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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EZH2
Full Name:
Histone-lysine N-methyltransferase EZH2
Alias:
enhancer of zeste 2; Enhancer of zeste homolog 2; ENX-1; EZH1; KMT6
Type:
Methyltransferase; EC 2.1.1.43
Mass (Da):
85363
Number AA:
746
UniProt ID:
Q15910
International Prot ID:
IPI00376787
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0035098
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0018024
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0048387
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
G
Q
T
G
K
K
S
E
K
G
P
V
C
W
Site 2
S21
C
W
R
K
R
V
K
S
E
Y
M
R
L
R
Q
Site 3
Y23
R
K
R
V
K
S
E
Y
M
R
L
R
Q
L
K
Site 4
S40
R
R
A
D
E
V
K
S
M
F
S
S
N
R
Q
Site 5
S44
E
V
K
S
M
F
S
S
N
R
Q
K
I
L
E
Site 6
S75
V
H
I
L
T
S
V
S
S
L
R
G
T
R
E
Site 7
S76
H
I
L
T
S
V
S
S
L
R
G
T
R
E
C
Site 8
T80
S
V
S
S
L
R
G
T
R
E
C
S
V
T
S
Site 9
S84
L
R
G
T
R
E
C
S
V
T
S
D
L
D
F
Site 10
T86
G
T
R
E
C
S
V
T
S
D
L
D
F
P
T
Site 11
S87
T
R
E
C
S
V
T
S
D
L
D
F
P
T
Q
Site 12
T93
T
S
D
L
D
F
P
T
Q
V
I
P
L
K
T
Site 13
S112
A
S
V
P
I
M
Y
S
W
S
P
L
Q
Q
N
Site 14
T144
E
V
L
D
Q
D
G
T
F
I
E
E
L
I
K
Site 15
S212
D
H
R
D
D
K
E
S
R
P
P
R
K
F
P
Site 16
S220
R
P
P
R
K
F
P
S
D
K
I
F
E
A
I
Site 17
S229
K
I
F
E
A
I
S
S
M
F
P
D
K
G
T
Site 18
T261
G
A
L
P
P
E
C
T
P
N
I
D
G
P
N
Site 19
S271
I
D
G
P
N
A
K
S
V
Q
R
E
Q
S
L
Site 20
S277
K
S
V
Q
R
E
Q
S
L
H
S
F
H
T
L
Site 21
S280
Q
R
E
Q
S
L
H
S
F
H
T
L
F
C
R
Site 22
T302
F
L
H
P
F
H
A
T
P
N
T
Y
K
R
K
Site 23
T305
P
F
H
A
T
P
N
T
Y
K
R
K
N
T
E
Site 24
T311
N
T
Y
K
R
K
N
T
E
T
A
L
D
N
K
Site 25
T313
Y
K
R
K
N
T
E
T
A
L
D
N
K
P
C
Site 26
Y325
K
P
C
G
P
Q
C
Y
Q
H
L
E
G
A
K
Site 27
T339
K
E
F
A
A
A
L
T
A
E
R
I
K
T
P
Site 28
T345
L
T
A
E
R
I
K
T
P
P
K
R
P
G
G
Site 29
S362
R
G
R
L
P
N
N
S
S
R
P
S
T
P
T
Site 30
S363
G
R
L
P
N
N
S
S
R
P
S
T
P
T
I
Site 31
S366
P
N
N
S
S
R
P
S
T
P
T
I
N
V
L
Site 32
T367
N
N
S
S
R
P
S
T
P
T
I
N
V
L
E
Site 33
T369
S
S
R
P
S
T
P
T
I
N
V
L
E
S
K
Site 34
S375
P
T
I
N
V
L
E
S
K
D
T
D
S
D
R
Site 35
T378
N
V
L
E
S
K
D
T
D
S
D
R
E
A
G
Site 36
S380
L
E
S
K
D
T
D
S
D
R
E
A
G
T
E
Site 37
T404
E
E
E
K
K
D
E
T
S
S
S
S
E
A
N
Site 38
S405
E
E
K
K
D
E
T
S
S
S
S
E
A
N
S
Site 39
S406
E
K
K
D
E
T
S
S
S
S
E
A
N
S
R
Site 40
S407
K
K
D
E
T
S
S
S
S
E
A
N
S
R
C
Site 41
S408
K
D
E
T
S
S
S
S
E
A
N
S
R
C
Q
Site 42
S412
S
S
S
S
E
A
N
S
R
C
Q
T
P
I
K
Site 43
T416
E
A
N
S
R
C
Q
T
P
I
K
M
K
P
N
Site 44
Y448
R
V
L
I
G
T
Y
Y
D
N
F
C
A
I
A
Site 45
T460
A
I
A
R
L
I
G
T
K
T
C
R
Q
V
Y
Site 46
T462
A
R
L
I
G
T
K
T
C
R
Q
V
Y
E
F
Site 47
Y467
T
K
T
C
R
Q
V
Y
E
F
R
V
K
E
S
Site 48
S475
E
F
R
V
K
E
S
S
I
I
A
P
A
P
A
Site 49
T487
A
P
A
E
D
V
D
T
P
P
R
K
K
K
R
Site 50
S513
I
Q
L
K
K
D
G
S
S
N
H
V
Y
N
Y
Site 51
Y518
D
G
S
S
N
H
V
Y
N
Y
Q
P
C
D
H
Site 52
Y520
S
S
N
H
V
Y
N
Y
Q
P
C
D
H
P
R
Site 53
Y574
N
T
K
Q
C
P
C
Y
L
A
V
R
E
C
D
Site 54
S605
N
V
S
C
K
N
C
S
I
Q
R
G
S
K
K
Site 55
S610
N
C
S
I
Q
R
G
S
K
K
H
L
L
L
A
Site 56
Y641
K
N
E
F
I
S
E
Y
C
G
E
I
I
S
Q
Site 57
S647
E
Y
C
G
E
I
I
S
Q
D
E
A
D
R
R
Site 58
Y658
A
D
R
R
G
K
V
Y
D
K
Y
M
C
S
F
Site 59
Y661
R
G
K
V
Y
D
K
Y
M
C
S
F
L
F
N
Site 60
Y696
H
S
V
N
P
N
C
Y
A
K
V
M
M
V
N
Site 61
Y726
G
E
E
L
F
F
D
Y
R
Y
S
Q
A
D
A
Site 62
Y728
E
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Site 63
S729
L
F
F
D
Y
R
Y
S
Q
A
D
A
L
K
Y
Site 64
Y736
S
Q
A
D
A
L
K
Y
V
G
I
E
R
E
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation