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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Fascin
Full Name:
Fascin
Alias:
55 kDa actin bundling protein; actin bundling protein; FAN1; fascin 1, actin-bundling protein; FLJ38511; FSC1; FSCN1; HSN; p55; Singed,-like; Singed-like protein; SNL
Type:
Cytoskeletal protein; Actin binding protein
Mass (Da):
54530
Number AA:
493
UniProt ID:
Q16658
International Prot ID:
IPI00163187
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0051015
GO:0030674
PhosphoSite+
KinaseNET
Biological Process:
GO:0051017
GO:0008283
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y23
L
I
N
C
G
N
K
Y
L
T
A
E
A
F
G
Site 2
T25
N
C
G
N
K
Y
L
T
A
E
A
F
G
F
K
Site 3
S36
F
G
F
K
V
N
A
S
A
S
S
L
K
K
K
Site 4
S38
F
K
V
N
A
S
A
S
S
L
K
K
K
Q
I
Site 5
S39
K
V
N
A
S
A
S
S
L
K
K
K
Q
I
W
Site 6
S57
Q
P
P
D
E
A
G
S
A
A
V
C
L
R
S
Site 7
S102
A
H
D
D
G
R
W
S
L
Q
S
E
A
H
R
Site 8
S105
D
G
R
W
S
L
Q
S
E
A
H
R
R
Y
F
Site 9
Y111
Q
S
E
A
H
R
R
Y
F
G
G
T
E
D
R
Site 10
T115
H
R
R
Y
F
G
G
T
E
D
R
L
S
C
F
Site 11
S120
G
G
T
E
D
R
L
S
C
F
A
Q
T
V
S
Site 12
T125
R
L
S
C
F
A
Q
T
V
S
P
A
E
K
W
Site 13
S127
S
C
F
A
Q
T
V
S
P
A
E
K
W
S
V
Site 14
Y145
M
H
P
Q
V
N
I
Y
S
V
T
R
K
R
Y
Site 15
Y152
Y
S
V
T
R
K
R
Y
A
H
L
S
A
R
P
Site 16
S156
R
K
R
Y
A
H
L
S
A
R
P
A
D
E
I
Site 17
Y186
L
A
F
Q
D
Q
R
Y
S
V
Q
T
A
D
H
Site 18
S187
A
F
Q
D
Q
R
Y
S
V
Q
T
A
D
H
R
Site 19
T190
D
Q
R
Y
S
V
Q
T
A
D
H
R
F
L
R
Site 20
T210
V
A
R
P
E
P
A
T
G
Y
T
L
E
F
R
Site 21
Y230
F
R
D
C
E
G
R
Y
L
A
P
S
G
P
S
Site 22
S234
E
G
R
Y
L
A
P
S
G
P
S
G
T
L
K
Site 23
T239
A
P
S
G
P
S
G
T
L
K
A
G
K
A
T
Site 24
S274
A
A
N
E
R
N
V
S
T
R
Q
G
M
D
L
Site 25
S282
T
R
Q
G
M
D
L
S
A
N
Q
D
E
E
T
Site 26
T289
S
A
N
Q
D
E
E
T
D
Q
E
T
F
Q
L
Site 27
T293
D
E
E
T
D
Q
E
T
F
Q
L
E
I
D
R
Site 28
T302
Q
L
E
I
D
R
D
T
K
K
C
A
F
R
T
Site 29
T311
K
C
A
F
R
T
H
T
G
K
Y
W
T
L
T
Site 30
Y314
F
R
T
H
T
G
K
Y
W
T
L
T
A
T
G
Site 31
T318
T
G
K
Y
W
T
L
T
A
T
G
G
V
Q
S
Site 32
S325
T
A
T
G
G
V
Q
S
T
A
S
S
K
N
A
Site 33
S328
G
G
V
Q
S
T
A
S
S
K
N
A
S
C
Y
Site 34
S329
G
V
Q
S
T
A
S
S
K
N
A
S
C
Y
F
Site 35
Y335
S
S
K
N
A
S
C
Y
F
D
I
E
W
R
D
Site 36
T346
E
W
R
D
R
R
I
T
L
R
A
S
N
G
K
Site 37
S350
R
R
I
T
L
R
A
S
N
G
K
F
V
T
S
Site 38
S366
K
N
G
Q
L
A
A
S
V
E
T
A
G
D
S
Site 39
T401
F
I
G
C
R
K
V
T
G
T
L
D
A
N
R
Site 40
T403
G
C
R
K
V
T
G
T
L
D
A
N
R
S
S
Site 41
S409
G
T
L
D
A
N
R
S
S
Y
D
V
F
Q
L
Site 42
S410
T
L
D
A
N
R
S
S
Y
D
V
F
Q
L
E
Site 43
Y411
L
D
A
N
R
S
S
Y
D
V
F
Q
L
E
F
Site 44
Y423
L
E
F
N
D
G
A
Y
N
I
K
D
S
T
G
Site 45
Y432
I
K
D
S
T
G
K
Y
W
T
V
G
S
D
S
Site 46
T434
D
S
T
G
K
Y
W
T
V
G
S
D
S
A
V
Site 47
S437
G
K
Y
W
T
V
G
S
D
S
A
V
T
S
S
Site 48
S439
Y
W
T
V
G
S
D
S
A
V
T
S
S
G
D
Site 49
S443
G
S
D
S
A
V
T
S
S
G
D
T
P
V
D
Site 50
S444
S
D
S
A
V
T
S
S
G
D
T
P
V
D
F
Site 51
T484
V
L
K
A
S
A
E
T
V
D
P
A
S
L
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation