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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PFKFB3
Full Name:
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Alias:
6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; 6-phosphofructo-2-kinase; F263; Fructose-2,6-bisphosphatase; IPFK-2; PFK-2/FBPase-2, brain/placenta-type; PFKFB-3
Type:
EC 3.1.3.46; EC 2.7.1.105; Carbohydrate Metabolism - fructose and mannose; Phosphatase (non-protein); Kinase (non-protein)
Mass (Da):
59609
Number AA:
520
UniProt ID:
Q16875
International Prot ID:
IPI00004511
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003873
GO:0005524
GO:0004331
PhosphoSite+
KinaseNET
Biological Process:
GO:0006003
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
P
L
E
L
T
Q
S
R
V
Q
K
I
Site 2
S8
M
P
L
E
L
T
Q
S
R
V
Q
K
I
W
V
Site 3
S22
V
P
V
D
H
R
P
S
L
P
R
S
C
G
P
Site 4
S26
H
R
P
S
L
P
R
S
C
G
P
K
L
T
N
Site 5
T32
R
S
C
G
P
K
L
T
N
S
P
T
V
I
V
Site 6
T49
G
L
P
A
R
G
K
T
Y
I
S
K
K
L
T
Site 7
Y50
L
P
A
R
G
K
T
Y
I
S
K
K
L
T
R
Site 8
S52
A
R
G
K
T
Y
I
S
K
K
L
T
R
Y
L
Site 9
Y58
I
S
K
K
L
T
R
Y
L
N
W
I
G
V
P
Site 10
S83
R
E
A
V
K
Q
Y
S
S
Y
N
F
F
R
P
Site 11
S84
E
A
V
K
Q
Y
S
S
Y
N
F
F
R
P
D
Site 12
Y85
A
V
K
Q
Y
S
S
Y
N
F
F
R
P
D
N
Site 13
S112
A
A
L
R
D
V
K
S
Y
L
A
K
E
G
G
Site 14
Y113
A
L
R
D
V
K
S
Y
L
A
K
E
G
G
Q
Site 15
T129
A
V
F
D
A
T
N
T
T
R
E
R
R
H
M
Site 16
S172
I
M
E
V
K
I
S
S
P
D
Y
K
D
C
N
Site 17
Y175
V
K
I
S
S
P
D
Y
K
D
C
N
S
A
E
Site 18
Y194
F
M
K
R
I
S
C
Y
E
A
S
Y
Q
P
L
Site 19
S197
R
I
S
C
Y
E
A
S
Y
Q
P
L
D
P
D
Site 20
S211
D
K
C
D
R
D
L
S
L
I
K
V
I
D
V
Site 21
Y250
H
V
Q
P
R
T
I
Y
L
C
R
H
G
E
N
Site 22
S269
Q
G
R
I
G
G
D
S
G
L
S
S
R
G
K
Site 23
S272
I
G
G
D
S
G
L
S
S
R
G
K
K
F
A
Site 24
S273
G
G
D
S
G
L
S
S
R
G
K
K
F
A
S
Site 25
S283
K
K
F
A
S
A
L
S
K
F
V
E
E
Q
N
Site 26
T298
L
K
D
L
R
V
W
T
S
Q
L
K
S
T
I
Site 27
S299
K
D
L
R
V
W
T
S
Q
L
K
S
T
I
Q
Site 28
S303
V
W
T
S
Q
L
K
S
T
I
Q
T
A
E
A
Site 29
Y315
A
E
A
L
R
L
P
Y
E
Q
W
K
A
L
N
Site 30
Y334
G
V
C
E
E
L
T
Y
E
E
I
R
D
T
Y
Site 31
T340
T
Y
E
E
I
R
D
T
Y
P
E
E
Y
A
L
Site 32
Y341
Y
E
E
I
R
D
T
Y
P
E
E
Y
A
L
R
Site 33
Y353
A
L
R
E
Q
D
K
Y
Y
Y
R
Y
P
T
G
Site 34
Y354
L
R
E
Q
D
K
Y
Y
Y
R
Y
P
T
G
E
Site 35
Y355
R
E
Q
D
K
Y
Y
Y
R
Y
P
T
G
E
S
Site 36
Y357
Q
D
K
Y
Y
Y
R
Y
P
T
G
E
S
Y
Q
Site 37
T359
K
Y
Y
Y
R
Y
P
T
G
E
S
Y
Q
D
L
Site 38
Y363
R
Y
P
T
G
E
S
Y
Q
D
L
V
Q
R
L
Site 39
S403
L
A
Y
F
L
D
K
S
A
E
E
M
P
Y
L
Site 40
Y409
K
S
A
E
E
M
P
Y
L
K
C
P
L
H
T
Site 41
S431
A
Y
G
C
R
V
E
S
I
Y
L
N
V
E
S
Site 42
S438
S
I
Y
L
N
V
E
S
V
C
T
H
R
E
R
Site 43
T441
L
N
V
E
S
V
C
T
H
R
E
R
S
E
D
Site 44
S446
V
C
T
H
R
E
R
S
E
D
A
K
K
G
P
Site 45
S461
N
P
L
M
R
R
N
S
V
T
P
L
A
S
P
Site 46
T463
L
M
R
R
N
S
V
T
P
L
A
S
P
E
P
Site 47
S467
N
S
V
T
P
L
A
S
P
E
P
T
K
K
P
Site 48
T471
P
L
A
S
P
E
P
T
K
K
P
R
I
N
S
Site 49
S478
T
K
K
P
R
I
N
S
F
E
E
H
V
A
S
Site 50
S485
S
F
E
E
H
V
A
S
T
S
A
A
L
P
S
Site 51
T500
C
L
P
P
E
V
P
T
Q
L
P
G
Q
N
M
Site 52
S510
P
G
Q
N
M
K
G
S
R
S
S
A
D
S
S
Site 53
S512
Q
N
M
K
G
S
R
S
S
A
D
S
S
R
K
Site 54
S513
N
M
K
G
S
R
S
S
A
D
S
S
R
K
H
Site 55
S516
G
S
R
S
S
A
D
S
S
R
K
H
_
_
_
Site 56
S517
S
R
S
S
A
D
S
S
R
K
H
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation