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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PFKFB4
Full Name:
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Alias:
EC 2.7.1.105; EC 3.1.3.46; F264
Type:
Enzyme - metabolite kinase/phosphatase
Mass (Da):
54040
Number AA:
469
UniProt ID:
Q16877
International Prot ID:
IPI00220070
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003873
GO:0005524
GO:0004331
PhosphoSite+
KinaseNET
Biological Process:
GO:0006003
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
A
S
P
R
E
L
T
Q
N
P
L
K
K
I
Site 2
Y19
L
K
K
I
W
M
P
Y
S
N
G
R
P
A
L
Site 3
T53
G
L
P
A
R
G
K
T
Y
I
S
K
K
L
T
Site 4
Y54
L
P
A
R
G
K
T
Y
I
S
K
K
L
T
R
Site 5
S56
A
R
G
K
T
Y
I
S
K
K
L
T
R
Y
L
Site 6
Y62
I
S
K
K
L
T
R
Y
L
N
W
I
G
V
P
Site 7
Y78
R
E
F
N
V
G
Q
Y
R
R
D
V
V
K
T
Site 8
T85
Y
R
R
D
V
V
K
T
Y
K
S
F
E
F
F
Site 9
Y86
R
R
D
V
V
K
T
Y
K
S
F
E
F
F
L
Site 10
S88
D
V
V
K
T
Y
K
S
F
E
F
F
L
P
D
Site 11
S119
R
D
V
R
R
F
L
S
E
E
G
G
H
V
A
Site 12
T140
T
T
R
E
R
R
A
T
I
F
N
F
G
E
Q
Site 13
Y150
N
F
G
E
Q
N
G
Y
K
T
F
F
V
E
S
Site 14
T152
G
E
Q
N
G
Y
K
T
F
F
V
E
S
I
C
Site 15
S176
I
V
Q
V
K
L
G
S
P
D
Y
V
N
R
D
Site 16
Y179
V
K
L
G
S
P
D
Y
V
N
R
D
S
D
E
Site 17
S184
P
D
Y
V
N
R
D
S
D
E
A
T
E
D
F
Site 18
T188
N
R
D
S
D
E
A
T
E
D
F
M
R
R
I
Site 19
Y198
F
M
R
R
I
E
C
Y
E
N
S
Y
E
S
L
Site 20
S201
R
I
E
C
Y
E
N
S
Y
E
S
L
D
E
D
Site 21
S214
E
D
L
D
R
D
L
S
Y
I
K
I
M
D
V
Site 22
Y215
D
L
D
R
D
L
S
Y
I
K
I
M
D
V
G
Site 23
Y253
H
V
T
P
R
S
I
Y
L
C
R
H
G
E
S
Site 24
S275
I
G
G
D
P
G
L
S
P
R
G
R
E
F
A
Site 25
S284
R
G
R
E
F
A
K
S
L
A
Q
F
I
S
D
Site 26
S290
K
S
L
A
Q
F
I
S
D
Q
N
I
K
D
L
Site 27
Y337
G
V
C
E
E
M
T
Y
E
E
I
Q
D
N
Y
Site 28
Y344
Y
E
E
I
Q
D
N
Y
P
L
E
F
A
L
R
Site 29
Y356
A
L
R
D
Q
D
K
Y
R
Y
R
Y
P
K
G
Site 30
Y358
R
D
Q
D
K
Y
R
Y
R
Y
P
K
G
E
S
Site 31
Y360
Q
D
K
Y
R
Y
R
Y
P
K
G
E
S
Y
E
Site 32
Y412
K
A
A
E
Q
L
P
Y
L
K
C
P
L
H
T
Site 33
T444
L
N
V
A
A
V
N
T
H
R
D
R
P
Q
N
Site 34
S455
R
P
Q
N
V
D
I
S
R
P
P
E
E
A
L
Site 35
T464
P
P
E
E
A
L
V
T
V
P
A
H
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation