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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
INA
Full Name:
Alpha-internexin
Alias:
66 kDa neurofilament; AINX; Alpha-Inx; Internexin neuronal intermediate filament protein, alpha; Internexin neuronal intermediate filament, alpha; NEF5; Neurofilament-66; NF-66; TXBP-1
Type:
Cytoskeletal protein
Mass (Da):
55391
Number AA:
499
UniProt ID:
Q16352
International Prot ID:
IPI00001453
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005883
Uniprot
OncoNet
Molecular Function:
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
F
G
S
E
H
Y
L
Site 2
S5
_
_
_
M
S
F
G
S
E
H
Y
L
C
S
S
Site 3
Y8
M
S
F
G
S
E
H
Y
L
C
S
S
S
S
Y
Site 4
S11
G
S
E
H
Y
L
C
S
S
S
S
Y
R
K
V
Site 5
S12
S
E
H
Y
L
C
S
S
S
S
Y
R
K
V
F
Site 6
S13
E
H
Y
L
C
S
S
S
S
Y
R
K
V
F
G
Site 7
S14
H
Y
L
C
S
S
S
S
Y
R
K
V
F
G
D
Site 8
Y15
Y
L
C
S
S
S
S
Y
R
K
V
F
G
D
G
Site 9
S23
R
K
V
F
G
D
G
S
R
L
S
A
R
L
S
Site 10
S26
F
G
D
G
S
R
L
S
A
R
L
S
G
A
G
Site 11
S30
S
R
L
S
A
R
L
S
G
A
G
G
A
G
G
Site 12
S40
G
G
A
G
G
F
R
S
Q
S
L
S
R
S
N
Site 13
S42
A
G
G
F
R
S
Q
S
L
S
R
S
N
V
A
Site 14
S44
G
F
R
S
Q
S
L
S
R
S
N
V
A
S
S
Site 15
S46
R
S
Q
S
L
S
R
S
N
V
A
S
S
A
A
Site 16
S50
L
S
R
S
N
V
A
S
S
A
A
C
S
S
A
Site 17
S51
S
R
S
N
V
A
S
S
A
A
C
S
S
A
S
Site 18
S56
A
S
S
A
A
C
S
S
A
S
S
L
G
L
G
Site 19
Y66
S
L
G
L
G
L
A
Y
R
R
P
P
A
S
D
Site 20
S72
A
Y
R
R
P
P
A
S
D
G
L
D
L
S
Q
Site 21
S78
A
S
D
G
L
D
L
S
Q
A
A
A
R
T
N
Site 22
Y87
A
A
A
R
T
N
E
Y
K
I
I
R
T
N
E
Site 23
S137
R
Q
R
H
A
E
P
S
R
V
G
E
L
F
Q
Site 24
S158
R
A
Q
L
E
E
A
S
S
A
R
S
Q
A
L
Site 25
S159
A
Q
L
E
E
A
S
S
A
R
S
Q
A
L
L
Site 26
S162
E
E
A
S
S
A
R
S
Q
A
L
L
E
R
D
Site 27
S186
R
A
R
C
E
E
E
S
R
G
R
E
G
A
E
Site 28
T207
Q
R
D
V
D
G
A
T
L
A
R
L
D
L
E
Site 29
S219
D
L
E
K
K
V
E
S
L
L
D
E
L
A
F
Site 30
T262
T
V
A
K
P
D
L
T
S
A
L
R
E
I
R
Site 31
S263
V
A
K
P
D
L
T
S
A
L
R
E
I
R
A
Site 32
Y272
L
R
E
I
R
A
Q
Y
E
S
L
A
A
K
N
Site 33
S274
E
I
R
A
Q
Y
E
S
L
A
A
K
N
L
Q
Site 34
Y287
L
Q
S
A
E
E
W
Y
K
S
K
F
A
N
L
Site 35
S289
S
A
E
E
W
Y
K
S
K
F
A
N
L
N
E
Site 36
T302
N
E
Q
A
A
R
S
T
E
A
I
R
A
S
R
Site 37
S308
S
T
E
A
I
R
A
S
R
E
E
I
H
E
Y
Site 38
Y315
S
R
E
E
I
H
E
Y
R
R
Q
L
Q
A
R
Site 39
S335
G
L
R
G
A
N
E
S
L
E
R
Q
I
L
E
Site 40
S348
L
E
L
E
E
R
H
S
A
E
V
A
G
Y
Q
Site 41
Y354
H
S
A
E
V
A
G
Y
Q
D
S
I
G
Q
L
Site 42
S357
E
V
A
G
Y
Q
D
S
I
G
Q
L
E
N
D
Site 43
T368
L
E
N
D
L
R
N
T
K
S
E
M
A
R
H
Site 44
S370
N
D
L
R
N
T
K
S
E
M
A
R
H
L
R
Site 45
Y379
M
A
R
H
L
R
E
Y
Q
D
L
L
N
V
K
Site 46
Y396
L
D
I
E
I
A
A
Y
R
K
L
L
E
G
E
Site 47
T405
K
L
L
E
G
E
E
T
R
F
S
T
S
G
L
Site 48
S408
E
G
E
E
T
R
F
S
T
S
G
L
S
I
S
Site 49
T409
G
E
E
T
R
F
S
T
S
G
L
S
I
S
G
Site 50
S410
E
E
T
R
F
S
T
S
G
L
S
I
S
G
L
Site 51
S415
S
T
S
G
L
S
I
S
G
L
N
P
L
P
N
Site 52
S424
L
N
P
L
P
N
P
S
Y
L
L
P
P
R
I
Site 53
Y425
N
P
L
P
N
P
S
Y
L
L
P
P
R
I
L
Site 54
S433
L
L
P
P
R
I
L
S
A
T
T
S
K
V
S
Site 55
T435
P
P
R
I
L
S
A
T
T
S
K
V
S
S
T
Site 56
T436
P
R
I
L
S
A
T
T
S
K
V
S
S
T
G
Site 57
S437
R
I
L
S
A
T
T
S
K
V
S
S
T
G
L
Site 58
S440
S
A
T
T
S
K
V
S
S
T
G
L
S
L
K
Site 59
S441
A
T
T
S
K
V
S
S
T
G
L
S
L
K
K
Site 60
T442
T
T
S
K
V
S
S
T
G
L
S
L
K
K
E
Site 61
S445
K
V
S
S
T
G
L
S
L
K
K
E
E
E
E
Site 62
S456
E
E
E
E
E
E
A
S
K
V
A
S
K
K
T
Site 63
S460
E
E
A
S
K
V
A
S
K
K
T
S
Q
I
G
Site 64
S464
K
V
A
S
K
K
T
S
Q
I
G
E
S
F
E
Site 65
S469
K
T
S
Q
I
G
E
S
F
E
E
I
L
E
E
Site 66
T484
T
V
I
S
T
K
K
T
E
K
S
N
I
E
E
Site 67
S487
S
T
K
K
T
E
K
S
N
I
E
E
T
T
I
Site 68
S496
I
E
E
T
T
I
S
S
Q
K
I
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation