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Updated November 2019
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Protein Info
Short Name:
TPRXL
Full Name:
Putative protein TPRXL
Alias:
Type:
Mass (Da):
24139
Number AA:
258
UniProt ID:
Q17RH7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
D
K
S
W
R
R
C
S
I
S
G
S
T
K
C
Site 2
S15
R
R
C
S
I
S
G
S
T
K
C
R
C
G
S
Site 3
S22
S
T
K
C
R
C
G
S
R
I
A
G
P
N
A
Site 4
S32
A
G
P
N
A
L
G
S
G
G
S
R
S
S
S
Site 5
S35
N
A
L
G
S
G
G
S
R
S
S
S
S
S
S
Site 6
S37
L
G
S
G
G
S
R
S
S
S
S
S
S
R
S
Site 7
S38
G
S
G
G
S
R
S
S
S
S
S
S
R
S
I
Site 8
S39
S
G
G
S
R
S
S
S
S
S
S
R
S
I
L
Site 9
S40
G
G
S
R
S
S
S
S
S
S
R
S
I
L
S
Site 10
S41
G
S
R
S
S
S
S
S
S
R
S
I
L
S
S
Site 11
S42
S
R
S
S
S
S
S
S
R
S
I
L
S
S
S
Site 12
S44
S
S
S
S
S
S
R
S
I
L
S
S
S
I
L
Site 13
S47
S
S
S
R
S
I
L
S
S
S
I
L
S
S
S
Site 14
S53
L
S
S
S
I
L
S
S
S
I
P
S
S
S
S
Site 15
S54
S
S
S
I
L
S
S
S
I
P
S
S
S
S
S
Site 16
S57
I
L
S
S
S
I
P
S
S
S
S
S
S
S
S
Site 17
S58
L
S
S
S
I
P
S
S
S
S
S
S
S
S
P
Site 18
S59
S
S
S
I
P
S
S
S
S
S
S
S
S
P
S
Site 19
S60
S
S
I
P
S
S
S
S
S
S
S
S
P
S
S
Site 20
S61
S
I
P
S
S
S
S
S
S
S
S
P
S
S
S
Site 21
S62
I
P
S
S
S
S
S
S
S
S
P
S
S
S
H
Site 22
S63
P
S
S
S
S
S
S
S
S
P
S
S
S
H
S
Site 23
S64
S
S
S
S
S
S
S
S
P
S
S
S
H
S
S
Site 24
S66
S
S
S
S
S
S
P
S
S
S
H
S
S
S
S
Site 25
S67
S
S
S
S
S
P
S
S
S
H
S
S
S
S
P
Site 26
S68
S
S
S
S
P
S
S
S
H
S
S
S
S
P
S
Site 27
S70
S
S
P
S
S
S
H
S
S
S
S
P
S
S
S
Site 28
S71
S
P
S
S
S
H
S
S
S
S
P
S
S
S
H
Site 29
S72
P
S
S
S
H
S
S
S
S
P
S
S
S
H
S
Site 30
S73
S
S
S
H
S
S
S
S
P
S
S
S
H
S
S
Site 31
S75
S
H
S
S
S
S
P
S
S
S
H
S
S
S
S
Site 32
S76
H
S
S
S
S
P
S
S
S
H
S
S
S
S
P
Site 33
S80
S
P
S
S
S
H
S
S
S
S
P
S
S
S
S
Site 34
S81
P
S
S
S
H
S
S
S
S
P
S
S
S
S
S
Site 35
S82
S
S
S
H
S
S
S
S
P
S
S
S
S
S
T
Site 36
S84
S
H
S
S
S
S
P
S
S
S
S
S
T
S
S
Site 37
S85
H
S
S
S
S
P
S
S
S
S
S
T
S
S
P
Site 38
S86
S
S
S
S
P
S
S
S
S
S
T
S
S
P
S
Site 39
S87
S
S
S
P
S
S
S
S
S
T
S
S
P
S
S
Site 40
S88
S
S
P
S
S
S
S
S
T
S
S
P
S
S
S
Site 41
T89
S
P
S
S
S
S
S
T
S
S
P
S
S
S
S
Site 42
S90
P
S
S
S
S
S
T
S
S
P
S
S
S
S
S
Site 43
S91
S
S
S
S
S
T
S
S
P
S
S
S
S
S
S
Site 44
S93
S
S
S
T
S
S
P
S
S
S
S
S
S
S
S
Site 45
S94
S
S
T
S
S
P
S
S
S
S
S
S
S
S
S
Site 46
S95
S
T
S
S
P
S
S
S
S
S
S
S
S
S
S
Site 47
S96
T
S
S
P
S
S
S
S
S
S
S
S
S
S
S
Site 48
S97
S
S
P
S
S
S
S
S
S
S
S
S
S
S
P
Site 49
S98
S
P
S
S
S
S
S
S
S
S
S
S
S
P
S
Site 50
S99
P
S
S
S
S
S
S
S
S
S
S
S
P
S
S
Site 51
S101
S
S
S
S
S
S
S
S
S
S
P
S
S
S
N
Site 52
S102
S
S
S
S
S
S
S
S
S
P
S
S
S
N
S
Site 53
S103
S
S
S
S
S
S
S
S
P
S
S
S
N
S
S
Site 54
S105
S
S
S
S
S
S
P
S
S
S
N
S
S
S
S
Site 55
S106
S
S
S
S
S
P
S
S
S
N
S
S
S
S
S
Site 56
S107
S
S
S
S
P
S
S
S
N
S
S
S
S
S
S
Site 57
S109
S
S
P
S
S
S
N
S
S
S
S
S
S
S
S
Site 58
S110
S
P
S
S
S
N
S
S
S
S
S
S
S
S
S
Site 59
S111
P
S
S
S
N
S
S
S
S
S
S
S
S
S
P
Site 60
S112
S
S
S
N
S
S
S
S
S
S
S
S
S
P
S
Site 61
S113
S
S
N
S
S
S
S
S
S
S
S
S
P
S
S
Site 62
S114
S
N
S
S
S
S
S
S
S
S
S
P
S
S
S
Site 63
S115
N
S
S
S
S
S
S
S
S
S
P
S
S
S
S
Site 64
S116
S
S
S
S
S
S
S
S
S
P
S
S
S
S
S
Site 65
S117
S
S
S
S
S
S
S
S
P
S
S
S
S
S
S
Site 66
S119
S
S
S
S
S
S
P
S
S
S
S
S
S
S
S
Site 67
S120
S
S
S
S
S
P
S
S
S
S
S
S
S
S
S
Site 68
S121
S
S
S
S
P
S
S
S
S
S
S
S
S
S
S
Site 69
S122
S
S
S
P
S
S
S
S
S
S
S
S
S
S
P
Site 70
S123
S
S
P
S
S
S
S
S
S
S
S
S
S
P
S
Site 71
S124
S
P
S
S
S
S
S
S
S
S
S
S
P
S
S
Site 72
S125
P
S
S
S
S
S
S
S
S
S
S
P
S
S
S
Site 73
S126
S
S
S
S
S
S
S
S
S
S
P
S
S
S
S
Site 74
S130
S
S
S
S
S
S
P
S
S
S
S
S
S
P
S
Site 75
S131
S
S
S
S
S
P
S
S
S
S
S
S
P
S
S
Site 76
S132
S
S
S
S
P
S
S
S
S
S
S
P
S
S
S
Site 77
S133
S
S
S
P
S
S
S
S
S
S
P
S
S
S
S
Site 78
S134
S
S
P
S
S
S
S
S
S
P
S
S
S
S
S
Site 79
S135
S
P
S
S
S
S
S
S
P
S
S
S
S
S
S
Site 80
S158
S
S
S
P
S
S
S
S
S
S
S
S
S
S
S
Site 81
S159
S
S
P
S
S
S
S
S
S
S
S
S
S
S
S
Site 82
S160
S
P
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 83
S161
P
S
S
S
S
S
S
S
S
S
S
S
S
S
P
Site 84
S162
S
S
S
S
S
S
S
S
S
S
S
S
S
P
S
Site 85
S163
S
S
S
S
S
S
S
S
S
S
S
S
P
S
S
Site 86
S166
S
S
S
S
S
S
S
S
S
P
S
S
S
S
P
Site 87
S167
S
S
S
S
S
S
S
S
P
S
S
S
S
P
S
Site 88
S169
S
S
S
S
S
S
P
S
S
S
S
P
S
S
S
Site 89
S170
S
S
S
S
S
P
S
S
S
S
P
S
S
S
G
Site 90
S171
S
S
S
S
P
S
S
S
S
P
S
S
S
G
S
Site 91
S172
S
S
S
P
S
S
S
S
P
S
S
S
G
S
S
Site 92
S174
S
P
S
S
S
S
P
S
S
S
G
S
S
P
S
Site 93
S175
P
S
S
S
S
P
S
S
S
G
S
S
P
S
S
Site 94
S176
S
S
S
S
P
S
S
S
G
S
S
P
S
S
S
Site 95
S178
S
S
P
S
S
S
G
S
S
P
S
S
S
N
S
Site 96
S179
S
P
S
S
S
G
S
S
P
S
S
S
N
S
S
Site 97
S181
S
S
S
G
S
S
P
S
S
S
N
S
S
P
S
Site 98
S182
S
S
G
S
S
P
S
S
S
N
S
S
P
S
S
Site 99
S183
S
G
S
S
P
S
S
S
N
S
S
P
S
S
S
Site 100
S185
S
S
P
S
S
S
N
S
S
P
S
S
S
S
S
Site 101
S186
S
P
S
S
S
N
S
S
P
S
S
S
S
S
S
Site 102
S188
S
S
S
N
S
S
P
S
S
S
S
S
S
P
S
Site 103
S189
S
S
N
S
S
P
S
S
S
S
S
S
P
S
S
Site 104
S190
S
N
S
S
P
S
S
S
S
S
S
P
S
S
S
Site 105
S191
N
S
S
P
S
S
S
S
S
S
P
S
S
S
S
Site 106
S196
S
S
S
S
S
P
S
S
S
S
S
S
P
S
P
Site 107
S197
S
S
S
S
P
S
S
S
S
S
S
P
S
P
R
Site 108
S198
S
S
S
P
S
S
S
S
S
S
P
S
P
R
S
Site 109
S199
S
S
P
S
S
S
S
S
S
P
S
P
R
S
S
Site 110
S200
S
P
S
S
S
S
S
S
P
S
P
R
S
S
S
Site 111
S202
S
S
S
S
S
S
P
S
P
R
S
S
S
P
S
Site 112
S205
S
S
S
P
S
P
R
S
S
S
P
S
S
S
S
Site 113
S206
S
S
P
S
P
R
S
S
S
P
S
S
S
S
S
Site 114
S207
S
P
S
P
R
S
S
S
P
S
S
S
S
S
S
Site 115
S209
S
P
R
S
S
S
P
S
S
S
S
S
S
T
S
Site 116
S210
P
R
S
S
S
P
S
S
S
S
S
S
T
S
S
Site 117
S211
R
S
S
S
P
S
S
S
S
S
S
T
S
S
P
Site 118
S212
S
S
S
P
S
S
S
S
S
S
T
S
S
P
S
Site 119
S213
S
S
P
S
S
S
S
S
S
T
S
S
P
S
T
Site 120
S214
S
P
S
S
S
S
S
S
T
S
S
P
S
T
S
Site 121
T215
P
S
S
S
S
S
S
T
S
S
P
S
T
S
S
Site 122
S216
S
S
S
S
S
S
T
S
S
P
S
T
S
S
P
Site 123
S217
S
S
S
S
S
T
S
S
P
S
T
S
S
P
S
Site 124
S219
S
S
S
T
S
S
P
S
T
S
S
P
S
S
S
Site 125
T220
S
S
T
S
S
P
S
T
S
S
P
S
S
S
S
Site 126
S221
S
T
S
S
P
S
T
S
S
P
S
S
S
S
P
Site 127
S222
T
S
S
P
S
T
S
S
P
S
S
S
S
P
S
Site 128
S224
S
P
S
T
S
S
P
S
S
S
S
P
S
S
S
Site 129
S225
P
S
T
S
S
P
S
S
S
S
P
S
S
S
S
Site 130
S226
S
T
S
S
P
S
S
S
S
P
S
S
S
S
P
Site 131
S227
T
S
S
P
S
S
S
S
P
S
S
S
S
P
S
Site 132
S229
S
P
S
S
S
S
P
S
S
S
S
P
S
S
S
Site 133
S230
P
S
S
S
S
P
S
S
S
S
P
S
S
S
C
Site 134
S231
S
S
S
S
P
S
S
S
S
P
S
S
S
C
P
Site 135
S232
S
S
S
P
S
S
S
S
P
S
S
S
C
P
S
Site 136
S234
S
P
S
S
S
S
P
S
S
S
C
P
S
A
A
Site 137
S235
P
S
S
S
S
P
S
S
S
C
P
S
A
A
L
Site 138
S236
S
S
S
S
P
S
S
S
C
P
S
A
A
L
G
Site 139
S239
S
P
S
S
S
C
P
S
A
A
L
G
R
R
P
Site 140
S248
A
L
G
R
R
P
Q
S
P
Q
S
S
H
C
A
Site 141
S251
R
R
P
Q
S
P
Q
S
S
H
C
A
P
F
P
Site 142
S252
R
P
Q
S
P
Q
S
S
H
C
A
P
F
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation