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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FAM83E
Full Name:
Protein FAM83E
Alias:
Type:
Mass (Da):
51750
Number AA:
478
UniProt ID:
Q2M2I3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
A
A
L
E
G
V
D
S
G
P
R
V
P
G
A
Site 2
S22
G
P
R
V
P
G
A
S
P
G
F
L
Y
S
E
Site 3
S28
A
S
P
G
F
L
Y
S
E
G
Q
R
L
A
L
Site 4
T48
K
G
A
E
A
F
Q
T
C
V
Q
R
E
E
L
Site 5
S60
E
E
L
W
P
F
L
S
A
D
E
V
Q
G
L
Site 6
T75
A
A
A
A
E
D
W
T
V
A
K
Q
E
P
S
Site 7
T90
G
M
A
E
G
A
T
T
A
D
V
D
A
G
S
Site 8
S97
T
A
D
V
D
A
G
S
L
S
Y
W
P
G
Q
Site 9
S99
D
V
D
A
G
S
L
S
Y
W
P
G
Q
S
E
Site 10
Y100
V
D
A
G
S
L
S
Y
W
P
G
Q
S
E
Q
Site 11
S105
L
S
Y
W
P
G
Q
S
E
Q
P
A
P
V
L
Site 12
S120
R
L
G
W
P
V
D
S
A
W
K
G
I
T
R
Site 13
Y131
G
I
T
R
A
Q
L
Y
T
Q
P
P
G
E
G
Site 14
T132
I
T
R
A
Q
L
Y
T
Q
P
P
G
E
G
Q
Site 15
Y185
T
R
R
W
V
P
V
Y
L
L
L
D
R
Q
Q
Site 16
S222
V
R
V
V
R
G
C
S
F
Q
S
R
W
R
R
Site 17
S225
V
R
G
C
S
F
Q
S
R
W
R
R
Q
V
S
Site 18
S232
S
R
W
R
R
Q
V
S
G
T
V
R
E
K
F
Site 19
T234
W
R
R
Q
V
S
G
T
V
R
E
K
F
V
L
Site 20
S249
L
D
G
E
R
V
I
S
G
S
Y
S
F
T
W
Site 21
S251
G
E
R
V
I
S
G
S
Y
S
F
T
W
S
D
Site 22
S253
R
V
I
S
G
S
Y
S
F
T
W
S
D
A
R
Site 23
T255
I
S
G
S
Y
S
F
T
W
S
D
A
R
L
H
Site 24
S257
G
S
Y
S
F
T
W
S
D
A
R
L
H
R
G
Site 25
S300
P
A
P
P
Q
K
P
S
V
I
G
G
L
Q
R
Site 26
S310
G
G
L
Q
R
G
R
S
P
H
R
V
S
R
R
Site 27
S315
G
R
S
P
H
R
V
S
R
R
R
S
V
A
P
Site 28
S319
H
R
V
S
R
R
R
S
V
A
P
A
S
P
P
Site 29
S324
R
R
S
V
A
P
A
S
P
P
P
P
D
G
P
Site 30
T345
A
C
R
V
S
P
A
T
P
G
P
A
L
S
D
Site 31
T362
R
S
V
Q
R
A
R
T
P
S
G
P
P
A
R
Site 32
S364
V
Q
R
A
R
T
P
S
G
P
P
A
R
P
S
Site 33
S371
S
G
P
P
A
R
P
S
R
S
M
W
D
L
S
Site 34
S373
P
P
A
R
P
S
R
S
M
W
D
L
S
R
L
Site 35
S378
S
R
S
M
W
D
L
S
R
L
S
Q
L
S
G
Site 36
S381
M
W
D
L
S
R
L
S
Q
L
S
G
S
S
D
Site 37
S384
L
S
R
L
S
Q
L
S
G
S
S
D
G
D
N
Site 38
S396
G
D
N
E
L
K
K
S
W
G
S
K
D
T
P
Site 39
T402
K
S
W
G
S
K
D
T
P
A
K
A
L
M
R
Site 40
T413
A
L
M
R
Q
R
G
T
G
G
G
P
W
G
E
Site 41
S423
G
P
W
G
E
V
D
S
R
P
P
W
G
G
A
Site 42
Y441
P
P
A
H
R
L
R
Y
L
S
P
A
R
R
R
Site 43
S443
A
H
R
L
R
Y
L
S
P
A
R
R
R
F
G
Site 44
T454
R
R
F
G
G
D
A
T
F
K
L
Q
E
P
R
Site 45
S466
E
P
R
G
V
R
P
S
D
W
A
P
R
A
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation