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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSMD5
Full Name:
26S proteasome non-ATPase regulatory subunit 5
Alias:
26S protease subunit S5 basic; 26S proteasome subunit S5B; KIAA0072; proteasome (prosome, macropain) 26S subunit, non-ATPase, 5; S5B
Type:
Protease; Proteasome complex
Mass (Da):
56065
Number AA:
503
UniProt ID:
Q16401
International Prot ID:
IPI00002134
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000502
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0031145
GO:0051436
GO:0051437
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S51
L
R
L
G
P
L
F
S
L
L
N
E
N
H
R
Site 2
T61
N
E
N
H
R
E
K
T
T
L
C
V
S
I
L
Site 3
T62
E
N
H
R
E
K
T
T
L
C
V
S
I
L
E
Site 4
T118
V
E
N
S
D
A
V
T
E
I
L
N
N
A
E
Site 5
Y132
E
L
L
K
Q
I
V
Y
C
I
G
G
E
N
L
Site 6
S173
N
L
L
D
D
L
K
S
V
M
K
T
N
D
I
Site 7
T177
D
L
K
S
V
M
K
T
N
D
I
V
R
Y
R
Site 8
Y183
K
T
N
D
I
V
R
Y
R
V
Y
E
L
I
I
Site 9
S199
I
S
S
V
S
P
E
S
L
N
Y
C
T
T
S
Site 10
T210
C
T
T
S
G
L
V
T
Q
L
L
R
E
L
T
Site 11
T217
T
Q
L
L
R
E
L
T
G
E
D
V
L
V
R
Site 12
T237
M
V
T
S
L
A
Y
T
H
H
G
R
Q
Y
L
Site 13
Y243
Y
T
H
H
G
R
Q
Y
L
A
Q
E
G
V
I
Site 14
S266
G
A
D
S
D
P
F
S
S
F
Y
L
P
G
F
Site 15
S285
G
N
L
A
V
M
D
S
P
Q
Q
I
C
E
R
Site 16
Y293
P
Q
Q
I
C
E
R
Y
P
I
F
V
E
K
V
Site 17
S306
K
V
F
E
M
I
E
S
Q
D
P
T
M
I
G
Site 18
S324
D
T
V
G
I
L
G
S
N
V
E
G
K
Q
V
Site 19
T335
G
K
Q
V
L
Q
K
T
G
T
R
F
E
R
L
Site 20
S350
L
M
R
I
G
H
Q
S
K
N
A
P
V
E
L
Site 21
Y370
D
A
I
S
S
L
L
Y
L
P
P
E
Q
Q
T
Site 22
T384
T
D
D
L
L
R
M
T
E
S
W
F
S
S
L
Site 23
S386
D
L
L
R
M
T
E
S
W
F
S
S
L
S
R
Site 24
S389
R
M
T
E
S
W
F
S
S
L
S
R
D
P
L
Site 25
S390
M
T
E
S
W
F
S
S
L
S
R
D
P
L
E
Site 26
S392
E
S
W
F
S
S
L
S
R
D
P
L
E
L
F
Site 27
S403
L
E
L
F
R
G
I
S
S
Q
P
F
P
E
L
Site 28
S404
E
L
F
R
G
I
S
S
Q
P
F
P
E
L
H
Site 29
Y440
N
S
P
G
F
V
E
Y
V
V
D
R
S
V
E
Site 30
S445
V
E
Y
V
V
D
R
S
V
E
H
D
K
A
S
Site 31
Y457
K
A
S
K
D
A
K
Y
E
L
V
K
A
L
A
Site 32
S466
L
V
K
A
L
A
N
S
K
T
I
A
E
I
F
Site 33
T468
K
A
L
A
N
S
K
T
I
A
E
I
F
G
N
Site 34
Y478
E
I
F
G
N
P
N
Y
L
R
L
R
T
Y
L
Site 35
T483
P
N
Y
L
R
L
R
T
Y
L
S
E
G
P
Y
Site 36
Y484
N
Y
L
R
L
R
T
Y
L
S
E
G
P
Y
Y
Site 37
S486
L
R
L
R
T
Y
L
S
E
G
P
Y
Y
V
K
Site 38
Y490
T
Y
L
S
E
G
P
Y
Y
V
K
P
V
S
T
Site 39
Y491
Y
L
S
E
G
P
Y
Y
V
K
P
V
S
T
T
Site 40
S496
P
Y
Y
V
K
P
V
S
T
T
A
V
E
G
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation