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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
INSC
Full Name:
Protein inscuteable homolog
Alias:
Type:
Mass (Da):
63469
Number AA:
579
UniProt ID:
Q1MX18
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
P
G
N
G
E
A
A
S
E
G
P
G
G
W
G
Site 2
S59
P
G
G
R
H
L
D
S
V
T
L
P
G
Q
R
Site 3
T61
G
R
H
L
D
S
V
T
L
P
G
Q
R
L
H
Site 4
S74
L
H
L
M
Q
V
D
S
V
Q
R
W
M
E
D
Site 5
S100
V
L
Q
A
K
P
I
S
L
E
E
D
A
Q
G
Site 6
S132
L
K
R
G
W
V
I
S
T
E
L
R
R
I
G
Site 7
S152
D
R
W
A
R
V
H
S
M
S
V
R
L
T
C
Site 8
T158
H
S
M
S
V
R
L
T
C
H
A
R
S
M
V
Site 9
S163
R
L
T
C
H
A
R
S
M
V
S
E
Y
S
A
Site 10
S166
C
H
A
R
S
M
V
S
E
Y
S
A
V
S
R
Site 11
Y168
A
R
S
M
V
S
E
Y
S
A
V
S
R
N
S
Site 12
S169
R
S
M
V
S
E
Y
S
A
V
S
R
N
S
L
Site 13
S175
Y
S
A
V
S
R
N
S
L
K
E
M
G
E
I
Site 14
S249
L
V
R
K
I
D
A
S
D
N
I
Y
T
T
E
Site 15
Y253
I
D
A
S
D
N
I
Y
T
T
E
S
T
T
G
Site 16
S257
D
N
I
Y
T
T
E
S
T
T
G
N
L
F
S
Site 17
S264
S
T
T
G
N
L
F
S
L
T
Q
E
G
A
P
Site 18
Y298
Q
D
S
F
R
C
L
Y
P
Q
A
L
R
T
L
Site 19
T359
T
S
P
H
L
P
V
T
Q
H
L
S
S
F
L
Site 20
S363
L
P
V
T
Q
H
L
S
S
F
L
E
S
M
E
Site 21
S364
P
V
T
Q
H
L
S
S
F
L
E
S
M
E
E
Site 22
S424
R
V
L
L
E
A
C
S
D
K
Q
R
V
D
T
Site 23
T431
S
D
K
Q
R
V
D
T
P
Y
T
R
D
Q
I
Site 24
Y433
K
Q
R
V
D
T
P
Y
T
R
D
Q
I
V
T
Site 25
S453
S
V
L
E
Q
C
A
S
D
I
I
Q
E
N
G
Site 26
S469
Q
L
I
M
G
M
L
S
E
K
P
R
S
G
T
Site 27
S474
M
L
S
E
K
P
R
S
G
T
P
A
E
V
A
Site 28
T476
S
E
K
P
R
S
G
T
P
A
E
V
A
A
C
Site 29
T493
V
Q
Q
K
A
A
V
T
L
A
R
L
S
R
D
Site 30
S498
A
V
T
L
A
R
L
S
R
D
P
D
V
A
R
Site 31
S522
R
L
I
E
L
C
R
S
P
S
E
R
N
S
S
Site 32
S524
I
E
L
C
R
S
P
S
E
R
N
S
S
D
A
Site 33
S528
R
S
P
S
E
R
N
S
S
D
A
V
L
V
A
Site 34
S529
S
P
S
E
R
N
S
S
D
A
V
L
V
A
C
Site 35
S554
C
P
E
G
L
Q
D
S
D
F
Q
Q
L
V
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation