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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DUSP5
Full Name:
Dual specificity protein phosphatase 5
Alias:
dual specificity phosphatase 5; Dual specificity protein phosphatase hVH3; DUS5; DUS5_HUMAN; HVH3; VH3
Type:
EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity
Mass (Da):
42110
Number AA:
UniProt ID:
Q16690
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0017017
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Dual specificity protein phosphatase 5 pan-specific antibody AB-NP039-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP039-1#Dual specificity protein phosphatase 5 pan-specific antibody AB-NP039-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP039-2#Dual specificity protein phosphatase 5 pan-specific antibody AB-NP039-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP039-3#Dual specificity protein phosphatase 5 (M1-L15, human) peptide - Powder PE-01BAX80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BAX80#Dual specificity protein phosphatase 5 (A59-L75, human) peptide - Powder PE-01BAY90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BAY90#Dual specificity protein phosphatase 5 (L286-V300, human) peptide - Powder PE-01BAZ90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BAZ90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S42
A
A
S
N
V
R
G
S
L
N
V
N
L
N
S
Site 2
S49
S
L
N
V
N
L
N
S
V
V
L
R
R
A
R
Site 3
S61
R
A
R
G
G
A
V
S
A
R
Y
V
L
P
D
Site 4
S103
W
Q
K
L
R
E
E
S
A
A
R
V
V
L
T
Site 5
T110
S
A
A
R
V
V
L
T
S
L
L
A
C
L
P
Site 6
Y123
L
P
A
G
P
R
V
Y
F
L
K
G
G
Y
E
Site 7
T131
F
L
K
G
G
Y
E
T
F
Y
S
E
Y
P
E
Site 8
Y133
K
G
G
Y
E
T
F
Y
S
E
Y
P
E
C
C
Site 9
Y136
Y
E
T
F
Y
S
E
Y
P
E
C
C
V
D
V
Site 10
S147
C
V
D
V
K
P
I
S
Q
E
K
I
E
S
E
Site 11
S153
I
S
Q
E
K
I
E
S
E
R
A
L
I
S
Q
Site 12
S159
E
S
E
R
A
L
I
S
Q
C
G
K
P
V
V
Site 13
S169
G
K
P
V
V
N
V
S
Y
R
P
A
Y
D
Q
Site 14
Y174
N
V
S
Y
R
P
A
Y
D
Q
G
G
P
V
E
Site 15
S195
L
G
S
A
Y
H
A
S
K
C
E
F
L
A
N
Site 16
T215
L
L
N
V
S
R
R
T
S
E
A
C
A
T
H
Site 17
S216
L
N
V
S
R
R
T
S
E
A
C
A
T
H
L
Site 18
S233
K
W
I
P
V
E
D
S
H
T
A
D
I
S
S
Site 19
T235
I
P
V
E
D
S
H
T
A
D
I
S
S
H
F
Site 20
Y277
S
P
T
I
C
M
A
Y
L
M
K
T
K
Q
F
Site 21
Y292
R
L
K
E
A
F
D
Y
I
K
Q
R
R
S
M
Site 22
S298
D
Y
I
K
Q
R
R
S
M
V
S
P
N
F
G
Site 23
S301
K
Q
R
R
S
M
V
S
P
N
F
G
F
M
G
Site 24
Y313
F
M
G
Q
L
L
Q
Y
E
S
E
I
L
P
S
Site 25
S315
G
Q
L
L
Q
Y
E
S
E
I
L
P
S
T
P
Site 26
S320
Y
E
S
E
I
L
P
S
T
P
N
P
Q
P
P
Site 27
T321
E
S
E
I
L
P
S
T
P
N
P
Q
P
P
S
Site 28
S328
T
P
N
P
Q
P
P
S
C
Q
G
E
A
A
G
Site 29
S336
C
Q
G
E
A
A
G
S
S
L
I
G
H
L
Q
Site 30
S337
Q
G
E
A
A
G
S
S
L
I
G
H
L
Q
T
Site 31
T344
S
L
I
G
H
L
Q
T
L
S
P
D
M
Q
G
Site 32
S346
I
G
H
L
Q
T
L
S
P
D
M
Q
G
A
Y
Site 33
Y353
S
P
D
M
Q
G
A
Y
C
T
F
P
A
S
V
Site 34
S368
L
A
P
V
P
T
H
S
T
V
S
E
L
S
R
Site 35
T369
A
P
V
P
T
H
S
T
V
S
E
L
S
R
S
Site 36
S371
V
P
T
H
S
T
V
S
E
L
S
R
S
P
V
Site 37
S374
H
S
T
V
S
E
L
S
R
S
P
V
A
T
A
Site 38
S376
T
V
S
E
L
S
R
S
P
V
A
T
A
T
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation