PhosphoNET

           
Protein Info 
   
Short Name:  DUSP6
Full Name:  Dual specificity protein phosphatase 6
Alias:  Dual specificity phosphatase 6; Dual specificity protein phosphatase PYST1; DUS6; EC 3.1.3.16; EC 3.1.3.48; MAP kinase phosphatase 3; Mitogen-activated protein kinase phosphatase 3; MKP3; MKP-3; PYST1
Type:  Protein phosphatase, dual-specificity; EC 3.1.3.16; EC 3.1.3.48
Mass (Da):  42320
Number AA:  381
UniProt ID:  Q16828
International Prot ID:  IPI00004390
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0005654  GO:0005625 Uniprot OncoNet
Molecular Function:  GO:0017017  GO:0004722  GO:0004725 PhosphoSite+ KinaseNET
Biological Process:  GO:0000188  GO:0006470  GO:0000074 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T19SEMAISKTVAWLNEQ
Site 2Y45DCRPQELYESSHIES
Site 3S47RPQELYESSHIESAI
Site 4S52YESSHIESAINVAIP
Site 5T87GEDRDRFTRRCGTDT
Site 6T92RFTRRCGTDTVVLYD
Site 7T94TRRCGTDTVVLYDES
Site 8Y98GTDTVVLYDESSSDW
Site 9S101TVVLYDESSSDWNEN
Site 10S102VVLYDESSSDWNENT
Site 11S103VLYDESSSDWNENTG
Site 12T109SSDWNENTGGESVLG
Site 13Y131DEGCRAFYLEGGFSK
Site 14S137FYLEGGFSKFQAEFS
Site 15S144SKFQAEFSLHCETNL
Site 16S154CETNLDGSCSSSSPP
Site 17S156TNLDGSCSSSSPPLP
Site 18S157NLDGSCSSSSPPLPV
Site 19S159DGSCSSSSPPLPVLG
Site 20S173GLGGLRISSDSSSDI
Site 21S174LGGLRISSDSSSDIE
Site 22S176GLRISSDSSSDIESD
Site 23S177LRISSDSSSDIESDL
Site 24S178RISSDSSSDIESDLD
Site 25S182DSSSDIESDLDRDPN
Site 26S190DLDRDPNSATDSDGS
Site 27T192DRDPNSATDSDGSPL
Site 28S194DPNSATDSDGSPLSN
Site 29S197SATDSDGSPLSNSQP
Site 30S200DSDGSPLSNSQPSFP
Site 31S202DGSPLSNSQPSFPVE
Site 32S205PLSNSQPSFPVEILP
Site 33T223LGCAKDSTNLDVLEE
Site 34Y255ENAGEFKYKQIPISD
Site 35S277QFFPEAISFIDEARG
Site 36S300CLAGISRSVTVTVAY
Site 37Y320NLSMNDAYDIVKMKK
Site 38S328DIVKMKKSNISPNFN
Site 39S331KMKKSNISPNFNFMG
Site 40T346QLLDFERTLGLSSPC
Site 41S350FERTLGLSSPCDNRV
Site 42S351ERTLGLSSPCDNRVP
Site 43Y363RVPAQQLYFTTPSNQ
Site 44T366AQQLYFTTPSNQNVY
Site 45Y373TPSNQNVYQVDSLQS
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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