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Updated November 2019
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Protein Info
Short Name:
PTGIS
Full Name:
Prostacyclin synthase
Alias:
Prostaglandin I2 synthase
Type:
Mass (Da):
57104
Number AA:
500
UniProt ID:
Q16647
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
L
L
L
L
L
L
L
S
R
R
R
T
R
R
P
Site 2
T24
L
L
L
S
R
R
R
T
R
R
P
G
E
P
P
Site 3
Y42
G
S
I
P
W
L
G
Y
A
L
D
F
G
K
D
Site 4
S52
D
F
G
K
D
A
A
S
F
L
T
R
M
K
E
Site 5
T66
E
K
H
G
D
I
F
T
I
L
V
G
G
R
Y
Site 6
Y115
F
D
V
Q
L
P
H
Y
S
P
S
D
E
K
A
Site 7
S116
D
V
Q
L
P
H
Y
S
P
S
D
E
K
A
R
Site 8
S118
Q
L
P
H
Y
S
P
S
D
E
K
A
R
M
K
Site 9
T189
G
I
E
A
L
P
R
T
H
E
S
Q
A
Q
D
Site 10
S192
A
L
P
R
T
H
E
S
Q
A
Q
D
R
V
H
Site 11
S200
Q
A
Q
D
R
V
H
S
A
D
V
F
H
T
F
Site 12
T206
H
S
A
D
V
F
H
T
F
R
Q
L
D
R
L
Site 13
S221
L
P
K
L
A
R
G
S
L
S
V
G
D
K
D
Site 14
S223
K
L
A
R
G
S
L
S
V
G
D
K
D
H
M
Site 15
S235
D
H
M
C
S
V
K
S
R
L
W
K
L
L
S
Site 16
S242
S
R
L
W
K
L
L
S
P
A
R
L
A
R
R
Site 17
S253
L
A
R
R
A
H
R
S
K
W
L
E
S
Y
L
Site 18
Y259
R
S
K
W
L
E
S
Y
L
L
H
L
E
E
M
Site 19
S315
A
V
R
G
E
L
E
S
I
L
W
Q
A
E
Q
Site 20
S325
W
Q
A
E
Q
P
V
S
Q
T
T
T
L
P
Q
Site 21
T329
Q
P
V
S
Q
T
T
T
L
P
Q
K
V
L
D
Site 22
S343
D
S
T
P
V
L
D
S
V
L
S
E
S
L
R
Site 23
Y398
P
Q
R
D
P
E
I
Y
T
D
P
E
V
F
K
Site 24
Y406
T
D
P
E
V
F
K
Y
N
R
F
L
N
P
D
Site 25
S415
R
F
L
N
P
D
G
S
E
K
K
D
F
Y
K
Site 26
Y421
G
S
E
K
K
D
F
Y
K
D
G
K
R
L
K
Site 27
Y430
D
G
K
R
L
K
N
Y
N
M
P
W
G
A
G
Site 28
Y446
N
H
C
L
G
R
S
Y
A
V
N
S
I
K
Q
Site 29
S479
E
I
P
E
F
D
L
S
R
Y
G
F
G
L
M
Site 30
Y481
P
E
F
D
L
S
R
Y
G
F
G
L
M
Q
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation