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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDB1
Full Name:
DNA damage-binding protein 1
Alias:
Damage-specific DNA binding protein 1, 127kDa; DDB p127 subunit; DDBa; DNA damage binding protein 1; UV-damaged DNA-binding protein 1; UV-DDB 1; X- associated protein 1; XAP-1; Xeroderma pigmentosum group E complementing protein; XPCe; XPE
Type:
DNA repair protein
Mass (Da):
126968
Number AA:
1140
UniProt ID:
Q16531
International Prot ID:
IPI00293464
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003684
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0000075
GO:0044419
GO:0000718
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
S
Y
N
Y
V
V
T
A
Q
K
P
T
A
V
Site 2
Y42
K
N
T
R
L
E
I
Y
V
V
T
A
E
G
L
Site 3
Y84
L
F
I
L
T
A
K
Y
N
A
C
I
L
E
Y
Site 4
Y91
Y
N
A
C
I
L
E
Y
K
Q
S
G
E
S
I
Site 5
T102
G
E
S
I
D
I
I
T
R
A
H
G
N
V
Q
Site 6
S116
Q
D
R
I
G
R
P
S
E
T
G
I
I
G
I
Site 7
Y182
A
P
T
I
C
F
V
Y
Q
D
P
Q
G
R
H
Site 8
T192
P
Q
G
R
H
V
K
T
Y
E
V
S
L
R
E
Site 9
Y193
Q
G
R
H
V
K
T
Y
E
V
S
L
R
E
K
Site 10
S196
H
V
K
T
Y
E
V
S
L
R
E
K
E
F
N
Site 11
Y239
I
G
Q
E
S
I
T
Y
H
N
G
D
K
Y
L
Site 12
Y245
T
Y
H
N
G
D
K
Y
L
A
I
A
P
P
I
Site 13
Y271
V
D
P
N
G
S
R
Y
L
L
G
D
M
E
G
Site 14
T294
K
E
E
Q
M
D
G
T
V
T
L
K
D
L
R
Site 15
T296
E
Q
M
D
G
T
V
T
L
K
D
L
R
V
E
Site 16
S340
L
V
K
L
N
V
D
S
N
E
Q
G
S
Y
V
Site 17
Y346
D
S
N
E
Q
G
S
Y
V
V
A
M
E
T
F
Site 18
S379
Q
G
Q
L
V
T
C
S
G
A
F
K
E
G
S
Site 19
S386
S
G
A
F
K
E
G
S
L
R
I
I
R
N
G
Site 20
S415
K
G
L
W
P
L
R
S
D
P
N
R
E
T
D
Site 21
T421
R
S
D
P
N
R
E
T
D
D
T
L
V
L
S
Site 22
T424
P
N
R
E
T
D
D
T
L
V
L
S
F
V
G
Site 23
T446
N
G
E
E
V
E
E
T
E
L
M
G
F
V
D
Site 24
S499
E
P
Q
A
K
N
I
S
V
A
S
C
N
S
S
Site 25
Y518
A
V
G
R
A
L
Y
Y
L
Q
I
H
P
Q
E
Site 26
S530
P
Q
E
L
R
Q
I
S
H
T
E
M
E
H
E
Site 27
T532
E
L
R
Q
I
S
H
T
E
M
E
H
E
V
A
Site 28
S549
D
I
T
P
L
G
D
S
N
G
L
S
P
L
C
Site 29
S573
A
R
I
L
K
L
P
S
F
E
L
L
H
K
E
Site 30
T594
I
P
R
S
I
L
M
T
T
F
E
S
S
H
Y
Site 31
T595
P
R
S
I
L
M
T
T
F
E
S
S
H
Y
L
Site 32
S624
N
I
E
T
G
L
L
S
D
R
K
K
V
T
L
Site 33
T633
R
K
K
V
T
L
G
T
Q
P
T
V
L
R
T
Site 34
T636
V
T
L
G
T
Q
P
T
V
L
R
T
F
R
S
Site 35
T640
T
Q
P
T
V
L
R
T
F
R
S
L
S
T
T
Site 36
S645
L
R
T
F
R
S
L
S
T
T
N
V
F
A
C
Site 37
T646
R
T
F
R
S
L
S
T
T
N
V
F
A
C
S
Site 38
T647
T
F
R
S
L
S
T
T
N
V
F
A
C
S
D
Site 39
T657
F
A
C
S
D
R
P
T
V
I
Y
S
S
N
H
Site 40
Y660
S
D
R
P
T
V
I
Y
S
S
N
H
K
L
V
Site 41
Y678
V
N
L
K
E
V
N
Y
M
C
P
L
N
S
D
Site 42
S684
N
Y
M
C
P
L
N
S
D
G
Y
P
D
S
L
Site 43
Y687
C
P
L
N
S
D
G
Y
P
D
S
L
A
L
A
Site 44
S690
N
S
D
G
Y
P
D
S
L
A
L
A
N
N
S
Site 45
Y718
H
I
R
T
V
P
L
Y
E
S
P
R
K
I
C
Site 46
S720
R
T
V
P
L
Y
E
S
P
R
K
I
C
Y
Q
Site 47
Y726
E
S
P
R
K
I
C
Y
Q
E
V
S
Q
C
F
Site 48
S737
S
Q
C
F
G
V
L
S
S
R
I
E
V
Q
D
Site 49
T745
S
R
I
E
V
Q
D
T
S
G
G
T
T
A
L
Site 50
T750
Q
D
T
S
G
G
T
T
A
L
R
P
S
A
S
Site 51
S755
G
T
T
A
L
R
P
S
A
S
T
Q
A
L
S
Site 52
S757
T
A
L
R
P
S
A
S
T
Q
A
L
S
S
S
Site 53
T758
A
L
R
P
S
A
S
T
Q
A
L
S
S
S
V
Site 54
S762
S
A
S
T
Q
A
L
S
S
S
V
S
S
S
K
Site 55
S763
A
S
T
Q
A
L
S
S
S
V
S
S
S
K
L
Site 56
S764
S
T
Q
A
L
S
S
S
V
S
S
S
K
L
F
Site 57
S766
Q
A
L
S
S
S
V
S
S
S
K
L
F
S
S
Site 58
S767
A
L
S
S
S
V
S
S
S
K
L
F
S
S
S
Site 59
S768
L
S
S
S
V
S
S
S
K
L
F
S
S
S
T
Site 60
S772
V
S
S
S
K
L
F
S
S
S
T
A
P
H
E
Site 61
S773
S
S
S
K
L
F
S
S
S
T
A
P
H
E
T
Site 62
S774
S
S
K
L
F
S
S
S
T
A
P
H
E
T
S
Site 63
T775
S
K
L
F
S
S
S
T
A
P
H
E
T
S
F
Site 64
S781
S
T
A
P
H
E
T
S
F
G
E
E
V
E
V
Site 65
T827
K
L
G
K
D
P
N
T
Y
F
I
V
G
T
A
Site 66
Y837
I
V
G
T
A
M
V
Y
P
E
E
A
E
P
K
Site 67
T860
Y
S
D
G
K
L
Q
T
V
A
E
K
E
V
K
Site 68
Y871
K
E
V
K
G
A
V
Y
S
M
V
E
F
N
G
Site 69
S872
E
V
K
G
A
V
Y
S
M
V
E
F
N
G
K
Site 70
S886
K
L
L
A
S
I
N
S
T
V
R
L
Y
E
W
Site 71
Y891
I
N
S
T
V
R
L
Y
E
W
T
T
E
K
E
Site 72
T894
T
V
R
L
Y
E
W
T
T
E
K
E
L
R
T
Site 73
Y906
L
R
T
E
C
N
H
Y
N
N
I
M
A
L
Y
Site 74
Y913
Y
N
N
I
M
A
L
Y
L
K
T
K
G
D
F
Site 75
T985
Q
K
D
S
A
A
T
T
D
E
E
R
Q
H
L
Site 76
S1011
V
N
V
F
C
H
G
S
L
V
M
Q
N
L
G
Site 77
T1022
Q
N
L
G
E
T
S
T
P
T
Q
G
S
V
L
Site 78
T1024
L
G
E
T
S
T
P
T
Q
G
S
V
L
F
G
Site 79
S1027
T
S
T
P
T
Q
G
S
V
L
F
G
T
V
N
Site 80
Y1048
T
S
L
S
E
S
W
Y
N
L
L
L
D
M
Q
Site 81
S1064
R
L
N
K
V
I
K
S
V
G
K
I
E
H
S
Site 82
T1082
S
F
H
T
E
R
K
T
E
P
A
T
G
F
I
Site 83
S1096
I
D
G
D
L
I
E
S
F
L
D
I
S
R
P
Site 84
Y1114
E
V
V
A
N
L
Q
Y
D
D
G
S
G
M
K
Site 85
S1118
N
L
Q
Y
D
D
G
S
G
M
K
R
E
A
T
Site 86
T1125
S
G
M
K
R
E
A
T
A
D
D
L
I
K
V
Site 87
T1137
I
K
V
V
E
E
L
T
R
I
H
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation