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Updated November 2019
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Protein Info
Short Name:
PTPN21
Full Name:
Tyrosine-protein phosphatase non-receptor type 21
Alias:
EC 3.1.3.48; Protein tyrosine phosphatase, non-receptor type 21; Protein-tyrosine phosphatase D1; PTN21; PTPD1; PTPRL10; Tyrosine-protein phosphatase non-receptor type 21
Type:
EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Mass (Da):
133281
Number AA:
1174
UniProt ID:
Q16825
International Prot ID:
IPI00004388
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
F
G
L
K
L
K
R
T
R
R
Y
T
V
S
S
Site 2
Y15
K
L
K
R
T
R
R
Y
T
V
S
S
K
S
C
Site 3
T16
L
K
R
T
R
R
Y
T
V
S
S
K
S
C
L
Site 4
S18
R
T
R
R
Y
T
V
S
S
K
S
C
L
V
A
Site 5
S19
T
R
R
Y
T
V
S
S
K
S
C
L
V
A
R
Site 6
S21
R
Y
T
V
S
S
K
S
C
L
V
A
R
I
Q
Site 7
T38
N
N
E
F
V
E
F
T
L
S
V
E
S
T
G
Site 8
S40
E
F
V
E
F
T
L
S
V
E
S
T
G
Q
E
Site 9
T44
F
T
L
S
V
E
S
T
G
Q
E
S
L
E
A
Site 10
T62
R
L
E
L
R
E
V
T
Y
F
S
L
W
Y
Y
Site 11
Y63
L
E
L
R
E
V
T
Y
F
S
L
W
Y
Y
N
Site 12
Y68
V
T
Y
F
S
L
W
Y
Y
N
K
Q
N
Q
R
Site 13
Y69
T
Y
F
S
L
W
Y
Y
N
K
Q
N
Q
R
R
Site 14
Y91
L
K
K
Q
L
D
K
Y
A
L
E
P
T
V
Y
Site 15
Y118
L
Q
Q
E
I
T
R
Y
Q
Y
Y
L
Q
L
K
Site 16
Y120
Q
E
I
T
R
Y
Q
Y
Y
L
Q
L
K
K
D
Site 17
Y121
E
I
T
R
Y
Q
Y
Y
L
Q
L
K
K
D
I
Site 18
S132
K
K
D
I
L
E
G
S
I
P
C
T
L
E
Q
Site 19
Y158
D
F
G
D
F
D
Q
Y
E
S
Q
D
F
L
Q
Site 20
S160
G
D
F
D
Q
Y
E
S
Q
D
F
L
Q
K
F
Site 21
T199
H
Q
K
Y
R
G
L
T
A
P
D
A
E
M
L
Site 22
Y207
A
P
D
A
E
M
L
Y
M
Q
E
V
E
R
M
Site 23
Y217
E
V
E
R
M
D
G
Y
G
E
E
S
Y
P
A
Site 24
Y222
D
G
Y
G
E
E
S
Y
P
A
K
D
S
Q
G
Site 25
S227
E
S
Y
P
A
K
D
S
Q
G
S
D
I
S
I
Site 26
S230
P
A
K
D
S
Q
G
S
D
I
S
I
G
A
C
Site 27
S233
D
S
Q
G
S
D
I
S
I
G
A
C
L
E
G
Site 28
S267
A
N
M
S
H
N
K
S
F
F
A
L
E
L
A
Site 29
Y292
E
D
M
E
T
A
K
Y
I
W
R
L
C
V
A
Site 30
T315
Q
C
N
L
Q
T
Q
T
V
T
V
N
P
I
R
Site 31
T317
N
L
Q
T
Q
T
V
T
V
N
P
I
R
R
R
Site 32
S325
V
N
P
I
R
R
R
S
S
S
R
M
S
L
P
Site 33
S326
N
P
I
R
R
R
S
S
S
R
M
S
L
P
K
Site 34
S327
P
I
R
R
R
S
S
S
R
M
S
L
P
K
P
Site 35
S330
R
R
S
S
S
R
M
S
L
P
K
P
Q
P
Y
Site 36
Y337
S
L
P
K
P
Q
P
Y
V
M
P
P
P
P
Q
Site 37
Y351
Q
L
H
Y
N
G
H
Y
T
E
P
Y
A
S
S
Site 38
T352
L
H
Y
N
G
H
Y
T
E
P
Y
A
S
S
Q
Site 39
Y355
N
G
H
Y
T
E
P
Y
A
S
S
Q
D
N
L
Site 40
Y370
F
V
P
N
Q
N
G
Y
Y
C
H
S
Q
T
S
Site 41
Y371
V
P
N
Q
N
G
Y
Y
C
H
S
Q
T
S
L
Site 42
S374
Q
N
G
Y
Y
C
H
S
Q
T
S
L
D
R
A
Site 43
T376
G
Y
Y
C
H
S
Q
T
S
L
D
R
A
Q
I
Site 44
S377
Y
Y
C
H
S
Q
T
S
L
D
R
A
Q
I
D
Site 45
S393
N
G
R
I
R
N
G
S
V
Y
S
A
H
S
T
Site 46
Y395
R
I
R
N
G
S
V
Y
S
A
H
S
T
N
S
Site 47
S396
I
R
N
G
S
V
Y
S
A
H
S
T
N
S
L
Site 48
S399
G
S
V
Y
S
A
H
S
T
N
S
L
N
N
P
Site 49
T400
S
V
Y
S
A
H
S
T
N
S
L
N
N
P
Q
Site 50
S402
Y
S
A
H
S
T
N
S
L
N
N
P
Q
P
Y
Site 51
Y409
S
L
N
N
P
Q
P
Y
L
Q
P
S
P
M
S
Site 52
S413
P
Q
P
Y
L
Q
P
S
P
M
S
S
N
P
S
Site 53
S416
Y
L
Q
P
S
P
M
S
S
N
P
S
I
T
G
Site 54
S417
L
Q
P
S
P
M
S
S
N
P
S
I
T
G
S
Site 55
S420
S
P
M
S
S
N
P
S
I
T
G
S
D
V
M
Site 56
S424
S
N
P
S
I
T
G
S
D
V
M
R
P
D
Y
Site 57
Y431
S
D
V
M
R
P
D
Y
L
P
S
H
R
H
S
Site 58
S434
M
R
P
D
Y
L
P
S
H
R
H
S
A
V
I
Site 59
S438
Y
L
P
S
H
R
H
S
A
V
I
P
P
S
Y
Site 60
S444
H
S
A
V
I
P
P
S
Y
R
P
T
P
D
Y
Site 61
Y445
S
A
V
I
P
P
S
Y
R
P
T
P
D
Y
E
Site 62
T448
I
P
P
S
Y
R
P
T
P
D
Y
E
T
V
M
Site 63
Y451
S
Y
R
P
T
P
D
Y
E
T
V
M
K
Q
L
Site 64
T453
R
P
T
P
D
Y
E
T
V
M
K
Q
L
N
R
Site 65
S469
L
V
H
A
E
R
Q
S
H
S
L
R
N
L
N
Site 66
S471
H
A
E
R
Q
S
H
S
L
R
N
L
N
I
G
Site 67
S479
L
R
N
L
N
I
G
S
S
Y
A
Y
S
R
P
Site 68
S480
R
N
L
N
I
G
S
S
Y
A
Y
S
R
P
A
Site 69
Y483
N
I
G
S
S
Y
A
Y
S
R
P
A
A
L
V
Site 70
Y491
S
R
P
A
A
L
V
Y
S
Q
P
E
I
R
E
Site 71
S492
R
P
A
A
L
V
Y
S
Q
P
E
I
R
E
H
Site 72
S504
R
E
H
A
Q
L
P
S
P
A
A
A
H
C
P
Site 73
S515
A
H
C
P
F
S
L
S
Y
S
F
H
S
P
S
Site 74
Y516
H
C
P
F
S
L
S
Y
S
F
H
S
P
S
P
Site 75
S517
C
P
F
S
L
S
Y
S
F
H
S
P
S
P
Y
Site 76
S520
S
L
S
Y
S
F
H
S
P
S
P
Y
P
Y
P
Site 77
S522
S
Y
S
F
H
S
P
S
P
Y
P
Y
P
A
E
Site 78
Y524
S
F
H
S
P
S
P
Y
P
Y
P
A
E
R
R
Site 79
Y526
H
S
P
S
P
Y
P
Y
P
A
E
R
R
P
V
Site 80
S538
R
P
V
V
G
A
V
S
V
P
E
L
T
N
A
Site 81
T543
A
V
S
V
P
E
L
T
N
A
Q
L
Q
A
Q
Site 82
Y552
A
Q
L
Q
A
Q
D
Y
P
S
P
N
I
M
R
Site 83
S554
L
Q
A
Q
D
Y
P
S
P
N
I
M
R
T
Q
Site 84
T560
P
S
P
N
I
M
R
T
Q
V
Y
R
P
P
P
Site 85
Y563
N
I
M
R
T
Q
V
Y
R
P
P
P
P
Y
P
Site 86
Y569
V
Y
R
P
P
P
P
Y
P
P
P
R
P
A
N
Site 87
S577
P
P
P
R
P
A
N
S
T
P
D
L
S
R
H
Site 88
T578
P
P
R
P
A
N
S
T
P
D
L
S
R
H
L
Site 89
S582
A
N
S
T
P
D
L
S
R
H
L
Y
I
S
S
Site 90
Y586
P
D
L
S
R
H
L
Y
I
S
S
S
N
P
D
Site 91
S588
L
S
R
H
L
Y
I
S
S
S
N
P
D
L
I
Site 92
S589
S
R
H
L
Y
I
S
S
S
N
P
D
L
I
T
Site 93
S590
R
H
L
Y
I
S
S
S
N
P
D
L
I
T
R
Site 94
T596
S
S
N
P
D
L
I
T
R
R
V
H
H
S
V
Site 95
S602
I
T
R
R
V
H
H
S
V
Q
T
F
Q
E
D
Site 96
T605
R
V
H
H
S
V
Q
T
F
Q
E
D
S
L
P
Site 97
S610
V
Q
T
F
Q
E
D
S
L
P
V
A
H
S
L
Site 98
S616
D
S
L
P
V
A
H
S
L
Q
E
V
S
E
P
Site 99
T625
Q
E
V
S
E
P
L
T
A
A
R
H
A
Q
L
Site 100
S637
A
Q
L
H
K
R
N
S
I
E
V
A
G
L
S
Site 101
T656
G
L
R
L
K
E
R
T
L
S
A
S
A
A
E
Site 102
S658
R
L
K
E
R
T
L
S
A
S
A
A
E
V
A
Site 103
S660
K
E
R
T
L
S
A
S
A
A
E
V
A
P
R
Site 104
S670
E
V
A
P
R
A
V
S
V
G
S
Q
P
S
V
Site 105
S673
P
R
A
V
S
V
G
S
Q
P
S
V
F
T
E
Site 106
S676
V
S
V
G
S
Q
P
S
V
F
T
E
R
T
Q
Site 107
T679
G
S
Q
P
S
V
F
T
E
R
T
Q
R
E
G
Site 108
T682
P
S
V
F
T
E
R
T
Q
R
E
G
P
E
E
Site 109
Y695
E
E
A
E
G
L
R
Y
G
H
K
K
S
L
S
Site 110
S700
L
R
Y
G
H
K
K
S
L
S
D
A
T
M
L
Site 111
S702
Y
G
H
K
K
S
L
S
D
A
T
M
L
I
H
Site 112
S710
D
A
T
M
L
I
H
S
S
E
E
E
E
D
E
Site 113
S711
A
T
M
L
I
H
S
S
E
E
E
E
D
E
D
Site 114
S775
E
K
R
M
M
D
S
S
P
V
R
T
T
A
E
Site 115
T780
D
S
S
P
V
R
T
T
A
E
A
Q
R
P
W
Site 116
S795
R
D
G
L
L
M
P
S
M
S
E
S
D
L
T
Site 117
S797
G
L
L
M
P
S
M
S
E
S
D
L
T
T
S
Site 118
S799
L
M
P
S
M
S
E
S
D
L
T
T
S
G
R
Site 119
T802
S
M
S
E
S
D
L
T
T
S
G
R
Y
R
A
Site 120
T803
M
S
E
S
D
L
T
T
S
G
R
Y
R
A
R
Site 121
S804
S
E
S
D
L
T
T
S
G
R
Y
R
A
R
R
Site 122
S813
R
Y
R
A
R
R
D
S
L
K
K
R
P
V
S
Site 123
S820
S
L
K
K
R
P
V
S
D
L
L
S
G
K
K
Site 124
S824
R
P
V
S
D
L
L
S
G
K
K
N
I
V
E
Site 125
S863
A
L
N
G
L
S
L
S
R
V
P
L
P
D
E
Site 126
T879
K
E
V
A
T
R
A
T
N
D
E
R
C
K
I
Site 127
Y900
Q
G
M
V
F
T
E
Y
E
R
I
L
K
K
R
Site 128
T915
L
V
D
G
E
C
S
T
A
R
L
P
E
N
A
Site 129
T943
A
R
V
E
L
V
P
T
K
E
N
N
T
G
Y
Site 130
Y950
T
K
E
N
N
T
G
Y
I
N
A
S
H
I
K
Site 131
S954
N
T
G
Y
I
N
A
S
H
I
K
V
S
V
S
Site 132
S959
N
A
S
H
I
K
V
S
V
S
G
I
E
W
D
Site 133
S1007
E
E
G
G
R
E
K
S
F
R
Y
W
P
R
L
Site 134
Y1010
G
R
E
K
S
F
R
Y
W
P
R
L
G
S
R
Site 135
S1016
R
Y
W
P
R
L
G
S
R
H
N
T
V
T
Y
Site 136
T1020
R
L
G
S
R
H
N
T
V
T
Y
G
R
F
K
Site 137
T1022
G
S
R
H
N
T
V
T
Y
G
R
F
K
I
T
Site 138
Y1023
S
R
H
N
T
V
T
Y
G
R
F
K
I
T
T
Site 139
T1029
T
Y
G
R
F
K
I
T
T
R
F
R
T
D
S
Site 140
T1030
Y
G
R
F
K
I
T
T
R
F
R
T
D
S
G
Site 141
T1034
K
I
T
T
R
F
R
T
D
S
G
C
Y
A
T
Site 142
S1036
T
T
R
F
R
T
D
S
G
C
Y
A
T
T
G
Site 143
S1079
E
D
L
K
G
F
L
S
Y
L
E
E
I
Q
S
Site 144
S1086
S
Y
L
E
E
I
Q
S
V
R
R
H
T
N
S
Site 145
T1091
I
Q
S
V
R
R
H
T
N
S
T
S
D
P
Q
Site 146
S1093
S
V
R
R
H
T
N
S
T
S
D
P
Q
S
P
Site 147
T1094
V
R
R
H
T
N
S
T
S
D
P
Q
S
P
N
Site 148
S1095
R
R
H
T
N
S
T
S
D
P
Q
S
P
N
P
Site 149
S1099
N
S
T
S
D
P
Q
S
P
N
P
P
L
L
V
Site 150
Y1157
L
V
Q
T
L
C
Q
Y
T
F
V
Y
R
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation