PhosphoNET

           
Protein Info 
   
Short Name:  GRK1
Full Name:  Rhodopsin kinase
Alias:  EC 2.7.11.14; Rhodopsin kinase; RHOK; RK
Type:  Protein-serine kinase, AGC group, GRK family, GRK subfamily
Mass (Da):  63526
Number AA:  563
UniProt ID:  Q15835
International Prot ID:  IPI00019980
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0031225     Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0004703  GO:0050254 PhosphoSite+ KinaseNET
Biological Process:  GO:0008277  GO:0009586  GO:0016056 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S5___MDFGSLETVVAN
Site 2T8MDFGSLETVVANSAF
Site 3S21AFIAARGSFDGSSSQ
Site 4S25ARGSFDGSSSQPSRD
Site 5S26RGSFDGSSSQPSRDK
Site 6S27GSFDGSSSQPSRDKK
Site 7S30DGSSSQPSRDKKYLA
Site 8Y35QPSRDKKYLAKLKLP
Site 9S45KLKLPPLSKCESLRD
Site 10S49PPLSKCESLRDSLSL
Site 11S53KCESLRDSLSLEFES
Site 12S55ESLRDSLSLEFESVC
Site 13S78LFQQFLQSAEKHLPA
Site 14Y95LWKDIEDYDTADNDL
Site 15T97KDIEDYDTADNDLQP
Site 16Y114AQTILAQYLDPQAKL
Site 17Y170QEYLGSLYFLRFLQW
Site 18S205KGGFGEVSACQMKAT
Site 19Y216MKATGKLYACKKLNK
Site 20Y232RLKKRKGYQGAMVEK
Site 21Y277MNGGDIRYHIYNVNE
Site 22Y280GDIRYHIYNVNEENP
Site 23Y315LHQRRIVYRDLKPEN
Site 24S334NDGNVRISDLGLAVE
Site 25S347VELLDGQSKTKGYAG
Site 26T355KTKGYAGTPGFMAPE
Site 27Y369ELLQGEEYDFSVDYF
Site 28S372QGEEYDFSVDYFALG
Site 29S410ELKHRIISEPVKYPD
Site 30Y415IISEPVKYPDKFSQA
Site 31S420VKYPDKFSQASKDFC
Site 32T445RLGFRDETCDKLRAH
Site 33S476MPPFIPDSKTVYAKD
Site 34T478PFIPDSKTVYAKDIQ
Site 35Y480IPDSKTVYAKDIQDV
Site 36S491IQDVGAFSTVKGVAF
Site 37T492QDVGAFSTVKGVAFD
Site 38T501KGVAFDKTDTEFFQE
Site 39T503VAFDKTDTEFFQEFA
Site 40T525WQEEMIETGIFGELN
Site 41S536GELNVWRSDGQMPDD
Site 42S548PDDMKGISGGSSSSS
Site 43S551MKGISGGSSSSSKSG
Site 44S552KGISGGSSSSSKSGM
Site 45S553GISGGSSSSSKSGMC
Site 46S554ISGGSSSSSKSGMCL
Site 47S555SGGSSSSSKSGMCLV
Site 48S557GSSSSSKSGMCLVS_
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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