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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LAMA3
Full Name:
Laminin subunit alpha-3
Alias:
Epiligrin 170 kDa; LAMNA; LOCS; nicein alpha
Type:
Mass (Da):
366649
Number AA:
3333
UniProt ID:
Q16787
International Prot ID:
IPI00003951
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005606
Uniprot
OncoNet
Molecular Function:
GO:0005102
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0008544
GO:0030155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y81
G
R
P
Q
P
E
L
Y
C
K
L
V
G
G
P
Site 2
T89
C
K
L
V
G
G
P
T
A
P
G
S
G
H
T
Site 3
S93
G
G
P
T
A
P
G
S
G
H
T
I
Q
G
Q
Site 4
Y104
I
Q
G
Q
F
C
D
Y
C
N
S
E
D
P
R
Site 5
T117
P
R
K
A
H
P
V
T
N
A
I
D
G
S
E
Site 6
S129
G
S
E
R
W
W
Q
S
P
P
L
S
S
G
T
Site 7
S133
W
W
Q
S
P
P
L
S
S
G
T
Q
Y
N
R
Site 8
Y138
P
L
S
S
G
T
Q
Y
N
R
V
N
L
T
L
Site 9
S174
D
L
W
V
L
E
R
S
V
D
F
G
S
T
Y
Site 10
S179
E
R
S
V
D
F
G
S
T
Y
S
P
W
Q
Y
Site 11
Y181
S
V
D
F
G
S
T
Y
S
P
W
Q
Y
F
A
Site 12
Y186
S
T
Y
S
P
W
Q
Y
F
A
H
S
K
V
D
Site 13
S232
E
N
G
E
V
V
V
S
L
I
N
G
R
P
G
Site 14
T244
R
P
G
A
K
N
F
T
F
S
H
T
L
R
E
Site 15
S246
G
A
K
N
F
T
F
S
H
T
L
R
E
F
T
Site 16
T248
K
N
F
T
F
S
H
T
L
R
E
F
T
K
A
Site 17
T253
S
H
T
L
R
E
F
T
K
A
T
N
I
R
L
Site 18
S274
T
L
L
G
H
L
I
S
K
A
Q
R
D
P
T
Site 19
T281
S
K
A
Q
R
D
P
T
V
T
R
R
Y
Y
Y
Site 20
T283
A
Q
R
D
P
T
V
T
R
R
Y
Y
Y
S
I
Site 21
Y286
D
P
T
V
T
R
R
Y
Y
Y
S
I
K
D
I
Site 22
Y287
P
T
V
T
R
R
Y
Y
Y
S
I
K
D
I
S
Site 23
Y288
T
V
T
R
R
Y
Y
Y
S
I
K
D
I
S
I
Site 24
S289
V
T
R
R
Y
Y
Y
S
I
K
D
I
S
I
G
Site 25
Y366
H
G
H
A
S
N
C
Y
Y
D
P
D
V
E
R
Site 26
Y367
G
H
A
S
N
C
Y
Y
D
P
D
V
E
R
Q
Site 27
Y409
C
E
Q
C
A
K
G
Y
Y
R
P
Y
G
V
P
Site 28
Y413
A
K
G
Y
Y
R
P
Y
G
V
P
V
D
A
P
Site 29
S476
R
I
P
I
F
P
V
S
T
P
S
S
E
D
P
Site 30
S480
F
P
V
S
T
P
S
S
E
D
P
V
A
G
D
Site 31
T522
V
E
G
P
R
C
D
T
C
R
S
G
F
Y
S
Site 32
Y528
D
T
C
R
S
G
F
Y
S
F
P
I
C
Q
A
Site 33
S549
G
S
Y
Q
M
P
C
S
S
V
T
G
Q
C
E
Site 34
Y574
D
R
C
L
S
G
A
Y
D
F
P
H
C
Q
G
Site 35
S582
D
F
P
H
C
Q
G
S
S
S
A
C
D
P
A
Site 36
S584
P
H
C
Q
G
S
S
S
A
C
D
P
A
G
T
Site 37
T591
S
A
C
D
P
A
G
T
I
N
S
N
L
G
Y
Site 38
Y598
T
I
N
S
N
L
G
Y
C
Q
C
K
L
H
V
Site 39
T609
D
L
P
R
K
A
K
T
L
S
S
N
S
D
K
Site 40
S611
P
R
K
A
K
T
L
S
S
N
S
D
K
L
L
Site 41
Y617
C
S
R
C
K
L
L
Y
W
N
L
D
K
E
N
Site 42
S626
N
L
D
K
E
N
P
S
G
C
S
E
C
K
C
Site 43
T638
C
K
C
H
K
A
G
T
V
S
G
T
G
E
C
Site 44
S662
K
S
H
V
G
G
D
S
C
D
T
C
E
D
G
Site 45
T665
V
G
G
D
S
C
D
T
C
E
D
G
Y
F
A
Site 46
Y670
C
D
T
C
E
D
G
Y
F
A
L
E
K
S
N
Site 47
Y678
F
A
L
E
K
S
N
Y
F
G
C
Q
G
C
Q
Site 48
S700
S
S
M
C
S
G
P
S
G
V
C
Q
C
R
E
Site 49
Y721
C
Q
R
P
E
N
N
Y
Y
F
P
D
L
H
H
Site 50
Y722
Q
R
P
E
N
N
Y
Y
F
P
D
L
H
H
M
Site 51
Y731
P
D
L
H
H
M
K
Y
E
I
E
D
G
S
T
Site 52
S737
K
Y
E
I
E
D
G
S
T
P
N
G
R
D
L
Site 53
T738
Y
E
I
E
D
G
S
T
P
N
G
R
D
L
R
Site 54
Y761
P
E
F
S
W
R
G
Y
A
Q
M
T
S
V
Q
Site 55
S766
R
G
Y
A
Q
M
T
S
V
Q
N
D
V
R
I
Site 56
T774
V
Q
N
D
V
R
I
T
L
N
V
G
K
S
S
Site 57
T796
L
R
Y
V
N
P
G
T
E
A
V
S
G
H
I
Site 58
T829
S
K
E
P
A
F
V
T
V
P
G
N
G
F
A
Site 59
Y883
P
V
T
E
P
C
A
Y
A
G
P
P
Q
E
N
Site 60
Y894
P
Q
E
N
C
L
L
Y
Q
H
L
P
V
T
R
Site 61
T905
P
V
T
R
F
P
C
T
L
A
C
E
A
R
H
Site 62
S938
H
P
V
M
V
D
L
S
G
R
E
V
E
L
H
Site 63
Y1012
H
M
S
R
I
A
M
Y
E
L
L
A
D
A
D
Site 64
Y1046
I
E
E
F
S
A
E
Y
V
R
P
Q
V
H
C
Site 65
Y1057
Q
V
H
C
I
A
S
Y
G
R
F
V
N
Q
S
Site 66
T1066
R
F
V
N
Q
S
A
T
C
V
S
L
A
H
E
Site 67
S1069
N
Q
S
A
T
C
V
S
L
A
H
E
T
P
P
Site 68
S1097
P
H
L
P
Q
Q
S
S
P
S
V
D
V
L
P
Site 69
S1099
L
P
Q
Q
S
S
P
S
V
D
V
L
P
G
V
Site 70
T1116
K
A
P
Q
N
Q
V
T
L
R
G
R
V
P
H
Site 71
S1146
P
T
F
P
A
Q
V
S
V
D
G
G
W
P
R
Site 72
S1156
G
G
W
P
R
A
G
S
F
H
A
S
F
C
P
Site 73
S1183
G
Q
I
E
F
D
I
S
E
P
E
V
A
A
T
Site 74
T1190
S
E
P
E
V
A
A
T
V
K
V
P
E
G
K
Site 75
Y1212
L
V
V
P
A
E
N
Y
D
Y
Q
I
L
H
K
Site 76
Y1214
V
P
A
E
N
Y
D
Y
Q
I
L
H
K
K
S
Site 77
S1221
Y
Q
I
L
H
K
K
S
M
D
K
S
L
E
F
Site 78
S1225
H
K
K
S
M
D
K
S
L
E
F
I
T
N
C
Site 79
T1230
D
K
S
L
E
F
I
T
N
C
G
K
N
S
F
Site 80
Y1238
N
C
G
K
N
S
F
Y
L
D
P
Q
T
A
S
Site 81
T1243
S
F
Y
L
D
P
Q
T
A
S
R
F
C
K
N
Site 82
S1251
A
S
R
F
C
K
N
S
A
R
S
L
V
A
F
Site 83
S1254
F
C
K
N
S
A
R
S
L
V
A
F
Y
H
K
Site 84
T1271
L
P
C
E
C
H
P
T
G
A
T
G
P
H
C
Site 85
S1279
G
A
T
G
P
H
C
S
P
E
G
G
Q
C
P
Site 86
T1301
R
Q
C
T
R
C
A
T
G
H
Y
G
F
P
R
Site 87
Y1304
T
R
C
A
T
G
H
Y
G
F
P
R
C
K
P
Site 88
T1332
Q
C
R
C
P
P
R
T
V
R
P
Q
C
E
V
Site 89
T1363
C
N
C
S
R
R
G
T
I
E
A
A
M
P
E
Site 90
Y1397
D
R
C
A
S
G
F
Y
R
F
P
E
C
V
P
Site 91
T1473
H
S
S
H
K
R
R
T
K
F
V
D
M
L
G
Site 92
S1494
D
R
V
D
I
P
V
S
F
N
P
G
S
N
S
Site 93
S1499
P
V
S
F
N
P
G
S
N
S
M
V
A
D
L
Site 94
S1501
S
F
N
P
G
S
N
S
M
V
A
D
L
Q
E
Site 95
T1512
D
L
Q
E
L
P
A
T
I
H
S
A
S
W
V
Site 96
S1517
P
A
T
I
H
S
A
S
W
V
A
P
T
S
Y
Site 97
S1523
A
S
W
V
A
P
T
S
Y
L
G
D
K
V
S
Site 98
Y1524
S
W
V
A
P
T
S
Y
L
G
D
K
V
S
S
Site 99
S1530
S
Y
L
G
D
K
V
S
S
Y
G
G
Y
L
T
Site 100
S1531
Y
L
G
D
K
V
S
S
Y
G
G
Y
L
T
Y
Site 101
Y1532
L
G
D
K
V
S
S
Y
G
G
Y
L
T
Y
Q
Site 102
Y1535
K
V
S
S
Y
G
G
Y
L
T
Y
Q
A
K
S
Site 103
T1537
S
S
Y
G
G
Y
L
T
Y
Q
A
K
S
F
G
Site 104
Y1538
S
Y
G
G
Y
L
T
Y
Q
A
K
S
F
G
L
Site 105
S1542
Y
L
T
Y
Q
A
K
S
F
G
L
P
G
D
M
Site 106
T1561
K
K
P
D
V
Q
L
T
G
Q
H
M
S
I
I
Site 107
Y1569
G
Q
H
M
S
I
I
Y
E
E
T
N
T
P
R
Site 108
T1572
M
S
I
I
Y
E
E
T
N
T
P
R
P
D
R
Site 109
T1574
I
I
Y
E
E
T
N
T
P
R
P
D
R
L
H
Site 110
S1596
E
G
N
F
R
H
A
S
S
R
A
P
V
S
R
Site 111
S1597
G
N
F
R
H
A
S
S
R
A
P
V
S
R
E
Site 112
S1602
A
S
S
R
A
P
V
S
R
E
E
L
M
T
V
Site 113
T1608
V
S
R
E
E
L
M
T
V
L
S
R
L
A
D
Site 114
Y1622
D
V
R
I
Q
G
L
Y
F
T
E
T
Q
R
L
Site 115
T1626
Q
G
L
Y
F
T
E
T
Q
R
L
T
L
S
E
Site 116
T1630
F
T
E
T
Q
R
L
T
L
S
E
V
G
L
E
Site 117
S1632
E
T
Q
R
L
T
L
S
E
V
G
L
E
E
A
Site 118
S1640
E
V
G
L
E
E
A
S
D
T
G
S
G
R
I
Site 119
T1642
G
L
E
E
A
S
D
T
G
S
G
R
I
A
L
Site 120
S1644
E
E
A
S
D
T
G
S
G
R
I
A
L
A
V
Site 121
S1664
P
P
A
Y
A
G
D
S
C
Q
G
C
S
P
G
Site 122
Y1672
C
Q
G
C
S
P
G
Y
Y
R
D
H
K
G
L
Site 123
Y1673
Q
G
C
S
P
G
Y
Y
R
D
H
K
G
L
Y
Site 124
Y1680
Y
R
D
H
K
G
L
Y
T
G
R
C
V
P
C
Site 125
T1681
R
D
H
K
G
L
Y
T
G
R
C
V
P
C
N
Site 126
Y1722
C
E
R
C
Q
E
G
Y
Y
G
N
A
V
H
G
Site 127
Y1723
E
R
C
Q
E
G
Y
Y
G
N
A
V
H
G
S
Site 128
T1739
R
A
C
P
C
P
H
T
N
S
F
A
T
G
C
Site 129
Y1773
C
E
R
C
A
P
G
Y
F
G
N
P
Q
K
F
Site 130
S1797
N
S
N
G
Q
L
G
S
C
H
P
L
T
G
D
Site 131
T1802
L
G
S
C
H
P
L
T
G
D
C
I
N
Q
E
Site 132
S1813
I
N
Q
E
P
K
D
S
S
P
A
E
E
C
D
Site 133
S1814
N
Q
E
P
K
D
S
S
P
A
E
E
C
D
D
Site 134
T1828
D
C
D
S
C
V
M
T
L
L
N
D
L
A
T
Site 135
T1835
T
L
L
N
D
L
A
T
M
G
E
Q
L
R
L
Site 136
S1845
E
Q
L
R
L
V
K
S
Q
L
Q
G
L
S
A
Site 137
S1851
K
S
Q
L
Q
G
L
S
A
S
A
G
L
L
E
Site 138
Y1877
L
R
N
Q
L
L
N
Y
R
S
A
I
S
N
H
Site 139
S1879
N
Q
L
L
N
Y
R
S
A
I
S
N
H
G
S
Site 140
S1886
S
A
I
S
N
H
G
S
K
I
E
G
L
E
R
Site 141
T1896
E
G
L
E
R
E
L
T
D
L
N
Q
E
F
E
Site 142
T1927
N
N
N
V
N
R
A
T
Q
S
A
K
E
L
D
Site 143
S1952
H
I
L
L
K
Q
I
S
G
T
D
G
E
G
N
Site 144
S1967
N
V
P
S
G
D
F
S
R
E
W
A
E
A
Q
Site 145
S1999
A
E
A
D
K
R
E
S
Q
L
L
L
N
R
I
Site 146
T2008
L
L
L
N
R
I
R
T
W
Q
K
T
H
Q
G
Site 147
T2012
R
I
R
T
W
Q
K
T
H
Q
G
E
N
N
G
Site 148
S2023
E
N
N
G
L
A
N
S
I
R
D
S
L
N
E
Site 149
S2027
L
A
N
S
I
R
D
S
L
N
E
Y
E
A
K
Site 150
Y2031
I
R
D
S
L
N
E
Y
E
A
K
L
S
D
L
Site 151
S2036
N
E
Y
E
A
K
L
S
D
L
R
A
R
L
Q
Site 152
S2075
R
Q
V
K
E
I
N
S
L
Q
S
D
F
T
K
Site 153
T2081
N
S
L
Q
S
D
F
T
K
Y
L
T
T
A
D
Site 154
Y2083
L
Q
S
D
F
T
K
Y
L
T
T
A
D
S
S
Site 155
T2085
S
D
F
T
K
Y
L
T
T
A
D
S
S
L
L
Site 156
T2086
D
F
T
K
Y
L
T
T
A
D
S
S
L
L
Q
Site 157
S2089
K
Y
L
T
T
A
D
S
S
L
L
Q
T
N
I
Site 158
S2090
Y
L
T
T
A
D
S
S
L
L
Q
T
N
I
A
Site 159
S2104
A
L
Q
L
M
E
K
S
Q
K
E
Y
E
K
L
Site 160
S2114
E
Y
E
K
L
A
A
S
L
N
E
A
R
Q
E
Site 161
S2123
N
E
A
R
Q
E
L
S
D
K
V
R
E
L
S
Site 162
S2130
S
D
K
V
R
E
L
S
R
S
A
G
K
T
S
Site 163
S2132
K
V
R
E
L
S
R
S
A
G
K
T
S
L
V
Site 164
T2136
L
S
R
S
A
G
K
T
S
L
V
E
E
A
E
Site 165
S2137
S
R
S
A
G
K
T
S
L
V
E
E
A
E
K
Site 166
S2164
E
E
I
K
R
N
A
S
G
D
E
L
V
R
C
Site 167
S2198
D
A
A
N
R
A
A
S
A
S
E
S
A
L
Q
Site 168
S2200
A
N
R
A
A
S
A
S
E
S
A
L
Q
T
V
Site 169
S2202
R
A
A
S
A
S
E
S
A
L
Q
T
V
I
K
Site 170
T2206
A
S
E
S
A
L
Q
T
V
I
K
E
D
L
P
Site 171
T2218
D
L
P
R
K
A
K
T
L
S
S
N
S
D
K
Site 172
S2220
P
R
K
A
K
T
L
S
S
N
S
D
K
L
L
Site 173
S2221
R
K
A
K
T
L
S
S
N
S
D
K
L
L
N
Site 174
S2242
K
K
L
K
Q
E
V
S
P
A
L
N
N
L
Q
Site 175
T2264
V
Q
K
E
V
I
D
T
N
L
T
T
L
R
D
Site 176
T2268
V
I
D
T
N
L
T
T
L
R
D
G
L
H
G
Site 177
S2286
G
D
I
D
A
M
I
S
S
A
K
S
M
V
R
Site 178
S2290
A
M
I
S
S
A
K
S
M
V
R
K
A
N
D
Site 179
T2299
V
R
K
A
N
D
I
T
D
E
V
L
D
G
L
Site 180
T2311
D
G
L
N
P
I
Q
T
D
V
E
R
I
K
D
Site 181
Y2320
V
E
R
I
K
D
T
Y
G
R
T
Q
N
E
D
Site 182
T2333
E
D
F
K
K
A
L
T
D
A
D
N
S
V
N
Site 183
S2338
A
L
T
D
A
D
N
S
V
N
K
L
T
N
K
Site 184
S2385
Q
Q
A
R
D
A
A
S
K
V
A
V
P
M
R
Site 185
S2397
P
M
R
F
N
G
K
S
G
V
E
V
R
L
P
Site 186
S2415
E
D
L
K
G
Y
T
S
L
S
L
F
L
Q
R
Site 187
S2417
L
K
G
Y
T
S
L
S
L
F
L
Q
R
P
N
Site 188
S2425
L
F
L
Q
R
P
N
S
R
E
N
G
G
T
E
Site 189
Y2448
N
K
D
A
S
R
D
Y
I
G
M
A
V
V
D
Site 190
Y2462
D
G
Q
L
T
C
V
Y
N
L
G
D
R
E
A
Site 191
S2480
V
D
Q
I
L
T
K
S
E
T
K
E
A
V
M
Site 192
T2482
Q
I
L
T
K
S
E
T
K
E
A
V
M
D
R
Site 193
Y2496
R
V
K
F
Q
R
I
Y
Q
F
A
R
L
N
Y
Site 194
Y2503
Y
Q
F
A
R
L
N
Y
T
K
G
A
T
S
S
Site 195
S2510
Y
T
K
G
A
T
S
S
K
P
E
T
P
G
V
Site 196
T2514
A
T
S
S
K
P
E
T
P
G
V
Y
D
M
D
Site 197
Y2518
K
P
E
T
P
G
V
Y
D
M
D
G
R
N
S
Site 198
S2525
Y
D
M
D
G
R
N
S
N
T
L
L
N
L
D
Site 199
Y2539
D
P
E
N
V
V
F
Y
V
G
G
Y
P
P
D
Site 200
S2551
P
P
D
F
K
L
P
S
R
L
S
F
P
P
Y
Site 201
S2554
F
K
L
P
S
R
L
S
F
P
P
Y
K
G
C
Site 202
Y2558
S
R
L
S
F
P
P
Y
K
G
C
I
E
L
D
Site 203
S2573
D
L
N
E
N
V
L
S
L
Y
N
F
K
K
T
Site 204
Y2575
N
E
N
V
L
S
L
Y
N
F
K
K
T
F
N
Site 205
T2580
S
L
Y
N
F
K
K
T
F
N
L
N
T
T
E
Site 206
T2585
K
K
T
F
N
L
N
T
T
E
V
E
P
C
R
Site 207
S2598
C
R
R
R
K
E
E
S
D
K
N
Y
F
E
G
Site 208
Y2602
K
E
E
S
D
K
N
Y
F
E
G
T
G
Y
A
Site 209
Y2608
N
Y
F
E
G
T
G
Y
A
R
V
P
T
Q
P
Site 210
T2613
T
G
Y
A
R
V
P
T
Q
P
H
A
P
I
P
Site 211
S2646
E
N
G
D
R
F
I
S
L
N
I
E
D
G
K
Site 212
Y2658
D
G
K
L
M
V
R
Y
K
L
N
S
E
L
P
Site 213
S2662
M
V
R
Y
K
L
N
S
E
L
P
K
E
R
G
Site 214
S2681
I
N
N
G
R
D
H
S
I
Q
I
K
I
G
K
Site 215
T2731
R
E
R
F
N
I
S
T
P
A
F
R
G
C
M
Site 216
T2757
L
N
D
T
V
G
V
T
K
K
C
S
E
D
W
Site 217
S2769
E
D
W
K
L
V
R
S
A
S
F
S
R
G
G
Site 218
S2771
W
K
L
V
R
S
A
S
F
S
R
G
G
Q
L
Site 219
S2773
L
V
R
S
A
S
F
S
R
G
G
Q
L
S
F
Site 220
S2779
F
S
R
G
G
Q
L
S
F
T
D
L
G
L
P
Site 221
T2781
R
G
G
Q
L
S
F
T
D
L
G
L
P
P
T
Site 222
T2788
T
D
L
G
L
P
P
T
D
H
L
Q
A
S
F
Site 223
S2794
P
T
D
H
L
Q
A
S
F
G
F
Q
T
F
Q
Site 224
S2803
G
F
Q
T
F
Q
P
S
G
I
L
L
D
H
Q
Site 225
T2811
G
I
L
L
D
H
Q
T
W
T
R
N
L
Q
V
Site 226
T2819
W
T
R
N
L
Q
V
T
L
E
D
G
Y
I
E
Site 227
Y2824
Q
V
T
L
E
D
G
Y
I
E
L
S
T
S
D
Site 228
S2828
E
D
G
Y
I
E
L
S
T
S
D
S
G
S
P
Site 229
T2829
D
G
Y
I
E
L
S
T
S
D
S
G
S
P
I
Site 230
S2830
G
Y
I
E
L
S
T
S
D
S
G
S
P
I
F
Site 231
S2832
I
E
L
S
T
S
D
S
G
S
P
I
F
K
S
Site 232
S2834
L
S
T
S
D
S
G
S
P
I
F
K
S
P
Q
Site 233
S2839
S
G
S
P
I
F
K
S
P
Q
T
Y
M
D
G
Site 234
T2842
P
I
F
K
S
P
Q
T
Y
M
D
G
L
L
H
Site 235
Y2843
I
F
K
S
P
Q
T
Y
M
D
G
L
L
H
Y
Site 236
S2852
D
G
L
L
H
Y
V
S
V
I
S
D
N
S
G
Site 237
S2872
D
D
Q
L
L
R
N
S
K
R
L
K
H
I
S
Site 238
S2879
S
K
R
L
K
H
I
S
S
S
R
Q
S
L
R
Site 239
S2880
K
R
L
K
H
I
S
S
S
R
Q
S
L
R
L
Site 240
S2881
R
L
K
H
I
S
S
S
R
Q
S
L
R
L
G
Site 241
S2884
H
I
S
S
S
R
Q
S
L
R
L
G
G
S
N
Site 242
S2890
Q
S
L
R
L
G
G
S
N
F
E
G
C
I
S
Site 243
T2914
S
P
E
V
L
D
L
T
S
N
S
L
K
R
D
Site 244
S2917
V
L
D
L
T
S
N
S
L
K
R
D
V
S
L
Site 245
S2923
N
S
L
K
R
D
V
S
L
G
G
C
S
L
N
Site 246
S2941
F
L
M
L
L
K
G
S
T
R
F
N
K
T
K
Site 247
T2949
T
R
F
N
K
T
K
T
F
R
I
N
Q
L
L
Site 248
T2959
I
N
Q
L
L
Q
D
T
P
V
A
S
P
R
S
Site 249
S2963
L
Q
D
T
P
V
A
S
P
R
S
V
K
V
W
Site 250
S2966
T
P
V
A
S
P
R
S
V
K
V
W
Q
D
A
Site 251
S2975
K
V
W
Q
D
A
C
S
P
L
P
K
T
Q
A
Site 252
T2980
A
C
S
P
L
P
K
T
Q
A
N
H
G
A
L
Site 253
S3010
Q
E
L
L
K
P
R
S
Q
F
A
V
D
M
Q
Site 254
T3018
Q
F
A
V
D
M
Q
T
T
S
S
R
G
L
V
Site 255
S3020
A
V
D
M
Q
T
T
S
S
R
G
L
V
F
H
Site 256
T3028
S
R
G
L
V
F
H
T
G
T
K
N
S
F
M
Site 257
S3033
F
H
T
G
T
K
N
S
F
M
A
L
Y
L
S
Site 258
S3059
G
K
K
L
R
I
K
S
K
E
K
C
N
D
G
Site 259
S3093
G
L
R
A
R
E
G
S
L
P
G
N
S
T
I
Site 260
S3098
E
G
S
L
P
G
N
S
T
I
S
I
R
A
P
Site 261
S3110
R
A
P
V
Y
L
G
S
P
P
S
G
K
P
K
Site 262
S3113
V
Y
L
G
S
P
P
S
G
K
P
K
S
L
P
Site 263
S3118
P
P
S
G
K
P
K
S
L
P
T
N
S
F
V
Site 264
T3121
G
K
P
K
S
L
P
T
N
S
F
V
G
C
L
Site 265
S3123
P
K
S
L
P
T
N
S
F
V
G
C
L
K
N
Site 266
S3135
L
K
N
F
Q
L
D
S
K
P
L
Y
T
P
S
Site 267
Y3139
Q
L
D
S
K
P
L
Y
T
P
S
S
S
F
G
Site 268
T3140
L
D
S
K
P
L
Y
T
P
S
S
S
F
G
V
Site 269
S3142
S
K
P
L
Y
T
P
S
S
S
F
G
V
S
S
Site 270
S3143
K
P
L
Y
T
P
S
S
S
F
G
V
S
S
C
Site 271
Y3160
G
P
L
E
K
G
I
Y
F
S
E
E
G
G
H
Site 272
S3162
L
E
K
G
I
Y
F
S
E
E
G
G
H
V
V
Site 273
S3185
P
E
F
K
L
V
F
S
I
R
P
R
S
L
T
Site 274
S3218
E
A
G
K
V
T
A
S
M
D
S
G
A
G
G
Site 275
S3221
K
V
T
A
S
M
D
S
G
A
G
G
T
S
T
Site 276
S3227
D
S
G
A
G
G
T
S
T
S
V
T
P
K
Q
Site 277
S3229
G
A
G
G
T
S
T
S
V
T
P
K
Q
S
L
Site 278
T3231
G
G
T
S
T
S
V
T
P
K
Q
S
L
C
D
Site 279
T3259
I
L
H
L
E
L
D
T
D
S
S
Y
T
A
G
Site 280
S3261
H
L
E
L
D
T
D
S
S
Y
T
A
G
Q
I
Site 281
S3262
L
E
L
D
T
D
S
S
Y
T
A
G
Q
I
P
Site 282
Y3263
E
L
D
T
D
S
S
Y
T
A
G
Q
I
P
F
Site 283
S3274
Q
I
P
F
P
P
A
S
T
Q
E
P
L
H
L
Site 284
T3275
I
P
F
P
P
A
S
T
Q
E
P
L
H
L
G
Site 285
S3326
L
E
V
Q
G
P
V
S
L
N
G
C
P
D
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation