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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRXR1
Full Name:
Thioredoxin reductase 1, cytoplasmic
Alias:
GRIM-12; Thioredoxin reductase 1; Thioredoxin reductase, cytoplasmic precursor; TR; TR1; Trxr1; TXNR; TXNRD1
Type:
Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; Oxidoreductase; EC 1.8.1.9
Mass (Da):
70906
Number AA:
649
UniProt ID:
Q16881
International Prot ID:
IPI00554786
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0050660
GO:0050661
GO:0009055
PhosphoSite+
KinaseNET
Biological Process:
GO:0045454
GO:0022900
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
N
G
D
G
R
R
R
S
A
K
D
H
H
P
G
Site 2
T39
K
D
H
H
P
G
K
T
L
P
E
N
P
A
G
Site 3
S55
T
S
T
A
T
A
D
S
R
A
L
L
Q
A
Y
Site 4
T80
R
S
T
C
T
R
C
T
E
V
K
K
L
F
K
Site 5
T101
F
V
L
E
L
D
Q
T
E
D
G
R
A
L
E
Site 6
T110
D
G
R
A
L
E
G
T
L
S
E
L
A
A
E
Site 7
S112
R
A
L
E
G
T
L
S
E
L
A
A
E
T
D
Site 8
Y140
H
G
P
T
L
K
A
Y
Q
E
G
R
L
Q
K
Site 9
S160
G
P
E
D
L
P
K
S
Y
D
Y
D
L
I
I
Site 10
Y161
P
E
D
L
P
K
S
Y
D
Y
D
L
I
I
I
Site 11
Y163
D
L
P
K
S
Y
D
Y
D
L
I
I
I
G
G
Site 12
Y184
A
A
K
E
A
A
Q
Y
G
K
K
V
M
V
L
Site 13
S233
L
G
Q
A
L
Q
D
S
R
N
Y
G
W
K
V
Site 14
Y236
A
L
Q
D
S
R
N
Y
G
W
K
V
E
E
T
Site 15
Y266
I
G
S
L
N
W
G
Y
R
V
A
L
R
E
K
Site 16
Y277
L
R
E
K
K
V
V
Y
E
N
A
Y
G
Q
F
Site 17
Y281
K
V
V
Y
E
N
A
Y
G
Q
F
I
G
P
H
Site 18
S303
K
G
K
E
K
I
Y
S
A
E
R
F
L
I
A
Site 19
T311
A
E
R
F
L
I
A
T
G
E
R
P
R
Y
L
Site 20
Y317
A
T
G
E
R
P
R
Y
L
G
I
P
G
D
K
Site 21
Y326
G
I
P
G
D
K
E
Y
C
I
S
S
D
D
L
Site 22
S329
G
D
K
E
Y
C
I
S
S
D
D
L
F
S
L
Site 23
S330
D
K
E
Y
C
I
S
S
D
D
L
F
S
L
P
Site 24
S335
I
S
S
D
D
L
F
S
L
P
Y
C
P
G
K
Site 25
T413
V
E
Q
I
E
A
G
T
P
G
R
L
R
V
V
Site 26
S423
R
L
R
V
V
A
Q
S
T
N
S
E
E
I
I
Site 27
Y434
E
E
I
I
E
G
E
Y
N
T
V
M
L
A
I
Site 28
T447
A
I
G
R
D
A
C
T
R
K
I
G
L
E
T
Site 29
T454
T
R
K
I
G
L
E
T
V
G
V
K
I
N
E
Site 30
T469
K
T
G
K
I
P
V
T
D
E
E
Q
T
N
V
Site 31
Y478
E
E
Q
T
N
V
P
Y
I
Y
A
I
G
D
I
Site 32
S511
A
Q
R
L
Y
A
G
S
T
V
K
C
D
Y
E
Site 33
Y517
G
S
T
V
K
C
D
Y
E
N
V
P
T
T
V
Site 34
T522
C
D
Y
E
N
V
P
T
T
V
F
T
P
L
E
Site 35
T523
D
Y
E
N
V
P
T
T
V
F
T
P
L
E
Y
Site 36
Y552
G
E
E
N
I
E
V
Y
H
S
Y
F
W
P
L
Site 37
Y555
N
I
E
V
Y
H
S
Y
F
W
P
L
E
W
T
Site 38
Y572
S
R
D
N
N
K
C
Y
A
K
I
I
C
N
T
Site 39
S617
L
T
K
K
Q
L
D
S
T
I
G
I
H
P
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation