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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP2B3
Full Name:
Plasma membrane calcium-transporting ATPase 3
Alias:
AT2B3; ATPase, Ca++ transporting, plasma membrane 3; EC 3.6.3.8; Plasma membrane calcium ATPase isoform 3; Plasma membrane calcium pump isoform 3; PMCA3
Type:
Plasma membrane, Golgi apparatus, Integral membrane protein
Mass (Da):
134197
Number AA:
1220
UniProt ID:
Q16720
International Prot ID:
IPI00219256
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005509
GO:0005388
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0006816
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
G
D
M
A
N
S
S
I
E
F
H
P
K
P
Site 2
Y53
L
Q
K
I
E
E
A
Y
G
D
V
S
G
L
C
Site 3
S57
E
E
A
Y
G
D
V
S
G
L
C
R
R
L
K
Site 4
T65
G
L
C
R
R
L
K
T
S
P
T
E
G
L
A
Site 5
S66
L
C
R
R
L
K
T
S
P
T
E
G
L
A
D
Site 6
Y85
L
E
K
R
R
Q
I
Y
G
Q
N
F
I
P
P
Site 7
T97
I
P
P
K
Q
P
K
T
F
L
Q
L
V
W
E
Site 8
Y127
V
S
L
G
L
S
F
Y
A
P
P
G
E
E
S
Site 9
T196
I
E
Q
E
Q
K
F
T
V
I
R
N
G
Q
L
Site 10
Y221
G
D
I
A
Q
V
K
Y
G
D
L
L
P
A
D
Site 11
S242
N
D
L
K
I
D
E
S
S
L
T
G
E
S
D
Site 12
S243
D
L
K
I
D
E
S
S
L
T
G
E
S
D
H
Site 13
T245
K
I
D
E
S
S
L
T
G
E
S
D
H
V
R
Site 14
S248
E
S
S
L
T
G
E
S
D
H
V
R
K
S
A
Site 15
S254
E
S
D
H
V
R
K
S
A
D
K
D
P
M
L
Site 16
S263
D
K
D
P
M
L
L
S
G
T
H
V
M
E
G
Site 17
T265
D
P
M
L
L
S
G
T
H
V
M
E
G
S
G
Site 18
T277
G
S
G
R
M
V
V
T
A
V
G
V
N
S
Q
Site 19
S283
V
T
A
V
G
V
N
S
Q
T
G
I
I
F
T
Site 20
S336
M
E
M
Q
P
L
K
S
A
E
G
G
E
M
E
Site 21
S358
N
A
P
K
K
E
K
S
V
L
Q
G
K
L
T
Site 22
T423
K
F
F
I
I
G
V
T
V
L
V
V
A
V
P
Site 23
Y443
A
V
T
I
S
L
A
Y
S
V
K
K
M
M
K
Site 24
S444
V
T
I
S
L
A
Y
S
V
K
K
M
M
K
D
Site 25
T475
T
A
I
C
S
D
K
T
G
T
L
T
T
N
R
Site 26
T479
S
D
K
T
G
T
L
T
T
N
R
M
T
V
V
Site 27
T484
T
L
T
T
N
R
M
T
V
V
Q
S
Y
L
G
Site 28
Y489
R
M
T
V
V
Q
S
Y
L
G
D
T
H
Y
K
Site 29
Y495
S
Y
L
G
D
T
H
Y
K
E
I
P
A
P
S
Site 30
T524
S
I
N
S
A
Y
T
T
K
I
L
P
P
E
K
Site 31
T543
P
R
Q
V
G
N
K
T
E
C
A
L
L
G
F
Site 32
Y571
Q
I
P
E
D
K
L
Y
K
V
Y
T
F
N
S
Site 33
Y574
E
D
K
L
Y
K
V
Y
T
F
N
S
V
R
K
Site 34
T575
D
K
L
Y
K
V
Y
T
F
N
S
V
R
K
S
Site 35
S578
Y
K
V
Y
T
F
N
S
V
R
K
S
M
S
T
Site 36
S582
T
F
N
S
V
R
K
S
M
S
T
V
I
R
M
Site 37
T585
S
V
R
K
S
M
S
T
V
I
R
M
P
D
G
Site 38
S598
D
G
G
F
R
L
F
S
K
G
A
S
E
I
L
Site 39
S602
R
L
F
S
K
G
A
S
E
I
L
L
K
K
C
Site 40
T610
E
I
L
L
K
K
C
T
N
I
L
N
S
N
G
Site 41
T700
K
C
Q
R
A
G
I
T
V
R
M
V
T
G
D
Site 42
S765
K
L
R
V
L
A
R
S
S
P
T
D
K
H
T
Site 43
S766
L
R
V
L
A
R
S
S
P
T
D
K
H
T
L
Site 44
T772
S
S
P
T
D
K
H
T
L
V
K
G
I
I
D
Site 45
S780
L
V
K
G
I
I
D
S
T
T
G
E
Q
R
Q
Site 46
T782
K
G
I
I
D
S
T
T
G
E
Q
R
Q
V
V
Site 47
T828
E
A
S
D
I
I
L
T
D
D
N
F
T
S
I
Site 48
Y846
V
M
W
G
R
N
V
Y
D
S
I
S
K
F
L
Site 49
S850
R
N
V
Y
D
S
I
S
K
F
L
Q
F
Q
L
Site 50
Y914
S
L
L
L
R
K
P
Y
G
R
D
K
P
L
I
Site 51
S955
E
L
F
F
D
I
D
S
G
R
N
A
P
L
H
Site 52
S963
G
R
N
A
P
L
H
S
P
P
S
E
H
Y
T
Site 53
S966
A
P
L
H
S
P
P
S
E
H
Y
T
I
I
F
Site 54
T970
S
P
P
S
E
H
Y
T
I
I
F
N
T
F
V
Site 55
S1029
Q
F
G
G
K
P
F
S
C
S
P
L
S
T
E
Site 56
S1031
G
G
K
P
F
S
C
S
P
L
S
T
E
Q
W
Site 57
T1079
G
P
G
K
D
E
M
T
D
E
E
L
A
E
G
Site 58
T1113
R
G
L
N
R
I
Q
T
Q
I
R
V
V
K
A
Site 59
S1123
R
V
V
K
A
F
R
S
S
L
Y
E
G
L
E
Site 60
S1124
V
V
K
A
F
R
S
S
L
Y
E
G
L
E
K
Site 61
Y1126
K
A
F
R
S
S
L
Y
E
G
L
E
K
P
E
Site 62
S1134
E
G
L
E
K
P
E
S
K
T
S
I
H
N
F
Site 63
T1136
L
E
K
P
E
S
K
T
S
I
H
N
F
M
A
Site 64
S1137
E
K
P
E
S
K
T
S
I
H
N
F
M
A
T
Site 65
Y1152
P
E
F
L
I
N
D
Y
T
H
N
I
P
L
I
Site 66
T1153
E
F
L
I
N
D
Y
T
H
N
I
P
L
I
D
Site 67
T1162
N
I
P
L
I
D
D
T
D
V
D
E
N
E
E
Site 68
S1178
L
R
A
P
P
P
P
S
P
N
Q
N
N
N
A
Site 69
S1199
L
T
T
H
V
T
K
S
A
T
S
S
V
F
S
Site 70
T1201
T
H
V
T
K
S
A
T
S
S
V
F
S
S
S
Site 71
S1202
H
V
T
K
S
A
T
S
S
V
F
S
S
S
P
Site 72
S1203
V
T
K
S
A
T
S
S
V
F
S
S
S
P
G
Site 73
S1206
S
A
T
S
S
V
F
S
S
S
P
G
S
P
L
Site 74
S1207
A
T
S
S
V
F
S
S
S
P
G
S
P
L
H
Site 75
S1208
T
S
S
V
F
S
S
S
P
G
S
P
L
H
S
Site 76
S1211
V
F
S
S
S
P
G
S
P
L
H
S
V
E
T
Site 77
S1215
S
P
G
S
P
L
H
S
V
E
T
S
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation