Y58
G
S
H
E
G
T
V
Y
F
K
C
R
H
P
T
Site 6
T65
Y
F
K
C
R
H
P
T
G
G
S
F
I
R
P
Site 7
S68
C
R
H
P
T
G
G
S
F
I
R
P
N
K
V
Site 8
T83
N
F
G
T
D
F
L
T
A
I
K
N
R
Y
V
Site 9
Y89
L
T
A
I
K
N
R
Y
V
L
E
D
G
P
E
Site 10
T105
D
R
K
E
Q
I
V
T
I
G
N
K
P
V
E
Site 11
S118
V
E
T
I
G
F
D
S
I
M
K
Q
Q
S
Q
Site 12
S124
D
S
I
M
K
Q
Q
S
Q
L
S
K
L
Q
E
Site 13
S127
M
K
Q
Q
S
Q
L
S
K
L
Q
E
V
S
L
Site 14
S133
L
S
K
L
Q
E
V
S
L
R
N
C
A
V
S
Site 15
S140
S
L
R
N
C
A
V
S
C
A
G
E
K
G
G
Site 16
S161
N
I
R
K
V
D
L
S
K
N
L
L
S
S
W
Site 17
S195
E
N
K
L
K
F
P
S
G
S
V
L
T
G
T
Site 18
Y235
C
P
G
L
E
E
L
Y
L
E
S
N
N
I
F
Site 19
S244
E
S
N
N
I
F
I
S
E
R
P
T
D
V
L
Site 20
T248
I
F
I
S
E
R
P
T
D
V
L
Q
T
V
K
Site 21
S260
T
V
K
L
L
D
L
S
S
N
Q
L
I
D
E
Site 22
S261
V
K
L
L
D
L
S
S
N
Q
L
I
D
E
N
Site 23
S291
L
S
D
T
G
I
S
S
L
H
F
P
D
A
G
Site 24
T303
D
A
G
I
G
C
K
T
S
M
F
P
S
L
K
Site 25
Y311
S
M
F
P
S
L
K
Y
L
V
V
N
D
N
Q
Site 26
S333
N
E
L
E
K
L
P
S
L
R
A
L
S
C
L
Site 27
T345
S
C
L
R
N
P
L
T
K
E
D
K
E
A
E
Site 28
Y385
R
R
R
A
E
L
D
Y
R
K
A
F
G
N
E
Site 29
S408
D
P
E
K
N
R
L
S
E
E
F
L
T
A
H
Site 30
T413
R
L
S
E
E
F
L
T
A
H
P
R
Y
Q
F
Site 31
Y425
Y
Q
F
L
C
L
K
Y
G
A
P
E
D
W
E
Site 32
T435
P
E
D
W
E
L
K
T
Q
Q
P
L
M
L
K
Site 33
Y452
L
L
T
L
K
I
K
Y
P
H
Q
L
D
Q
K
Site 34
S468
L
E
K
Q
L
P
G
S
M
T
I
Q
K
V
K
Site 35
T470
K
Q
L
P
G
S
M
T
I
Q
K
V
K
G
L
Site 36
S479
Q
K
V
K
G
L
L
S
R
L
L
K
V
P
V
Site 37
S487
R
L
L
K
V
P
V
S
D
L
L
L
S
Y
E
Site 38
S492
P
V
S
D
L
L
L
S
Y
E
S
P
K
K
P
Site 39
Y493
V
S
D
L
L
L
S
Y
E
S
P
K
K
P
G
Site 40
S495
D
L
L
L
S
Y
E
S
P
K
K
P
G
R
E
Site 41
S511
E
L
E
N
D
L
K
S
L
Q
F
Y
S
V
E
Site 42
Y515
D
L
K
S
L
Q
F
Y
S
V
E
N
G
D
C
Site 43
S516
L
K
S
L
Q
F
Y
S
V
E
N
G
D
C
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation