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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ENOX2
Full Name:
Ecto-NOX disulfide-thiol exchanger 2
Alias:
APK1; APK1 antigen; COVA1; Cytosolic ovarian carcinoma 1; EC 1.-.-.-; Protein disulfide-thiol oxidoreductase; TNOX; Tumor-associated hydroquinone oxidase
Type:
Extracellular region, Plasma membrane, Cytoplasm, External side of plasma membrane, Cytosol, Nucleus, Cytoskeleton protein
Mass (Da):
70082
Number AA:
610
UniProt ID:
Q16206
International Prot ID:
IPI00181376
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0005829
GO:0009897
Uniprot
OncoNet
Molecular Function:
GO:0005507
GO:0003676
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0016049
GO:0022900
GO:0040008
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
S
R
T
L
N
V
D
S
T
A
M
T
L
P
M
Site 2
T28
R
T
L
N
V
D
S
T
A
M
T
L
P
M
S
Site 3
T31
N
V
D
S
T
A
M
T
L
P
M
S
D
P
T
Site 4
T107
I
I
H
C
K
S
C
T
L
F
P
P
N
P
N
Site 5
T120
P
N
L
P
P
P
A
T
R
E
R
P
P
G
C
Site 6
T129
E
R
P
P
G
C
K
T
V
F
V
G
G
L
P
Site 7
T140
G
G
L
P
E
N
G
T
E
Q
I
I
V
E
V
Site 8
Y173
H
I
R
F
A
E
E
Y
M
V
D
K
A
L
Y
Site 9
Y180
Y
M
V
D
K
A
L
Y
L
S
G
Y
R
I
R
Site 10
S182
V
D
K
A
L
Y
L
S
G
Y
R
I
R
L
G
Site 11
Y184
K
A
L
Y
L
S
G
Y
R
I
R
L
G
S
S
Site 12
S190
G
Y
R
I
R
L
G
S
S
T
D
K
K
D
T
Site 13
T192
R
I
R
L
G
S
S
T
D
K
K
D
T
G
R
Site 14
Y212
A
Q
A
R
D
D
L
Y
E
W
E
C
K
Q
R
Site 15
S240
E
E
R
L
R
P
P
S
P
P
P
V
V
H
Y
Site 16
Y247
S
P
P
P
V
V
H
Y
S
D
H
E
C
S
I
Site 17
S248
P
P
P
V
V
H
Y
S
D
H
E
C
S
I
V
Site 18
T271
K
F
S
E
A
V
Q
T
L
L
T
W
I
E
R
Site 19
S285
R
G
E
V
N
R
R
S
A
N
N
F
Y
S
M
Site 20
S291
R
S
A
N
N
F
Y
S
M
I
Q
S
A
N
S
Site 21
S298
S
M
I
Q
S
A
N
S
H
V
R
R
L
V
N
Site 22
S326
E
K
F
K
Q
A
L
S
G
I
L
I
Q
F
E
Site 23
Y339
F
E
Q
I
V
A
V
Y
H
S
A
S
K
Q
K
Site 24
S343
V
A
V
Y
H
S
A
S
K
Q
K
A
W
D
H
Site 25
S389
R
E
E
E
M
E
M
S
D
D
E
I
E
E
M
Site 26
T399
E
I
E
E
M
T
E
T
K
E
T
E
E
S
A
Site 27
T402
E
M
T
E
T
K
E
T
E
E
S
A
L
V
S
Site 28
S405
E
T
K
E
T
E
E
S
A
L
V
S
Q
A
E
Site 29
S409
T
E
E
S
A
L
V
S
Q
A
E
A
L
K
E
Site 30
S420
A
L
K
E
E
N
D
S
L
R
W
Q
L
D
A
Site 31
Y428
L
R
W
Q
L
D
A
Y
R
N
E
V
E
L
L
Site 32
S504
E
N
L
K
E
K
E
S
C
A
S
R
L
C
A
Site 33
S512
C
A
S
R
L
C
A
S
N
Q
D
S
E
Y
P
Site 34
S516
L
C
A
S
N
Q
D
S
E
Y
P
L
E
K
T
Site 35
Y518
A
S
N
Q
D
S
E
Y
P
L
E
K
T
M
N
Site 36
T523
S
E
Y
P
L
E
K
T
M
N
S
S
P
I
K
Site 37
S526
P
L
E
K
T
M
N
S
S
P
I
K
S
E
R
Site 38
S527
L
E
K
T
M
N
S
S
P
I
K
S
E
R
E
Site 39
S531
M
N
S
S
P
I
K
S
E
R
E
A
L
L
V
Site 40
Y560
S
I
E
Y
I
C
S
Y
L
H
R
L
D
N
K
Site 41
T583
L
M
G
R
L
Q
H
T
F
K
Q
E
M
T
G
Site 42
S594
E
M
T
G
V
G
A
S
L
E
K
R
W
K
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation