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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPRN
Full Name:
Receptor-type tyrosine-protein phosphatase-like N
Alias:
FLJ16131; IA2; IA-2; IA-2,PTP; ICA 512, Islet cell antigen 512; ICA3; ICA512; Islet cell autoantigen 3; R-PTP-N
Type:
Protein-tyrosine phosphatase (receptor)
Mass (Da):
105848
Number AA:
979
UniProt ID:
Q16849
International Prot ID:
IPI00004440
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005001
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
S
S
R
P
G
G
C
S
A
V
S
A
H
G
C
Site 2
S308
S
S
S
R
A
E
D
S
P
E
G
Y
E
K
E
Site 3
T625
E
G
A
H
G
D
T
T
F
E
Y
Q
D
L
C
Site 4
Y628
H
G
D
T
T
F
E
Y
Q
D
L
C
R
Q
H
Site 5
T638
L
C
R
Q
H
M
A
T
K
S
L
F
N
R
A
Site 6
S640
R
Q
H
M
A
T
K
S
L
F
N
R
A
E
G
Site 7
S652
A
E
G
P
P
E
P
S
R
V
S
S
V
S
S
Site 8
S655
P
P
E
P
S
R
V
S
S
V
S
S
Q
F
S
Site 9
S656
P
E
P
S
R
V
S
S
V
S
S
Q
F
S
D
Site 10
S658
P
S
R
V
S
S
V
S
S
Q
F
S
D
A
A
Site 11
S659
S
R
V
S
S
V
S
S
Q
F
S
D
A
A
Q
Site 12
S662
S
S
V
S
S
Q
F
S
D
A
A
Q
A
S
P
Site 13
S668
F
S
D
A
A
Q
A
S
P
S
S
H
S
S
T
Site 14
S670
D
A
A
Q
A
S
P
S
S
H
S
S
T
P
S
Site 15
S671
A
A
Q
A
S
P
S
S
H
S
S
T
P
S
W
Site 16
S673
Q
A
S
P
S
S
H
S
S
T
P
S
W
C
E
Site 17
S674
A
S
P
S
S
H
S
S
T
P
S
W
C
E
E
Site 18
T675
S
P
S
S
H
S
S
T
P
S
W
C
E
E
P
Site 19
S677
S
S
H
S
S
T
P
S
W
C
E
E
P
A
Q
Site 20
Y698
T
G
H
M
I
L
A
Y
M
E
D
H
L
R
N
Site 21
Y746
R
H
P
D
F
L
P
Y
D
H
A
R
I
K
L
Site 22
S757
R
I
K
L
K
V
E
S
S
P
S
R
S
D
Y
Site 23
S758
I
K
L
K
V
E
S
S
P
S
R
S
D
Y
I
Site 24
S760
L
K
V
E
S
S
P
S
R
S
D
Y
I
N
A
Site 25
S762
V
E
S
S
P
S
R
S
D
Y
I
N
A
S
P
Site 26
Y764
S
S
P
S
R
S
D
Y
I
N
A
S
P
I
I
Site 27
S768
R
S
D
Y
I
N
A
S
P
I
I
E
H
D
P
Site 28
Y780
H
D
P
R
M
P
A
Y
I
A
T
Q
G
P
L
Site 29
T783
R
M
P
A
Y
I
A
T
Q
G
P
L
S
H
T
Site 30
T790
T
Q
G
P
L
S
H
T
I
A
D
F
W
Q
M
Site 31
Y823
G
V
K
Q
C
D
R
Y
W
P
D
E
G
A
S
Site 32
Y832
P
D
E
G
A
S
L
Y
H
V
Y
E
V
N
L
Site 33
Y855
D
F
L
V
R
S
F
Y
L
K
N
V
Q
T
Q
Site 34
T868
T
Q
E
T
R
T
L
T
Q
F
H
F
L
S
W
Site 35
S874
L
T
Q
F
H
F
L
S
W
P
A
E
G
T
P
Site 36
T880
L
S
W
P
A
E
G
T
P
A
S
T
R
P
L
Site 37
S883
P
A
E
G
T
P
A
S
T
R
P
L
L
D
F
Site 38
Y898
R
R
K
V
N
K
C
Y
R
G
R
S
C
P
I
Site 39
Y919
G
A
G
R
T
G
T
Y
I
L
I
D
M
V
L
Site 40
T941
K
E
I
D
I
A
A
T
L
E
H
V
R
D
Q
Site 41
S955
Q
R
P
G
L
V
R
S
K
D
Q
F
E
F
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation