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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CHRNA2
Full Name:
Neuronal acetylcholine receptor subunit alpha-2
Alias:
ACHA2; Cholinergic receptor, nicotinic, alpha 2 (neuronal); Neuronal acetylcholine receptor alpha-2
Type:
Receptor - Ion channel; Plasma membrane, postsynaptic membrane, synapse, cell junction, integral membrane protein
Mass (Da):
59735
Number AA:
529
UniProt ID:
Q15822
International Prot ID:
IPI00019942
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005892
GO:0045211
Uniprot
OncoNet
Molecular Function:
GO:0015464
GO:0004889
PhosphoSite+
KinaseNET
Biological Process:
GO:0006811
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S42
R
A
P
G
D
P
L
S
S
P
S
P
T
A
L
Site 2
S43
A
P
G
D
P
L
S
S
P
S
P
T
A
L
P
Site 3
S45
G
D
P
L
S
S
P
S
P
T
A
L
P
Q
G
Site 4
T47
P
L
S
S
P
S
P
T
A
L
P
Q
G
G
S
Site 5
S54
T
A
L
P
Q
G
G
S
H
T
E
T
E
D
R
Site 6
T58
Q
G
G
S
H
T
E
T
E
D
R
L
F
K
H
Site 7
Y70
F
K
H
L
F
R
G
Y
N
R
W
A
R
P
V
Site 8
Y118
L
K
Q
E
W
S
D
Y
K
L
R
W
N
P
A
Site 9
T131
P
A
D
F
G
N
I
T
S
L
R
V
P
S
E
Site 10
S132
A
D
F
G
N
I
T
S
L
R
V
P
S
E
M
Site 11
Y148
W
I
P
D
I
V
L
Y
N
N
A
D
G
E
F
Site 12
T158
A
D
G
E
F
A
V
T
H
M
T
K
A
H
L
Site 13
Y179
H
W
V
P
P
A
I
Y
K
S
S
C
S
I
D
Site 14
T188
S
S
C
S
I
D
V
T
F
F
P
F
D
Q
Q
Site 15
T219
D
L
E
Q
M
E
Q
T
V
D
L
K
D
Y
W
Site 16
Y225
Q
T
V
D
L
K
D
Y
W
E
S
G
E
W
A
Site 17
Y240
I
V
N
A
T
G
T
Y
N
S
K
K
Y
D
C
Site 18
Y245
G
T
Y
N
S
K
K
Y
D
C
C
A
E
I
Y
Site 19
Y252
Y
D
C
C
A
E
I
Y
P
D
V
T
Y
A
F
Site 20
S356
V
L
N
V
H
H
R
S
P
S
T
H
T
M
P
Site 21
S398
H
P
L
R
L
K
L
S
P
S
Y
H
W
L
E
Site 22
S400
L
R
L
K
L
S
P
S
Y
H
W
L
E
S
N
Site 23
Y401
R
L
K
L
S
P
S
Y
H
W
L
E
S
N
V
Site 24
S438
P
S
V
G
T
L
C
S
H
G
H
L
H
S
G
Site 25
S444
C
S
H
G
H
L
H
S
G
A
S
G
P
K
A
Site 26
S463
Q
E
G
E
L
L
L
S
P
H
M
Q
K
A
L
Site 27
Y475
K
A
L
E
G
V
H
Y
I
A
D
H
L
R
S
Site 28
S482
Y
I
A
D
H
L
R
S
E
D
A
D
S
S
V
Site 29
S487
L
R
S
E
D
A
D
S
S
V
K
E
D
W
K
Site 30
S488
R
S
E
D
A
D
S
S
V
K
E
D
W
K
Y
Site 31
Y495
S
V
K
E
D
W
K
Y
V
A
M
V
I
D
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation