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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAN2A1
Full Name:
Alpha-mannosidase 2
Alias:
Golgi alpha-mannosidase II;Mannosidase alpha class 2A member 1;Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Type:
Enzyme, hydrolase
Mass (Da):
131141
Number AA:
1144
UniProt ID:
Q16706
International Prot ID:
IPI00003802
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0004559
GO:0030246
GO:0004572
PhosphoSite+
KinaseNET
Biological Process:
GO:0006013
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y33
L
D
R
G
H
L
D
Y
P
R
N
P
R
R
E
Site 2
S42
R
N
P
R
R
E
G
S
F
P
Q
G
Q
L
S
Site 3
S49
S
F
P
Q
G
Q
L
S
M
L
Q
E
K
I
D
Site 4
S70
A
E
N
N
E
I
I
S
N
I
R
D
S
V
I
Site 5
S80
R
D
S
V
I
N
L
S
E
S
V
E
D
G
P
Site 6
S82
S
V
I
N
L
S
E
S
V
E
D
G
P
K
S
Site 7
S89
S
V
E
D
G
P
K
S
S
Q
S
N
F
S
Q
Site 8
S90
V
E
D
G
P
K
S
S
Q
S
N
F
S
Q
G
Site 9
S92
D
G
P
K
S
S
Q
S
N
F
S
Q
G
A
G
Site 10
S95
K
S
S
Q
S
N
F
S
Q
G
A
G
S
H
L
Site 11
S100
N
F
S
Q
G
A
G
S
H
L
L
P
S
Q
L
Site 12
S108
H
L
L
P
S
Q
L
S
L
S
V
D
T
A
D
Site 13
S120
T
A
D
C
L
F
A
S
Q
S
G
S
H
N
S
Site 14
S122
D
C
L
F
A
S
Q
S
G
S
H
N
S
D
V
Site 15
S124
L
F
A
S
Q
S
G
S
H
N
S
D
V
Q
M
Site 16
S127
S
Q
S
G
S
H
N
S
D
V
Q
M
L
D
V
Site 17
S139
L
D
V
Y
S
L
I
S
F
D
N
P
D
G
G
Site 18
Y156
K
Q
G
F
D
I
T
Y
E
S
N
E
W
D
T
Site 19
Y187
W
L
K
T
F
N
D
Y
F
R
D
K
T
Q
Y
Site 20
Y194
Y
F
R
D
K
T
Q
Y
I
F
N
N
M
V
L
Site 21
S207
V
L
K
L
K
E
D
S
R
R
K
F
I
W
S
Site 22
S214
S
R
R
K
F
I
W
S
E
I
S
Y
L
S
K
Site 23
Y218
F
I
W
S
E
I
S
Y
L
S
K
W
W
D
I
Site 24
S236
Q
K
K
D
A
V
K
S
L
I
E
N
G
Q
L
Site 25
Y260
P
D
E
A
T
P
H
Y
F
A
L
I
D
Q
L
Site 26
S284
N
I
G
V
K
P
R
S
G
W
A
I
D
P
F
Site 27
T296
D
P
F
G
H
S
P
T
M
A
Y
L
L
N
R
Site 28
T359
Y
S
Y
D
I
P
H
T
C
G
P
D
P
K
I
Site 29
T390
P
W
G
V
P
P
E
T
I
H
P
G
N
V
Q
Site 30
S398
I
H
P
G
N
V
Q
S
R
A
R
M
L
L
D
Site 31
Y407
A
R
M
L
L
D
Q
Y
R
K
K
S
K
L
F
Site 32
S411
L
D
Q
Y
R
K
K
S
K
L
F
R
T
K
V
Site 33
Y429
P
L
G
D
D
F
R
Y
C
E
Y
T
E
W
D
Site 34
Y442
W
D
L
Q
F
K
N
Y
Q
Q
L
F
D
Y
M
Site 35
Y448
N
Y
Q
Q
L
F
D
Y
M
N
S
Q
S
K
F
Site 36
S451
Q
L
F
D
Y
M
N
S
Q
S
K
F
K
V
K
Site 37
T477
A
L
D
K
A
D
E
T
Q
R
D
K
G
Q
S
Site 38
S484
T
Q
R
D
K
G
Q
S
M
F
P
V
L
S
G
Site 39
Y496
L
S
G
D
F
F
T
Y
A
D
R
D
D
H
Y
Site 40
Y503
Y
A
D
R
D
D
H
Y
W
S
G
Y
F
T
S
Site 41
Y507
D
D
H
Y
W
S
G
Y
F
T
S
R
P
F
Y
Site 42
T509
H
Y
W
S
G
Y
F
T
S
R
P
F
Y
K
R
Site 43
Y514
Y
F
T
S
R
P
F
Y
K
R
M
D
R
I
M
Site 44
Y532
L
R
A
A
E
I
L
Y
Y
F
A
L
R
Q
A
Site 45
Y533
R
A
A
E
I
L
Y
Y
F
A
L
R
Q
A
H
Site 46
Y542
A
L
R
Q
A
H
K
Y
K
I
N
K
F
L
S
Site 47
Y553
K
F
L
S
S
S
L
Y
T
A
L
T
E
A
R
Site 48
T557
S
S
L
Y
T
A
L
T
E
A
R
R
N
L
G
Site 49
Y584
K
D
W
V
V
V
D
Y
G
T
R
L
F
H
S
Site 50
T613
L
I
L
K
D
K
L
T
Y
D
S
Y
S
P
D
Site 51
Y614
I
L
K
D
K
L
T
Y
D
S
Y
S
P
D
T
Site 52
S616
K
D
K
L
T
Y
D
S
Y
S
P
D
T
F
L
Site 53
Y617
D
K
L
T
Y
D
S
Y
S
P
D
T
F
L
E
Site 54
S618
K
L
T
Y
D
S
Y
S
P
D
T
F
L
E
M
Site 55
T621
Y
D
S
Y
S
P
D
T
F
L
E
M
D
L
K
Site 56
S631
E
M
D
L
K
Q
K
S
Q
D
S
L
P
Q
K
Site 57
S634
L
K
Q
K
S
Q
D
S
L
P
Q
K
N
I
I
Site 58
S644
Q
K
N
I
I
R
L
S
A
E
P
R
Y
L
V
Site 59
Y649
R
L
S
A
E
P
R
Y
L
V
V
Y
N
P
L
Site 60
Y653
E
P
R
Y
L
V
V
Y
N
P
L
E
Q
D
R
Site 61
S665
Q
D
R
I
S
L
V
S
V
Y
V
S
S
P
T
Site 62
S688
K
P
V
E
V
Q
V
S
A
V
W
D
T
A
N
Site 63
Y702
N
T
I
S
E
T
A
Y
E
I
S
F
R
A
H
Site 64
S705
S
E
T
A
Y
E
I
S
F
R
A
H
I
P
P
Site 65
S723
K
V
Y
K
I
L
E
S
A
S
S
N
S
H
L
Site 66
S725
Y
K
I
L
E
S
A
S
S
N
S
H
L
A
D
Site 67
S726
K
I
L
E
S
A
S
S
N
S
H
L
A
D
Y
Site 68
Y733
S
N
S
H
L
A
D
Y
V
L
Y
K
N
K
V
Site 69
S743
Y
K
N
K
V
E
D
S
G
I
F
T
I
K
N
Site 70
T747
V
E
D
S
G
I
F
T
I
K
N
M
I
N
T
Site 71
S805
T
T
I
K
R
D
K
S
G
A
Y
L
F
L
P
Site 72
Y819
P
D
G
N
A
K
P
Y
V
Y
T
T
P
P
F
Site 73
Y821
G
N
A
K
P
Y
V
Y
T
T
P
P
F
V
R
Site 74
T822
N
A
K
P
Y
V
Y
T
T
P
P
F
V
R
V
Site 75
T823
A
K
P
Y
V
Y
T
T
P
P
F
V
R
V
T
Site 76
T830
T
P
P
F
V
R
V
T
H
G
R
I
Y
S
E
Site 77
Y852
V
T
H
R
V
R
L
Y
H
I
Q
G
I
E
G
Site 78
S865
E
G
Q
S
V
E
V
S
N
I
V
D
I
R
K
Site 79
Y874
I
V
D
I
R
K
V
Y
N
R
E
I
A
M
K
Site 80
S884
E
I
A
M
K
I
S
S
D
I
K
S
Q
N
R
Site 81
S888
K
I
S
S
D
I
K
S
Q
N
R
F
Y
T
D
Site 82
Y893
I
K
S
Q
N
R
F
Y
T
D
L
N
G
Y
Q
Site 83
T894
K
S
Q
N
R
F
Y
T
D
L
N
G
Y
Q
I
Site 84
T906
Y
Q
I
Q
P
R
M
T
L
S
K
L
P
L
Q
Site 85
S908
I
Q
P
R
M
T
L
S
K
L
P
L
Q
A
N
Site 86
T933
Q
D
A
K
H
R
L
T
L
L
S
A
Q
S
L
Site 87
S936
K
H
R
L
T
L
L
S
A
Q
S
L
G
V
S
Site 88
S943
S
A
Q
S
L
G
V
S
S
L
N
S
G
Q
I
Site 89
S944
A
Q
S
L
G
V
S
S
L
N
S
G
Q
I
E
Site 90
S988
R
I
L
L
E
K
R
S
A
V
N
T
E
E
E
Site 91
T992
E
K
R
S
A
V
N
T
E
E
E
K
K
S
V
Site 92
S998
N
T
E
E
E
K
K
S
V
S
Y
P
S
L
L
Site 93
S1000
E
E
E
K
K
S
V
S
Y
P
S
L
L
S
H
Site 94
Y1001
E
E
K
K
S
V
S
Y
P
S
L
L
S
H
I
Site 95
S1003
K
K
S
V
S
Y
P
S
L
L
S
H
I
T
S
Site 96
T1009
P
S
L
L
S
H
I
T
S
S
L
M
N
H
P
Site 97
S1026
P
M
A
N
K
F
S
S
P
T
L
E
L
Q
G
Site 98
S1036
L
E
L
Q
G
E
F
S
P
L
Q
S
S
L
P
Site 99
S1040
G
E
F
S
P
L
Q
S
S
L
P
C
D
I
H
Site 100
S1041
E
F
S
P
L
Q
S
S
L
P
C
D
I
H
L
Site 101
S1056
V
N
L
R
T
I
Q
S
K
V
G
N
G
H
S
Site 102
S1063
S
K
V
G
N
G
H
S
N
E
A
A
L
I
L
Site 103
S1080
K
G
F
D
C
R
F
S
S
K
G
T
G
L
F
Site 104
S1081
G
F
D
C
R
F
S
S
K
G
T
G
L
F
C
Site 105
S1113
V
E
S
L
T
P
S
S
L
S
L
M
H
S
P
Site 106
S1115
S
L
T
P
S
S
L
S
L
M
H
S
P
P
G
Site 107
S1119
S
S
L
S
L
M
H
S
P
P
G
T
Q
N
I
Site 108
T1123
L
M
H
S
P
P
G
T
Q
N
I
S
E
I
N
Site 109
S1127
P
P
G
T
Q
N
I
S
E
I
N
L
S
P
M
Site 110
S1137
N
L
S
P
M
E
I
S
T
F
R
I
Q
L
R
Site 111
T1138
L
S
P
M
E
I
S
T
F
R
I
Q
L
R
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation