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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP2R5E
Full Name:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
Alias:
Protein phosphatase 2, regulatory subunit '' epsilon
Type:
Protein phosphatase type 2A complex, Cytoplasm, Intracellular membrane-bound organelle protein
Mass (Da):
54699
Number AA:
467
UniProt ID:
Q16537
International Prot ID:
IPI00002853
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0043231
GO:0000159
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008601
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
A
P
T
T
P
P
Site 2
S3
_
_
_
_
_
M
S
S
A
P
T
T
P
P
S
Site 3
T6
_
_
M
S
S
A
P
T
T
P
P
S
V
D
K
Site 4
T7
_
M
S
S
A
P
T
T
P
P
S
V
D
K
V
Site 5
S10
S
A
P
T
T
P
P
S
V
D
K
V
D
G
F
Site 6
S21
V
D
G
F
S
R
K
S
V
R
K
A
R
Q
K
Site 7
S30
R
K
A
R
Q
K
R
S
Q
S
S
S
Q
F
R
Site 8
S32
A
R
Q
K
R
S
Q
S
S
S
Q
F
R
S
Q
Site 9
S33
R
Q
K
R
S
Q
S
S
S
Q
F
R
S
Q
G
Site 10
S34
Q
K
R
S
Q
S
S
S
Q
F
R
S
Q
G
K
Site 11
S38
Q
S
S
S
Q
F
R
S
Q
G
K
P
I
E
L
Site 12
T46
Q
G
K
P
I
E
L
T
P
L
P
L
L
K
D
Site 13
S56
P
L
L
K
D
V
P
S
S
E
Q
P
E
L
F
Site 14
S57
L
L
K
D
V
P
S
S
E
Q
P
E
L
F
L
Site 15
Y88
S
D
L
K
M
K
E
Y
K
R
S
T
L
N
E
Site 16
S91
K
M
K
E
Y
K
R
S
T
L
N
E
L
V
D
Site 17
T92
M
K
E
Y
K
R
S
T
L
N
E
L
V
D
Y
Site 18
Y99
T
L
N
E
L
V
D
Y
I
T
I
S
R
G
C
Site 19
T101
N
E
L
V
D
Y
I
T
I
S
R
G
C
L
T
Site 20
S103
L
V
D
Y
I
T
I
S
R
G
C
L
T
E
Q
Site 21
T108
T
I
S
R
G
C
L
T
E
Q
T
Y
P
E
V
Site 22
T126
V
S
C
N
I
F
R
T
L
P
P
S
D
S
N
Site 23
S130
I
F
R
T
L
P
P
S
D
S
N
E
F
D
P
Site 24
S132
R
T
L
P
P
S
D
S
N
E
F
D
P
E
E
Site 25
T143
D
P
E
E
D
E
P
T
L
E
A
S
W
P
H
Site 26
S170
E
S
Q
E
F
Q
P
S
I
A
K
K
Y
I
D
Site 27
S190
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
Site 28
Y198
E
D
P
R
E
R
D
Y
L
K
T
V
L
H
R
Site 29
T201
R
E
R
D
Y
L
K
T
V
L
H
R
I
Y
G
Site 30
Y207
K
T
V
L
H
R
I
Y
G
K
F
L
G
L
R
Site 31
Y230
N
I
F
L
R
F
V
Y
E
T
E
H
F
N
G
Site 32
S297
Q
F
L
E
K
D
P
S
L
T
E
P
V
I
R
Site 33
T299
L
E
K
D
P
S
L
T
E
P
V
I
R
G
L
Site 34
S354
Q
I
A
K
C
V
S
S
P
H
F
Q
V
A
E
Site 35
Y365
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
Site 36
Y366
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
Site 37
Y392
P
I
M
F
S
S
L
Y
R
I
S
K
E
H
W
Site 38
S395
F
S
S
L
Y
R
I
S
K
E
H
W
N
P
A
Site 39
T426
S
T
M
F
D
E
L
T
A
T
Y
K
S
D
R
Site 40
T428
M
F
D
E
L
T
A
T
Y
K
S
D
R
Q
R
Site 41
S431
E
L
T
A
T
Y
K
S
D
R
Q
R
E
K
K
Site 42
T467
R
R
D
G
I
I
P
T
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation