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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HIF1A
Full Name:
Hypoxia-inducible factor 1-alpha
Alias:
ARNT-interacting protein;Basic-helix-loop-helix-PAS protein MOP1;Class E basic helix-loop-helix protein 78;Member of PAS protein 1;PAS domain-containing protein 8
Type:
Transcription protein
Mass (Da):
92670
Number AA:
826
UniProt ID:
Q16665
International Prot ID:
IPI00003442
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0051879
GO:0003705
GO:0035035
PhosphoSite+
KinaseNET
Biological Process:
GO:0032963
GO:0002248
GO:0051541
Phosida
TranscriptoNet
STRING
Kinexus Products
Hypoxia-inducible factor 1-alpha pan-specific antibody AB-NN267-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN267-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
A
N
D
K
K
K
I
S
S
E
R
R
K
E
K
Site 2
S15
N
D
K
K
K
I
S
S
E
R
R
K
E
K
S
Site 3
S22
S
E
R
R
K
E
K
S
R
D
A
A
R
S
R
Site 4
S28
K
S
R
D
A
A
R
S
R
R
S
K
E
S
E
Site 5
S31
D
A
A
R
S
R
R
S
K
E
S
E
V
F
Y
Site 6
S34
R
S
R
R
S
K
E
S
E
V
F
Y
E
L
A
Site 7
Y38
S
K
E
S
E
V
F
Y
E
L
A
H
Q
L
P
Site 8
S51
L
P
L
P
H
N
V
S
S
H
L
D
K
A
S
Site 9
S52
P
L
P
H
N
V
S
S
H
L
D
K
A
S
V
Site 10
S58
S
S
H
L
D
K
A
S
V
M
R
L
T
I
S
Site 11
Y66
V
M
R
L
T
I
S
Y
L
R
V
R
K
L
L
Site 12
Y111
T
D
D
G
D
M
I
Y
I
S
D
N
V
N
K
Site 13
S113
D
G
D
M
I
Y
I
S
D
N
V
N
K
Y
M
Site 14
Y119
I
S
D
N
V
N
K
Y
M
G
L
T
Q
F
E
Site 15
T149
E
E
M
R
E
M
L
T
H
R
N
G
L
V
K
Site 16
T163
K
K
G
K
E
Q
N
T
Q
R
S
F
F
L
R
Site 17
T174
F
F
L
R
M
K
C
T
L
T
S
R
G
R
T
Site 18
T176
L
R
M
K
C
T
L
T
S
R
G
R
T
M
N
Site 19
T181
T
L
T
S
R
G
R
T
M
N
I
K
S
A
T
Site 20
Y201
C
T
G
H
I
H
V
Y
D
T
N
S
N
Q
P
Site 21
Y212
S
N
Q
P
Q
C
G
Y
K
K
P
P
M
T
C
Site 22
S231
C
E
P
I
P
H
P
S
N
I
E
I
P
L
D
Site 23
S239
N
I
E
I
P
L
D
S
K
T
F
L
S
R
H
Site 24
T241
E
I
P
L
D
S
K
T
F
L
S
R
H
S
L
Site 25
S244
L
D
S
K
T
F
L
S
R
H
S
L
D
M
K
Site 26
S247
K
T
F
L
S
R
H
S
L
D
M
K
F
S
Y
Site 27
Y254
S
L
D
M
K
F
S
Y
C
D
E
R
I
T
E
Site 28
T260
S
Y
C
D
E
R
I
T
E
L
M
G
Y
E
P
Site 29
Y265
R
I
T
E
L
M
G
Y
E
P
E
E
L
L
G
Site 30
Y276
E
L
L
G
R
S
I
Y
E
Y
Y
H
A
L
D
Site 31
Y278
L
G
R
S
I
Y
E
Y
Y
H
A
L
D
S
D
Site 32
Y279
G
R
S
I
Y
E
Y
Y
H
A
L
D
S
D
H
Site 33
S284
E
Y
Y
H
A
L
D
S
D
H
L
T
K
T
H
Site 34
T288
A
L
D
S
D
H
L
T
K
T
H
H
D
M
F
Site 35
T290
D
S
D
H
L
T
K
T
H
H
D
M
F
T
K
Site 36
Y314
M
L
A
K
R
G
G
Y
V
W
V
E
T
Q
A
Site 37
T322
V
W
V
E
T
Q
A
T
V
I
Y
N
T
K
N
Site 38
S330
V
I
Y
N
T
K
N
S
Q
P
Q
C
I
V
C
Site 39
S366
C
V
L
K
P
V
E
S
S
D
M
K
M
T
Q
Site 40
S367
V
L
K
P
V
E
S
S
D
M
K
M
T
Q
L
Site 41
S380
Q
L
F
T
K
V
E
S
E
D
T
S
S
L
F
Site 42
T383
T
K
V
E
S
E
D
T
S
S
L
F
D
K
L
Site 43
S384
K
V
E
S
E
D
T
S
S
L
F
D
K
L
K
Site 44
S385
V
E
S
E
D
T
S
S
L
F
D
K
L
K
K
Site 45
T398
K
K
E
P
D
A
L
T
L
L
A
P
A
A
G
Site 46
T407
L
A
P
A
A
G
D
T
I
I
S
L
D
F
G
Site 47
S410
A
A
G
D
T
I
I
S
L
D
F
G
S
N
D
Site 48
T420
F
G
S
N
D
T
E
T
D
D
Q
Q
L
E
E
Site 49
Y431
Q
L
E
E
V
P
L
Y
N
D
V
M
L
P
S
Site 50
S438
Y
N
D
V
M
L
P
S
P
N
E
K
L
Q
N
Site 51
S451
Q
N
I
N
L
A
M
S
P
L
P
T
A
E
T
Site 52
T455
L
A
M
S
P
L
P
T
A
E
T
P
K
P
L
Site 53
T458
S
P
L
P
T
A
E
T
P
K
P
L
R
S
S
Site 54
S464
E
T
P
K
P
L
R
S
S
A
D
P
A
L
N
Site 55
S465
T
P
K
P
L
R
S
S
A
D
P
A
L
N
Q
Site 56
S484
K
L
E
P
N
P
E
S
L
E
L
S
F
T
M
Site 57
S488
N
P
E
S
L
E
L
S
F
T
M
P
Q
I
Q
Site 58
T490
E
S
L
E
L
S
F
T
M
P
Q
I
Q
D
Q
Site 59
T498
M
P
Q
I
Q
D
Q
T
P
S
P
S
D
G
S
Site 60
S500
Q
I
Q
D
Q
T
P
S
P
S
D
G
S
T
R
Site 61
S502
Q
D
Q
T
P
S
P
S
D
G
S
T
R
Q
S
Site 62
S505
T
P
S
P
S
D
G
S
T
R
Q
S
S
P
E
Site 63
T506
P
S
P
S
D
G
S
T
R
Q
S
S
P
E
P
Site 64
S509
S
D
G
S
T
R
Q
S
S
P
E
P
N
S
P
Site 65
S510
D
G
S
T
R
Q
S
S
P
E
P
N
S
P
S
Site 66
S515
Q
S
S
P
E
P
N
S
P
S
E
Y
C
F
Y
Site 67
S517
S
P
E
P
N
S
P
S
E
Y
C
F
Y
V
D
Site 68
Y519
E
P
N
S
P
S
E
Y
C
F
Y
V
D
S
D
Site 69
Y522
S
P
S
E
Y
C
F
Y
V
D
S
D
M
V
N
Site 70
T544
E
K
L
F
A
E
D
T
E
A
K
N
P
F
S
Site 71
S551
T
E
A
K
N
P
F
S
T
Q
D
T
D
L
D
Site 72
T555
N
P
F
S
T
Q
D
T
D
L
D
L
E
M
L
Site 73
S576
D
D
D
F
Q
L
R
S
F
D
Q
L
S
P
L
Site 74
S581
L
R
S
F
D
Q
L
S
P
L
E
S
S
S
A
Site 75
S585
D
Q
L
S
P
L
E
S
S
S
A
S
P
E
S
Site 76
S587
L
S
P
L
E
S
S
S
A
S
P
E
S
A
S
Site 77
S589
P
L
E
S
S
S
A
S
P
E
S
A
S
P
Q
Site 78
S592
S
S
S
A
S
P
E
S
A
S
P
Q
S
T
V
Site 79
S594
S
A
S
P
E
S
A
S
P
Q
S
T
V
T
V
Site 80
S597
P
E
S
A
S
P
Q
S
T
V
T
V
F
Q
Q
Site 81
T598
E
S
A
S
P
Q
S
T
V
T
V
F
Q
Q
T
Site 82
T600
A
S
P
Q
S
T
V
T
V
F
Q
Q
T
Q
I
Site 83
T626
A
T
T
D
E
L
K
T
V
T
K
D
R
M
E
Site 84
S641
D
I
K
I
L
I
A
S
P
S
P
T
H
I
H
Site 85
S643
K
I
L
I
A
S
P
S
P
T
H
I
H
K
E
Site 86
T645
L
I
A
S
P
S
P
T
H
I
H
K
E
T
T
Site 87
T651
P
T
H
I
H
K
E
T
T
S
A
T
S
S
P
Site 88
T652
T
H
I
H
K
E
T
T
S
A
T
S
S
P
Y
Site 89
S653
H
I
H
K
E
T
T
S
A
T
S
S
P
Y
R
Site 90
S657
E
T
T
S
A
T
S
S
P
Y
R
D
T
Q
S
Site 91
T662
T
S
S
P
Y
R
D
T
Q
S
R
T
A
S
P
Site 92
S664
S
P
Y
R
D
T
Q
S
R
T
A
S
P
N
R
Site 93
T666
Y
R
D
T
Q
S
R
T
A
S
P
N
R
A
G
Site 94
S668
D
T
Q
S
R
T
A
S
P
N
R
A
G
K
G
Site 95
T680
G
K
G
V
I
E
Q
T
E
K
S
H
P
R
S
Site 96
S683
V
I
E
Q
T
E
K
S
H
P
R
S
P
N
V
Site 97
S687
T
E
K
S
H
P
R
S
P
N
V
L
S
V
A
Site 98
S692
P
R
S
P
N
V
L
S
V
A
L
S
Q
R
T
Site 99
S696
N
V
L
S
V
A
L
S
Q
R
T
T
V
P
E
Site 100
T700
V
A
L
S
Q
R
T
T
V
P
E
E
E
L
N
Site 101
S727
R
K
M
E
H
D
G
S
L
F
Q
A
V
G
I
Site 102
T747
Q
P
D
D
H
A
A
T
T
S
L
S
W
K
R
Site 103
S749
D
D
H
A
A
T
T
S
L
S
W
K
R
V
K
Site 104
S751
H
A
A
T
T
S
L
S
W
K
R
V
K
G
C
Site 105
S760
K
R
V
K
G
C
K
S
S
E
Q
N
G
M
E
Site 106
S761
R
V
K
G
C
K
S
S
E
Q
N
G
M
E
Q
Site 107
T770
Q
N
G
M
E
Q
K
T
I
I
L
I
P
S
D
Site 108
S786
A
C
R
L
L
G
Q
S
M
D
E
S
G
L
P
Site 109
S790
L
G
Q
S
M
D
E
S
G
L
P
Q
L
T
S
Site 110
T796
E
S
G
L
P
Q
L
T
S
Y
D
C
E
V
N
Site 111
S797
S
G
L
P
Q
L
T
S
Y
D
C
E
V
N
A
Site 112
Y798
G
L
P
Q
L
T
S
Y
D
C
E
V
N
A
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation