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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRRC36
Full Name:
Leucine-rich repeat-containing protein 36
Alias:
ROR gamma-binding protein 70
Type:
Mass (Da):
83823
Number AA:
754
UniProt ID:
Q1X8D7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
E
Q
P
E
L
V
E
S
L
S
L
Q
G
S
Y
Site 2
S30
P
E
L
V
E
S
L
S
L
Q
G
S
Y
A
G
Site 3
S34
E
S
L
S
L
Q
G
S
Y
A
G
K
I
H
S
Site 4
S41
S
Y
A
G
K
I
H
S
I
G
D
A
F
R
N
Site 5
S54
R
N
F
K
N
L
R
S
L
D
L
S
R
N
L
Site 6
S58
N
L
R
S
L
D
L
S
R
N
L
I
T
S
L
Site 7
S73
K
G
I
Q
Y
L
C
S
L
Q
D
L
N
L
Y
Site 8
Y80
S
L
Q
D
L
N
L
Y
Y
N
N
I
P
S
L
Site 9
T114
N
P
V
V
R
K
D
T
D
Y
R
L
F
A
V
Site 10
Y116
V
V
R
K
D
T
D
Y
R
L
F
A
V
Y
T
Site 11
Y122
D
Y
R
L
F
A
V
Y
T
L
Q
T
L
E
K
Site 12
T134
L
E
K
L
D
D
R
T
V
R
E
G
E
R
K
Site 13
S148
K
A
A
K
L
H
F
S
Q
L
G
N
S
E
N
Site 14
S153
H
F
S
Q
L
G
N
S
E
N
F
L
L
E
V
Site 15
S163
F
L
L
E
V
E
K
S
S
R
E
K
T
M
K
Site 16
T168
E
K
S
S
R
E
K
T
M
K
N
C
V
T
G
Site 17
T174
K
T
M
K
N
C
V
T
G
E
S
S
A
S
K
Site 18
S178
N
C
V
T
G
E
S
S
A
S
K
V
S
A
N
Site 19
S180
V
T
G
E
S
S
A
S
K
V
S
A
N
V
D
Site 20
S183
E
S
S
A
S
K
V
S
A
N
V
D
S
R
I
Site 21
S194
D
S
R
I
E
M
D
S
N
K
G
L
F
I
P
Site 22
S210
P
N
R
E
I
K
D
S
L
S
T
S
A
T
Q
Site 23
S212
R
E
I
K
D
S
L
S
T
S
A
T
Q
G
N
Site 24
S214
I
K
D
S
L
S
T
S
A
T
Q
G
N
G
T
Site 25
T216
D
S
L
S
T
S
A
T
Q
G
N
G
T
R
D
Site 26
T228
T
R
D
Q
K
L
D
T
F
P
L
G
T
Q
T
Site 27
S245
V
A
R
R
E
M
P
S
D
N
H
Q
E
D
E
Site 28
Y256
Q
E
D
E
F
R
H
Y
S
P
R
Q
S
T
V
Site 29
S257
E
D
E
F
R
H
Y
S
P
R
Q
S
T
V
R
Site 30
S261
R
H
Y
S
P
R
Q
S
T
V
R
S
P
E
K
Site 31
T262
H
Y
S
P
R
Q
S
T
V
R
S
P
E
K
M
Site 32
S265
P
R
Q
S
T
V
R
S
P
E
K
M
T
R
E
Site 33
Y274
E
K
M
T
R
E
G
Y
Q
V
S
F
L
D
N
Site 34
S277
T
R
E
G
Y
Q
V
S
F
L
D
N
K
S
S
Site 35
S283
V
S
F
L
D
N
K
S
S
G
S
S
P
E
K
Site 36
S284
S
F
L
D
N
K
S
S
G
S
S
P
E
K
E
Site 37
S287
D
N
K
S
S
G
S
S
P
E
K
E
L
I
P
Site 38
T298
E
L
I
P
K
P
D
T
F
H
L
T
H
D
A
Site 39
T302
K
P
D
T
F
H
L
T
H
D
A
S
L
S
K
Site 40
S308
L
T
H
D
A
S
L
S
K
C
L
D
V
G
D
Site 41
S316
K
C
L
D
V
G
D
S
S
Q
I
H
P
Y
Q
Site 42
S317
C
L
D
V
G
D
S
S
Q
I
H
P
Y
Q
L
Site 43
Y322
D
S
S
Q
I
H
P
Y
Q
L
P
S
D
V
G
Site 44
S326
I
H
P
Y
Q
L
P
S
D
V
G
L
E
N
Y
Site 45
Y333
S
D
V
G
L
E
N
Y
D
S
C
Y
S
Q
T
Site 46
S335
V
G
L
E
N
Y
D
S
C
Y
S
Q
T
L
S
Site 47
Y337
L
E
N
Y
D
S
C
Y
S
Q
T
L
S
L
H
Site 48
S338
E
N
Y
D
S
C
Y
S
Q
T
L
S
L
H
G
Site 49
T340
Y
D
S
C
Y
S
Q
T
L
S
L
H
G
S
L
Site 50
S342
S
C
Y
S
Q
T
L
S
L
H
G
S
L
G
K
Site 51
S346
Q
T
L
S
L
H
G
S
L
G
K
R
P
Q
R
Site 52
Y357
R
P
Q
R
S
K
N
Y
Q
E
Y
S
I
K
P
Site 53
S361
S
K
N
Y
Q
E
Y
S
I
K
P
S
N
D
I
Site 54
S365
Q
E
Y
S
I
K
P
S
N
D
I
K
T
T
A
Site 55
T370
K
P
S
N
D
I
K
T
T
A
S
H
S
C
G
Site 56
T371
P
S
N
D
I
K
T
T
A
S
H
S
C
G
D
Site 57
S373
N
D
I
K
T
T
A
S
H
S
C
G
D
L
L
Site 58
S375
I
K
T
T
A
S
H
S
C
G
D
L
L
T
S
Site 59
T381
H
S
C
G
D
L
L
T
S
L
S
N
P
D
S
Site 60
S382
S
C
G
D
L
L
T
S
L
S
N
P
D
S
S
Site 61
S384
G
D
L
L
T
S
L
S
N
P
D
S
S
T
G
Site 62
S388
T
S
L
S
N
P
D
S
S
T
G
R
L
L
K
Site 63
S389
S
L
S
N
P
D
S
S
T
G
R
L
L
K
L
Site 64
T390
L
S
N
P
D
S
S
T
G
R
L
L
K
L
S
Site 65
S397
T
G
R
L
L
K
L
S
S
D
L
Y
A
T
T
Site 66
S398
G
R
L
L
K
L
S
S
D
L
Y
A
T
T
H
Site 67
Y401
L
K
L
S
S
D
L
Y
A
T
T
H
F
N
S
Site 68
T404
S
S
D
L
Y
A
T
T
H
F
N
S
D
P
A
Site 69
S408
Y
A
T
T
H
F
N
S
D
P
A
V
L
V
N
Site 70
S421
V
N
V
E
Q
Q
L
S
T
S
L
D
D
L
T
Site 71
S423
V
E
Q
Q
L
S
T
S
L
D
D
L
T
P
A
Site 72
T428
S
T
S
L
D
D
L
T
P
A
H
G
S
V
P
Site 73
T449
N
R
T
T
P
L
R
T
L
L
L
S
P
G
T
Site 74
S453
P
L
R
T
L
L
L
S
P
G
T
S
E
H
R
Site 75
S457
L
L
L
S
P
G
T
S
E
H
R
K
I
F
T
Site 76
T464
S
E
H
R
K
I
F
T
K
R
S
L
S
P
S
Site 77
S467
R
K
I
F
T
K
R
S
L
S
P
S
K
R
G
Site 78
S469
I
F
T
K
R
S
L
S
P
S
K
R
G
F
K
Site 79
S471
T
K
R
S
L
S
P
S
K
R
G
F
K
W
K
Site 80
T495
K
H
G
F
Q
D
A
T
G
S
E
P
L
S
S
Site 81
S497
G
F
Q
D
A
T
G
S
E
P
L
S
S
D
L
Site 82
S501
A
T
G
S
E
P
L
S
S
D
L
G
S
L
H
Site 83
S502
T
G
S
E
P
L
S
S
D
L
G
S
L
H
G
Site 84
S506
P
L
S
S
D
L
G
S
L
H
G
L
A
G
N
Site 85
S515
H
G
L
A
G
N
H
S
P
P
I
S
A
R
T
Site 86
S519
G
N
H
S
P
P
I
S
A
R
T
P
H
V
A
Site 87
T527
A
R
T
P
H
V
A
T
V
L
R
Q
L
L
E
Site 88
S545
K
H
W
N
G
S
G
S
L
L
L
N
K
K
F
Site 89
S562
P
A
R
D
L
L
L
S
L
V
V
P
A
P
S
Site 90
S569
S
L
V
V
P
A
P
S
Q
P
R
C
C
S
H
Site 91
S575
P
S
Q
P
R
C
C
S
H
P
E
D
T
M
K
Site 92
S604
L
V
P
N
D
M
E
S
L
K
Q
K
L
V
R
Site 93
S620
L
E
E
N
L
I
L
S
E
K
I
Q
Q
L
E
Site 94
S640
S
I
V
S
G
Q
Q
S
H
T
Y
D
D
L
L
Site 95
T642
V
S
G
Q
Q
S
H
T
Y
D
D
L
L
H
K
Site 96
Y643
S
G
Q
Q
S
H
T
Y
D
D
L
L
H
K
N
Site 97
T673
Q
L
K
K
L
E
K
T
V
A
I
L
H
E
S
Site 98
S683
I
L
H
E
S
Q
R
S
L
V
V
T
N
E
Y
Site 99
T687
S
Q
R
S
L
V
V
T
N
E
Y
L
L
Q
Q
Site 100
Y690
S
L
V
V
T
N
E
Y
L
L
Q
Q
L
N
K
Site 101
Y702
L
N
K
E
P
K
G
Y
S
G
K
A
L
L
P
Site 102
S719
K
G
H
H
L
G
R
S
S
P
F
G
K
S
T
Site 103
S720
G
H
H
L
G
R
S
S
P
F
G
K
S
T
L
Site 104
S725
R
S
S
P
F
G
K
S
T
L
S
S
S
S
P
Site 105
T726
S
S
P
F
G
K
S
T
L
S
S
S
S
P
V
Site 106
S728
P
F
G
K
S
T
L
S
S
S
S
P
V
A
H
Site 107
S729
F
G
K
S
T
L
S
S
S
S
P
V
A
H
E
Site 108
S730
G
K
S
T
L
S
S
S
S
P
V
A
H
E
T
Site 109
S731
K
S
T
L
S
S
S
S
P
V
A
H
E
T
G
Site 110
S744
T
G
Q
Y
L
I
Q
S
V
L
D
A
A
P
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation