PhosphoNET

           
Protein Info 
   
Short Name:  CPSF6
Full Name:  Cleavage and polyadenylation specificity factor subunit 6
Alias:  CFIM; CFIM68; Cleavage and polyadenylation specific factor 6, 68kDa; Cleavage and polyadenylation specificity factor 6; Cleavage and polyadenylation specificity factor 68 kDa; CPSF 68 kD; CPSF 68 kDa subunit; HPBRII-4; HPBRII-4,7; HPBRII-4/7; HPBRII-7; Pre-mRNA cleavage factor Im 68 kDa
Type:  RNA processing; RNA binding protein
Mass (Da):  59210
Number AA:  551
UniProt ID:  Q16630
International Prot ID:  IPI00012998
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005849  GO:0042382  GO:0030529 Uniprot OncoNet
Molecular Function:  GO:0003723  GO:0000166  GO:0005515 PhosphoSite+ KinaseNET
Biological Process:  GO:0006397     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1Y11GVDHIDIYADVGEEF
Site 2Y33GHDQIDLYDDVISPS
Site 3S38DLYDDVISPSANNGD
Site 4S40YDDVISPSANNGDAP
Site 5Y52DAPEDRDYMDTLPPT
Site 6T55EDRDYMDTLPPTVGD
Site 7T59YMDTLPPTVGDDVGK
Site 8Y74GAAPNVVYTYTGKRI
Site 9T75AAPNVVYTYTGKRIA
Site 10Y76APNVVYTYTGKRIAL
Site 11T77PNVVYTYTGKRIALY
Site 12T98WTTDEDLTEAVHSLG
Site 13S123ENRANGQSKGFALVG
Site 14S137GVGSEASSKKLMDLL
Site 15T157HGQNPVVTPCNKQFL
Site 16S165PCNKQFLSQFEMQSR
Site 17S171LSQFEMQSRKTTQSG
Site 18T174FEMQSRKTTQSGQMS
Site 19T175EMQSRKTTQSGQMSG
Site 20S177QSRKTTQSGQMSGEG
Site 21S181TTQSGQMSGEGKAGP
Site 22S193AGPPGGSSRAAFPQG
Site 23T235PPFPAGQTPPRPPLG
Site 24Y303PPPPVPGYGPPPGPP
Site 25T366PAFFPPPTNSGMPTS
Site 26S368FFPPPTNSGMPTSDS
Site 27T372PTNSGMPTSDSRGPP
Site 28S373TNSGMPTSDSRGPPP
Site 29S375SGMPTSDSRGPPPTD
Site 30T381DSRGPPPTDPYGRPP
Site 31Y384GPPPTDPYGRPPPYD
Site 32Y390PYGRPPPYDRGDYGP
Site 33Y395PPYDRGDYGPPGREM
Site 34T404PPGREMDTARTPLSE
Site 35T407REMDTARTPLSEAEF
Site 36S410DTARTPLSEAEFEEI
Site 37S425MNRNRAISSSAISRA
Site 38S426NRNRAISSSAISRAV
Site 39S427RNRAISSSAISRAVS
Site 40S434SAISRAVSDASAGDY
Site 41S437SRAVSDASAGDYGSA
Site 42Y441SDASAGDYGSAIETL
Site 43S443ASAGDYGSAIETLVT
Site 44S482DCLHGIESKSYGSGS
Site 45S484LHGIESKSYGSGSRR
Site 46Y485HGIESKSYGSGSRRE
Site 47S487IESKSYGSGSRRERS
Site 48S489SKSYGSGSRRERSRE
Site 49S494SGSRRERSRERDHSR
Site 50S500RSRERDHSRSREKSR
Site 51S502RERDHSRSREKSRRH
Site 52S506HSRSREKSRRHKSRS
Site 53S511EKSRRHKSRSRDRHD
Site 54S513SRRHKSRSRDRHDDY
Site 55Y520SRDRHDDYYRERSRE
Site 56Y521RDRHDDYYRERSRER
Site 57S525DDYYRERSRERERHR
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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