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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRIK4
Full Name:
Glutamate receptor, ionotropic kainate 4
Alias:
EAA1; excitatory amino acid receptor 1; glutamate receptor KA-1; KA1
Type:
Channel, ligand-gated
Mass (Da):
107229
Number AA:
956
UniProt ID:
Q16099
International Prot ID:
IPI00292269
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0045211
Uniprot
OncoNet
Molecular Function:
GO:0005234
GO:0015277
PhosphoSite+
KinaseNET
Biological Process:
GO:0007215
GO:0006811
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S44
C
S
R
G
E
R
L
S
I
T
L
A
K
N
R
Site 2
T46
R
G
E
R
L
S
I
T
L
A
K
N
R
I
N
Site 3
S75
I
F
E
L
L
R
D
S
E
Y
E
T
A
E
T
Site 4
Y77
E
L
L
R
D
S
E
Y
E
T
A
E
T
M
C
Site 5
T82
S
E
Y
E
T
A
E
T
M
C
Q
I
L
P
K
Site 6
S103
G
P
S
S
S
P
A
S
S
S
I
I
S
N
I
Site 7
S104
P
S
S
S
P
A
S
S
S
I
I
S
N
I
C
Site 8
S108
P
A
S
S
S
I
I
S
N
I
C
G
E
K
E
Site 9
T135
K
F
Q
F
Q
R
F
T
T
L
N
L
H
P
S
Site 10
T136
F
Q
F
Q
R
F
T
T
L
N
L
H
P
S
N
Site 11
S142
T
T
L
N
L
H
P
S
N
T
D
I
S
V
A
Site 12
S190
L
I
S
K
D
T
L
S
V
R
M
L
D
D
T
Site 13
T197
S
V
R
M
L
D
D
T
R
D
P
T
P
L
L
Site 14
T201
L
D
D
T
R
D
P
T
P
L
L
K
E
I
R
Site 15
T212
K
E
I
R
D
D
K
T
A
T
I
I
I
H
A
Site 16
S257
F
S
L
Q
R
M
D
S
L
V
D
D
R
V
N
Site 17
T299
N
C
D
H
V
P
F
T
G
P
A
L
S
S
A
Site 18
S325
A
V
Q
E
L
N
R
S
Q
E
I
G
V
K
P
Site 19
S346
Q
I
W
Q
H
G
T
S
L
M
N
Y
L
R
M
Site 20
Y350
H
G
T
S
L
M
N
Y
L
R
M
V
E
L
E
Site 21
S367
T
G
H
I
E
F
N
S
K
G
Q
R
S
N
Y
Site 22
Y374
S
K
G
Q
R
S
N
Y
A
L
K
I
L
Q
F
Site 23
S402
A
E
G
L
S
M
D
S
H
L
Y
A
S
N
I
Site 24
Y405
L
S
M
D
S
H
L
Y
A
S
N
I
S
D
T
Site 25
Y428
T
T
I
L
E
N
P
Y
L
M
L
K
G
N
H
Site 26
Y444
E
M
E
G
N
D
R
Y
E
G
F
C
V
D
M
Site 27
Y463
A
E
I
L
R
F
N
Y
K
I
R
L
V
G
D
Site 28
Y473
R
L
V
G
D
G
V
Y
G
V
P
E
A
N
G
Site 29
T481
G
V
P
E
A
N
G
T
W
T
G
M
V
G
E
Site 30
S514
R
E
K
V
I
D
F
S
K
P
F
M
T
L
G
Site 31
Y536
H
M
G
R
K
P
G
Y
F
S
F
L
D
P
F
Site 32
S538
G
R
K
P
G
Y
F
S
F
L
D
P
F
S
P
Site 33
Y571
L
V
A
R
L
T
P
Y
E
W
Y
S
P
H
P
Site 34
S596
N
Q
Y
S
L
G
N
S
L
W
F
P
V
G
G
Site 35
S609
G
G
F
M
Q
Q
G
S
T
I
A
P
R
A
L
Site 36
T610
G
F
M
Q
Q
G
S
T
I
A
P
R
A
L
S
Site 37
S655
R
M
D
V
P
I
E
S
V
D
D
L
A
D
Q
Site 38
T663
V
D
D
L
A
D
Q
T
A
I
E
Y
G
T
I
Site 39
Y667
A
D
Q
T
A
I
E
Y
G
T
I
H
G
G
S
Site 40
S675
G
T
I
H
G
G
S
S
M
T
F
F
Q
N
S
Site 41
T677
I
H
G
G
S
S
M
T
F
F
Q
N
S
R
Y
Site 42
S700
Y
M
Y
S
K
Q
P
S
V
F
V
K
S
T
E
Site 43
Y729
L
E
S
T
M
N
E
Y
Y
R
Q
R
N
C
N
Site 44
Y730
E
S
T
M
N
E
Y
Y
R
Q
R
N
C
N
L
Site 45
T738
R
Q
R
N
C
N
L
T
Q
I
G
G
L
L
D
Site 46
S834
F
L
W
T
L
R
H
S
E
A
T
E
V
S
V
Site 47
S858
S
I
I
L
C
Q
D
S
I
H
P
R
R
R
R
Site 48
T884
E
E
R
R
P
R
G
T
A
T
L
S
N
G
K
Site 49
T886
R
R
P
R
G
T
A
T
L
S
N
G
K
L
C
Site 50
S888
P
R
G
T
A
T
L
S
N
G
K
L
C
G
A
Site 51
S936
Q
G
L
R
A
R
P
S
P
A
R
S
E
E
S
Site 52
S940
A
R
P
S
P
A
R
S
E
E
S
L
E
W
E
Site 53
S943
S
P
A
R
S
E
E
S
L
E
W
E
K
T
T
Site 54
T949
E
S
L
E
W
E
K
T
T
N
S
S
E
P
E
Site 55
T950
S
L
E
W
E
K
T
T
N
S
S
E
P
E
_
Site 56
S953
W
E
K
T
T
N
S
S
E
P
E
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation