KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SCC-112
Full Name:
Sister chromatid cohesion protein PDS5 homolog A
Alias:
KIAA0648; PDS5, regulator of cohesion maintenance, A; PDS5A; PIG54; Sister chromatid cohesion protein 112
Type:
Cell cycle regulation
Mass (Da):
150830
Number AA:
1337
UniProt ID:
Q29RF7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y25
S
A
D
G
K
I
A
Y
P
P
G
V
K
E
I
Site 2
T51
R
L
K
M
V
V
K
T
F
M
D
M
D
Q
D
Site 3
Y66
S
E
D
E
K
Q
Q
Y
L
P
L
A
L
H
L
Site 4
T108
Y
A
P
E
A
P
Y
T
S
H
D
K
L
K
D
Site 5
T130
Q
L
K
G
L
E
D
T
K
S
P
Q
F
N
R
Site 6
S132
K
G
L
E
D
T
K
S
P
Q
F
N
R
Y
F
Site 7
Y138
K
S
P
Q
F
N
R
Y
F
Y
L
L
E
N
L
Site 8
Y140
P
Q
F
N
R
Y
F
Y
L
L
E
N
L
A
W
Site 9
S173
Q
L
F
R
T
L
F
S
V
I
N
N
S
H
N
Site 10
S192
M
H
M
L
D
L
M
S
S
I
I
M
E
G
D
Site 11
S193
H
M
L
D
L
M
S
S
I
I
M
E
G
D
G
Site 12
S224
H
K
N
L
N
K
Q
S
F
D
L
A
K
V
L
Site 13
S262
R
S
S
V
S
D
L
S
E
H
V
F
D
L
I
Site 14
S293
Q
L
E
F
K
L
K
S
N
D
G
E
E
R
L
Site 15
T319
S
K
D
S
D
L
A
T
Q
N
R
P
L
W
Q
Site 16
S343
H
V
P
V
R
L
E
S
V
K
F
A
S
H
C
Site 17
T362
P
D
L
A
K
D
L
T
E
Y
L
K
V
R
S
Site 18
Y364
L
A
K
D
L
T
E
Y
L
K
V
R
S
H
D
Site 19
S369
T
E
Y
L
K
V
R
S
H
D
P
E
E
A
I
Site 20
T407
L
G
F
V
R
E
R
T
L
D
K
R
W
R
V
Site 21
Y426
M
M
G
L
A
Q
L
Y
K
K
Y
C
L
H
G
Site 22
Y429
L
A
Q
L
Y
K
K
Y
C
L
H
G
E
A
G
Site 23
Y454
K
D
K
L
L
H
I
Y
Y
Q
N
S
I
D
D
Site 24
Y455
D
K
L
L
H
I
Y
Y
Q
N
S
I
D
D
K
Site 25
Y488
E
E
R
M
K
C
L
Y
Y
L
Y
A
S
L
D
Site 26
Y489
E
R
M
K
C
L
Y
Y
L
Y
A
S
L
D
P
Site 27
S514
K
C
Q
N
M
L
R
S
H
V
R
E
L
L
D
Site 28
S528
D
L
H
K
Q
P
T
S
E
A
N
C
S
A
M
Site 29
S533
P
T
S
E
A
N
C
S
A
M
F
G
K
L
M
Site 30
S571
G
D
D
E
K
L
R
S
Q
L
E
L
L
I
S
Site 31
S578
S
Q
L
E
L
L
I
S
P
T
C
S
C
K
Q
Site 32
S638
L
V
K
L
M
N
K
S
I
E
G
T
A
D
D
Site 33
S651
D
D
E
E
E
G
V
S
P
D
T
A
I
R
S
Site 34
T654
E
E
G
V
S
P
D
T
A
I
R
S
G
L
E
Site 35
S673
L
S
F
T
H
P
T
S
F
H
S
A
E
T
Y
Site 36
Y680
S
F
H
S
A
E
T
Y
E
S
L
L
Q
C
L
Site 37
S682
H
S
A
E
T
Y
E
S
L
L
Q
C
L
R
M
Site 38
T705
A
I
Q
I
F
R
N
T
G
H
K
I
E
T
D
Site 39
T732
H
Q
K
A
K
R
G
T
P
H
Q
A
K
Q
A
Site 40
S762
A
Q
I
F
E
P
L
S
R
S
L
N
A
D
V
Site 41
S764
I
F
E
P
L
S
R
S
L
N
A
D
V
P
E
Site 42
S793
L
A
P
D
Q
F
A
S
P
M
K
S
V
V
A
Site 43
S813
D
L
L
M
N
D
R
S
T
G
E
K
N
G
K
Site 44
T814
L
L
M
N
D
R
S
T
G
E
K
N
G
K
L
Site 45
S823
E
K
N
G
K
L
W
S
P
D
E
E
V
S
P
Site 46
S829
W
S
P
D
E
E
V
S
P
E
V
L
A
K
V
Site 47
S854
L
G
M
K
N
N
Q
S
K
S
A
N
S
T
L
Site 48
S856
M
K
N
N
Q
S
K
S
A
N
S
T
L
R
L
Site 49
S859
N
Q
S
K
S
A
N
S
T
L
R
L
L
S
A
Site 50
T860
Q
S
K
S
A
N
S
T
L
R
L
L
S
A
M
Site 51
S865
N
S
T
L
R
L
L
S
A
M
L
V
S
E
G
Site 52
S870
L
L
S
A
M
L
V
S
E
G
D
L
T
E
Q
Site 53
T875
L
V
S
E
G
D
L
T
E
Q
K
R
I
S
K
Site 54
S881
L
T
E
Q
K
R
I
S
K
S
D
M
S
R
L
Site 55
S883
E
Q
K
R
I
S
K
S
D
M
S
R
L
R
L
Site 56
S886
R
I
S
K
S
D
M
S
R
L
R
L
A
A
G
Site 57
S894
R
L
R
L
A
A
G
S
A
I
M
K
L
A
Q
Site 58
Y905
K
L
A
Q
E
P
C
Y
H
E
I
I
T
P
E
Site 59
T910
P
C
Y
H
E
I
I
T
P
E
Q
F
Q
L
C
Site 60
Y949
K
L
L
L
P
L
E
Y
M
A
I
F
A
L
C
Site 61
S977
Q
C
L
L
K
N
I
S
I
R
R
E
Y
I
K
Site 62
Y982
N
I
S
I
R
R
E
Y
I
K
Q
N
P
M
A
Site 63
S1018
H
D
P
D
F
T
R
S
Q
D
V
D
Q
L
R
Site 64
S1065
K
L
T
R
D
A
Q
S
P
D
E
S
K
T
N
Site 65
S1069
D
A
Q
S
P
D
E
S
K
T
N
E
K
L
Y
Site 66
T1071
Q
S
P
D
E
S
K
T
N
E
K
L
Y
T
V
Site 67
Y1076
S
K
T
N
E
K
L
Y
T
V
C
D
V
A
L
Site 68
S1097
S
A
L
C
N
A
D
S
P
K
D
P
V
L
P
Site 69
S1120
K
D
F
C
N
D
K
S
Y
I
S
E
E
T
R
Site 70
Y1121
D
F
C
N
D
K
S
Y
I
S
E
E
T
R
V
Site 71
T1132
E
T
R
V
L
L
L
T
G
K
P
K
P
A
G
Site 72
S1149
G
A
V
N
K
P
L
S
A
T
G
R
K
P
Y
Site 73
T1151
V
N
K
P
L
S
A
T
G
R
K
P
Y
V
R
Site 74
Y1156
S
A
T
G
R
K
P
Y
V
R
S
T
G
T
E
Site 75
S1159
G
R
K
P
Y
V
R
S
T
G
T
E
T
G
S
Site 76
T1160
R
K
P
Y
V
R
S
T
G
T
E
T
G
S
N
Site 77
T1162
P
Y
V
R
S
T
G
T
E
T
G
S
N
I
N
Site 78
S1172
G
S
N
I
N
V
N
S
E
L
N
P
S
T
G
Site 79
S1177
V
N
S
E
L
N
P
S
T
G
N
R
S
R
E
Site 80
T1178
N
S
E
L
N
P
S
T
G
N
R
S
R
E
Q
Site 81
S1182
N
P
S
T
G
N
R
S
R
E
Q
S
S
E
A
Site 82
S1186
G
N
R
S
R
E
Q
S
S
E
A
A
E
T
G
Site 83
S1187
N
R
S
R
E
Q
S
S
E
A
A
E
T
G
V
Site 84
T1192
Q
S
S
E
A
A
E
T
G
V
S
E
N
E
E
Site 85
S1195
E
A
A
E
T
G
V
S
E
N
E
E
N
P
V
Site 86
S1206
E
N
P
V
R
I
I
S
V
T
P
V
K
N
I
Site 87
T1208
P
V
R
I
I
S
V
T
P
V
K
N
I
D
P
Site 88
S1223
V
K
N
K
E
I
N
S
D
Q
A
T
Q
G
N
Site 89
T1227
E
I
N
S
D
Q
A
T
Q
G
N
I
S
S
D
Site 90
S1232
Q
A
T
Q
G
N
I
S
S
D
R
G
K
K
R
Site 91
S1233
A
T
Q
G
N
I
S
S
D
R
G
K
K
R
T
Site 92
T1240
S
D
R
G
K
K
R
T
V
T
A
A
G
A
E
Site 93
T1242
R
G
K
K
R
T
V
T
A
A
G
A
E
N
I
Site 94
S1260
T
D
E
K
V
D
E
S
G
P
P
A
P
S
K
Site 95
S1266
E
S
G
P
P
A
P
S
K
P
R
R
G
R
R
Site 96
S1276
R
R
G
R
R
P
K
S
E
S
Q
G
N
A
T
Site 97
S1278
G
R
R
P
K
S
E
S
Q
G
N
A
T
K
N
Site 98
S1305
R
A
A
V
G
Q
E
S
P
G
G
L
E
A
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation